Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects

Dear Colleagues,

Neurodevelopmental disorders arise from genetic and environmental perturbations that disrupt the finely tuned processes of brain development, including neuronal proliferation, migration, differentiation, and synaptic maturation. Recent advances in genomics, cellular neuroscience, and imaging have greatly expanded our understanding of the molecular and cellular cascades governing brain development, revealing convergent mechanisms across apparently distinct conditions such as intellectual disability, autism spectrum disorder, epilepsy, and rare monogenic syndromes. This Special Issue, entitled “Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects”, aims to present original research and reviews that dissect how alterations in key cellular pathways—such as those controlling synaptic plasticity, neurogenesis, glial function, and neuronal connectivity—contribute to the onset and progression of developmental brain dysfunction. Particular emphasis will be placed on studies employing cutting-edge experimental models, as well as those exploring innovative therapeutic strategies. By integrating mechanistic insights with translational perspectives, this collection seeks to advance our understanding of neurodevelopmental pathology in order to foster the development of targeted, mechanism-based interventions for these complex and often lifelong disorders.

Dr. Sandra Guidi
Dr. Fiorenza Stagni
Dr. Beatrice Uguagliati
Dr. Marco Emili
Guest Editors

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