Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multiple Sclerosis Pathogenesis: Bridging Innate and Adaptive Immunity
edited by Jo Anne Stratton, Stephanie Zandee and Simon Thebault
submission deadline 30 Nov 2025 | Submission Open
Keywords: multiple sclerosis; innate– adaptive immune crosstalk; glial biology and complement; cellular immunology; biomarkers
Lipid Signaling in Human Disease
edited by Berit Johansen and Felicity Ashcroft
submission deadline 10 Dec 2025 | Viewed by 22 | Submission Open
Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids
(This special issue belongs to the Section Lipids)
Role of TRAF in Regulating Inflammation and Cell Survival
edited by Ali Abdul-Sater
submission deadline 15 Dec 2025 | 2 articles | Viewed by 3787 | Submission Open
Keywords: TRAF; inflammation; inflammasome; TNFRs; apoptosis; cellular survival
(This special issue belongs to the Section Biological Factors)
Novel Insights on Cancer Stem Cells
edited by
submission deadline 15 Dec 2025 | Viewed by 424 | Submission Open
Keywords: cancer stem cells; cancer initiating cells; stemness; self-renewal; therapy resistance; epigenetic reprogramming
(This special issue belongs to the Section Molecular Medicine)
Nanomaterials and Smart Delivery Systems in Combating Drug-Resistant Infections
edited by Hanif Haidari and
submission deadline 15 Dec 2025 | Viewed by 130 | Submission Open
Keywords: nanomaterials; antimicrobial biomolecules; tissue engineering; metallic nanoparticles; smart hydrogels; drug-resistant infections; controlled drug delivery; biomaterial-tissue interactions
(This special issue belongs to the Section Bio-Engineered Materials)
Recent Molecular Research on Protein Structure and Function
edited by
submission deadline 15 Dec 2025 | Viewed by 82 | Submission Open
Keywords: protein structure; protein function; molecular mechanisms; protein folding; structural biology
(This special issue belongs to the Section Molecular Biology)
Biochemistry in Medicine—Honorary Special Issue Commemorating Research and Work of Professors Jan O. Aaseth and Jan Alexander
edited by Sonia Distante and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 27781 | Submission Open
Keywords: medical biochemistry; endocrinology; neurotoxic metals
(This special issue belongs to the Section Molecular Medicine)
Feature Papers in the Natural and Bio-Derived Molecules Section submission deadline 31 Dec 2025 | 7 articles | Viewed by 19909 | Submission Open
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Cell Biology and Biomedical Application of Galectins submission deadline 31 Dec 2025 | 4 articles | Viewed by 10751 | Submission Open
Keywords: galectins; cell differentiation; stem cells; apoptosis; autophagy; cell adhesion; glycobiology; post-translational modifications; transmembrane signaling; protein trafficking; cancer; heart diseases; fibrosis; inflammation; targeted therapeutics; galectin inhibitors
(This special issue belongs to the Section Chemical Biology)
New Insight into the Molecular Genetics of Neurodevelopmental Disorders
edited by and Flavio Faletra
submission deadline 31 Dec 2025 | 4 articles | Viewed by 8646 | Submission Open
Keywords: neurodevelopmental disorders; next generation sequencing; pathomechanisms; phenotypic spectra; phenotype-genotype correlation
(This special issue belongs to the Section Molecular Genetics)
Advances in Melanoma Targeted Therapy
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7131 | Submission Open
Keywords: melanoma; drug discovery; new targets; target discovery
(This special issue belongs to the Section Molecular Medicine)
Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou submission deadline 31 Dec 2025 | 3 articles | Viewed by 5648 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Cardiometabolic Disease: Molecular Basis and Therapeutic Approaches
edited by and Maria Nikolaou
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5618 | Submission Open
Keywords: cardiometabolic medicine; preventive cardiology; cardiovascular endocrinology and metabolism; obesity; diabetes mellitus; cardiovascular disease
(This special issue belongs to the Section Molecular Medicine)
Antitumor Agents from Natural Sources 2024–2025 submission deadline 31 Dec 2025 | 2 articles | Viewed by 5472 | Submission Open
Keywords: antitumor agents; natural sources; cancer prevention and therapy
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Natural Bioactives as Leading Molecules for Drug Development
edited by , and
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4745 | Submission Open
Keywords: drug discovery; natural products; leading molecules; isolation and identification; phytochemical investigation; omics approaches
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Advances in Galectins
edited by Anu Paul and Diyoly Ayona
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4268 | Submission Open
