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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration

edited by Aurora Almadori

submission deadline 31 May 2026 | 5 articles | Viewed by 13904 | Submission Open

Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; ageing; immune response; inflammation; scarring

(This special issue belongs to the Section Stem Cells)

Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)

edited by

Joni H. Ylostalo

submission deadline 31 May 2026 | 3 articles | Viewed by 7090 | Submission Open

Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression

(This special issue belongs to the Section Stem Cells)

Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases

edited by

Lisbeth Birk Møller

submission deadline 31 May 2026 | 2 articles | Viewed by 5993 | Submission Open

Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha

Adipose-Derived Stem Cells for Tissue Regeneration

edited by

Lukas Prantl, MD, PhD, MHBA, FACS

submission deadline 31 May 2026 | 2 articles | Viewed by 5323 | Submission Open

Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies

(This special issue belongs to the Section Tissues and Organs)

Glial Cells: Physiological and Pathological Perspective

edited by

Qing Richard Lu

submission deadline 31 May 2026 | 4 articles | Viewed by 5292 | Submission Open

Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies

(This special issue belongs to the Section Cellular Neuroscience)

Natural Killer (NK) Cells in Immunity: Limitations and Potential

edited by Rehan Mujeeb Faridi

submission deadline 31 May 2026 | 2 articles | Viewed by 3976 | Submission Open

Keywords: natural killer cells; adaptive NK cells; infection

(This special issue belongs to the Section Cellular Immunology)

Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research

edited by

Elena Coccia

submission deadline 31 May 2026 | 1 articles | Viewed by 3738 | Submission Open

Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine

(This special issue belongs to the Section Stem Cells)

The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function

edited by

Alessandra Maria Vitale

and Federica Scalia

submission deadline 31 May 2026 | 1 articles | Viewed by 2020 | Submission Open

Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches

Non-Coding RNAs as Regulators of Cellular Function and Disease

edited by

Lucia Natarelli

submission deadline 31 May 2026 | 1 articles | Viewed by 1669 | Submission Open

Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms

Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity

edited by Jiabei Lin

submission deadline 31 May 2026 | 1 articles | Viewed by 1354 | Submission Open

Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer

Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics

edited by

Roshanak Rahimian

and

Mitra Esfandiarei

submission deadline 31 May 2026 | 1 articles | Viewed by 1119 | Submission Open

Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets

Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease

edited by

Elie Seaayfan

and

Martin Kömhoff

submission deadline 31 May 2026 | 1 articles | Viewed by 1113 | Submission Open

Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions

G Protein-Coupled Receptors and Diseases

edited by

Yongqiang Chen

submission deadline 31 May 2026 | 1 articles | Viewed by 1001 | Submission Open

Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation

Development and Characterization of Innovative In Vitro Models

edited by Fengyan Deng and Chongbei Zhao

submission deadline 31 May 2026 | 1 articles | Viewed by 818 | Submission Open

Keywords: 3D organoid development; iPSC; iPSC reprogramming; primary cell derivation; cell immortalization; disease model development; stem cell therapy; molecular biology; cell signaling

Cellular and Molecular Basis of Brain Tumor

edited by

Wojciech Czyżewski

, Tomasz S. Mandat, Grzegorz Turek and Radosław Mlak

submission deadline 31 May 2026 | 1 articles | Viewed by 470 | Submission Open

Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research

(This special issue belongs to the Section Cellular Pathology)

Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)

edited by Robert Sharp and

Itamar Raz

submission deadline 31 May 2026 | Viewed by 441 | Submission Open

Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology

(This special issue belongs to the Section Cellular Pathology)

Exploring Morphological Changes and Diversity in Cancer

edited by

Mustapha Kandouz

submission deadline 31 May 2026 | Viewed by 368 | Submission Open

Keywords: morphology; heterogeneity; cancer; phenotype; shape

Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms

edited by

Girish Chandra Melkani

submission deadline 31 May 2026 | Viewed by 239 | Submission Open

Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration

Role of Lysosomes in Mediating Cancer Drug Resistance

edited by

Petr Mlejnek

submission deadline 31 May 2026 | Viewed by 226 | Submission Open

Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments

edited by Konrad Talbot

submission deadline 31 May 2026 | Viewed by 193 | Submission Open

Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Mechanisms of Drug Delivery in Ophthalmology

edited by Alekha K. Dash and Surabhi Shukla

submission deadline 31 May 2026 | Viewed by 191 | Submission Open

Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery

(This special issue belongs to the Section Tissues and Organs)

Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis

edited by

Qianman Peng

and Jianzhong Shen

submission deadline 31 May 2026 | Viewed by 168 | Submission Open

Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling

Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine

edited by Renata Kelly Da Palma

submission deadline 31 May 2026 | Viewed by 166 | Submission Open

Keywords: cell therapy; lung diseases; tissue regeneration

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles in Reproductive Communication: From Gametogenesis to Implantation

edited by

Nima Azari-Dolatabad

and Osvaldo Bogado Pascottini

submission deadline 31 May 2026 | Viewed by 148 | Submission Open

Keywords: extracellular vesicles; reproductive biology; gametogenesis; oocyte maturation; embryo-maternal communication; implantation; reproductive disorders; epigenetic regulation; EV Cargo; intercellular signaling

