Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Neuroscience".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 926
Special Issue Editors
Interests: down syndrome; pathological mechanism of brain development; molecular mechanisms of neurodegeneration; therapeutic approaches for neurodevelopmental defects and neurodegeneration; physiological and pathological activity of neural networks involved in memory and learning functions
Special Issues, Collections and Topics in MDPI journals
Interests: down syndrome; physiological and pathological molecular mechanisms underlying brain development; therapeutic ap-proaches for neurodevelopmental defects; synaptic plasticity in physiological and pathological conditions
Special Issues, Collections and Topics in MDPI journals
Interests: brain development; neurogenesis; neurodevelopmental disease; dendritic spine; synapses; synaptic plasticity; learning and memory
Special Issues, Collections and Topics in MDPI journals
Interests: down syndrome; physiological and pathological molecular mechanisms underlying brain development; therapeutic ap-proaches for neurodevelopmental defects; synaptic plasticity in physiological and pathological conditions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodevelopmental disorders arise from genetic and environmental perturbations that disrupt the finely tuned processes of brain development, including neuronal proliferation, migration, differentiation, and synaptic maturation. Recent advances in genomics, cellular neuroscience, and imaging have greatly expanded our understanding of the molecular and cellular cascades governing brain development, revealing convergent mechanisms across apparently distinct conditions such as intellectual disability, autism spectrum disorder, epilepsy, and rare monogenic syndromes. This Special Issue, entitled “Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects”, aims to present original research and reviews that dissect how alterations in key cellular pathways—such as those controlling synaptic plasticity, neurogenesis, glial function, and neuronal connectivity—contribute to the onset and progression of developmental brain dysfunction. Particular emphasis will be placed on studies employing cutting-edge experimental models, as well as those exploring innovative therapeutic strategies. By integrating mechanistic insights with translational perspectives, this collection seeks to advance our understanding of neurodevelopmental pathology in order to foster the development of targeted, mechanism-based interventions for these complex and often lifelong disorders.
Dr. Sandra Guidi
Dr. Fiorenza Stagni
Dr. Beatrice Uguagliati
Dr. Marco Emili
Guest Editors
Manuscript Submission Information
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Keywords
- neurodevelopmental disorders
- neuronal connectivity
- precocious therapies
- synaptic plasticity
- neurogenesis
- glial function
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