Molecular Basis of Pathogenesis in Autoimmune Diseases

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 761

Special Issue Editors


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Guest Editor
School of Medicine, College of Life Science and Medicine, National Tsing Hua University, Hsinchu, Taiwan
Interests: systemic lupus erythematosus; immunology; autoimmune diseases
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Biochemistry, National Defense Medical Center, Taipei 114201, Taiwan
2. Department of Medical Research, Cathay General Hospital, Taipei 106438, Taiwan
Interests: inflammation; autoimmune diseases

Special Issue Information

Dear Colleagues,

Autoimmune diseases represent a significant health burden worldwide, affecting millions of individuals and presenting diverse clinical manifestations. Recent advances in molecular biology have provided deeper insights into the pathogenesis of these diseases, uncovering the intricate interplay between genetic, environmental and immunological factors. Despite these advancements, the precise molecular mechanisms driving the onset and progression of autoimmune disorders remain incompletely understood. This Special Issue aims to explore the latest research findings in this field. We invite contributions that shed light on the molecular underpinnings of autoimmune disease pathogenesis, including the identification of novel molecular targets, signaling pathways and genetic determinants. The goal is to enhance our understanding of these complex diseases, paving the way for the development of targeted therapeutic strategies and improved patient outcomes. We welcome original research articles, reviews and case studies that address these critical aspects and contribute to the broader knowledge base of autoimmune disease research.

Dr. I-Tsu Chyuan
Dr. Chi-Jung Huang
Guest Editors

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Keywords

  • autoimmune diseases
  • molecular pathogenesis
  • genetic determinants
  • signaling pathways
  • immunopathology
  • therapeutic targets
  • novel molecular targets

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Published Papers (1 paper)

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Review

33 pages, 637 KiB  
Review
Molecular Pathogenesis of Connective Tissue Disease-Associated Pulmonary Arterial Hypertension: A Narrative Review
by Fu-Chiang Yeh, I-Ting Tsai and I-Tsu Chyuan
Biomolecules 2025, 15(6), 772; https://doi.org/10.3390/biom15060772 - 27 May 2025
Viewed by 216
Abstract
Pulmonary arterial hypertension (PAH) is a lethal condition marked by the proliferation and remodeling of small pulmonary arteries, ultimately leading to right ventricular hypertrophy and right heart failure. PAH secondary to connective tissue diseases (CTDs) is a progressive complication with a complex pathogenesis [...] Read more.
Pulmonary arterial hypertension (PAH) is a lethal condition marked by the proliferation and remodeling of small pulmonary arteries, ultimately leading to right ventricular hypertrophy and right heart failure. PAH secondary to connective tissue diseases (CTDs) is a progressive complication with a complex pathogenesis that results in the reduced efficacy of vasodilation-based therapies and poor clinical outcomes. Systemic sclerosis is the most commonly associated CTD with PAH in Western countries and has been most extensively investigated. Systemic lupus erythematosus and other CTDs may also be associated with PAH; however, they are less studied. In this review, we explore the general pathobiology of PAH, with a particular emphasis on recent advances in the molecular pathogenesis of CTD-PAH, including endothelial cell dysfunction, dysregulated cell proliferation and vascular remodeling, extracellular matrix remodeling, in situ thrombosis, right ventricular dysfunction, genetic aberrations, and immune dysregulation. We also conduct a thorough investigation into the potential serum biomarkers and immune dysregulation associated with CTD-PAH, summarizing the associated autoantibodies, cytokines, and chemokines. Furthermore, relevant animal models that may help unravel the pathogenesis and contribute to the development of new treatments are also reviewed. Full article
(This article belongs to the Special Issue Molecular Basis of Pathogenesis in Autoimmune Diseases)
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