Cellular and Molecular Mechanisms of Heart Development

edited by Jun K. Takeuchi

submission deadline 31 May 2026 | Viewed by 148 | Submission Open

Keywords: heart development; cardiovascular; epigenetics; cell fate; differentiation; cardiac growth; cardiac morphogenesis; heart regeneration; cardiac organoid

Mitochondria Beyond Energy: Signaling, Immunity, and Cell Fate

edited by

Martha E Diaz-Hernandez

submission deadline 31 May 2026 | Viewed by 144 | Submission Open

Keywords: mitochondria; stem cells; cell fate; organogenesis; immunometabolism

Cancer and Vessels: Insights at the Cellular and Molecular Levels

edited by Francesco Pezzella and Tom Donnem

submission deadline 31 May 2026 | Viewed by 143 | Submission Open

Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis

(This special issue belongs to the Section Cellular Pathology)

Regulatory Mechanisms of Vascular Smooth Muscle Cells and Immune Cells in Vascular Disease Progression

edited by

Kunzhe Dong

and

Liming Yu

submission deadline 31 May 2026 | Viewed by 139 | Submission Open

Keywords: vascular smooth muscle cells; immune cells; inflammation; vascular disease; atherosclerosis; aneurysm; cellular crosstalk; phenotypic transition

(This special issue belongs to the Section Cells of the Cardiovascular System)

Immunotherapy-Induced Cardiotoxicity: Unraveling the Immune Landscape of Myocarditis

edited by

Pan Ma

submission deadline 31 May 2026 | Viewed by 134 | Submission Open

Keywords: immunotherapy; immune checkpoints; adoptive cell therapy; cardiac adverse events; cardiac inflammation; immune checkpoint inhibitor associated myocarditis; cardiac immune landscape; innate immune response; adaptive immune response; myeloid cells; macrophages; antigen presentation & phagocytosis; T cells; T cell clonality; cytokines; chemokines; chemotaxis; immune crosstalk; immune– stromal crosstalk; multi-omics

New Advances in Cardiac and Vascular Physiology

edited by Robert M. Lust

submission deadline 31 May 2026 | Viewed by 132 | Submission Open

Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure

(This special issue belongs to the Section Tissues and Organs)

Skeletal Muscle Aging and Regeneration: Mitochondrial Health, Molecular Signaling, and Therapeutic Interventions

edited by

Stephen E. Alway

submission deadline 31 May 2026 | Viewed by 131 | Submission Open

Keywords: aging; skeletal muscle; regeneration; satellite cells; muscle stem cells; muscle wasting; mitochondria; fibro-adipogenic progenitor cells; repair

Cellular and Molecular Pathways in Immune Tolerance and Autoimmune Regulation

edited by

Md Jahangir Alam

submission deadline 31 May 2026 | Viewed by 107 | Submission Open

Keywords: immune tolerance; autoimmune regulation; immune homeostasis; regulatory T cells; regulatory B cells; cytokine networks; molecular mechanisms; therapeutic strategies

(This special issue belongs to the Section Cellular Immunology)

Molecular Mechanisms and Therapeutic Strategies for Skeletal Muscle Disorders

edited by

Valentina Di Felice

submission deadline 31 May 2026 | Viewed by 106 | Submission Open

Keywords: skeletal muscle; muscular disorders; myokines; muscle regeneration; muscle atrophy; inflammation; stress response; myoblast

B Cells in Action: Interaction Dynamics and Functional Decisions

edited by Michael L. Atchison and

Sulagna Sanyal

submission deadline 31 May 2026 | Viewed by 105 | Submission Open

Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response

(This special issue belongs to the Section Cellular Immunology)

Cellular Responses to Heavy Metals: From Intestinal Uptake to Disease

edited by

Aleksandar Cirovic

, Ana V. Ćirović,

Alessandra Pacini

and

Jacopo Junio Valerio Branca

submission deadline 31 May 2026 | Viewed by 99 | Submission Open

Keywords: cadmium (Cd) bioavailability; heavy metal intestinal uptake; heavy metal-induced cardiotoxicity; heavy metal-induced neurotoxicity; heavy metal-induced osteotoxicity; heavy metals and malignancies

DNA Damage and Repair in Targeted Cancer Therapy

edited by Mohd Saleem Dar, Sajad Ahmad Bhat and

Mohsin Maqbool

submission deadline 31 May 2026 | Viewed by 99 | Submission Open

Keywords: cancer cells; DNA damage and repair mechanism; genome organization; BER; NER; MMR; HR; and NHEJ; targeted therapy; inhibitors/PROATCS; drug resistance; drug toxicity; biomarkers; personalized medicine

