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Cells
Special Issues
Immunoregulation in Cardiovascular Disease
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Immunoregulation in Cardiovascular Disease

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 10 November 2025 | Viewed by 593

Special Issue Editor

Prof. Dr. Hong Wang

E-Mail Website
Guest Editor
Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA
Interests: cardiovascular diseases; hyperlipidemia; hyperglycemia; hyperinsulinemia; hyperhomocysteinemia; obesity; vascular inflammation; diabetes; stroke; peripheral artery disease; myocardial infarction; chronic kidney disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue on “Immunoregulation in Cardiovascular Disease”. Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide. In recent years, there has been a growing recognition of the crucial role played by the immune system in the development and progression of CVDs.

This Special Issue aims to bring together the latest research on immunoregulation in cardiovascular disease, highlighting the complex interactions between the immune and cardiovascular systems. By understanding these interactions, we hope to identify new therapeutic targets and strategies for preventing and treating CVDs.

In this Special Issue, original research articles and comprehensive reviews are welcome. Research areas may include (but are not limited to) the following:

  • The role of immune cells, such as T, B, macrophages, and dendritic cells, in CVD pathogenesis and systemic inflammation.
  • Immune mediators, including cytokines, chemokines, and adhesion molecules, and their impact on cardiovascular function and systemic inflammation.
  • Mechanisms of immune regulation in atherosclerosis, myocardial infarction, heart failure, and systemic inflammation.
  • The interplay between innate and adaptive immunity in cardiovascular disease and systemic inflammation.
  • Immunomodulatory therapies for CVDs and systemic inflammation including anti-inflammatory drugs, immune checkpoint inhibitors, and cell-based therapies.
  • The role of the microbiome in modulating the immune response and cardiovascular health.
  • Epigenetic regulation of immune responses in CVDs and systemic inflammation.
  • Immune-related biomarkers and therapeutic targeting in CVDs and systemic inflammation.
  • The application of cellular methods/technologies in immune research.

We look forward to receiving your contributions.

Prof. Dr. Hong Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disease (CVD)
  • immunoregulation
  • inflammation
  • immune cells
  • immune mediators
  • immunomodulatory therapies
  • biomarkers
  • epigenetics
  • microbiome
  • cellular methods/technologies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

27 pages, 2444 KB  
Review
The Role of Neutrophil Extracellular Networks in Cardiovascular Pathology
by Zofia Szymańska, Antoni Staniewski, Michał Karpiński, Katarzyna Zalewska, Oliwia Kalus, Zofia Gramala, Joanna Maćkowiak, Sebastian Mertowski, Krzysztof J. Filipiak, Mansur Rahnama-Hezavah, Ewelina Grywalska and Tomasz Urbanowicz
Cells 2025, 14(19), 1562; https://doi.org/10.3390/cells14191562 - 8 Oct 2025
Viewed by 373
Abstract
Cardiovascular diseases (CVDs) are increasingly being defined not only in terms of metabolic or purely vascular disorders, but also as complex immunometabolic disorders. One of the most groundbreaking discoveries in recent years is the role of neutrophil extracellular networks (NETs/NENs) as a key [...] Read more.
Cardiovascular diseases (CVDs) are increasingly being defined not only in terms of metabolic or purely vascular disorders, but also as complex immunometabolic disorders. One of the most groundbreaking discoveries in recent years is the role of neutrophil extracellular networks (NETs/NENs) as a key link between chronic vascular wall inflammation and thrombotic processes. In this article, we present a synthetic overview of the latest data on the biology of NETs/NENs and their impact on the development of atherosclerosis, endothelial dysfunction, and the mechanisms of immunothrombosis. We highlight how these structures contribute to the weakening of atherosclerotic plaque stability, impaired endothelial barrier integrity, platelet activation, and the initiation of the coagulation cascade. We also discuss the modulating role of classic risk factors such as hypertension, dyslipidemia, and exposure to tobacco smoke, which may increase the formation or hinder the elimination of NETs/NENs. We also focus on the practical application of this knowledge: we present biomarkers associated with the presence of NETs/NENs (cfDNA, MPO–DNA complexes, CitH3, NE), which may be useful in diagnostics and risk stratification, and we discuss innovative therapeutic strategies. In addition to classic methods for indirectly inhibiting NET/NEN formation (antiplatelet, anti-inflammatory, and immunometabolic agents), we present experimental approaches aimed at their neutralization and removal (e.g., DNase I, elastase, and myeloperoxidase inhibitors). We pay particular attention to the context of cardiac and cardiac surgical procedures (Percutaneous Coronary Intervention-PCI, coronary artery bypass grafting-CABG), where rapid NET/NEN bursts can increase the risk of acute thrombotic complications. The overall evidence indicates that NETs/NENs represent an innovative and promising research and therapeutic target, allowing us to view cardiovascular diseases in a new light—as a dynamic interaction of inflammatory, atherosclerotic, and thrombotic processes. This opens up new possibilities in diagnostics, combination treatment and personalisation of therapy, although further research and standardization of detection methods remain necessary. Full article
(This article belongs to the Special Issue Immunoregulation in Cardiovascular Disease)
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