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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Alcohol Consumption as a Cardiovascular Risk Factor: Focusing on Molecular Mechanisms

edited by

Ichiro Wakabayashi

and

Klaus Groschner

submission deadline 31 Jan 2026 | Viewed by 66 | Submission Open

Keywords: alcohol; ethanol metabolism; ethanol– protein interactions; ethanol– membrane interactions; cardiovascular health and disease

(This special issue belongs to the Section Molecular Medicine)

Pain and Therapy: Molecular Perspectives and Future Directions

edited by

Francesco Scaglione

submission deadline 31 Jan 2026 | Viewed by 63 | Submission Open

Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment

(This special issue belongs to the Section Molecular Biology)

Sterol Biosynthesis in Organisms

edited by Damjana Rozman and

Cene Skubic

submission deadline 31 Jan 2026 | Viewed by 56 | Submission Open

Keywords: sterol biosynthesis; sterol metabolism; sterol regulation; sterol-related diseases

(This special issue belongs to the Section Cellular Biochemistry)

Genetic and Epigenetic Mechanisms Underlying Neurodevelopmental Disorders

edited by

Andrea L. Gropman

submission deadline 31 Jan 2026 | Viewed by 55 | Submission Open

Keywords: neurodevelopmental disorders; epigenetics; gene– environment interaction; chromatin remodeling; neurogenomics

(This special issue belongs to the Section Molecular Genetics)

Advances and Novel Strategies for Studying Underexplored Post-Translational Modifications (PTMs)

edited by

Yue Chen

submission deadline 31 Jan 2026 | Viewed by 48 | Submission Open

Keywords: post-translational modifications proteomics; chemical biology; cell signaling; epigenetics; metabolic regulation; cancer; diabetes; microbiome; aging

(This special issue belongs to the Section Molecular Biology)

Regulation of Sperm Function and Embryo Development

edited by

Jacob Thundathil

and

John P. Kastelic

submission deadline 31 Jan 2026 | Viewed by 35 | Submission Open

Keywords: sperm; oocyte; embryo; genes; reproductive technologies

(This special issue belongs to the Section Molecular Reproduction)

Pathogenesis and Targeted Therapy of Neurodegenerative Diseases

edited by

Wioletta Rozpędek-Kamińska

submission deadline 31 Jan 2026 | Viewed by 33 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; targeted therapy; molecular mechanisms; disease-modifying treatments

(This special issue belongs to the Section Molecular Medicine)

Cell Adhesion and Migration in the Nervous System

edited by

Igor Jakovčevski

submission deadline 31 Jan 2026 | Viewed by 25 | Submission Open

Keywords: cell adhesion molecules; extracellular matrix; glycans; nervous system regeneration; nervous system development; immune system; neurodegeneration

Antioxidant Effects of Bioactive Compounds

edited by

Katarzyna Dos Santos Szewczyk

submission deadline 5 Feb 2026 | Viewed by 131 | Submission Open

Keywords: bioactive compounds; polyphenols; oxidative stress; chronic diseases; nutraceuticals

Advances in Cold Therapies: Novel Physical Approaches for Musculoskeletal Repair–Molecular Insights

edited by Fackson Mwale

submission deadline 6 Feb 2026 | Viewed by 50 | Submission Open

Keywords: cold therapy; cryotherapy; cryoablation; musculoskeletal repair; inflammation modulation; regenerative medicine; extracellular matrix; cold shock proteins; tissue regeneration; physical therapy

Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair and Regeneration

edited by

Carl Randall Harrell

and

Crissy Fellabaum

submission deadline 11 Feb 2026 | Viewed by 90 | Submission Open

Keywords: MSC; vesicles; exosomes; tissue repair and regeneration

CD5 and CD6 Immunobiology: Multitask Immunomodulatory Molecules in Infection, Cancer and Autoimmunity

edited by Lozano Francisco and María Velasco-de Andrés

submission deadline 13 Feb 2026 | Viewed by 47 | Submission Open

Keywords: CD5; CD6; T cells; B1a cells; NK cells; immunomodulation; infection; cancer; autoimmunity; immunotherapy

(This special issue belongs to the Section Biological Factors)

