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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Autophagy in Stress Responses: From Molecular Mechanisms to Disease Relevance

edited by

Katrina F. Cooper

and Kleiton Silva

submission deadline 30 May 2026 | Viewed by 95 | Submission Open

Keywords: autophagy; stress response; proteostasis; mitophagy; neurodegeneration; aging; stress granules; mTOR signaling; selective autophagy; disease models; exercise; muscle disorders

(This special issue belongs to the Section Autophagy)

Therapeutic Targeting of Myeloid Cells in Tumor

edited by Mirko Farina and

Giovanni Micheloni

submission deadline 30 May 2026 | Viewed by 53 | Submission Open

Keywords: myeloid cells; therapeutic targeting; tumor microenvironment; leukemia; myelodysplastic syndromes; tumor development

Genome Editing in Biomedicine

edited by

Fu-Lei Tang

submission deadline 30 May 2026 | Viewed by 40 | Submission Open

Keywords: genome manipulation; CRISPR/Cas systems; base editing and prime editing; cellular models (organoids/stem cells); stem cell editing; animal models; genetically engineered mouse models (GEMMs); translational research; cell therapy; editing efficiency; virus-like particles (VLPs)

(This special issue belongs to the Section Cell and Gene Therapy)

Protein-Protein Interaction in Health and Disease

edited by

Riccardo Sgarra

and

Sara Petrosino

submission deadline 30 May 2026 | Viewed by 36 | Submission Open

Keywords: protein– protein interactions; mass spectrometry; cross-linking; disease mechanisms; structural biology; proteomics; therapeutic targets; protein complexes

(This special issue belongs to the Section Cell Signaling)

Perinatal Brain Injury—from Pathophysiology to Therapy

edited by Cora H.A. Nijboer,

Bobbi Fleiss

and

Ivo Bendix

submission deadline 31 May 2026 | 11 articles | Viewed by 22779 | Submission Open

Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells

(This special issue belongs to the Section Cellular Neuroscience)

Proteomic Applications in Ageing and Neurodegenerative Conditions

edited by

Thomas Wishart

Rachel A. Kline

and

Dominic Kurian

submission deadline 31 May 2026 | 4 articles | Viewed by 19344 | Submission Open

(This special issue belongs to the Section Cell Methods)

3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures

edited by

Annunziata Mauro

Barbara Barboni

and

Giovanna Della Porta

submission deadline 31 May 2026 | 7 articles | Viewed by 16772 | Submission Open

Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling

(This special issue belongs to the Section Cell Methods)

Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition

edited by

Hideki Sudo

submission deadline 31 May 2026 | 4 articles | Viewed by 13683 | Submission Open

Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy

(This special issue belongs to the Section Cellular Pathology)

Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration

edited by Aurora Almadori

submission deadline 31 May 2026 | 5 articles | Viewed by 12977 | Submission Open

Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; ageing; immune response; inflammation; scarring

(This special issue belongs to the Section Stem Cells)

Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)

edited by

Joni H. Ylostalo

submission deadline 31 May 2026 | 3 articles | Viewed by 6624 | Submission Open

Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression

(This special issue belongs to the Section Stem Cells)

Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases

edited by

Lisbeth Birk Møller

submission deadline 31 May 2026 | 2 articles | Viewed by 5792 | Submission Open

Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha

Glial Cells: Physiological and Pathological Perspective

edited by

Qing Richard Lu

submission deadline 31 May 2026 | 4 articles | Viewed by 4701 | Submission Open

Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies

(This special issue belongs to the Section Cellular Neuroscience)

Adipose-Derived Stem Cells for Tissue Regeneration

edited by

Lukas Prantl, MD, PhD, MHBA, FACS

submission deadline 31 May 2026 | 2 articles | Viewed by 4552 | Submission Open

Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies

(This special issue belongs to the Section Tissues and Organs)

Natural Killer (NK) Cells in Immunity: Limitations and Potential

edited by Rehan Mujeeb Faridi

submission deadline 31 May 2026 | 2 articles | Viewed by 3783 | Submission Open

Keywords: natural killer cells; adaptive NK cells; infection

(This special issue belongs to the Section Cellular Immunology)

Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research

edited by

Elena Coccia

submission deadline 31 May 2026 | 1 articles | Viewed by 3536 | Submission Open

Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine

(This special issue belongs to the Section Stem Cells)

The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function

edited by

Alessandra Maria Vitale

and Federica Scalia

submission deadline 31 May 2026 | 1 articles | Viewed by 1889 | Submission Open

Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches

Non-Coding RNAs as Regulators of Cellular Function and Disease

edited by

Lucia Natarelli

submission deadline 31 May 2026 | 1 articles | Viewed by 1599 | Submission Open

Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms

Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity

edited by Jiabei Lin

submission deadline 31 May 2026 | 1 articles | Viewed by 1138 | Submission Open

Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer

G Protein-Coupled Receptors and Diseases

edited by

Yongqiang Chen

submission deadline 31 May 2026 | 1 articles | Viewed by 660 | Submission Open

Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation

Development and Characterization of Innovative In Vitro Models

edited by Fengyan Deng and Chongbei Zhao

submission deadline 31 May 2026 | 1 articles | Viewed by 606 | Submission Open

Keywords: 3D organoid development; iPSC; iPSC reprogramming; primary cell derivation; cell immortalization; disease model development; stem cell therapy; molecular biology; cell signaling

Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics

edited by

Roshanak Rahimian

and

Mitra Esfandiarei

submission deadline 31 May 2026 | 1 articles | Viewed by 440 | Submission Open

Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets

Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)

edited by Robert Sharp and

Itamar Raz

submission deadline 31 May 2026 | Viewed by 429 | Submission Open

Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology

(This special issue belongs to the Section Cellular Pathology)

Exploring Morphological Changes and Diversity in Cancer

edited by

Mustapha Kandouz

submission deadline 31 May 2026 | Viewed by 353 | Submission Open

Keywords: morphology; heterogeneity; cancer; phenotype; shape

Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms

edited by

Girish Chandra Melkani

submission deadline 31 May 2026 | Viewed by 216 | Submission Open

Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration

Role of Lysosomes in Mediating Cancer Drug Resistance

edited by

Petr Mlejnek

submission deadline 31 May 2026 | Viewed by 213 | Submission Open

Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Basis of Brain Tumor

edited by

Wojciech Czyżewski

, Tomasz S. Mandat, Grzegorz Turek and Radosław Mlak

submission deadline 31 May 2026 | Viewed by 199 | Submission Open

Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Drug Delivery in Ophthalmology

edited by Alekha K. Dash and Surabhi Shukla

submission deadline 31 May 2026 | Viewed by 183 | Submission Open

Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery

(This special issue belongs to the Section Tissues and Organs)

Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments

edited by Konrad Talbot

submission deadline 31 May 2026 | Viewed by 182 | Submission Open

Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease

(This special issue belongs to the Section Cellular Neuroscience)

Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis

edited by

Qianman Peng

and Jianzhong Shen

submission deadline 31 May 2026 | Viewed by 163 | Submission Open

Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling

Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine

edited by Renata Kelly Da Palma

submission deadline 31 May 2026 | Viewed by 153 | Submission Open

Keywords: cell therapy; lung diseases; tissue regeneration

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles in Reproductive Communication: From Gametogenesis to Implantation

edited by

Nima Azari-Dolatabad

and Osvaldo Bogado Pascottini

submission deadline 31 May 2026 | Viewed by 133 | Submission Open

Keywords: extracellular vesicles; reproductive biology; gametogenesis; oocyte maturation; embryo-maternal communication; implantation; reproductive disorders; epigenetic regulation; EV Cargo; intercellular signaling

Regulatory Mechanisms of Vascular Smooth Muscle Cells and Immune Cells in Vascular Disease Progression

edited by

Kunzhe Dong

and

Liming Yu

submission deadline 31 May 2026 | Viewed by 131 | Submission Open

Keywords: vascular smooth muscle cells; immune cells; inflammation; vascular disease; atherosclerosis; aneurysm; cellular crosstalk; phenotypic transition

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Mechanisms of Heart Development

edited by Jun K. Takeuchi

submission deadline 31 May 2026 | Viewed by 128 | Submission Open

Keywords: heart development; cardiovascular; epigenetics; cell fate; differentiation; cardiac growth; cardiac morphogenesis; heart regeneration; cardiac organoid

Immunotherapy-Induced Cardiotoxicity: Unraveling the Immune Landscape of Myocarditis

edited by

Pan Ma

submission deadline 31 May 2026 | Viewed by 122 | Submission Open

Keywords: immunotherapy; immune checkpoints; adoptive cell therapy; cardiac adverse events; cardiac inflammation; immune checkpoint inhibitor associated myocarditis; cardiac immune landscape; innate immune response; adaptive immune response; myeloid cells; macrophages; antigen presentation & phagocytosis; T cells; T cell clonality; cytokines; chemokines; chemotaxis; immune crosstalk; immune– stromal crosstalk; multi-omics

New Advances in Cardiac and Vascular Physiology

edited by Robert M. Lust

submission deadline 31 May 2026 | Viewed by 121 | Submission Open

Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure

(This special issue belongs to the Section Tissues and Organs)

Cancer and Vessels: Insights at the Cellular and Molecular Levels

edited by Francesco Pezzella and Tom Donnem

submission deadline 31 May 2026 | Viewed by 120 | Submission Open

Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis

(This special issue belongs to the Section Cellular Pathology)

