Beyond the Brain: Merging Embodied Mind and AI in the Clinical Neuroscience of Psychotherapy

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuropsychology".

Deadline for manuscript submissions: 24 April 2026 | Viewed by 1194

Special Issue Editors


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Guest Editor
School of Integrated Gestalt Psychotherapy—SIPGI, 80058 Torre Annunziata, Italy
Interests: neuroscience; psychotherapy; pscychopathology; artificial intelligence; embodied mind; neural nets

E-Mail Website
Guest Editor
School of Integrated Gestalt Psychotherapy—SIPGI, 80058 Torre Annunziata, Italy
Interests: neuroscience; psychotherapy; pscychopathology; artificial intelligence; embodied mind; neural nets

Special Issue Information

Dear Colleagues,

A complex holistic approach, integrating neuroscience and psychotherapy, has progressively spread in order to provide a global response to mental distress. Clinical neuroscience evidence integrates psychotherapy by offering a complete and multifaceted understanding of the human being, joining the biological dimension and the relational-cultural one, to create effective treatments. Additionally, due to AI, the patient–therapist system is explored as a complex, self-organizing, and autopoietic network. Overcoming the traditional mind–body distinction, and its related scientific simplifications, permits new interdisciplinary understanding. According to Cozolino, clinical neuroscience epistemology aims to understand the human mind as an integrated system, in which genetics, brain development, epigenetics, and attachment interact deeply to shape behavior and mental health. The aim of this Special Issue is to welcome contributions that embrace these epistemological perspectives, exploring projects that demonstrate the effectiveness of therapeutic processes through a complexity-oriented lens towards an integrated perspective in clinical neuroscience and psychotherapy.

Prof. Dr. Raffaele Sperandeo
Dr. Valeria Cioffi
Guest Editors

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Keywords

  • holistic approach
  • psychotherapy
  • neuroscience
  • complex systems
  • self-organization
  • interdisciplinary research
  • artificial intelligence
  • embodied mind

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Published Papers (1 paper)

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Review

21 pages, 488 KB  
Review
Entangled Autopoiesis: Reframing Psychotherapy and Neuroscience Through Cognitive Science and Systems Engineering
by Dana Rad, Monica Maier, Zorica Triff and Radiana Marcu
Brain Sci. 2025, 15(10), 1032; https://doi.org/10.3390/brainsci15101032 - 24 Sep 2025
Viewed by 128
Abstract
The increasing intersection of psychotherapy, cognitive science, neuroscience, and systems engineering beckons us to rethink what it means to talk the language of the human mind in the clinical setting. This position paper proposes the idea of entangled autopoiesis, a metatheoretical paradigm that [...] Read more.
The increasing intersection of psychotherapy, cognitive science, neuroscience, and systems engineering beckons us to rethink what it means to talk the language of the human mind in the clinical setting. This position paper proposes the idea of entangled autopoiesis, a metatheoretical paradigm that addresses the mind and therapy not as linear processes but as self-organizing, adaptive processes enfolded across neural, cognitive, relational, and cultural domains. Psychotherapy, from this viewpoint, is less a corrective technique and more a zone of systemic integration, wherein resilience and meaning are co-created in the interaction of embodied brains, lived stories, and relational fields. Neuroscience informs us about plasticity and regulation; cognitive science emphasizes the embodied and extended nature of cognition; and systems engineering sheds light on feedback, emergence, and adaptive dynamics. Artificial intelligence appears as a double presence: as a metaphor for complexity and as a practical tool able to chart patterns below human sensibility. By adopting a complexity-aware epistemology, we advocate a relocation in clinical thinking—one recognizing the psyche as an autopoietic network, entangled with culture and technology and able to renew itself in therapeutic encounters. The implications for clinical methodology, therapist training, and future interdisciplinary research are discussed. Full article
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