Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Biophysics".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 49
Special Issue Editors
Interests: structural biology; molecular mechanisms; bioinformatics
Interests: bioactive peptides; protein–protein events modulation; nanodelivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Protein–protein interactions (PPIs) are fundamental to all biological processes, playing crucial roles in cellular signaling, immune responses, and metabolic pathways. The intricate network of PPIs governs the functionality of cells, and their dysregulation is often implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases. As our understanding of the molecular mechanisms underlying these interactions deepens, targeting PPIs for therapeutic intervention has emerged as a promising frontier in drug discovery.
Recent advancements in high-throughput screening techniques, structural biology, and computational modeling have significantly enhanced our ability to identify and characterize PPIs. These tools allow researchers to elucidate the dynamic nature of protein interactions and to explore the conformational changes that occur during binding events. Importantly, the development of small molecules, peptides, and biologics that can selectively disrupt or stabilize specific PPIs offers a novel approach to modulate biological pathways and restore homeostasis in diseased states. This Special Issue aims to highlight the latest research and innovative strategies in the field of PPI-targeted therapies.
We welcome contributions that explore various aspects of PPIs, including their role in disease mechanisms, methodologies for PPI identification and validation, and the design of therapeutic agents aimed at modulating these interactions. By bringing together diverse perspectives and innovative findings, we hope to foster a deeper understanding of the therapeutic potential of targeting protein–protein interactions and to inspire future research directions in this exciting area of biomedical science.
Dr. Roberta Montanari
Dr. Alberto Vitali
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- protein–protein interactions
- PPI modulators
- nanodelivery
- molecular mechanisms
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