Decoding Heart Failure: From Mechanisms to Treatment

Dear Colleagues,

Heart Failure is a major global public health problem. However, major issues regarding this devastating syndrome remain unresolved. The main purposes of this Issue of Cells are as follows:

1. Synthesis and dissemination of cutting-edge research on the molecular, cellular, and genetic mechanisms underlying cardiac dysfunction in Heart Failure.
2. Highlighting the dual role of fibrosis in Heart Failure as a major pathological process and a salient therapeutic target.
3. Promoting the view that the current classification of Heart Failure, as well as treatment guidance based on the results of randomized controlled trials, are incompatible with precision medicine.
4. Emphasizing the pressing necessity to accurately determine the risk of adverse events (e.g., sudden cardiac death, pump failure, hospitalization, etc.) to guide device treatment or heart transplantation.

Our effort is grounded in the imperative to move beyond the current understanding and therapeutic approach of Heart Failure. We firmly believe this will profoundly benefit healthcare providers by moving them away from a one-size-fits-all approach toward precision medicine in Heart Failure.

Prof. Dr. Filippos Triposkiadis
Prof. Dr. Dirk L. Brutsaert
Guest Editors

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