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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases

edited by

Balraj Gopula

Tamal Kanti Das

and Arun Raja

submission deadline 31 Dec 2025 | Viewed by 43 | Submission Open

Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology

(This special issue belongs to the Section Chemical Biology)

Recent Advances in Laccases and Laccase-Based Bioproducts: 2nd Edition

edited by

Grzegorz Janusz

and

Anna Pawlik

submission deadline 31 Dec 2025 | Viewed by 37 | Submission Open

Keywords: laccase; application; heterologous expression; bioproducts; laccase engineering

(This special issue belongs to the Section Enzymology)

Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function

edited by

Cassandra E. Holbert

and

Tracy Murray Stewart

submission deadline 31 Dec 2025 | Viewed by 34 | Submission Open

Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology

(This special issue belongs to the Section Cellular Biochemistry)

Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine

edited by Xiao Fan and Youngil Lee

submission deadline 31 Dec 2025 | Viewed by 32 | Submission Open

Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype– phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy

(This special issue belongs to the Section Molecular Genetics)

Biomolecules in Myocarditis and Inflammatory Heart Disease

edited by

Amarylis Claudine Bonito A. Wanschel

submission deadline 31 Dec 2025 | Viewed by 29 | Submission Open

Keywords: cardiomyocyte; macrophage; cardiac remodeling; oxidative and nitrosative stress; neutrophils

(This special issue belongs to the Section Molecular Medicine)

Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications

edited by

Marina Piscopo

and

Carmen Di Giovanni

submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open

Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine

Updates on Mitochondria and Cancer

edited by

Antonella Cormio

and

Clara Musicco

submission deadline 15 Jan 2026 | Viewed by 109 | Submission Open

Keywords: mitochondrial dysfunction in cancer; mitochondrial metabolomics; mitochondria and cancer therapy; mitochondria and cancer drug resistance; prognostic/predictive mitochondrial markers in cancer tissues and body fluids

(This special issue belongs to the Section Biological Factors)

Inflammation and Immunity in Lung Disease

edited by

Xuexian Yang

submission deadline 15 Jan 2026 | Viewed by 52 | Submission Open

Keywords: lung; infection; inflammation; host defense; cytokine release syndrome; genetic deficiency

(This special issue belongs to the Section Cellular Biochemistry)

Epigenetic Programming of Cellular States

edited by

Benjamin Carone

submission deadline 15 Jan 2026 | Viewed by 21 | Submission Open

Keywords: iPSCs; stem cells; reprogramming; chromatin; epigenetics

Skeletal Muscle Homeostasis and Regeneration: 2nd Edition

edited by

Ernő Zádor

submission deadline 15 Jan 2026 | Viewed by 20 | Submission Open

Keywords: skeletal muscle; homeostasis; regeneration; satellite cells; fiber type

(This special issue belongs to the Section Molecular Medicine)

Lipid Signaling in Neuroinflammation and Neurodegeneration

edited by

Jason R. Gerstner

submission deadline 20 Jan 2026 | Viewed by 25 | Submission Open

Keywords: lipid signaling; neuroinflammation; neurodegeneration; sphingolipids; eicosanoids; phospholipids; endocannabinoids; lipid mediators; molecular mechanisms; brain health

Novel Mechanisms in Renal Blood Pressure Regulation: From Neuropeptides to Angiotensin II and Dopamine Receptors

edited by

Hewang Lee

and

Pedro A. José

submission deadline 23 Jan 2026 | Viewed by 48 | Submission Open

Keywords: neuropeptides; dopamine; blood pressure; G protein-coupled receptors; oxidative stress kidney; vasculature; brain

Cellular Stress Responses in Oncogenesis and Metabolic Reprogramming

edited by

Kuo Hui Su

submission deadline 30 Jan 2026 | Viewed by 27 | Submission Open

Keywords: cellular stress response; metabolic reprogramming; oncogenesis; lipid metabolism; tumor adaptation; mitochondrial metabolism

