Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Biophysics".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 32
Special Issue Editors
Interests: structural biology; molecular mechanisms; bioinformatics
Interests: bioactive peptides; protein–protein events modulation; nanodelivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Protein–protein interactions (PPIs) are fundamental to all biological processes, playing crucial roles in cellular signaling, immune responses, and metabolic pathways. The intricate network of PPIs governs the functionality of cells, and their dysregulation is often implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases. As our understanding of the molecular mechanisms underlying these interactions deepens, targeting PPIs for therapeutic intervention has emerged as a promising frontier in drug discovery.
Recent advancements in high-throughput screening techniques, structural biology, and computational modeling have significantly enhanced our ability to identify and characterize PPIs. These tools allow researchers to elucidate the dynamic nature of protein interactions and to explore the conformational changes that occur during binding events. Importantly, the development of small molecules, peptides, and biologics that can selectively disrupt or stabilize specific PPIs offers a novel approach to modulate biological pathways and restore homeostasis in diseased states. This Special Issue aims to highlight the latest research and innovative strategies in the field of PPI-targeted therapies.
We welcome contributions that explore various aspects of PPIs, including their role in disease mechanisms, methodologies for PPI identification and validation, and the design of therapeutic agents aimed at modulating these interactions. By bringing together diverse perspectives and innovative findings, we hope to foster a deeper understanding of the therapeutic potential of targeting protein–protein interactions and to inspire future research directions in this exciting area of biomedical science.
Dr. Roberta Montanari
Dr. Alberto Vitali
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- protein–protein interactions
- PPI modulators
- nanodelivery
- molecular mechanisms
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
