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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Electronics: Insights and Challenges

edited by

Stuart Lindsay

submission deadline 30 Nov 2026 | Viewed by 104 | Submission Open

Keywords: single-molecule electronics; molecular electronics; single-molecule conductance; charge transport in molecules; nanoscale transport mechanisms; quantum transport in molecular junctions; coherence and dephasing; hopping transport; electron– phonon interactions; ion and proton-coupled transport; electrode– molecule interfaces; charge injection barriers; molecular junctions; scanning probe measurements (STM; cAFM); molecular sensing; label-free detection; molecular-scale devices; molecular assemblies; organic and polymer electronics; biomolecular electronics; protein electronics; DNA electronics; electron transport in DNA; hybrid bioelectronic systems; molecular device integration

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Structure-Based Mechanisms of Protein Functions

edited by Vasiliki Fadouloglou

submission deadline 30 Nov 2026 | Viewed by 97 | Submission Open

Keywords: pseudoenzymes; moonlighting proteins; metamorphic proteins; intrinsically disordered proteins

(This special issue belongs to the Section Molecular Biology)

Molecular Therapies and Metabolic Mechanisms in Genetic Disorders

edited by Estera Rintz

submission deadline 30 Nov 2026 | Viewed by 95 | Submission Open

Keywords: genetic disorders; molecular therapies; gene therapy; genome editing; RNA therapeutics; metabolic mechanisms; metabolic dysregulation; inherited diseases; mitochondrial dysfunction; precision medicine; multi-omics; biomarker discovery; translational research

(This special issue belongs to the Section Molecular Genetics)

Targeting Early Life Exposures: From Epigenetic Marks to Interventions

edited by

Daliao Xiao

submission deadline 30 Nov 2026 | Viewed by 89 | Submission Open

Keywords: early life exposures; epigenetic programming; fetal origins of disease; translational interventions

(This special issue belongs to the Section Molecular Genetics)

Electrochemical Biosensors: From Molecular Recognition to Real World Applications

edited by

Angel A. J. Torriero

submission deadline 30 Nov 2026 | Viewed by 88 | Submission Open

Keywords: electrochemistry; bioelectrochemistry; biosensors

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

RNAs in Health and Disease: Potential Function as Biomarkers and Therapeutic Targets

edited by

Yei-Tsung Chen

submission deadline 30 Nov 2026 | Viewed by 85 | Submission Open

Keywords: non-coding RNAs; biomarkers; RNA therapeutics; metabolic diseases; cardiovascular diseases

(This special issue belongs to the Section Molecular Medicine)

Advances in Plant Genetics and Cytogenetics

edited by

John McLaughlin

submission deadline 30 Nov 2026 | Viewed by 65 | Submission Open

Keywords: plant genetics; cytogenetics; plant stress response

(This special issue belongs to the Section Molecular Genetics)

Cardiovascular Risk in Rheumatic Diseases: Inflammation, Autoantibodies and Sex Differences

edited by George Karpouzas and

Nicoletta Ronda

submission deadline 30 Nov 2026 | Viewed by 65 | Submission Open

Keywords: sex; sex hormones; disease activity; disease-related autoantibodies; inflammation; cholesterol loading capacity; cholesterol efflux capacity; atherosclerosis; cardiovascular events

(This special issue belongs to the Section Chemical Biology)

Genetic and Molecular Mechanisms, Diagnoses, and Potential Therapies for Atherosclerosis and Other Cardiovascular Diseases

edited by Monika Ewa Rać

submission deadline 30 Nov 2026 | Viewed by 50 | Submission Open

Keywords: cardiovascular diseases; signalling pathways; genetic risk factors; molecular mechanisms; therapies

(This special issue belongs to the Section Molecular Medicine)

Advances and Emerging Strategies in Gene Therapy

edited by Xin Chen

submission deadline 1 Dec 2026 | Viewed by 240 | Submission Open

Keywords: AAV; gene-editing; base editing; prime editing; RNA editing; lipid nanoparticles; liposomes; exosomes; tRNA therapy; small activating RNAs

(This special issue belongs to the Section Molecular Medicine)

Novel Approaches to Harness Neuropathic Pain: Modulation of Glial Cells as a Therapeutic Strategy

edited by

Célia Duarte Cruz

and

José Tiago Costa-Pereira

submission deadline 6 Dec 2026 | Viewed by 313 | Submission Open

Keywords: neuropathic pain; neuroinflammation; descending pain modulation; glial cells; pharmacological therapies; non-pharmacological therapies; microglia; astrocytes

Transcription Factors in Hematopoiesis and Immunity: From Development to Therapeutic Targeting

edited by Amiya Kumar Patra

submission deadline 7 Dec 2026 | 3 articles | Viewed by 3682 | Submission Open

Keywords: transcription factors; immune regulation; epigenetics; cytokines and chemokines; molecular interaction; immunodeficiency; allergy; leukemia and lymphoma; small molecule inhibitors; hematopoietic disorders