(This special issue belongs to the Section Cellular Biochemistry)

Inositol Phosphates in Health and Disease, 2nd Edition

edited by

Ivana Vucenik

and

Abulkalam M. Shamsuddin

submission deadline 31 Jan 2026 | 6 articles | Viewed by 14558 | Submission Open

Keywords: inositol polyphosphates (IPs); IP6; inositol pyrophosphate (PP-Ips); signal transduction; energy metabolism; anticancer activity; PCOS; metabolic diseases; pathological calcification; neuropsychiatric disease

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Metabolic Regulation Used by G Protein-Coupled Receptors

edited by

Hongxia Ren

and Jason M. Conley

submission deadline 31 Jan 2026 | 3 articles | Viewed by 7147 | Submission Open

Keywords: diabetes; obesity; metabolism; GPCR; signaling

(This special issue belongs to the Section Molecular Biology)

Advances in Metabolites Produced by Microbiota

edited by

Arancha Llama-Palacios

submission deadline 31 Jan 2026 | 3 articles | Viewed by 7016 | Submission Open

Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins

(This special issue belongs to the Section Cellular Biochemistry)

The Immune System and Allergies

edited by

Marco Casciaro

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6948 | Submission Open

Keywords: immune system; allergy; inflammation; hypersensitivity; immunology

(This special issue belongs to the Section Cellular Biochemistry)

Retinal Diseases: Molecular Mechanisms and Therapies

edited by

Ana Raquel Santiago

and Raquel Boia

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3251 | Submission Open

Keywords: retinal diseases; molecular mechanisms; therapeutic strategies; vision impairment; gene therapy; retinal degeneration; neuroprotection; innovative treatments

(This special issue belongs to the Section Cellular Biochemistry)

Pharmacology of Cardiovascular Diseases

edited by

Istvan Lekli

, Alexandra Gyongyosi and

Istvan Bak

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2925 | Submission Open

Keywords: cardioprotection autophagy; redox balance; heart faliure; cardiovascular pharmacotherapy

(This special issue belongs to the Section Molecular Medicine)

Natural Products and Their Derivatives with Antiviral Activity

edited by

Zhijun Zhang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 818 | Submission Open

Keywords: natural products; synthetic antivirals; antiviral drugs; antiviral strategies; influenza; HBV; HIV; RSV; COVID-19; SARS-CoV-2

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Developmental Biology of the Kidney: From Molecular Mechanisms to Congenital Disorders

edited by

Katarina Vukojević

and Anita Racetin

submission deadline 31 Jan 2026 | 1 articles | Viewed by 595 | Submission Open

Keywords: kidney development; renal physiology; kidney disease; molecular mechanisms; cellular signaling; gene expression; biomarkers; renal pathophysiology; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

Pluripotent Stem Cells: From Basic Research to Therapeutic Applications

edited by

Claudia Spits

and

Diana Al Delbany

submission deadline 31 Jan 2026 | Viewed by 316 | Submission Open

Keywords: pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells; organoids; differentiation; regenerative medicine; disease modeling; cell therapy; therapeutic applications

(This special issue belongs to the Section Molecular Biology)

Inflammation Biology in Orthodontic Tooth Movement

edited by

Masaru Yamaguchi

submission deadline 31 Jan 2026 | Viewed by 288 | Submission Open

Keywords: orthodontic tooth movement; inflammation; cytokine; root resorption; accelerated orthodontic tooth movement; relapse

(This special issue belongs to the Section Biological Factors)

Advances in Molecular Therapy Targeting DNA Damage and Repair Systems

edited by

Joy Mitra

Anirban Chakraborty

and Anahita Mojiri

submission deadline 31 Jan 2026 | Viewed by 250 | Submission Open

Keywords: DNA repair; DNA repair inhibitors; homologous recombination; genome instability; inflammation; DNA damage; cell death; apoptosis

(This special issue belongs to the Section Biological Factors)

