From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 December 2025 | Viewed by 52
Special Issue Editors
Interests: asthma; chronic obstructive pulmonary disease (COPD); end-stage lung disease
Special Issue Information
Dear Colleagues,
The mitochondria are motile organelles having metabolic flexibility, which can adapt to energy requirements, stress stimulus, and to the maintenance of an invariable steady-state internal microenvironment. They are metabolic factories that participate in a wide range of significant activities, such as ATP synthesis, fatty acid oxidation, oxidative phosphorylation, calcium regulation, thermal regulation, and ROS generation. However, it is also important to note that the mitochondrial ROS are signaling molecules in immune defense, particularly in inflammatory pathways. Mitochondrial impairment has been related to many diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Most mitochondrial disorders are caused by mutations in mitochondrial DNA, or errors that disturb the delicate play of actions of the hundreds of proteins that are necessary to carry out mitochondrial structure and function, which are present throughout the body (and the body's primary energy source). Symptoms may also differ in type and severity based on the location in the body where the abnormal mitochondria are found and what organs are affected. These include organs with high energy demands, like the brain, heart, muscles, and sensory organs. Muscle weakness, neurologic impairment, sensory loss, heart failure, diabetes, and growth failure are common clinical phenotypes. An understanding of mitochondrial biology is important in the development of therapeutics for these polygenic systemic diseases.
Dr. Amy H. Attaway
Dr. Saurabh Mishra
Guest Editors
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Keywords
- mitochondrial oxidation
- ROS
- aging
- disease
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