State of the Art and Perspectives in Retinal Pigment Epithelium
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 582
Special Issue Editors
Interests: translational research in oncology, onco-hematology, cardiovascular and metabolic diseases, eye diseases physiopathology and therapies; preclinical testing of innovative molecule/drugs and delivery systems
Special Issues, Collections and Topics in MDPI journals
Interests: cell and molecular biology; anticancer and antiinflammatory effects of new compounds; flow cytometry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Retinal pigment epithelium (RPE) plays a fundamental role in retina physiopathology and in visual function maintenance. Indeed, first of all, it guarantees photoreceptor renewal, through its phagocytic activity; RPE also contributes to the establishment of the blood–retinal barrier and controls incoming and outgoing molecular transports. Moreover, RPE cells can protect the neural components of the retina from light damage thanks to its melanin content and their ability to call upon several metabolic pathways that are able to enhance the scavenging of reactive oxygen species within the eye, thereby counteracting oxidative damage. Consequently, RPE integrity alterations, as well as unbalanced RPE renewal and proliferation, can lead to the development of different retinopathies, which, to date, deeply lack effective and resolutive therapies.
The focus of this Special Issue is to highlight the recent advances in RPE physiopathology and in new potential therapeutic approaches for retinopathies that have arisen from RPE dysfunctionality. Recent advances and overviews on study models, including new methodology and technologies for RPE investigation, will be considered. We also encourage the submission of reports exploring the therapeutic or ameliorative effects on retinal diseases of natural extracts, natural bioactive and synthetic molecules, or innovative delivery strategies for eye administration, including chemical hybrids and nanocarriers, or even combination treatments.
As a part of this Special Issue, we invite the submission of original manuscripts spanning basic to pre-clinical and clinical research, brief reports, meta-analysis, and narrative and systematic reviews proposing novelties or overviews in the aforementioned fields.
Prof. Dr. Paola Secchiero
Dr. Elisabetta Melloni
Guest Editors
Manuscript Submission Information
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Keywords
- retinal pigment epithelium
- innovative treatments/therapeutic approaches
- retinal diseases
- bioactive molecules
- eye delivery strategy
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