Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: 22 May 2025 | Viewed by 135
Special Issue Editors
Interests: metabolism; epigenetics; cancer; hepatoblastoma; liver cancer
Interests: metabolism; epigenetics; energy; medulloblastoma; memory
Special Issue Information
Dear Colleagues,
Recent advances in cancer research have highlighted the critical role of metabolic and epigenetic reprogramming in driving tumorigenesis and therapeutic resistance. Tumor cells often exhibit altered metabolic pathways, including heightened glycolysis, oxidative phosphorylation modulation, and lipid synthesis adaptations, to sustain rapid proliferation and evade cellular death. These metabolic shifts, collectively known as metabolic reprogramming, not only fuel tumor growth but also create an environment conducive to immune evasion and metastatic progression. Concurrently, epigenetic modifications, such as DNA methylation, histone modification, and chromatin remodeling, play pivotal roles in silencing tumor suppressor genes and activating oncogenes, thus reinforcing malignancy at a cellular level. These modifications are often influenced by metabolic intermediates, suggesting a tightly regulated crosstalk between metabolic and epigenetic pathways that sustains tumor cell survival and adaptability.
Targeting these dual mechanisms offers a promising therapeutic approach. Metabolic inhibitors, such as glycolysis blockers and inhibitors of fatty acid synthesis, are currently in various stages of clinical evaluation. Similarly, epigenetic drugs targeting DNA methyltransferases and histone deacetylases have shown potential in preclinical models and clinical trials. This Special Issue seeks to gather cutting-edge research and reviews on the underlying mechanisms of tumor metabolism and epigenetics, and to explore therapeutic strategies that target these interconnected pathways. The goal is to provide a comprehensive understanding of how targeting these processes could lead to more effective cancer treatments and personalized therapy approaches, particularly in tumors resistant to conventional therapies.
Dr. Jorge Mata-Garrido
Dr. Raquel Francés
Dr. Íñigo Casafont
Guest Editors
Manuscript Submission Information
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Keywords
- tumor metabolism
- epigenetics
- metabolic reprogramming
- DNA methylation
- histone modification
- warburg effect
- glycolysis inhibitors
- fatty acid synthesis
- chromatin remodeling
- cancer therapy
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