Regulation of Iron Homeostasis
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 20 May 2026 | Viewed by 1147
Special Issue Editor
Special Issue Information
Dear Colleagues,
Iron is an indispensable trace element required by virtually all living organisms. It functions predominantly within proteins as part of mononuclear iron, iron–sulfur clusters, or heme prosthetic groups, facilitating a broad spectrum of physiological processes, including DNA replication and repair, RNA synthesis and modification, amino acid biosynthesis, co-factor biosynthesis, energy metabolism, and signal transduction. Despite its essential role, excessive accumulation of intracellular iron is deleterious, as ferrous iron can catalyze the formation of reactive oxygen species through the Fenton reaction under aerobic conditions, thereby inducing oxidative cellular damage. To mitigate these detrimental effects and provide accessible iron, organisms have evolved intricate regulatory networks that tightly control iron homeostasis through the coordinated regulation of iron uptake, transport, and storage. This Special Issue will highlight recent advances in elucidating the molecular mechanisms that underlie cellular iron homeostasis.
Prof. Dr. Huangen Ding
Guest Editor
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Keywords
- iron homeostasis
- iron transport
- iron storage
- iron-containing proteins
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