Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease
edited by and Museer Ahmad Lone
submission deadline 20 Sep 2026 | 5 articles | Viewed by 13729 | Submission Open
Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders, nutrient sensing and lipid regulation
(This special issue belongs to the Section Cellular Biophysics)
Ovarian Cancer and Endometriosis
edited by and
submission deadline 20 Sep 2026 | 2 articles | Viewed by 7399 | Submission Open
Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product
(This special issue belongs to the Section Cellular Pathology)
Lipid Homeostasis in Health and Disease
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2567 | Submission Open
Keywords: lipids; metabolism; homeostasis; disease mechanisms; biomarkers; therapeutic targets; nutrition; cellular signaling; systems biology
Cellular and Molecular Mechanisms in Sepsis: Pathogenesis, Immune Response, and Therapeutic Strategies
edited by and
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1914 | Submission Open
Keywords: sepsis; cytokine signaling; immune cell dynamics; epigenetic regulation; metabolic reprogramming; non-coding RNAs; redox signaling; receptor polymorphisms; systems immunology; single-cell omics
(This special issue belongs to the Section Cellular Pathology)
Single-Molecule Tracking for Live Cells
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1880 | Submission Open
Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory
Role of Transposons in Regulating the Neural Genome and the Mechanisms of Neuropsychiatric Diseases
edited by Fabio M. Macciardi
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1742 | Submission Open
Keywords: transposable elements; genome evolution; central nervous system development; neural genome; neural gene regulation; neuropsychiatric disorders
(This special issue belongs to the Section Cellular Neuroscience)
Mechanisms of miRNA Metabolism and Extracellular Transport submission deadline 20 Sep 2026 | 1 articles | Viewed by 865 | Submission Open
Keywords: miRNA metabolism; miRNA transport; miRNA exchange; miRNA storage; mRNA biogenesis; extracellular vesicles and miRNA; non-EV miRNA export; miRNA binding proteins; miRNA sponge and inhibitors; miRNA biomarkers
New Insights in Translational Pain Research
edited by
submission deadline 20 Sep 2026 | Viewed by 341 | Submission Open
Keywords: translational pain research; chronic pain; neuroinflammation; pain mechanisms; therapeutic targets
The Role of Glial Cells in Neurodegenerative Disorders
edited by Osama Al Dalahmah and Sebastian Quintremil
submission deadline 20 Sep 2026 | Viewed by 282 | Submission Open
Keywords: astrocytes; oligodendrocytes; microglia; neuropathology
(This special issue belongs to the Section Cellular Neuroscience)
Advances in DNA Damage Responses in Viral Infection
edited by Roger J. Grand
submission deadline 20 Sep 2026 | Viewed by 255 | Submission Open
Keywords: DNA damage response; DNA viruses; RNA viruses; viral replication; DNA repair pathways
(This special issue belongs to the Section Cellular Pathology)
The Silent Regulators: Non-Coding RNAs in Cell Function and Disease submission deadline 25 Sep 2026 | 5 articles | Viewed by 9218 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics
(This special issue belongs to the Section Cell and Gene Therapy)
Breaking the Balance: Cellular Stress, Proteostasis, Aggregates and Neurodegeneration
edited by
submission deadline 25 Sep 2026 | 2 articles | Viewed by 2105 | Submission Open
Keywords: proteostasis; cellular stress; protein aggregation; neurodegeneration; autophagy; unfolded protein response; oxidative stress; aging; molecular chaperones; protein quality control
Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance submission deadline 25 Sep 2026 | 1 articles | Viewed by 1369 | Submission Open
Keywords: atherosclerosis; thrombosis; molecular mechanisms; translational research; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Stem Cells and Metabolism in Acute Myeloid Leukemia: Mechanisms, Models, and Therapeutic Opportunities
edited by , Aditi Chatterjee and Maria Baer
submission deadline 25 Sep 2026 | Viewed by 757 | Submission Open
Keywords: AML; leukemic stem cells; hypoxia; metabolism; fatty-acid oxidation; one-carbon metabolism; proteostasis; bone-marrow niche; multi-omics; metabolic inhibitors
Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches
edited by
submission deadline 25 Sep 2026 | Viewed by 418 | Submission Open
Keywords: chronic pain; synaptic plasticity; circuit dysfunction
(This special issue belongs to the Section Cellular Pathology)
New Molecular Perspectives in Pelvic Floor and Genitourinary Disorders
edited by Mahadevan Rajasekaran
submission deadline 25 Sep 2026 | Viewed by 289 | Submission Open
Keywords: pelvic floor disorders; genitourinary diseases; molecular mechanisms; biomarkers; biomaterials; regenerative medicine; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Natural Products and Their Derivatives Against Human Disease—2nd Edition
edited by
submission deadline 25 Sep 2026 | Viewed by 288 | Submission Open