Molecular Insights into the Mechanism of Antipsychotic Drugs

edited by Serdar Dursun and

Massimo Tusconi

submission deadline 15 Feb 2026 | 2 articles | Viewed by 7981 | Submission Open

Keywords: psychotropic medications; antipsychotic drugs; schizophrenia; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Advances in Antiviral Drug Development

edited by Angel S. Galabov

submission deadline 15 Feb 2026 | Viewed by 113 | Submission Open

Keywords: viral inhibitors; mechanism of action; antiviral tests

(This special issue belongs to the Section Molecular Medicine)

Advances in Various Roles of High-Density Lipoproteins

edited by

Yoshinari Uehara

submission deadline 15 Feb 2026 | Viewed by 41 | Submission Open

Keywords: atherosclerosis; high-density lipoprotein (HDL); HDL functions; apolipoproteins; lipid and glucose metabolism

(This special issue belongs to the Section Lipids)

Recent Advances in Immunotherapy for Mesothelioma

edited by Licun Wu

submission deadline 15 Feb 2026 | Viewed by 21 | Submission Open

Keywords: mesothelioma; immunotherapy; tumor microenvironment; biomarkers; tumor heterogeneity

(This special issue belongs to the Section Molecular Medicine)

Targeting Protein Misfolding: From Alzheimer's Amyloids to Therapeutic Peptides

edited by

Dariusz Stępkowski

submission deadline 16 Feb 2026 | Viewed by 49 | Submission Open

Keywords: amyloidogenesis; amyloidosis; amyloid fibrils; dissolution of amyloid fibrils; beta-sheet breakers; peptide inhibitors; small molecule inhibitors

TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition

edited by

Susan D. Brain

and Soraia Katia Pereira Costa

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1182 | Submission Open

Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation

(This special issue belongs to the Section Molecular Medicine)

Evolutionary Genomics of Bacterial Endosymbionts: From Mutualism to Parasitism

edited by

Amit Sinha

submission deadline 20 Feb 2026 | Viewed by 69 | Submission Open

Keywords: host– symbiont coevolution; metabolic pathways; horizontal DNA transfer; phylogenetics

Molecular Mechanisms of Traumatic Brain Injury

edited by Xiang Gao

submission deadline 22 Feb 2026 | Viewed by 88 | Submission Open

Keywords: traumatic brain injury; cell death; neural degeneration/regeneration; genetic modification; neuroprotection

Endocrine Regulation of Reproductive Tissues: From Molecular Mechanisms to Therapies

edited by

Waldemar Grzegorzewski

submission deadline 25 Feb 2026 | Viewed by 44 | Submission Open

Keywords: hormone signaling; reproductive physiology; steroid receptors; infertility; endocrine disruptors; epigenetic regulation; gonadal steroids; hormone-dependent cancers; therapeutic targeting; gametogenesis

(This special issue belongs to the Section Biological Factors)

Role of Oxidative Stress in Vascular Diseases

edited by

Vittoria Cammisotto

and

Valentina Castellani

submission deadline 26 Feb 2026 | Viewed by 61 | Submission Open

Keywords: oxidative stress; vascular disease; endothelial dysfunction; NADPH oxidase/NOX2; platelet activation; autophagy; gut microbiota; inflammation; reactive oxygen species (ROS); cardiovascular risk

Extracellular Vesicles as Natural Nanocarriers: Advances in Cancer, Tissue Regeneration and Skin Health

edited by

Salvatore Panza

submission deadline 26 Feb 2026 | Viewed by 13 | Submission Open

Keywords: extracellular vesicles; natural nanocarriers; drug delivery; cancer therapy; regenerative medicine; skin health; dermocosmetics; tumor microenvironment; bioactive cargo; targeted delivery

Molecular Advances in Wound Healing and Skin Regeneration

edited by

Hiroyuki Ijima

and Muhammad Shafiq

submission deadline 28 Feb 2026 | 2 articles | Viewed by 14381 | Submission Open

Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair

(This special issue belongs to the Section Biological Factors)

Cannabinoids in Neurobehavioral Modulation

edited by

Francisco Navarrete

and

María S. García Gutiérrez

submission deadline 28 Feb 2026 | 3 articles | Viewed by 7660 | Submission Open

Keywords: cannabinoids; neurobehavior; brain diseases; therapeutic; translational

(This special issue belongs to the Section Molecular Biology)

Innovative Biomolecular Structure Analysis Techniques

edited by Tzanko I. Doukov

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5496 | Submission Open

Keywords: macromolecular crystallography; room temperature crystallography; protein ensembles; NMR; MD simulations