(This special issue belongs to the Section Molecular Biology)

Recent Molecular Research on Protein Structure and Function

edited by

Sonani Ravi Raghav

submission deadline 15 Dec 2026 | 3 articles | Viewed by 3405 | Submission Open

Keywords: protein structure; protein function; molecular mechanisms; protein folding; structural biology

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapeutic Innovations in Musculoskeletal Disorders

edited by Fackson Mwale and Michael P. Grant

submission deadline 15 Dec 2026 | 1 articles | Viewed by 409 | Submission Open

Keywords: musculoskeletal; disorders; therapeutics; inflammation; degeneration

(This special issue belongs to the Section Molecular Medicine)

Neuromodulation of Hippocampal Circuits in Health and Disease

edited by Costas Papatheodoropoulos

submission deadline 15 Dec 2026 | Viewed by 143 | Submission Open

Keywords: neuromodulation; hippocampus; dopamine; serotonin; acetylcholine; norepinephrine; endocannabinoids; adenosine; oxytocin; opioids; brain rhythms; synaptic transmission; synaptic plasticity; behavior; neuropsychiatric disorders; neurological diseases

(This special issue belongs to the Section Biological Factors)

Molecular Mechanisms and Regulation of Kidney Disease

edited by

Syed J. Khundmiri

submission deadline 15 Dec 2026 | Viewed by 142 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; inflammation; renal repair and regeneration; gene expression; epigenetic mechanisms; systems biology; mathematical modeling

(This special issue belongs to the Section Biological Factors)

Adenosine and Its Receptors: Emerging Targets in Neurodegenerative Diseases

edited by

Soo-Ho Choi

submission deadline 15 Dec 2026 | Viewed by 140 | Submission Open

Keywords: adenosine; adenosine receptors; neuroinflammation; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

Innovative Approaches and New Directions in Drug Design and Chemical Biology

edited by Arshad Ansari and Avinash Gothwal

submission deadline 15 Dec 2026 | Viewed by 124 | Submission Open

Keywords: drug design; chemical biology; medicinal chemistry; protein– ligand interactions; chemical probes; target validation; computational drug discovery; drug discovery; structure-based design; novel therapeutics

(This special issue belongs to the Section Chemical Biology)

Helicases in DNA Repair: From Molecular Mechanisms to Medical and Biotechnological Applications

edited by Li Fan

submission deadline 16 Dec 2026 | 1 articles | Viewed by 1346 | Submission Open

Keywords: DNA unwinding; DNA damage response; damage verification; genetic disease; premature aging; cancer; chemotherapy; gene therapy

(This special issue belongs to the Section Molecular Genetics)

Ion Homeostasis and Metal Biology in Diseases

edited by

Yuting Wu

and Zhenglin Yang

submission deadline 17 Dec 2026 | Viewed by 101 | Submission Open

Keywords: metal ion homeostasis; metal biology; metalloproteins; metal-protein interactions; ion signaling and redox regulation; multi-metal crosstalk; bioinorganic mechanisms in metal biology; metal-targeted therapeutics; metal sensing methods; metals as medicines

(This special issue belongs to the Section Biological Factors)

Metagenomics and Genomics of Marine Organisms

edited by

Padmanabhan Mahadevan

submission deadline 18 Dec 2026 | Viewed by 240 | Submission Open

Keywords: metagenomics genomics viruses bacteria symbiosis microbiome

Melanin Biosynthesis and Degradation: Molecular Mechanisms and Pathophysiological Roles

edited by Kazumasa Wakamatsu

submission deadline 18 Dec 2026 | Viewed by 106 | Submission Open

Keywords: melanogenesis; tyrosinase-related proteins (TRPs); melanosomal turnover; autophagy-mediated degradation; pigmentary homeostasis; molecular signalling pathways; pathophysiological dysregulation

(This special issue belongs to the Section Chemical Biology)

Inflammation and Immunity in Lung Disease

edited by

Xuexian Yang

submission deadline 20 Dec 2026 | 3 articles | Viewed by 3015 | Submission Open

Keywords: lung; infection; inflammation; host defense; cytokine release syndrome; genetic deficiency

(This special issue belongs to the Section Cellular Biochemistry)

The Urokinase System in Cancer: From Stress Responses to Therapeutic Targeting

edited by

Maja Matulić

and

Petra Korać

submission deadline 20 Dec 2026 | 2 articles | Viewed by 2610 | Submission Open

Keywords: urokinase plasminogen activator; PAI1; urokinase plasminogen activator receptor; transcription; regulation; cancer; migration; invasion; stress

