State of the Art and Perspectives in Retinal Pigment Epithelium

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 1502

Special Issue Editors


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Guest Editor
Department of Translational Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy
Interests: translational research in oncology, onco-hematology, cardiovascular and metabolic diseases, eye diseases physiopathology and therapies; preclinical testing of innovative molecule/drugs and delivery systems
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Translational Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy
Interests: cell and molecular biology; anticancer and antiinflammatory effects of new compounds; flow cytometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Retinal pigment epithelium (RPE) plays a fundamental role in retina physiopathology and in visual function maintenance. Indeed, first of all, it guarantees photoreceptor renewal, through its phagocytic activity; RPE also contributes to the establishment of the blood–retinal barrier and controls incoming and outgoing molecular transports. Moreover, RPE cells can protect the neural components of the retina from light damage thanks to its melanin content and their ability to call upon several metabolic pathways that are able to enhance the scavenging of reactive oxygen species within the eye, thereby counteracting oxidative damage. Consequently, RPE integrity alterations, as well as unbalanced RPE renewal and proliferation, can lead to the development of different retinopathies, which, to date, deeply lack effective and resolutive therapies.

The focus of this Special Issue is to highlight the recent advances in RPE physiopathology and in new potential therapeutic approaches for retinopathies that have arisen from RPE dysfunctionality. Recent advances and overviews on study models, including new methodology and technologies for RPE investigation, will be considered. We also encourage the submission of reports exploring the therapeutic or ameliorative effects on retinal diseases of natural extracts, natural bioactive and synthetic molecules, or innovative delivery strategies for eye administration, including chemical hybrids and nanocarriers, or even combination treatments.

As a part of this Special Issue, we invite the submission of original manuscripts spanning basic to pre-clinical and clinical research, brief reports, meta-analysis, and narrative and systematic reviews proposing novelties or overviews in the aforementioned fields.

Prof. Dr. Paola Secchiero
Dr. Elisabetta Melloni
Guest Editors

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Keywords

  • retinal pigment epithelium
  • innovative treatments/therapeutic approaches
  • retinal diseases
  • bioactive molecules
  • eye delivery strategy

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Published Papers (1 paper)

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Review

23 pages, 852 KB  
Review
Retinal Pigment Epithelium Transplantation in Retinal Disease: Clinical Trial Development, Challenges, and Future Directions
by Qin Chen, Ting Zhang, Zhi Chen, Jingwen Zeng, Aine O’Connor, Meidong Zhu, Mark C. Gillies, Fang Lu and Ling Zhu
Biomolecules 2025, 15(8), 1167; https://doi.org/10.3390/biom15081167 - 15 Aug 2025
Viewed by 818
Abstract
Replacement of the retinal pigment epithelium (RPE) is emerging as a promising approach to treat degenerative retinal diseases, including age-related macular degeneration and Stargardt disease, in which RPE function cannot otherwise be restored. Despite the limitations of existing treatments, advances in cell sourcing [...] Read more.
Replacement of the retinal pigment epithelium (RPE) is emerging as a promising approach to treat degenerative retinal diseases, including age-related macular degeneration and Stargardt disease, in which RPE function cannot otherwise be restored. Despite the limitations of existing treatments, advances in cell sourcing and surgical methods have enabled initial human trials of RPE transplantation, with early results indicating potential efficacy. This review comprehensively examines the evolution of RPE transplantation in recent decades, highlighting the advantages and limitations of different cell sources and delivery methods. Current clinical trial data are analyzed with a particular focus on immune rejection risks, surgical complications, and long-term safety. Despite encouraging safety profiles, achieving consistent and sustained visual improvement remains a challenge, as vision outcomes might be influenced by factors such as disease stage at intervention, transplantation site, number of cells transplanted, and duration of follow-up. Key challenges, such as cell or graft survival and integration with the host retina, are discussed in depth, as overcoming these obstacles is essential for achieving stable and effective RPE replacement. Future research directions, including innovations in biomaterials, molecular modification strategies, and personalized approaches, hold promise for enhancing the efficacy and durability of RPE transplantation for retinal disease. Full article
(This article belongs to the Special Issue State of the Art and Perspectives in Retinal Pigment Epithelium)
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