Caveolae Function in Cell Membrane Dynamics and Signal Transduction

Dear Colleagues,

The plasma membrane functions as a dynamic interface that preserves cellular integrity while coordinating signaling, endocytosis, mechanotransduction, and metabolic regulation. Within this context, caveolae are specialized flask-shaped invaginations enriched in cholesterol and sphingolipids, stabilized by caveolin and cavin complexes. Beyond their structural features, caveolae act as mechanosensitive hubs that coordinate extracellular cues and intracellular responses.

Membrane tension induces caveolar flattening and coat remodeling, releasing or reorganizing signaling molecules and thereby influencing cytoskeletal dynamics, transcriptional programs, and pathways controlling growth, metabolism, and survival. Recent evidence also implicates caveolae in lipid trafficking, vesicular transport, and the fine-tuning of membrane composition, reinforcing their central role in homeostasis.

Alterations in caveolar function contribute to a diverse range of human diseases, including muscular dystrophies, lipodystrophies, pulmonary hypertension, cardiomyopathies, and cancer, and they have increasingly recognized roles in metabolic, inflammatory, and fibrotic disorders. These associations underscore the importance of caveolae both as regulators of cell physiology and as potential therapeutic targets.

Further studies are needed to clarify the molecular mechanisms behind caveola-mediated signaling and the interplay between caveolae and other membrane microdomains. Innovations in imaging, cryo-EM, proteomics, and systems biology are leading to the development of powerful tools for addressing these questions and may reveal novel pathogenic mechanisms and therapeutic opportunities.

We invite original research articles, reviews, short communications, and perspectives addressing the molecular, cellular, physiological, and pathological roles of caveolae and plasma membrane dynamics. We are excited to receive your contribution and look forward to your participation in shaping this timely and pertinent Special Issue.

Dr. Alessio D'Alessio
Dr. Antonio Filippini
Guest Editor

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