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Novel Molecules for Cancer Treatment (3rd Edition)

edited by

Javier Martínez Useros

submission deadline 28 Feb 2026 | 4 articles | Viewed by 4286 | Submission Open

Keywords: cancer; small molecules; antibody-drug-conjugated; tyrosine kinase inhibitors; target therapy; monoclonal antibodies; immunotherapy; natural compounds

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Chronic Heart Failure: From Molecular Mechanisms to Therapies Strategies

edited by

Josep Comín-Colet

and

Marta Tajes

submission deadline 28 Feb 2026 | 5 articles | Viewed by 3732 | Submission Open

Keywords: chronic heart failure; pathophysiology; comorbidities; new therapies; molecular pathways

(This special issue belongs to the Section Molecular Medicine)

Inflammatory Mechanisms and Molecular Targets in Neurological Disorders: Effects of Neuroprotective Drugs

edited by

Jose Joaquin Merino

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3623 | Submission Open

Keywords: neuroinflammation; neurological disorders; molecular targets; therapeutic strategies; neuroimmunology

(This special issue belongs to the Section Molecular Medicine)

Genetic and Genomic Biomarkers in Cancer Diagnosis, Prognosis, and Treatment Prediction

edited by

Jianli Dong

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3376 | Submission Open

Keywords: laboratory genetics and genomics; genetic and genomic biomarkers; diagnostic; prognostic; predictive; companion diagnosis; targeted therapy; nucleic acid

(This special issue belongs to the Section Molecular Biomarkers)

Molecular and Cellular Mechanisms in Anti-Thrombosis

edited by

Joen-Rong Sheu

and

Thanasekaran Jayakumar

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3041 | Submission Open

Keywords: platelet activation and thrombosis; neuroprotection; antithrombotic mechanisms

(This special issue belongs to the Section Molecular Medicine)

Biomarkers and Molecular Basis of Psychiatry

edited by

Massimo Tusconi

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2972 | Submission Open

Keywords: mental health; bipolar disorders; mood; anxiety; psychosis; schizophrenia; biomarkers

(This special issue belongs to the Section Biological Factors)

Heterocyclic Compounds as Novel Anti-Cancer Agents and Their Mechanisms of Action

edited by Chandra Mishra and

Dnyaneshwar N. Garad

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2805 | Submission Open

Keywords: heterocyclic compounds; anticancer; synthetic; natural

(This special issue belongs to the Section Molecular Medicine)

Glutamate and Glutamate Receptors in Health and Diseases, Second Edition

edited by

Jolanta H. Kotlińska

and

Marta Marszalek-Grabska

submission deadline 28 Feb 2026 | 3 articles | Viewed by 2683 | Submission Open

Keywords: glutamate receptors; addiction; pain; learning and memory; anxiety; depression; autism; neurodegeneration

(This special issue belongs to the Section Molecular Biology)

Molecular Signalling Pathways in Tumorigenesis and Tumor Suppression

edited by

Kiyoshi Ohtani

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2497 | Submission Open

Keywords: E2F; RB; p53; cancer; tumor suppression

(This special issue belongs to the Section Biological Factors)

Structural Biology of Protein

edited by

Nabanita Saikia

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2256 | Submission Open

Keywords: structural characterization; protein structure– function paradigm; biophysical techniques; computational methods; conformational dynamics; drug discovery; protein– protein interactions

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Advancing Molecular Regulation in Brain Injury Research: Mechanisms, Diagnosis, and Rehabilitation

edited by Guanglin Zhang and

Pavan Thapak

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1756 | Submission Open

Keywords: brain injury; biomarkers; neurodegeneration; neuroplasticity; neuroimaging; microbial dysbiosis; gut– brain axis; cognitive rehabilitation

(This special issue belongs to the Section Molecular Biology)

Tumor Genomics and Liquid Biopsy in Cancer Biology

edited by

Milena Urbini

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1579 | Submission Open

Keywords: circulating tumor DNA (ctDNA); circulating tumor cells (CTCs); exosomes and extracellular vesicles; circulating free RNAs and microRNAs; tumor heterogeneity; mechanisms of metastasis; tumor clonal evolution; drug resistance; tumor microenvironment; multi-omics integration

(This special issue belongs to the Section Molecular Biology)

Single-Molecule Protein Electronics

edited by

Stuart Lindsay

and Bintian Zhang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1471 | Submission Open

