Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 December 2025 | Viewed by 323
Special Issue Editors
Interests: cellular stress; cAMP/PKA signaling pathway; protein trafficking; ER stress; salt transporters; Bartter syndrome; cancer biology; protein–protein interactions; post-translation modifications (PTMs); ubiquitination; protein degradation; autophagy; hypoxia
Interests: cellular stress; cAMP/PKA signaling pathway; protein trafficking; ER stress; salt transporters; Bartter syndrome; cancer biology; protein–protein interactions; renal physiology; macula densa; autophagy; hypoxia
Special Issue Information
Dear Colleagues,
This Special Issue, “Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease”, aims to explore the intricate molecular mechanisms that regulate the cyclic AMP (cAMP)/Protein Kinase A (PKA) signaling pathway and its impact on cellular function in both normal physiology and disease states. The cAMP/PKA pathway is a critical signaling cascade involved in numerous biological processes, including metabolism, cellular stress responses, gene regulation, and neurotransmission. Dysregulation of this pathway has been implicated in a range of diseases, including metabolic disorders, cardiovascular diseases, cancer, and neurodegenerative conditions.
The contributions in this issue will address various aspects of cAMP/PKA signaling, including its role in cellular homeostasis, cross-talk with other signaling pathways, molecular regulators, and therapeutic interventions targeting pathway dysregulation. We invite original research articles and reviews that provide novel insights into this vital signaling axis, with a particular focus on its implications in disease pathology and potential therapeutic strategies.
Dr. Elie Seaayfan
Prof. Dr. Martin Kömhoff
Guest Editors
Manuscript Submission Information
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Keywords
- cAMP/PKA signaling
- protein kinase A (PKA)
- cyclic AMP
- EPAC
- signal transduction
- cellular homeostasis
- metabolic regulation
- disease mechanisms
- molecular signaling
- therapeutic targets
- cross-talk in signaling pathways
- protein–protein interactions
- post-translational modifications
- pharmacological interventions
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