Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: 1 June 2026
Special Issue Editors
Interests: hiPSCs; organoids; liver
Special Issue Information
Dear Colleagues,
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem cells, have become indispensable tools for advancing developmental biology, disease modeling, and regenerative medicine. The emergence of organoid technologies derived from hPSCs has provided unprecedented opportunities to recapitulate aspects of human tissue architecture and function in vitro, offering a powerful alternative to traditional two-dimensional cultures and animal models.
This rapidly evolving field is now at the crossroads of several disciplines. Refining protocols to enhance reproducibility, reduce heterogeneity, and achieve long-term maturation remains a critical challenge. Moreover, recent efforts integrating genome editing, biomaterials engineering, microfluidics, vascularization strategies, and immune system components are expanding the scope of organoid applications. Such advances are paving the way for precision medicine approaches, high-throughput drug discovery, and potentially clinical translation.
This Special Issue of Cells, “Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives”, welcomes original research articles and reviews that address recent developments across this spectrum. Topics of interest include novel culture methods, single-cell and multi-omics profiling, disease-specific models, therapeutic applications, and bioengineering innovations. By gathering contributions from leading experts, this issue aims to provide an integrated perspective on current achievements and future directions for hPSC and organoid research.
Dr. Eléanor Luce
Dr. Anne Dubart-Kupperschmitt
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- human pluripotent stem cells
- organoids
- disease modeling
- regenerative medicine
- genome editing
- single-cell omics
- tissue engineering
- drug discovery
- precision medicine
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