Keywords: protein electronics; molecular electronics; single-molecule conductance; protein detection; protein sensing; label-free detection; conductance gating in proteins; electron transport mechanisms in proteins; coherence and dephasing in proteins; role of water in protein conductance; extended electronic states in proteins; hopping conductance in proteins; long-range hopping in proteins; electrode– protein interfaces; charge injection barriers at protein– electrode interfaces; proteins as electronic devices; protein assemblies as electronic devices; DNA electronics; electron transport in DNA; DNA– electrode interfaces; charge injection at a DNA– electrode interface; barrier to charge injection at a DNA– electrode interface

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition

edited by

Luciana Bordin

, Alessandra Andrisani and Chiara Sabbadin

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1172 | Submission Open

Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism and Detection of SARS-CoV-2

edited by

Zaki A. Sherif

submission deadline 28 Feb 2026 | 1 articles | Viewed by 745 | Submission Open

Keywords: SARS-CoV-2 spike protein; ACE2 receptor; viral pathogenesis; host-viral protein interactions; molecular diagnostics; RNA virus replication; immune response; viral structural proteins; pathobiology; RT-PCR detection

(This special issue belongs to the Section Molecular Biology)

Polyphosphate (PolyP) in Health and Disease

edited by

Félix A. Ruiz

submission deadline 28 Feb 2026 | 1 articles | Viewed by 634 | Submission Open

Keywords: polyphosphate; polyP; biomarker and therapeutic target

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Exploring Novel Molecular Pathways and Emerging Treatments for Neuromuscular Disorders

edited by

Arturo Lopez-Castel

submission deadline 28 Feb 2026 | Viewed by 317 | Submission Open

Keywords: gene therapy; repurposing; therapeutic oligonucleotides; personalized medicine; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Molecular Biology of Age-Related Macular Degeneration: From Pathogenesis to Therapeutic Strategies

edited by

Serena Fragiotta

, Pier Luigi Grenga and Chiara Ciancimino

submission deadline 28 Feb 2026 | Viewed by 233 | Submission Open

Keywords: age-related macular degeneration; vascular endothelial growth factor (VEGF); inflammation; neurodegeneration; single-nucleotide polymorphisms (SNP)

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress and Ferroptosis in Health and Disease

edited by Udayakumar Karunakaran and Suma Elumalai

submission deadline 28 Feb 2026 | Viewed by 220 | Submission Open

Keywords: reactive oxygen species; antioxidants; glutathione; iron; H2S signaling; diabetes; metabolic disease; mitochondrial biology; ferroptosis; cell death; inflammation; aging; neurodegenerative diseases

(This special issue belongs to the Section Chemical Biology)

Novel Drug Targets and RNA Epigenetics in Cancer Therapy

edited by Manjeet K. Rao

submission deadline 28 Feb 2026 | Viewed by 200 | Submission Open

Keywords: RNA modifications; cancer epigenetics; novel drug targets; RNA therapeutics; tumorigenesis

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Mechanisms in Cardiorenal Syndrome

edited by

Rosemary Wangensteen

, María Carmen Ruiz Fuentes and Maria José Espigares Huete

submission deadline 28 Feb 2026 | Viewed by 198 | Submission Open

Keywords: cardiorenal syndrome; renal failure; heart; kidney; heart failure

(This special issue belongs to the Section Molecular Biology)

Insights into Mitochondria in Psychiatric Disorders

edited by Ji Geng

submission deadline 28 Feb 2026 | Viewed by 180 | Submission Open

Keywords: mitochondria; depression; schizophrenia; autism; neurodevelopmental disorders

(This special issue belongs to the Section Cellular Biochemistry)

Virus-Host Protein Interactions

edited by

Benoit Coulombe

submission deadline 28 Feb 2026 | Viewed by 135 | Submission Open

Keywords: protein– protein interactions; antiviral drug discovery; protein target inhibitors

Unveiling Protein Functions, Dynamics and Interactions in Health and Disease Using Experimental and Theoretical Approaches, 2nd Edition

edited by Alice Romagnoli,

Stefano Motta

and

Jesmina Rexha

submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open

Keywords: protein structure and dynamics; protein– protein interactions; point mutations; molecular biology; molecular modeling; molecular dynamics; biochemistry; bioinformatics; protein– ligand interaction; protein– nucleic acid interaction; protein conformational changes

(This special issue belongs to the Section Chemical Biology)

Displaying special issue 351-400 on page 8 of 10.

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