Keywords: galectins; carbohydrate-binding proteins; galectin– microbe
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
The Role of Non-Coding RNAs in Health and Disease submission deadline 31 Dec 2025 | 5 articles | Viewed by 3892 | Submission Open
Keywords: non-coding RNA; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications
(This special issue belongs to the Section Molecular Genetics)
Insights from the Editorial Board Members
edited by
submission deadline 31 Dec 2025 | 9 articles | Viewed by 3835 | Submission Open
Keywords: structure and function; bioactive and biogenic substances; molecular mechanisms; biomaterials
Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities submission deadline 31 Dec 2025 | 2 articles | Viewed by 2880 | Submission Open
Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD
(This special issue belongs to the Section Molecular Medicine)
Mechanisms of Formation of Biomolecule Complexes: Theory, Experiment, Applications submission deadline 31 Dec 2025 | 2 articles | Viewed by 2872 | Submission Open
Keywords: biomolecule complexes; biomolecule coacervates; complex stability; mechanisms of formation of biomolecule complexes; phase separation; application of biomolecule complexes in biomedical industry
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition
edited by , and Haiting Chai
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2760 | Submission Open
Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1884 | Submission Open
Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials
(This special issue belongs to the Section Bio-Engineered Materials)
Non-Invasive Biomarkers in Saliva or Urine: Technical and Biological Variability
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1802 | Submission Open
Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
The Role of Nanoparticles in Tumor Treatment
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1536 | Submission Open
Keywords: nanoparticles; cancer therapy; nanotechnology
(This special issue belongs to the Section Chemical Biology)
Novel Mechanisms of Bacterial Antibiotic Resistance submission deadline 31 Dec 2025 | 1 articles | Viewed by 1517 | Submission Open
Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches
(This special issue belongs to the Section Biological Factors)
Molecular Biomarkers in Cardiology 2025
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1410 | Submission Open
Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart
(This special issue belongs to the Section Molecular Biomarkers)
Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications
edited by Yalin Qi
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1138 | Submission Open
Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection
(This special issue belongs to the Section Chemical Biology)
Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials
edited by and Rachael Dickman
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1063 | Submission Open
Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Melatonin in Normal Physiology and Disease, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1021 | Submission Open
Keywords: circadian rhythms; immunity; skin; reproduction; aging; viral and bacterial infection; inflammation; mesenchymal stem cells; cancer; neurodegenerative diseases; osteoporosis
(This special issue belongs to the Section Molecular Biology)
Necrotic Cell Death Mechanisms and Therapies
edited by and
submission deadline 31 Dec 2025 | Viewed by 609 | Submission Open
Keywords: necrosis; mitochondria; lysosomes; reactive oxygen species (ROS); calcium signalling; caspase-independent proteases: serine proteases like CELA; ELA; as well as cathepsin C and B etc.; heat shock proteins (HSPs); epigenetics; necrosis in diseases and therapeutic intervention; necroptosis; ferroptosis; paraptosis; pyroptosis
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Basis of Pathogenesis in Autoimmune Diseases
edited by I-Tsu Chyuan and
submission deadline 31 Dec 2025 | Viewed by 494 | Submission Open
Keywords: autoimmune diseases; molecular pathogenesis; genetic determinants; signaling pathways; immunopathology; therapeutic targets; novel molecular targets
(This special issue belongs to the Section Molecular Medicine)
Phytohormones 2024–2025
edited by Guzel Kudoyarova
submission deadline 31 Dec 2025 | Viewed by 448 | Submission Open
Keywords: plant hormones; auxins; cytokinins; gibberellins; abscisic acid; ethylene; salicylic acid; jasmonates
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 407 | Submission Open
Keywords: proteins; peptides; amyloid; Alzheimer disease; Parkinson’ s disease; neurodrugs; G-quadruplex nucleic acids; biotechnology; biomolecular targets; peptide aggregation; natural products; synthetic drugs; anti-amyloid therapeutics; machine learning
(This special issue belongs to the Section Chemical Biology)
