Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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State-of-the-Art Insights into the Cell Microenvironment
edited by
submission deadline 20 May 2026 | Viewed by 168 | Submission Open
Keywords: cell microenvironment; stem cells; organoid and 3D culture models
(This special issue belongs to the Section Cell Microenvironment)
Pathology and Therapies in Brain Tumor
edited by Bachuchu Lal
submission deadline 20 May 2026 | Viewed by 99 | Submission Open
Keywords: brain tumor; gliomas; target treatment; pathogenesis; animal models
(This special issue belongs to the Section Cellular Pathology)
Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine
edited by Emanuela Mari
submission deadline 20 May 2026 | Viewed by 87 | Submission Open
Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome
(This special issue belongs to the Section Stem Cells)
Regulation of Iron Homeostasis
edited by
submission deadline 20 May 2026 | Viewed by 64 | Submission Open
Keywords: iron homeostasis; iron transport; iron storage; iron-containing proteins
Molecular Pathogenesis of Ovarian Cancer and Therapeutic Strategies
edited by Jayakumar R. Nair
submission deadline 20 May 2026 | Viewed by 43 | Submission Open
Keywords: ovarian cancer; pathogenic mutations; target therapy; genetic heterogeneity                                 
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Basis of Sjögren’s Syndrome
edited by Muhammad Shahnawaz Soyfoo
submission deadline 20 May 2026 | Viewed by 43 | Submission Open
Keywords: Sjö gren disease; epithelial dysfunction; immune tolerance; autoimmunity
Non-Coding and Coding RNAs in Targeted Cancer Therapy submission deadline 25 May 2026 | 4 articles | Viewed by 8268 | Submission Open
Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets
(This special issue belongs to the Section Cell and Gene Therapy)
Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory
edited by
submission deadline 25 May 2026 | 2 articles | Viewed by 5279 | Submission Open
Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity
(This special issue belongs to the Section Cellular Neuroscience)
Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition submission deadline 25 May 2026 | 2 articles | Viewed by 3799 | Submission Open
Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering
(This special issue belongs to the Section Stem Cells)
Recent Advances in Astrocyte Neuron Communication submission deadline 25 May 2026 | Viewed by 994 | Submission Open
Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity
(This special issue belongs to the Section Cellular Neuroscience)
Cell Therapy for Retinal Diseases submission deadline 25 May 2026 | Viewed by 403 | Submission Open
Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration
(This special issue belongs to the Section Tissues and Organs)
Cell Signaling in Neurodegenerative Disease
edited by , Yasuhiro Funahashi, , and Md-nadim Hossain
submission deadline 25 May 2026 | Viewed by 342 | Submission Open
Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience
(This special issue belongs to the Section Cellular Neuroscience)
Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury
edited by and Angela R. Filous
submission deadline 25 May 2026 | Viewed by 157 | Submission Open
Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia
Cellular and Molecular Insights into Female Reproductive Biology
edited by
submission deadline 25 May 2026 | Viewed by 133 | Submission Open
Keywords: female reproductive biology; cellular mechanisms; reproductive aging; microfluidics; fertility preservation; stem cells; uterine endocrinology; infertility; reproductive health; gametogenesis
(This special issue belongs to the Section Reproductive Cells and Development)
Metabolic Regulation of Cell Behavior and Implications for Aging
edited by and José Antonio Rodríguez Navarro
submission deadline 25 May 2026 | Viewed by 103 | Submission Open
Keywords: metabolism; cellular aging; senescence; proteostasis; oxidative stress; glycation; autophagy
Brain Function and Structure: Mapping Complexity in Neuronal Cells submission deadline 25 May 2026 | Viewed by 64 | Submission Open
Keywords: optogenetics; lab-on-chip platforms and brain organoids; neuronal and glial networks; neuromechanobiology; system neuroscience
Resistance of Hematological Malignancies and Solid Tumors to CAR T Cell Therapy
edited by
submission deadline 25 May 2026 | Viewed by 61 | Submission Open
Keywords: solid tumors; hematological malignancies; CAR T cell; immunotherapy; resistance; apoptosis
Human DNA Replication/Repair Factors submission deadline 25 May 2026 | Viewed by 42 | Submission Open
Keywords: DNA replication; replisome; DNA polymerase; helicase; replication fork; DNA repair; replication stress; DNA damage response; homologous recombination; replication-coupled DNA repair
From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies submission deadline 29 May 2026 | Viewed by 247 | Submission Open
Keywords: obesity; inflammasomes; immune system; microbiota
(This special issue belongs to the Section Tissues and Organs)
Advanced Research in Neurogenesis and Neuroinflammation
edited by
submission deadline 30 May 2026 | 2 articles | Viewed by 2112 | Submission Open
Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions
(This special issue belongs to the Section Cellular Neuroscience)
Autophagy in Stress Responses: From Molecular Mechanisms to Disease Relevance
edited by and Kleiton Silva
submission deadline 30 May 2026 | Viewed by 86 | Submission Open
Keywords: autophagy; stress response; proteostasis; mitophagy; neurodegeneration; aging; stress granules; mTOR signaling; selective autophagy; disease models; exercise; muscle disorders
(This special issue belongs to the Section Autophagy)
Therapeutic Targeting of Myeloid Cells in Tumor
edited by Mirko Farina and
submission deadline 30 May 2026 | Viewed by 51 | Submission Open
Keywords: myeloid cells; therapeutic targeting; tumor microenvironment; leukemia; myelodysplastic syndromes; tumor development
Protein-Protein Interaction in Health and Disease submission deadline 30 May 2026 | Viewed by 24 | Submission Open
Keywords: protein– protein interactions; mass spectrometry; cross-linking; disease mechanisms; structural biology; proteomics; therapeutic targets; protein complexes
(This special issue belongs to the Section Cell Signaling)
Genome Editing in Biomedicine
edited by
submission deadline 30 May 2026 | Viewed by 24 | Submission Open