Impact of Lifestyle Changes on Biomolecular Profiles Across the Lifespan

edited by

Sergio Maroto-Izquierdo

and

Kayvan Khoramipour

submission deadline 30 Dec 2026 | 1 articles | Viewed by 993 | Submission Open

Keywords: lifestyle; microRNAs; disease

(This special issue belongs to the Section Chemical Biology)

Linking Excess Adiposity to Cancer: Molecular and Cellular Perspectives

edited by Marion Korach-André and Amena Archer

submission deadline 30 Dec 2026 | Viewed by 173 | Submission Open

Keywords: obesity; cancer; tumor microenvironment; adipose tissue; liver; inflammation; microbiota; metabolic reprogramming; novel therapeutic; omics

(This special issue belongs to the Section Cellular Biochemistry)

Lung Diseases: From Molecular Mechanisms to Therapeutics

edited by

Satoshi Kawakami

submission deadline 30 Dec 2026 | Viewed by 138 | Submission Open

Keywords: interstitial pneumonia; COPD; lung diseases; lung cancer; therapeutic targets; lifestyle factors; immunology; epigenetics; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Feature Papers in the Natural and Bio-Derived Molecules Section

edited by

Hang Fai (Henry) Kwok

submission deadline 31 Dec 2026 | 12 articles | Viewed by 83541 | Submission Open

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Insights from the Editorial Board Members

edited by

Peter E. Nielsen

submission deadline 31 Dec 2026 | 13 articles | Viewed by 43029 | Submission Open

Keywords: structure and function; bioactive and biogenic substances; molecular mechanisms; biomaterials

Cell Biology and Biomedical Application of Galectins

edited by

Alexander Timoshenko

submission deadline 31 Dec 2026 | 6 articles | Viewed by 20561 | Submission Open

Keywords: galectins; cell differentiation; stem cells; apoptosis; autophagy; cell adhesion; glycobiology; post-translational modifications; transmembrane signaling; protein trafficking; cancer; heart diseases; fibrosis; inflammation; targeted therapeutics; galectin inhibitors

(This special issue belongs to the Section Chemical Biology)

Antitumor Agents from Natural Sources 2026

edited by

Hang Fai (Henry) Kwok

submission deadline 31 Dec 2026 | 4 articles | Viewed by 16365 | Submission Open

Keywords: antitumor agents; natural sources; cancer prevention and therapy

(This special issue belongs to the Section Natural and Bio-derived Molecules)

State of the Art and Perspectives in Retinal Pigment Epithelium

edited by

Paola Secchiero

and

Elisabetta Melloni

submission deadline 31 Dec 2026 | 4 articles | Viewed by 14892 | Submission Open

Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy

(This special issue belongs to the Section Cellular Biochemistry)

Matrix Metalloproteinases: Mechanisms, Functions and Therapeutic Potential

edited by

Alireza Shoari

and Muhammad Faheem

submission deadline 31 Dec 2026 | 2 articles | Viewed by 12224 | Submission Open

Keywords: matrix metalloproteinases; endopeptidases; MMP inhibitor; tissue homeostasis; disease progression

(This special issue belongs to the Section Enzymology)

Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials

edited by

Mire Zloh

and

Rachael Dickman

submission deadline 31 Dec 2026 | 5 articles | Viewed by 11813 | Submission Open

Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Biomarkers in Cardiology 2026

edited by

Pietro Scicchitano

submission deadline 31 Dec 2026 | 4 articles | Viewed by 11120 | Submission Open

Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Advances in Rett Syndrome and Other Chromatin Related Disorders

edited by

Floriana Della Ragione

and Salvatore Fioriniello

submission deadline 31 Dec 2026 | 3 articles | Viewed by 8276 | Submission Open

Keywords: Rett syndrome and other chromatin disorders; epigenetic diseases; molecular alterations in Rett syndrome and other chromatin diseases; novel genes associated with chromatin disorders; MeCP2-mediated molecular mechanisms; roles of epigenetic modulators in chromatin-related diseases; preclinical studies for chromatin diseases; novel diagnostic; prognostic and therapeutic approaches for chromatin disorders

(This special issue belongs to the Section Molecular Medicine)

Advances in Galectins

edited by Anu Paul and Diyoly Ayona

submission deadline 31 Dec 2026 | 3 articles | Viewed by 7712 | Submission Open

Keywords: galectins; carbohydrate-binding proteins; galectin– microbe

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Unraveling the Complexity of Autoimmune and Autoinflammatory Skin Diseases: From Molecular Pathways to Targeted Therapies

edited by

Chiara Moltrasio

Angelo Valerio Marzano

and

Sergio Crovella

submission deadline 31 Dec 2026 | 1 articles | Viewed by 6675 | Submission Open

Keywords: autoimmune/autoinflammatory skin diseases; omics; bioinformatics; pathogenesis; tailored medicine

