Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.064
Journals
Biomolecules
Special Issues
Cell Biology and Biomedical Application of Galectins
share announcement

Special Issue "Cell Biology and Biomedical Application of Galectins"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: 30 September 2023 | Viewed by 1879

Special Issue Editor

Dr. Alexander Timoshenko

E-Mail Website
Guest Editor
Department of Biology, The University of Western Ontario, 1151 Richmond St. N., London, ON N6A 5B7, Canada
Interests: galectins; O-GlcNAc; cellular differentiation; glycobiology; cell aggregation; neutrophils
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Galectins are a family of soluble b-galactoside-binding proteins with diverse glycan-dependent and glycan-independent functions, both outside and inside the cell. Galectins play a role in many fundamental cellular processes, such as cell growth, differentiation, self-renewal, apoptosis, autophagy, phagocytosis, and cellular interactions. Changes in the expression of galectins are linked to diseases such as cancer, heart disease, and fibrosis, among others, which suggests that they are potential candidates for biomedical applications. However, current success in these directions is limited, primarily due to the complex network of interacting galectins in cells and their different modes of action. The functions of galectins depend on their localization in specific cellular compartments and organelles (cytosol, lipid droplets, cytoskeleton, mitochondria, nucleus, lysosomes, and plasma membrane) and related intracellular trafficking and secretion, which occurs through non-classical pathways. An integrated vision of galectin cell biology is still needed, and advanced studies of galectin trafficking, post-translational modifications, the transcriptional regulation of galectin gene expression, and galectin-mediated transmembrane signaling are highly warranted. This Special Issue covers recent progress in the fields of the cell biology of galectins and the biomedical aspects of these molecules as biomarkers and clinical targets in the context of human diseases.

Dr. Alexander Timoshenko
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • galectins
  • cell differentiation
  • stem cells
  • apoptosis
  • autophagy
  • cell adhesion
  • glycobiology
  • post-translational modifications
  • transmembrane signaling
  • protein trafficking
  • cancer
  • heart diseases
  • fibrosis
  • inflammation
  • targeted therapeutics
  • galectin inhibitors

Related Special Issue

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

get_app
Article
Diffuse Myocardial Fibrosis on Cardiac Magnetic Resonance Imaging Is Related to Galectin-3 and Predicts Outcome in Heart Failure
by
Elles M. Screever
,
Thomas M. Gorter
,
Tineke P. Willems
,
Joseph Pierre Aboumsallem
,
Navin Suthahar
,
Belend Mahmoud
,
Dirk J. van Veldhuisen
,
Rudolf A. de Boer
and
Wouter C. Meijers
Biomolecules 2023, 13(3), 410; https://doi.org/10.3390/biom13030410 - 22 Feb 2023
Viewed by 576
Abstract
Aims: Ongoing adverse remodeling is a hallmark of heart failure (HF), which might be reflected by either focal or diffuse myocardial fibrosis. Therefore, in (pre)clinical settings, we used immunohistochemistry or cardiac magnetic resonance imaging (CMR) to investigate the association of (focal or diffuse) [...] Read more.
Aims: Ongoing adverse remodeling is a hallmark of heart failure (HF), which might be reflected by either focal or diffuse myocardial fibrosis. Therefore, in (pre)clinical settings, we used immunohistochemistry or cardiac magnetic resonance imaging (CMR) to investigate the association of (focal or diffuse) fibrosis with cardiac biomarkers and adverse events in HF. Methods and results: In C57Bl/6J mice, we determined the presence and extent of myocardial fibrosis 6 weeks post-myocardial infarction (MI). Furthermore, we studied 159 outpatient HF patients who underwent CMR, and determined focal and diffuse fibrosis by late gadolinium enhancement (LGE) and post-contrast T1 time of the non-LGE myocardium, respectively. HF patients were categorized based on the presence of LGE, and by the median post-contrast T1 time. Kaplan–Meier and Cox regression analyses were used to determine the association of fibrosis with HF hospitalization and all-cause mortality. LGE was detected in 61 (38%) patients. Cardiac biomarker levels were comparable between LGE-positive and LGE-negative patients. LGE-positive patients with a short T1 time had elevated levels of both NT-proBNP and galectin-3 (1611 vs. 453 ng/L, p = 0.026 and 20 vs. 15 μg/L, p = 0.004, respectively). This was not observed in LGE-negative patients. Furthermore, a short T1 time in LGE-positive patients was associated with a higher risk of adverse events (log-rank p = 0.01). Conclusion: This study implies that cardiac biomarkers reflect active remodeling of the non-infarcted myocardium of patients with focal myocardial scarring. Diffuse fibrosis, in contrast to focal scarring, might have a higher prognostic value regarding adverse outcomes in HF patients. Full article
(This article belongs to the Special Issue Cell Biology and Biomedical Application of Galectins)
►▼ Show Figures

Graphical abstract

get_app
Article
O-GlcNAc-Mediated Regulation of Galectin Expression and Secretion in Human Promyelocytic HL-60 Cells Undergoing Neutrophilic Differentiation
by
Adam McTague
,
Rada Tazhitdinova
and
Alexander V. Timoshenko
Biomolecules 2022, 12(12), 1763; https://doi.org/10.3390/biom12121763 - 27 Nov 2022
Viewed by 935
Abstract
In this study, we have tested the hypothesis that the expression and secretion of galectins are driven through mechanisms globally impacted by homeostatic regulation involving the post-translational modification of intracellular proteins with O-linked N-acetylglucosamine (O-GlcNAc). We showed that neutrophilic differentiation [...] Read more.
In this study, we have tested the hypothesis that the expression and secretion of galectins are driven through mechanisms globally impacted by homeostatic regulation involving the post-translational modification of intracellular proteins with O-linked N-acetylglucosamine (O-GlcNAc). We showed that neutrophilic differentiation of HL-60 cells induced by all-trans retinoic acid (ATRA) and 6-diazo-5-oxo-L-norleucine (DON) was associated with a significant drop of cellular O-GlcNAc levels in serum-contained and serum-free cell culture media. Galectin gene and protein expression profiles in HL-60 cells were specifically modified by ATRA and by inhibitors of O-GlcNAc cycle enzymes, however overall trends for each drug were similar between cells growing in the presence or absence of serum except for LGALS9 and LGALS12. The secretion of four galectins (-1, -3, -9, and -10) by HL-60 cells in a serum-free medium was stimulated by O-GlcNAc-reducing ATRA and DON while O-GlcNAc-elevating thiamet G (O-GlcNAcase inhibitor) failed to change the basal levels of extracellular galectins. Taken together, these results demonstrate that O-GlcNAc homeostasis is essential not only for regulation of galectin expression in cells but also for the secretion of multiple members of this protein family, which can be an important novel aspect of unconventional secretion mechanisms. Full article
(This article belongs to the Special Issue Cell Biology and Biomedical Application of Galectins)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Galectins — Evidence for GlycoLipid-Lectin Endocytosis and Lattices
Authors: Ludger JOHANNES; Massiullah Shafaq-Zadah；Estelle Dransart
Affiliation: Institut Curie – Paris

Back to TopTop