Keywords: genome manipulation; CRISPR/Cas systems; base editing and prime editing; cellular models (organoids/stem cells); stem cell editing; animal models; genetically engineered mouse models (GEMMs); translational research; cell therapy; editing efficiency; virus-like particles (VLPs)
(This special issue belongs to the Section Cell and Gene Therapy)
Perinatal Brain Injury—from Pathophysiology to Therapy
edited by Cora H.A. Nijboer, and
submission deadline 31 May 2026 | 10 articles | Viewed by 21572 | Submission Open
Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells
(This special issue belongs to the Section Cellular Neuroscience)
Proteomic Applications in Ageing and Neurodegenerative Conditions submission deadline 31 May 2026 | 4 articles | Viewed by 19181 | Submission Open
(This special issue belongs to the Section Cell Methods)
3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures submission deadline 31 May 2026 | 6 articles | Viewed by 15652 | Submission Open
Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling
(This special issue belongs to the Section Cell Methods)
Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition
edited by
submission deadline 31 May 2026 | 4 articles | Viewed by 13187 | Submission Open
Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy
(This special issue belongs to the Section Cellular Pathology)
Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration
edited by Aurora Almadori
submission deadline 31 May 2026 | 5 articles | Viewed by 12389 | Submission Open
Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; ageing; immune response; inflammation; scarring
(This special issue belongs to the Section Stem Cells)
Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 6222 | Submission Open
Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression
(This special issue belongs to the Section Stem Cells)
Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases submission deadline 31 May 2026 | 2 articles | Viewed by 5631 | Submission Open
Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha
Glial Cells: Physiological and Pathological Perspective
edited by
submission deadline 31 May 2026 | 4 articles | Viewed by 4344 | Submission Open
Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies
(This special issue belongs to the Section Cellular Neuroscience)
Adipose-Derived Stem Cells for Tissue Regeneration submission deadline 31 May 2026 | 2 articles | Viewed by 4031 | Submission Open
Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies
(This special issue belongs to the Section Tissues and Organs)
Natural Killer (NK) Cells in Immunity: Limitations and Potential
edited by Rehan Mujeeb Faridi
submission deadline 31 May 2026 | 2 articles | Viewed by 3614 | Submission Open
Keywords: natural killer cells; adaptive NK cells; infection
(This special issue belongs to the Section Cellular Immunology)
Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 3348 | Submission Open
Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine
(This special issue belongs to the Section Stem Cells)
The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function
edited by and Federica Scalia
submission deadline 31 May 2026 | 1 articles | Viewed by 1833 | Submission Open
Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches
Non-Coding RNAs as Regulators of Cellular Function and Disease
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 1559 | Submission Open
Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms
Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity
edited by Jiabei Lin
submission deadline 31 May 2026 | 1 articles | Viewed by 1006 | Submission Open
Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer
G Protein-Coupled Receptors and Diseases
edited by
submission deadline 31 May 2026 | Viewed by 641 | Submission Open
Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation
Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)
edited by Robert Sharp and
submission deadline 31 May 2026 | Viewed by 422 | Submission Open
Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology
(This special issue belongs to the Section Cellular Pathology)
Exploring Morphological Changes and Diversity in Cancer
edited by
submission deadline 31 May 2026 | Viewed by 352 | Submission Open
Keywords: morphology; heterogeneity; cancer; phenotype; shape
Development and Characterization of Innovative In Vitro Models
edited by Fengyan Deng and Chongbei Zhao
submission deadline 31 May 2026 | 1 articles | Viewed by 330 | Submission Open
Keywords: 3D organoid development; iPSC; iPSC reprogramming; primary cell derivation; cell immortalization; disease model development; stem cell therapy; molecular biology; cell signaling
Role of Lysosomes in Mediating Cancer Drug Resistance
edited by
submission deadline 31 May 2026 | Viewed by 212 | Submission Open
Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
Cellular and Molecular Basis of Brain Tumor
edited by , Tomasz S. Mandat, Grzegorz Turek and Radosław Mlak
submission deadline 31 May 2026 | Viewed by 193 | Submission Open
Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research
(This special issue belongs to the Section Cellular Pathology)
Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms submission deadline 31 May 2026 | Viewed by 185 | Submission Open
Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration
Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics submission deadline 31 May 2026 | Viewed by 182 | Submission Open
Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets
Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments
edited by Konrad Talbot
submission deadline 31 May 2026 | Viewed by 177 | Submission Open
Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Mechanisms of Drug Delivery in Ophthalmology
edited by Alekha K. Dash and Surabhi Shukla
submission deadline 31 May 2026 | Viewed by 175 | Submission Open
Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery
(This special issue belongs to the Section Tissues and Organs)
Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis
edited by and Jianzhong Shen
submission deadline 31 May 2026 | Viewed by 161 | Submission Open
Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling
Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine
edited by Renata Kelly Da Palma
submission deadline 31 May 2026 | Viewed by 140 | Submission Open
Keywords: cell therapy; lung diseases; tissue regeneration
(This special issue belongs to the Section Tissues and Organs)
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