Keywords: microbiome-mediated modulation; biomarker; therapeutic strategies; drug delivery
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Targeting Metabolic Vulnerabilities to Selectively Eliminate Cancer Cells
edited by Nina Semenova and
submission deadline 29 Sep 2026 | Viewed by 460 | Submission Open
Keywords: cancer cell metabolism; cancer cell signaling pathways; cancer epigenetic regulation; nutrient deprivation; tumor microenvironment; chemotherapy; chemoresistance; radiotherapy; cell death
Role of Extracellular Matrix in Cancer and Disease submission deadline 30 Sep 2026 | 8 articles | Viewed by 26634 | Submission Open
Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling
(This special issue belongs to the Section Cell Microenvironment)
Mechanisms of Immune Responses and Therapy submission deadline 30 Sep 2026 | 3 articles | Viewed by 13523 | Submission Open
Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Antioxidants in Redox Homeostasis of Plant Development submission deadline 30 Sep 2026 | 3 articles | Viewed by 11237 | Submission Open
Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
The Potential of Induced Pluripotent Stem Cells
edited by Yun Chang
submission deadline 30 Sep 2026 | 3 articles | Viewed by 10904 | Submission Open
Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials
(This special issue belongs to the Section Stem Cells)
Targeting Tumor Microenvironments for Enhanced Cancer Immunotherapy
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 10205 | Submission Open
Keywords: tumor microenvironment; cancer immunotherapy; immune modulation; immunosuppressive mechanisms; combination therapies
(This special issue belongs to the Section Cell Microenvironment)
The Cell Biology of Heart Disease
edited by Rajeshwary Ghosh and
submission deadline 30 Sep 2026 | 8 articles | Viewed by 9671 | Submission Open
Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure
(This special issue belongs to the Section Cells of the Cardiovascular System)
Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 8481 | Submission Open
Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling
(This special issue belongs to the Section Cellular Neuroscience)
Novel Insights into Cancer Immune Responsiveness submission deadline 30 Sep 2026 | 4 articles | Viewed by 8312 | Submission Open
Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines
Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis
edited by
submission deadline 30 Sep 2026 | 7 articles | Viewed by 7471 | Submission Open
Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application
edited by and
submission deadline 30 Sep 2026 | 3 articles | Viewed by 6854 | Submission Open
Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics
The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies submission deadline 30 Sep 2026 | 2 articles | Viewed by 6138 | Submission Open
Keywords: ovarian aging; folliculogenesis; oocyte quality; hormonal regulation; epigenetics of reproduction; reproductive lifespan; stem cells in ovarian function; oxidative stress and fertility; metabolic influences on reproduction; cellular signaling in ovarian decline
(This special issue belongs to the Section Reproductive Cells and Development)
Parkinson's Disease: Advances in Molecular Understanding and Emerging Therapies
edited by and Sara Elfarrash
submission deadline 30 Sep 2026 | 1 articles | Viewed by 5886 | Submission Open
Keywords: Parkinson’s disease; atypical Parkinsonism; neurodegeneration; neuroinflammation; alpha-synuclein; disease models; brain organoids; human induced pluripotent stem cells (iPSCs); transcriptomics; proteomics; multi-omics; spatial biology; multiplex imaging; PD genetics
(This special issue belongs to the Section Cellular Aging)
Cell Therapeutics for Corneal Diseases submission deadline 30 Sep 2026 | 2 articles | Viewed by 5552 | Submission Open
Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair
(This special issue belongs to the Section Tissues and Organs)
The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention
edited by Vivek Kumar Kashyap and Himanshu Narayan Singh
submission deadline 30 Sep 2026 | 1 articles | Viewed by 5271 | Submission Open
Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors
(This special issue belongs to the Section Cellular Pathology)
Molecular and Cellular Drivers of Parkinson's Disease
edited by and
submission deadline 30 Sep 2026 | 3 articles | Viewed by 4558 | Submission Open
Keywords: Parkinson’s disease; neurodegeneration; mitochondrial dysfunction; α-synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene–environment interactions; cell death
(This special issue belongs to the Section Cellular Neuroscience)
The Role of Light in Ocular Health and Disease
edited by Krisztina Valter, and
submission deadline 30 Sep 2026 | 2 articles | Viewed by 3914 | Submission Open
Keywords: light; photobiology; light exposure; circadian rhythms; vision; light-induced retinal damage; phototoxicity; photoprotection; retinal degeneration; light modulation; oxidative stress; light therapy; photobiomodulation; blue light effects; Protective wavelengths; harmful wavelengths; ocular phototransduction; light-based therapeutics
