Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling
edited by Jianjie Ma, Long-Sheng Song, and
submission deadline 15 May 2026 | 2 articles | Viewed by 2312 | Submission Open
Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease
Placenta in Tissue Engineering and Regeneration
edited by
submission deadline 15 May 2026 | Viewed by 202 | Submission Open
Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration
Molecular and Translational Advances in Metastatic Breast Cancer Research
edited by
submission deadline 15 May 2026 | Viewed by 108 | Submission Open
Keywords: metastatic breast cancer; tumor microenvironment; therapeutic resistance; immunotherapy; targeted therapy; cancer biomarkers; personalized medicine; translational oncology; circulating tumor cells; molecular mechanisms of metastasis
The Role of Light in Ocular Health and Disease
edited by Krisztina Valter, and
submission deadline 15 May 2026 | Viewed by 96 | Submission Open
Keywords: light; photobiology; light exposure; circadian rhythms; vision; light-induced retinal damage; phototoxicity; photoprotection; retinal degeneration; light modulation; oxidative stress; light therapy; photobiomodulation; blue light effects; Protective wavelengths; harmful wavelengths; ocular phototransduction; light-based therapeutics
Molecular Pathogenesis and Novel Therapeutic Strategies in Chordoma
edited by , Patricia L Sullivan and Jeremy J Reynolds
submission deadline 15 May 2026 | Viewed by 14 | Submission Open
Keywords: chordoma; targeted therapy; brachyury; tumor microenvironment; epigenetics; immunotherapy; biomarkers; drug resistance; translational oncology; radiation resistance
Advances in Spermatogenesis—Second Edition
edited by and Changmin Niu
submission deadline 15 May 2026 | Submission Open
Keywords: spermatogenesis; mitosis; meiosis; spermiogenesis; omics; organoid culture; infertility; contraception
(This special issue belongs to the Section Reproductive Cells and Development)
Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition submission deadline 20 May 2026 | 6 articles | Viewed by 8274 | Submission Open
Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β
(This special issue belongs to the Section Cell Signaling)
Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery
edited by Roberta Montanari and
submission deadline 20 May 2026 | 1 articles | Viewed by 2748 | Submission Open
Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms
(This special issue belongs to the Section Cellular Biophysics)
Heparanase and Heparanase-2: Function, Regulation, Signaling, and Disease submission deadline 20 May 2026 | 1 articles | Viewed by 1607 | Submission Open
Keywords: heparanase (Hpa1); heparanase-2 (Hpa2); tumor microenvironment; extracellular matrix; tumor progression; tumor suppression; metastatic niche; glycocalyx; immune cells; inflammation
(This special issue belongs to the Section Cell Signaling)
The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses submission deadline 20 May 2026 | 2 articles | Viewed by 1596 | Submission Open
Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications
(This special issue belongs to the Section Cellular Pathology)
The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1358 | Submission Open
Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation
(This special issue belongs to the Section Tissues and Organs)
Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies
edited by , and Íñigo Casafont
submission deadline 20 May 2026 | Viewed by 285 | Submission Open
Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy
(This special issue belongs to the Section Cellular Metabolism)
New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets
edited by
submission deadline 20 May 2026 | Viewed by 230 | Submission Open
Keywords: cancer; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Immunology)
State-of-the-Art Insights into the Cell Microenvironment
edited by
submission deadline 20 May 2026 | Viewed by 159 | Submission Open
Keywords: cell microenvironment; stem cells; organoid and 3D culture models
(This special issue belongs to the Section Cell Microenvironment)
Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine
edited by Emanuela Mari
submission deadline 20 May 2026 | Viewed by 57 | Submission Open
Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome
(This special issue belongs to the Section Stem Cells)
Regulation of Iron Homeostasis
edited by
submission deadline 20 May 2026 | Viewed by 38 | Submission Open
Keywords: iron homeostasis; iron transport; iron storage; iron-containing proteins
Cellular and Molecular Basis of Sjögren’s Syndrome
edited by Muhammad Shahnawaz Soyfoo
submission deadline 20 May 2026 | Viewed by 36 | Submission Open
Keywords: Sjö gren disease; epithelial dysfunction; immune tolerance; autoimmunity
Molecular Pathogenesis of Ovarian Cancer and Therapeutic Strategies
edited by Jayakumar R. Nair
submission deadline 20 May 2026 | Viewed by 34 | Submission Open
Keywords: ovarian cancer; pathogenic mutations; target therapy; genetic heterogeneity                                 
(This special issue belongs to the Section Cellular Pathology)
Pathology and Therapies in Brain Tumor
edited by Bachuchu Lal
submission deadline 20 May 2026 | Viewed by 26 | Submission Open
Keywords: brain tumor; gliomas; target treatment; pathogenesis; animal models
(This special issue belongs to the Section Cellular Pathology)
Non-Coding and Coding RNAs in Targeted Cancer Therapy submission deadline 25 May 2026 | 4 articles | Viewed by 7645 | Submission Open
Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets
(This special issue belongs to the Section Cell and Gene Therapy)
Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory
edited by
submission deadline 25 May 2026 | 2 articles | Viewed by 5053 | Submission Open
Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity
(This special issue belongs to the Section Cells of the Nervous System)
Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition submission deadline 25 May 2026 | 2 articles | Viewed by 3655 | Submission Open
Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering
(This special issue belongs to the Section Stem Cells)
Recent Advances in Astrocyte Neuron Communication submission deadline 25 May 2026 | Viewed by 987 | Submission Open
Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity
(This special issue belongs to the Section Cells of the Nervous System)
Cell Therapy for Retinal Diseases submission deadline 25 May 2026 | Viewed by 393 | Submission Open
Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration
(This special issue belongs to the Section Tissues and Organs)
