From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 December 2025 | Viewed by 32
Special Issue Editors
Interests: asthma; chronic obstructive pulmonary disease (COPD); end-stage lung disease
Special Issue Information
Dear Colleagues,
The mitochondria are motile organelles having metabolic flexibility, which can adapt to energy requirements, stress stimulus, and to the maintenance of an invariable steady-state internal microenvironment. They are metabolic factories that participate in a wide range of significant activities, such as ATP synthesis, fatty acid oxidation, oxidative phosphorylation, calcium regulation, thermal regulation, and ROS generation. However, it is also important to note that the mitochondrial ROS are signaling molecules in immune defense, particularly in inflammatory pathways. Mitochondrial impairment has been related to many diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Most mitochondrial disorders are caused by mutations in mitochondrial DNA, or errors that disturb the delicate play of actions of the hundreds of proteins that are necessary to carry out mitochondrial structure and function, which are present throughout the body (and the body's primary energy source). Symptoms may also differ in type and severity based on the location in the body where the abnormal mitochondria are found and what organs are affected. These include organs with high energy demands, like the brain, heart, muscles, and sensory organs. Muscle weakness, neurologic impairment, sensory loss, heart failure, diabetes, and growth failure are common clinical phenotypes. An understanding of mitochondrial biology is important in the development of therapeutics for these polygenic systemic diseases.
Dr. Amy H. Attaway
Dr. Saurabh Mishra
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondrial oxidation
- ROS
- aging
- disease
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.