Genetics and Epigenetics of Substance Use Disorders

Dear Colleagues,

Investigations of the genetic and epigenetic factors in substance use disorders have significantly advanced our understanding of these complex conditions. Genetic research has identified numerous markers associated with addiction, emphasizing the role of the dopamine system in reward pathways. Epigenetic studies have further elucidated how environmental factors, such as stress and drug exposure, can modify gene expression. These modifications can influence the risk of developing SUDs, explaining the variations in susceptibility among individuals with similar genetic backgrounds. The relevance of this research lies in its potential to inform personalized treatment and prevention strategies, tailored to an individual’s unique genetic and epigenetic profile. Future research directions include exploring the intricate interactions between genetic predispositions and environmental influences, as well as developing targeted interventions that consider both genetic and epigenetic factors. This comprehensive approach promises to enhance the effectiveness of treatments and improve outcomes for individuals affected by SUDs.

The Topic Issue encourages researchers to submit original manuscripts and reviews that examine the genetic and epigenetic mechanisms in substance use disorders.

Dr. Aleksandra Suchanecka
Prof. Dr. Anna Maria Grzywacz
Dr. Kszysztof Chmielowiec
Topic Editors