Advances in Ion Channel Biology: From Molecular Mechanisms to Therapeutic Targets

edited by Shridhar Sanghvi,

Yang Zheng

and

Md Shahidul Islam

submission deadline 31 May 2026 | Viewed by 97 | Submission Open

Keywords: ion channels; electrophysiology; cryo-electron microscopy; channelopathy; membrane protein; gating mechanism; structural biology

Epigenetic and Cellular Regulation in Hematologic Disorders

edited by

Halina Leung

submission deadline 31 May 2026 | Viewed by 93 | Submission Open

Keywords: epigenetics; hematologic disorders; leukemia; myelodysplastic syndrome; thrombosis; thrombocytopenia; bleeding

Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects

edited by

and

submission deadline 31 May 2026 | Viewed by 91 | Submission Open

Keywords: neurodevelopmental disorders; neuronal connectivity; precocious therapies; synaptic plasticity; neurogenesis; glial function

(This special issue belongs to the Section Cellular Neuroscience)

Endometrial Cancer: From Molecular Mechanisms to Therapeutic Approaches

edited by Tomaž Büdefeld and

Jure Knez

submission deadline 31 May 2026 | Viewed by 77 | Submission Open

Keywords: endometrial cancer; genetic mutation; epigenetics; cell signaling; TIME; metastasis; biomarker; therapy; drug delivery; risk factor

Decoding Heart Failure: From Mechanisms to Treatment

edited by

Filippos Triposkiadis

and Dirk L. Brutsaert

submission deadline 31 May 2026 | Viewed by 63 | Submission Open

Keywords: heart failure; pathological process; molecular mechanisms; cellular mechanisms; genetic mechanisms; therapeutic target

Stem Cell-Based Strategies for Cardiac Tissue Engineering and Regeneration

edited by Munira Xaymardan and

Nona Farbehi

submission deadline 31 May 2026 | Viewed by 55 | Submission Open

Keywords: cardiac tissue engineering; stem cells; cardiomyocytes; cardiac organoids; engineered heart tissues; biomaterials; scaffolds; gene therapy; RNA reprogramming; cardiac fibrosis; cardiac regeneration; myocardial repair; translational studies

(This special issue belongs to the Section Stem Cells)

Molecular Bases Underlying Early Embryonic Development in Mammals

edited by

Rebeca González Fernández

, Julio Ávila Marrero and Angela Palumbo

submission deadline 31 May 2026 | Viewed by 51 | Submission Open

Keywords: embryonic development; early embryogenesis; gene expression; miRNA profile; reproductive physiology; cell signalling; embryo quality; developmental competence; in vitro embryo culture

(This special issue belongs to the Section Reproductive Cells and Development)

Modeling Lung Regeneration and Injury Responses Using Organoids and Engineered Niches

edited by Tristan Frum

submission deadline 31 May 2026 | Viewed by 49 | Submission Open

Keywords: lung biology; regeneration; stem cells; intra- and extracellular signaling; cell techniques; organoids; bioengineering

(This special issue belongs to the Section Tissues and Organs)

Advancements in Research on Metabolic Syndrome

edited by Gautam Kumar Pandey

submission deadline 31 May 2026 | Viewed by 44 | Submission Open

Keywords: metabolic syndrome; multi-omics; insulin resistance; cell signaling in metabolic disease

Cellular Metabolism and Immune Regulation in Cancer Progression and Metastasis

edited by Xu Jing

submission deadline 31 May 2026 | Viewed by 41 | Submission Open

Keywords: cellular metabolism; tumor immunology; cancer progression; metastasis; immunometabolism; metabolic reprogramming; tumor microenvironment; immune evasion; cancer therapy; metabolic biomarkers

(This special issue belongs to the Section Cellular Metabolism)

Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives

edited by

Eléanor Luce

and

Anne Dubart-Kupperschmitt

submission deadline 1 Jun 2026 | 1 articles | Viewed by 1031 | Submission Open

Keywords: human pluripotent stem cells; organoids; disease modeling; regenerative medicine; genome editing; single-cell omics; tissue engineering; drug discovery; precision medicine

(This special issue belongs to the Section Stem Cells)

Molecular Mechanisms of Fibrosis in Chronic Liver Diseases

edited by

Ahmad Salhab

, Regina Golan-Gerstl and Ihab Ansari

submission deadline 1 Jun 2026 | Viewed by 217 | Submission Open

Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS

Mechanisms, Biomarkers, and Therapeutics of Neurodegeneration

edited by

Xiao Bin

submission deadline 1 Jun 2026 | Viewed by 35 | Submission Open

Keywords: neurodegeneration; biomarkers; mechanistic studies; protein aggregation; protein degradation; neuroinflammation; targeted therapies; genetics; precision medicine

(This special issue belongs to the Section Cellular Neuroscience)

Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy

edited by

Abdullah Saeed

submission deadline 5 Jun 2026 | 3 articles | Viewed by 12691 | Submission Open

Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment

(This special issue belongs to the Section Cellular Immunology)

Displaying special issue 401-450 on page 9 of 13.

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