Signaling Pathways as Therapeutic Targets for Cancer
edited by Fabian Benencia
submission deadline 31 Dec 2025 | Viewed by 329 | Submission Open
Keywords: cancer signaling pathways; cancer metabolism; small molecules; anticancer antibodies; tumor models; combinatorial therapies
(This special issue belongs to the Section Molecular Biology)
Molecular Basis and Oxidative Stress of Thyroid Diseases submission deadline 31 Dec 2025 | Viewed by 302 | Submission Open
Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease
(This special issue belongs to the Section Biological Factors)
Harnessing the Immune System Against Solid Cancer: New Targets and Novel Therapeutic Approaches submission deadline 31 Dec 2025 | Viewed by 260 | Submission Open
Keywords: immune response in cancer; molecular mechanisms of immunosuppression; cysteine proteases and their inhibitors
(This special issue belongs to the Section Molecular Biology)
The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication
edited by
submission deadline 31 Dec 2025 | Viewed by 247 | Submission Open
Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis
(This special issue belongs to the Section Cellular Biochemistry)
Functional Peptides and Their Interactions (3rd Edition) submission deadline 31 Dec 2025 | Viewed by 183 | Submission Open
Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications
edited by and Eleonora Martegani
submission deadline 31 Dec 2025 | Viewed by 111 | Submission Open
Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits
State-of-the-Art Molecular Structure and Dynamics and Biophysics in Asia
edited by and
submission deadline 31 Dec 2025 | Viewed by 101 | Submission Open
Keywords: molecular modeling; molecular dynamics simulation; protein– protein interaction; protein folding; bioinformatics; molecular docking; drug design; machine learning
Sjogren’s Syndrome: Recent Updates and Perspectives
edited by
submission deadline 31 Dec 2025 | Viewed by 100 | Submission Open
Keywords: Sjogren’ s syndrome; autoimmune inflammatory disease; genetics; biomarkers; Toll-like receptors; inflammasome chemokines
Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism submission deadline 31 Dec 2025 | Viewed by 66 | Submission Open
Keywords: biomolecular signaling in exercise adaptation; exercise and immune cell metabolism; inflammatory pathways and exercise; mitochondrial bioenergetics and exercise; exercise and adaptive immunity; neuroimmunometabolism and brain health; exercise and cancer immunometabolism; metabolic biomarkers of exercise-induced immunomodulation
(This special issue belongs to the Section Molecular Biology)
Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies
edited by Takashi Onodera and
submission deadline 31 Dec 2025 | Viewed by 55 | Submission Open
Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)
Ion Channels in Neurological and Psychological Disorders
edited by
submission deadline 31 Dec 2025 | Viewed by 53 | Submission Open
Keywords: ion channels; neurological disorders; psychological disorder; brain; therapeutic target
(This special issue belongs to the Section Molecular Biology)
p53 Family: The Molecular Landscape in Cancer and Beyond
edited by and Michele Pellegrino
submission deadline 31 Dec 2025 | Viewed by 47 | Submission Open
Keywords: p53 family; microRNA; tumorigenesis; aging; neurodegenerative diseases; immune regulation; biomarkers; therapy
(This special issue belongs to the Section Molecular Biology)
Lung Cancer: From Molecular Basis to Therapy
edited by
submission deadline 31 Dec 2025 | Viewed by 44 | Submission Open
Keywords: biomarkers; prognostic factors; predictive factors; genetic mutations and oncogenes; tumor suppressor genes; immune checkpoints and PD-L1; proteomic; genomic; radiomic
(This special issue belongs to the Section Molecular Biology)
Function and Regulation of Hyaluronan and Hyalectins in Disease submission deadline 31 Dec 2025 | Viewed by 39 | Submission Open
Keywords: hyaluonan; glycosaminoglycan; hyalectan; cancer; extracellular matrix; cellular signaling
Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress
edited by
submission deadline 31 Dec 2025 | Viewed by 33 | Submission Open
Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research
(This special issue belongs to the Section Molecular Biology)
The Value of Natural Compounds as Therapeutic Agents: 3rd Edition submission deadline 31 Dec 2025 | Viewed by 28 | Submission Open
Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Biomaterial Innovations for Tissue Engineering and Regeneration submission deadline 31 Dec 2025 | Viewed by 22 | Submission Open
Keywords: biomaterials; tissue engineering; regenerative medicine; cellular responses; 3D pathophysiological tissue models
(This special issue belongs to the Section Bio-Engineered Materials)
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