Mechanisms of Gene Regulation in Embryos

edited by

Jo Qian

and Adam Davis

submission deadline 31 Jan 2026 | Viewed by 249 | Submission Open

Keywords: embryonic development; gene regulation; epigenetics; transcriptional control; post-transcriptional control; translational control; post-translational modification; signaling pathways; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Basis of Parasite Infection

edited by

Adekunle Sanyaolu

and

Ricardo Izurieta

submission deadline 31 Jan 2026 | Viewed by 244 | Submission Open

Keywords: parasite infection; host– parasite interaction; cellular invasion; molecular mechanisms; immune evasion

(This special issue belongs to the Section Molecular Medicine)

The Role of Extracellular Vesicles in Drug Delivery

edited by

Davide Brocco

submission deadline 31 Jan 2026 | Viewed by 227 | Submission Open

Keywords: extracellular vesicles; drug delivery systems; extracellular vesicle engineering; cancer treatment; gene therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms, Novel Diagnostics and Treatments of Gynecologic Cancer

edited by Panneerdoss Subbarayalu

submission deadline 31 Jan 2026 | Viewed by 139 | Submission Open

Keywords: biomarker; cancer biology; novel drug targets and therapeutics; cancer stem cells; tumorigenesis

(This special issue belongs to the Section Molecular Medicine)

New Insights into Mesothelial Cell

edited by Francesca Bodega and Cristina Porta

submission deadline 31 Jan 2026 | Viewed by 115 | Submission Open

Keywords: mesothelial cells; serous cavities; lubricating fluids; epithelial– mesenchymal transition; fibrosis; tissue repair; mesothelioma; tumor microenvironment; immune response

(This special issue belongs to the Section Molecular Biology)

Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease

edited by

Melina M. Musri

and

Victor I. Peinado

submission deadline 31 Jan 2026 | Viewed by 105 | Submission Open

Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation

(This special issue belongs to the Section Molecular Biology)

Metabolic Diseases: From Molecular Mechanisms to Therapy Strategies

edited by

Livia Lenzini

and

Nicola Vitturi

submission deadline 31 Jan 2026 | Viewed by 101 | Submission Open

Keywords: inborn errors of metabolism; molecular mechanisms; gene identification; therapeutic; approaches; translation

Mechanisms in Stress-Related Disorders, Anxiety and Fear

edited by Veronica Begni

submission deadline 31 Jan 2026 | Viewed by 76 | Submission Open

Keywords: stress-related disorders; anxiety; fear; genetic and environmental interactions; behavioral neuroscience; biological pathways; biomarkers; therapeutic interventions

(This special issue belongs to the Section Molecular Biology)

Nucleic Acid-Lipid Interactions: Bridging Molecular Insights with Therapeutic Applications

edited by Weiwei He and Serdal Kirmizialtin

submission deadline 31 Jan 2026 | Viewed by 51 | Submission Open

Keywords: nucleic acids; lipid membranes; interactions; structural transitions; physical mechanism

New Insights into Mechanisms and Therapeutics for Cardiovascular Disorders: 2nd Edition

edited by

Carola Yvette Förster

Mohsin Saleet Jafri

and Tarun W. Dasari

submission deadline 31 Jan 2026 | Viewed by 49 | Submission Open

Keywords: brain– heart axis; heart and stroke; stress-induced cardiomyopathy; cardiovascular disease

(This special issue belongs to the Section Molecular Medicine)

Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants: 2nd Edition

edited by

Daniela Grimm

submission deadline 31 Jan 2026 | Viewed by 48 | Submission Open

Keywords: cells; humans; animals; plants; microorganisms; microgravity; weightlessness; cancer research; tissue engineering; space-related health problems

(This special issue belongs to the Section Cellular Biochemistry)

Endometriosis: Molecular Pathogenesis and Translational Implications

edited by

Ie-Ming Shih

submission deadline 31 Jan 2026 | Viewed by 43 | Submission Open

Keywords: endometriosis; pathogenesis; adenomyosis; diagnosis; detection

(This special issue belongs to the Section Molecular Medicine)