Cell Signaling in Neurodegeneration Disease
edited by , Yasuhiro Funahashi, , and Md-nadim Hossain
submission deadline 25 May 2026 | Viewed by 292 | Submission Open
Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience
(This special issue belongs to the Section Cells of the Nervous System)
Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury
edited by and Angela R. Filous
submission deadline 25 May 2026 | Viewed by 150 | Submission Open
Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia
Metabolic Regulation of Cell Behavior and Implications for Aging
edited by and José Antonio Rodríguez Navarro
submission deadline 25 May 2026 | Viewed by 82 | Submission Open
Keywords: metabolism; cellular aging; senescence; proteostasis; oxidative stress; glycation; autophagy
Cellular and Molecular Insights into Female Reproductive Biology
edited by
submission deadline 25 May 2026 | Viewed by 73 | Submission Open
Keywords: female reproductive biology; cellular mechanisms; reproductive aging; microfluidics; fertility preservation; stem cells; uterine endocrinology; infertility; reproductive health; gametogenesis
(This special issue belongs to the Section Reproductive Cells and Development)
Resistance of Hematological Malignancies and Solid Tumors to CAR T Cell Therapy
edited by
submission deadline 25 May 2026 | Viewed by 49 | Submission Open
Keywords: solid tumors; hematological malignancies; CAR T cell; immunotherapy; resistance; apoptosis
Brain Function and Structure: Mapping Complexity in Neuronal Cells submission deadline 25 May 2026 | Viewed by 38 | Submission Open
Keywords: optogenetics; lab-on-chip platforms and brain organoids; neuronal and glial networks; neuromechanobiology; system neuroscience
Human DNA Replication/Repair Factors submission deadline 25 May 2026 | Viewed by 12 | Submission Open
Keywords: DNA replication; replisome; DNA polymerase; helicase; replication fork; DNA repair; replication stress; DNA damage response; homologous recombination; replication-coupled DNA repair
From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies submission deadline 29 May 2026 | Viewed by 237 | Submission Open
Keywords: obesity; inflammasomes; immune system; microbiota
(This special issue belongs to the Section Tissues and Organs)
Therapeutic Targeting of Myeloid Cells in Tumor
edited by Mirko Farina and
submission deadline 30 May 2026 | Viewed by 47 | Submission Open
Keywords: myeloid cells; therapeutic targeting; tumor microenvironment; leukemia; myelodysplastic syndromes; tumor development
Autophagy in Stress Responses: From Molecular Mechanisms to Disease Relevance
edited by and Kleiton Silva
submission deadline 30 May 2026 | Viewed by 23 | Submission Open
Keywords: autophagy; stress response; proteostasis; mitophagy; neurodegeneration; aging; stress granules; mTOR signaling; selective autophagy; disease models; exercise; muscle disorders
(This special issue belongs to the Section Autophagy)
Perinatal Brain Injury—from Pathophysiology to Therapy
edited by Cora H.A. Nijboer, and
submission deadline 31 May 2026 | 8 articles | Viewed by 18997 | Submission Open
Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells
(This special issue belongs to the Section Cells of the Nervous System)
Proteomic Applications in Ageing and Neurodegenerative Conditions submission deadline 31 May 2026 | 4 articles | Viewed by 18725 | Submission Open
(This special issue belongs to the Section Cell Methods)
3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures submission deadline 31 May 2026 | 5 articles | Viewed by 13123 | Submission Open
Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling
(This special issue belongs to the Section Cell Methods)
Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition
edited by
submission deadline 31 May 2026 | 4 articles | Viewed by 11648 | Submission Open
Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy
(This special issue belongs to the Section Cellular Pathology)
Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases submission deadline 31 May 2026 | 2 articles | Viewed by 5328 | Submission Open
Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha
Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 4962 | Submission Open
Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression
(This special issue belongs to the Section Stem Cells)
Glial Cells: Physiological and Pathological Perspective
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 3834 | Submission Open
Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies
(This special issue belongs to the Section Cells of the Nervous System)
Natural Killer (NK) Cells in Immunity: Limitations and Potential
edited by Rehan Mujeeb Faridi
submission deadline 31 May 2026 | 2 articles | Viewed by 3224 | Submission Open
Keywords: natural killer cells; adaptive NK cells; infection
(This special issue belongs to the Section Cellular Immunology)
Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 2799 | Submission Open
Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine
(This special issue belongs to the Section Stem Cells)
The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function
edited by and Federica Scalia
submission deadline 31 May 2026 | 1 articles | Viewed by 1596 | Submission Open
Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches
Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity
edited by Jiabei Lin
submission deadline 31 May 2026 | 1 articles | Viewed by 688 | Submission Open
Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer
G Protein-Coupled Receptors and Diseases
edited by
submission deadline 31 May 2026 | Viewed by 624 | Submission Open
Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation
Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)
edited by Robert Sharp and
submission deadline 31 May 2026 | Viewed by 392 | Submission Open
Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology
(This special issue belongs to the Section Cellular Pathology)
Role of Lysosomes in Mediating Cancer Drug Resistance
edited by
submission deadline 31 May 2026 | Viewed by 203 | Submission Open
Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics submission deadline 31 May 2026 | Viewed by 167 | Submission Open
Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets
Cellular and Molecular Basis of Brain Tumor
edited by , Tomasz S. Mandat and Grzegorz Turek
submission deadline 31 May 2026 | Viewed by 162 | Submission Open
Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research
(This special issue belongs to the Section Cellular Pathology)
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