Mitochondria Beyond Energy: Signaling, Immunity, and Cell Fate

edited by

Martha E Diaz-Hernandez

submission deadline 31 May 2026 | Viewed by 118 | Submission Open

Keywords: mitochondria; stem cells; cell fate; organogenesis; immunometabolism

Skeletal Muscle Aging and Regeneration: Mitochondrial Health, Molecular Signaling, and Therapeutic Interventions

edited by

Stephen E. Alway

submission deadline 31 May 2026 | Viewed by 115 | Submission Open

Keywords: aging; skeletal muscle; regeneration; satellite cells; muscle stem cells; muscle wasting; mitochondria; fibro-adipogenic progenitor cells; repair

Cellular and Molecular Pathways in Immune Tolerance and Autoimmune Regulation

edited by

Md Jahangir Alam

submission deadline 31 May 2026 | Viewed by 97 | Submission Open

Keywords: immune tolerance; autoimmune regulation; immune homeostasis; regulatory T cells; regulatory B cells; cytokine networks; molecular mechanisms; therapeutic strategies

(This special issue belongs to the Section Cellular Immunology)

B Cells in Action: Interaction Dynamics and Functional Decisions

edited by Michael L. Atchison and

Sulagna Sanyal

submission deadline 31 May 2026 | Viewed by 96 | Submission Open

Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response

(This special issue belongs to the Section Cellular Immunology)

DNA Damage and Repair in Targeted Cancer Therapy

edited by Mohd Saleem Dar, Sajad Ahmad Bhat and

Mohsin Maqbool

submission deadline 31 May 2026 | Viewed by 89 | Submission Open

Keywords: cancer cells; DNA damage and repair mechanism; genome organization; BER; NER; MMR; HR; and NHEJ; targeted therapy; inhibitors/PROATCS; drug resistance; drug toxicity; biomarkers; personalized medicine

Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects

edited by

and

submission deadline 31 May 2026 | Viewed by 85 | Submission Open

Keywords: neurodevelopmental disorders; neuronal connectivity; precocious therapies; synaptic plasticity; neurogenesis; glial function

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Mechanisms and Therapeutic Strategies for Skeletal Muscle Disorders

edited by

Valentina Di Felice

submission deadline 31 May 2026 | Viewed by 84 | Submission Open

Keywords: skeletal muscle; muscular disorders; myokines; muscle regeneration; muscle atrophy; inflammation; stress response; myoblast

Advances in Ion Channel Biology: From Molecular Mechanisms to Therapeutic Targets

edited by Shridhar Sanghvi,

Yang Zheng

and

Md Shahidul Islam

submission deadline 31 May 2026 | Viewed by 82 | Submission Open

Keywords: ion channels; electrophysiology; cryo-electron microscopy; channelopathy; membrane protein; gating mechanism; structural biology

Epigenetic and Cellular Regulation in Hematologic Disorders

edited by

Halina Leung

submission deadline 31 May 2026 | Viewed by 77 | Submission Open

Keywords: epigenetics; hematologic disorders; leukemia; myelodysplastic syndrome; thrombosis; thrombocytopenia; bleeding

Endometrial Cancer: From Molecular Mechanisms to Therapeutic Approaches

edited by Tomaž Büdefeld and

Jure Knez

submission deadline 31 May 2026 | Viewed by 63 | Submission Open

Keywords: endometrial cancer; genetic mutation; epigenetics; cell signaling; TIME; metastasis; biomarker; therapy; drug delivery; risk factor

Cellular Responses to Heavy Metals: From Intestinal Uptake to Disease

edited by

Aleksandar Cirovic

, Ana V. Ćirović,

Alessandra Pacini

and

Jacopo Junio Valerio Branca

submission deadline 31 May 2026 | Viewed by 63 | Submission Open

Keywords: cadmium (Cd) bioavailability; heavy metal intestinal uptake; heavy metal-induced cardiotoxicity; heavy metal-induced neurotoxicity; heavy metal-induced osteotoxicity; heavy metals and malignancies

Decoding Heart Failure: From Mechanisms to Treatment

edited by

Filippos Triposkiadis

and Dirk L. Brutsaert

submission deadline 31 May 2026 | Viewed by 57 | Submission Open

Keywords: heart failure; pathological process; molecular mechanisms; cellular mechanisms; genetic mechanisms; therapeutic target

Stem Cell-Based Strategies for Cardiac Tissue Engineering and Regeneration

edited by Munira Xaymardan and

Nona Farbehi

submission deadline 31 May 2026 | Viewed by 44 | Submission Open

Keywords: cardiac tissue engineering; stem cells; cardiomyocytes; cardiac organoids; engineered heart tissues; biomaterials; scaffolds; gene therapy; RNA reprogramming; cardiac fibrosis; cardiac regeneration; myocardial repair; translational studies

(This special issue belongs to the Section Stem Cells)

Modeling Lung Regeneration and Injury Responses Using Organoids and Engineered Niches

edited by Tristan Frum

submission deadline 31 May 2026 | Viewed by 36 | Submission Open

Keywords: lung biology; regeneration; stem cells; intra- and extracellular signaling; cell techniques; organoids; bioengineering

(This special issue belongs to the Section Tissues and Organs)

Displaying special issue 451-500 on page 10 of 14.

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