Neurotoxicity: Focusing on Molecular and Cellular Mechanisms
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 October 2026 | Viewed by 81
Special Issue Editors
Interests: central nervous system; cerebellar cortex; sodium-potassium-exchanging ATPase; optic nerve; retina; dorsal root ganglia; cancer chemotherapy; glioblastoma (GBM)
Special Issues, Collections and Topics in MDPI journals
Interests: central nervous system; cerebellar cortex; dorsal root ganglia; neurotoxicity; cancer chemotherapy; glioblastoma (GBM); colorectal cancer; neuroinflammation
Interests: glioblastoma (GBM); neuroinflammation; cancer chemotherapy; oxidative stress; dorsal root ganglia; neurotoxicity; nuclear receptors
Special Issue Information
Dear Colleagues,
Neurotoxicity plays a critical role in the development and progression of many neurological disorders, arising from exposure to environmental pollutants, endogenous metabolites, or therapeutic compounds such as chemotherapeutic drugs. The cellular and molecular mechanisms of neurotoxicity encompass oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, neuroinflammation, and regulated forms of cell death. Despite growing evidence, the precise pathways driving neuronal vulnerability and damage remain incompletely understood, limiting the development of effective neuroprotective strategies. Advances in molecular and cellular biology now allow deeper insights into these mechanisms, offering opportunities to identify novel biomarkers and therapeutic targets. Understanding neurotoxicity is essential not only in elucidating the pathogenesis of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis, but also in addressing drug-induced and environmentally triggered neuropathologies.
This Special Issue will gather contributions that deepen our understanding of the fundamental processes underlying neuronal injury and dysfunction under physiological and pathological conditions. Bridging basic molecular mechanisms and translational applications is therefore of paramount importance to prevent and mitigate neuronal injury, preserve cognitive and sensory functions, and improve patient outcomes. We encourage researchers to submit manuscripts sharing mechanistic perspectives, experimental models, and translational insights related to neuronal injury, dysfunction, and protection.
Prof. Dr. Pablo Martín-Vasallo
Prof. Dr. Manuel José Morales
Dr. Rita Martín-Ramírez
Guest Editors
Manuscript Submission Information
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Keywords
- neurotoxicity
- neuroinflammation
- neurodegeneration
- chemotherapy-induced neuropathy
- neuroprotection
- neuronal injury
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