Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 408
Special Issue Editors
Interests: diabetic cornea; limbal stem cells; microRNA; extracellular vesicles/exosomes; wound healing; gene therapy; stem cell therapy; corneal epithelial regeneration; intercellular communication
Special Issues, Collections and Topics in MDPI journals
Interests: extracellular matrix; corneal development and wound healing; limbal stem cells; stem cell therapy; corneal regeneration; dry eye disease; meibomian gland dysfunction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This is the expanded second edition of the Special Issue “Mechanism of Cell Signaling During Eye Development and Diseases”. Previous articles published in the 1st edition can be read by clicking the following link: https://www.mdpi.com/journal/cells/special_issues/UCD4H97HG7.
Cell signaling pathways are important in mediating essential processes in embryonic eye development and adult tissues. Their coordination and integration are critical for mediating processes ranging from cell proliferation and differentiation to cell fate determination and polarity. Cellular communication is compelled by these pathways and is driven by hormones, transcription factors, or other signaling molecules.
Several major signaling pathways in eye development, such as Hedgehog, Wnt, retinoic acid, FGF, TGF-β, and Notch, operate during development in a precise temporal and spatial patterning in the embryo and in adult tissues, generating diverse cellular responses in a cell-type-specific manner. Altered expressions of these pathways can lead to a large number of eye diseases, such as photoreceptor degeneration as a result of a dysregulated Wnt signaling pathway, Glaucoma as a result of altered TGF-β signaling, and pathological angiogenesis-related eye disorders due to defects in Notch signaling.
Therefore, delineating the mechanisms of cell signaling during eye development and disease can unveil their potential as targets for novel therapeutic strategies for the treatment of ocular diseases.
Dr. Mehrnoosh Saghizadeh Ghiam
Dr. Vivien Coulson-Thomas
Guest Editors
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Keywords
- cell signaling
- ocular
- eye disorders
- Wnt signaling
- TGF-β
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