Pediatric Liver Tumors: Molecular Mechanisms and Therapeutic Strategies submission deadline 30 Sep 2026 | 3 articles | Viewed by 3890 | Submission Open
Keywords: hepatoblastoma; hepatocellular carcinoma; pediatric liver tumors; fibrolamellar carcinoma; Beck-with-Wiedmann syndrome; hereditary tyrosinemia; molecular mechanisms; therapeutic strategies
Cellular and Molecular Insights into Gynecologic Tumors
edited by and
submission deadline 30 Sep 2026 | 3 articles | Viewed by 3794 | Submission Open
Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies
Stress Signaling and Cell Fate Determination: The Role of Mitochondria submission deadline 30 Sep 2026 | 2 articles | Viewed by 3410 | Submission Open
Keywords: mitochondria; cell death; integrated stress response; retrograde signaling; apoptosis; necroptosis; ferroptosis; mitophagy; mitochondrial dynamics; ROS; calcium signaling; inter-organelle communication
Brain Organoids for Disease Modeling
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2478 | Submission Open
Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening
(This special issue belongs to the Section Stem Cells)
Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration
edited by Mukund Srinivasan
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2322 | Submission Open
Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress
Cell Signaling of Cancer Therapy
edited by and Anna Wawruszak
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2012 | Submission Open
Keywords: cell signaling; cancer therapy; signal transduction; targeted therapy; gene therapy; RNA-based therapeutics; drug resistance; tumor microenvironment; precision oncology
(This special issue belongs to the Section Cell Signaling)
State of the Art in Tumor Immunotherapy: From Cell Biology to Therapeutic Perspectives submission deadline 30 Sep 2026 | 1 articles | Viewed by 1799 | Submission Open
Keywords: T-cell exhaustion; immune checkpoint blockade (PD-1/PD-L1); CAR-T cell engineering; tumor microenvironment (TME); antigen presentation machinery; TCR signaling; myeloid-derived suppressor cells (MDSCs); cancer immunoediting; immunogenic cell death; adoptive cell transfer
(This special issue belongs to the Section Cellular Immunology)
Neural Governance of Gastrointestinal Motility
edited by Jiande Chen
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1710 | Submission Open
Keywords: enteric nervous system; gastrointestinal motility; neural circuitry; neurotransmitter signaling; smooth muscle regulation; neuron–epithelial; organoid models; gut-brain axis; neuro-immune interaction; neuromodulation
Role of Endothelial Progenitor Cells in Vascular Dysfunction submission deadline 30 Sep 2026 | 1 articles | Viewed by 1517 | Submission Open
Keywords: cardiovascular diseases; endothelial progenitor cells; vasculogenesis; angiogenesis; inflammation; oxidative stress; cellular senescence; developmental programming; cellular therapy
Novel Insights into Endothelial Cells in Vascular Disease
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1358 | Submission Open
Keywords: endothelial cells; vascular diseases; vascular signaling
Ubiquitin Ligases in Health and Diseases
edited by Haitao Luan
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1280 | Submission Open
Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting
(This special issue belongs to the Section Cell Signaling)
Aging, Oxidative Stress, and Inflammation in Ocular Diseases
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1111 | Submission Open
Keywords: aging; oxidative stress; inflammation; ocular diseases
New Tools to Address Old Challenges in Tolerogenic Cellular Therapies
edited by Konstantinos Mengrelis and
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1075 | Submission Open
Keywords: tolerogenic strategies; immune tolerance; allogeneic cellular therapies; autoimmunity; allergy; systems immunology; artificial intelligence; biomarkers; immune regulation
Advances in Cardiometabolic Pathophysiology and Treatment
edited by and
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1045 | Submission Open
Keywords: insulin resistance; immunometabolism; low-grade chronic inflammation; cardiovascular diseases; obesity; type 2 diabetes mellitus; adipose/adipocyte dysfunction; dyslipidemia; atherosclerosis; metabolic-associated steatotic liver disease
(This special issue belongs to the Section Cellular Metabolism)
Noncoding RNAs: Immunity, Mechanisms, and Biomarker Potential
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 887 | Submission Open
Keywords: noncoding RNAs (ncRNAs); MicroRNAs (miRNAs); long noncoding RNAs (lncRNAs); circular RNAs (circRNAs); immune regulation; tumor microenvironment; immune checkpoints; cancer immunotherapy; liquid biopsy biomarkers; immune evasion
Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders
edited by , Benedikt Schaefgen and
submission deadline 30 Sep 2026 | Viewed by 712 | Submission Open
Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling
(This special issue belongs to the Section Stem Cells)
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