Structure-Based Mechanisms of Protein Functions
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 97
Special Issue Editor
Special Issue Information
Dear Colleagues,
Our aim is to showcase the fascinating world of protein structure and how its structural diversity, adaptability, and plasticity enable and enhance protein function.
Protein structure ultimately defines the repertoire of possible functions. Mounting evidence reveals that protein structures are far more dynamic than previously appreciated: proteins can moonlight by performing multiple functions; adopt diverse quaternary assemblies atop a shared tertiary fold; assume multiple native conformations (metamorphic proteins); or switch structures based on interaction partners. Even enzymes inactivated by point mutations (pseudoenzymes) persist in cells, hinting at undiscovered roles. In this Special Issue, we gather recent evidence on the multifaceted nature of protein structure and its intimate ties to function.
Dr. Vasiliki Fadouloglou
Guest Editor
Manuscript Submission Information
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Keywords
- pseudoenzymes
- moonlighting proteins
- metamorphic proteins
- intrinsically disordered proteins
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