Molecular Pathogenesis and Novel Therapeutic Strategies in Chordoma
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 May 2026 | Viewed by 26
Special Issue Editors
Interests: chordoma; neurosurgery
Interests: spine tumors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chordoma is a rare and aggressive malignant bone tumor arising from remnants of the notochord, most commonly affecting the skull base and spine. Despite advances in surgical and radiation techniques, high recurrence rates and limited systemic treatment options continue to challenge clinical management. Recent progress in understanding the molecular pathogenesis of chordoma, including the roles of key signaling pathways, epigenetic regulation, and the tumor microenvironment, has opened up new avenues for therapeutic intervention. This Special Issue will highlight cutting-edge research focused on biology, molecular mechanisms, and therapeutic innovations in chordoma.
Dr. Margot Martinez-Moreno
Dr. Patricia L Sullivan
Dr. Jeremy J Reynolds
Guest Editors
Manuscript Submission Information
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Keywords
- chordoma
- targeted therapy
- brachyury
- tumor microenvironment
- epigenetics
- immunotherapy
- biomarkers
- drug resistance
- translational oncology
- radiation resistance
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