Transcription Factors in Hematopoiesis and Immunity: From Development to Therapeutic Targeting
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 1 November 2025 | Viewed by 9
Special Issue Editor
Special Issue Information
Dear Colleagues,
Biomolecules invites submissions to a Special Issue focused on the transcriptional regulation of hematopoiesis and its impact on immune system functioning in health and disease.
It has been established that various types of transcription factors control key stages of the hematopoietic stem cell cycle as well as the entirety of hematopoietic lineage cell development. While these factors usually facilitate hematopoiesis and provide immunity against a range of diseases, alterations in terms of deficiency or overactivity can lead to severe consequences ranging from immunodeficiency to cancer. Although lineage commitment, proliferation, and differentiation are the common processes for all hematopoietic lineage cells, these activities are regulated by distinct transcription factors via precisely controlled signaling and epigenetic mechanisms in every lineage. Although huge progress has been made in understanding the fundamental regulation of various hematopoietic cell functions in immunity, an integrated picture of the interaction and counteraction of the transcription factors maintaining the balance between health and disease is yet to emerge.
This Special Issue invites submissions that focus on novel understandings of the underlying transcriptional mechanisms of hematopoietic/immune lineage cell development and the opportunities and challenges to target lineage-specific transcription factors to control associated disease pathogenesis.
Dr. Amiya Kumar Patra
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- transcription factors
- immune regulation
- epigenetics
- cytokines and chemokines
- molecular interaction
- immunodeficiency
- allergy
- leukemia and lymphoma
- small molecule inhibitors
- hematopoietic disorders
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