Alcohol Consumption as a Cardiovascular Risk Factor: Focusing on Molecular Mechanisms

edited by

Ichiro Wakabayashi

and

Klaus Groschner

submission deadline 31 Jan 2026 | Viewed by 34 | Submission Open

Keywords: alcohol; ethanol metabolism; ethanol– protein interactions; ethanol– membrane interactions; cardiovascular health and disease

(This special issue belongs to the Section Molecular Medicine)

Lung Disease: From Molecular Mechanism to Therapeutic Opportunities

edited by

Patrick G. Arndt

submission deadline 31 Jan 2026 | Viewed by 32 | Submission Open

Keywords: biomarkers; pharmacotherapeutics; cell signaling; innate immunity; inflammation

(This special issue belongs to the Section Molecular Biology)

Molecular Biology and Therapy of Breast Cancer

edited by

Norbert Nass

submission deadline 31 Jan 2026 | Viewed by 28 | Submission Open

Keywords: breast cancer; molecular pathology; biomarkers; novel therapy targets; personalized therapy; immunotherapy; tumor microenvironment; tumor stem cells; therapy resistance; non-coding RNA

Pain and Therapy: Molecular Perspectives and Future Directions

edited by

Francesco Scaglione

submission deadline 31 Jan 2026 | Viewed by 23 | Submission Open

Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment

(This special issue belongs to the Section Molecular Biology)

Sterol Biosynthesis in Organisms

edited by Damjana Rozman and

Cene Skubic

submission deadline 31 Jan 2026 | Viewed by 18 | Submission Open

Keywords: sterol biosynthesis; sterol metabolism; sterol regulation; sterol-related diseases

(This special issue belongs to the Section Cellular Biochemistry)

Synthesis, Characterization and Validation of Small Molecule Compounds

edited by Mohamed Fares Metwaly

submission deadline 31 Jan 2026 | Viewed by 16 | Submission Open

Keywords: medicinal chemistry; structure-based drug design; enzyme inhibitors; multi-target therapeutics

(This special issue belongs to the Section Synthetic Biology and Bioengineering)

Genetic and Epigenetic Mechanisms Underlying Neurodevelopmental Disorders

edited by

Andrea L. Gropman

submission deadline 31 Jan 2026 | Viewed by 10 | Submission Open

Keywords: neurodevelopmental disorders; epigenetics; gene– environment interaction; chromatin remodeling; neurogenomics

(This special issue belongs to the Section Molecular Genetics)

Advances and Novel Strategies for Studying Underexplored Post-Translational Modifications (PTMs)

edited by

Yue Chen

submission deadline 31 Jan 2026 | Viewed by 8 | Submission Open

Keywords: post-translational modifications proteomics; chemical biology; cell signaling; epigenetics; metabolic regulation; cancer; diabetes; microbiome; aging

(This special issue belongs to the Section Molecular Biology)

Regulation of Sperm Function and Embryo Development

edited by

Jacob Thundathil

and

John P. Kastelic

submission deadline 31 Jan 2026 | Viewed by 8 | Submission Open

Keywords: sperm; oocyte; embryo; genes; reproductive technologies

(This special issue belongs to the Section Molecular Reproduction)

Antioxidant Effects of Bioactive Compounds

edited by

Katarzyna Dos Santos Szewczyk

submission deadline 5 Feb 2026 | Viewed by 62 | Submission Open

Keywords: bioactive compounds; polyphenols; oxidative stress; chronic diseases; nutraceuticals

Advances in Cold Therapies: Novel Physical Approaches for Musculoskeletal Repair–Molecular Insights

edited by Fackson Mwale

submission deadline 6 Feb 2026 | Viewed by 19 | Submission Open

Keywords: cold therapy; cryotherapy; cryoablation; musculoskeletal repair; inflammation modulation; regenerative medicine; extracellular matrix; cold shock proteins; tissue regeneration; physical therapy

Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair and Regeneration

edited by