(This special issue belongs to the Section Molecular Genetics)

Industrial Microorganisms and Enzyme Technologies

edited by

Yunjun Yan

submission deadline 31 Dec 2026 | 4 articles | Viewed by 6103 | Submission Open

Keywords: enzyme engineering; enzyme kinetics and optimization; industrial biotechnology; industrial microbiology; microbial metabolism

(This special issue belongs to the Section Enzymology)

Pluripotent Stem Cells: From Basic Research to Therapeutic Applications

edited by

Claudia Spits

and

Diana Al Delbany

submission deadline 31 Dec 2026 | 2 articles | Viewed by 5848 | Submission Open

Keywords: pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells; organoids; differentiation; regenerative medicine; disease modeling; cell therapy; therapeutic applications

(This special issue belongs to the Section Molecular Biology)

Advances in Pharmacognosy and Phytochemistry: From Molecular to Pre-Clinical Insights

edited by

Hilal Zaid

Zipora Tietel

and

Akhilesh K. Tamrakar

submission deadline 31 Dec 2026 | 2 articles | Viewed by 5440 | Submission Open

Keywords: metabolomics; drug discovery; phytopharmacology; medicinal plants

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Basis of Pathogenesis in Autoimmune Diseases

edited by

I-Tsu Chyuan

and

Chi-Jung Huang

submission deadline 31 Dec 2026 | 1 articles | Viewed by 4798 | Submission Open

Keywords: autoimmune diseases; molecular pathogenesis; genetic determinants; signaling pathways; immunopathology; therapeutic targets; novel molecular targets

(This special issue belongs to the Section Molecular Medicine)

Feature Papers in "Molecular Biology" Section 2026

edited by

Claudia Tanja Mierke

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4075 | Submission Open

Keywords: mechanobiology; cellular processes including metabolism; proliferation and motility; molecular motors and forces; molecular and biophysical techniques; organelle and membrane transport; exo- and endosomal trafficking; cell and biophysical signal transduction; the biomolecular synthesis of proteins; protein folding and post-translational modification of proteins and macromolecular assemblies

(This special issue belongs to the Section Molecular Biology)

Epigenetic Regulation of Cell Differentiation During Development and Disease: From Vascular Plasticity to Immune Signaling

edited by

Melina M. Musri

and

Victor I. Peinado

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3844 | Submission Open

Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications

edited by Yalin Qi

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3785 | Submission Open

Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection

(This special issue belongs to the Section Chemical Biology)

Advances in Membrane Proteins: From Structure to Function and Molecular Engineering

edited by

Ximin Chi

and Renhong Yan

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3558 | Submission Open

Keywords: membrane transport; transmembrane signaling; membrane protein complex; membrane-based reactions; membrane and protein interaction; regulation of membrane proteins; membrane protein design; membrane protein engineering

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

DNA Damage Repair and Cancer Therapeutics

edited by

Wenjing Li

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3455 | Submission Open

Keywords: DNA damage repair; cancer therapy; genomic stability; targeted therapy; biomarkers

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Studies of Protein Dynamics, Interactions, and Concentration by Fluorescence Fluctuation Correlation Spectroscopy (FFCS)

edited by Jieqiong Lou and Elvis Pandžić

submission deadline 31 Dec 2026 | 4 articles | Viewed by 3382 | Submission Open

Keywords: fluorescence fluctuation correlation spectroscopy (FFCS); fluorescence correlation spectroscopy (FCS); image correlation spectroscopy (ICS); pair correlation function (pCF) analysis; line-scan correlation; protein dynamics; molecular diffusion; molecular flow; confinement dynamics; protein– protein interactions; membrane organization; intracellular transport; molecular crowding; spatiotemporal fluctuations; concentration heterogeneity; live-cell imaging; single-molecule analysis; quantitative fluorescence microscopy; biophysics; super-resolution fluctuation analysis

Metal-Based Complexes in Medicine: From Therapeutics to Diagnostics and Theranostics

edited by

Iogann Tolbatov

and

Andrea Melchior

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3089 | Submission Open

Keywords: anticancer metal complexes; antitumor metallodrugs; antimicrobial agents; antiviral metallodrugs; medicinal inorganic chemistry; bioinorganic chemistry; computational design; molecular dynamics; docking; spectroscopic methods; NMR; mechanistic studies; rational drug development; synthesis; biological evaluation; drug delivery; experimental; in vitro; in vivo; theranostics; medicinal imaging

Vertebrate Comparative Genomics

edited by Ya-Xiong Tao and

Shan He

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3015 | Submission Open

Keywords: vertebrate; comparative genomics; physiology; biochemistry; pathophysiology; protein structure-function; gene

(This special issue belongs to the Section Molecular Genetics)

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