Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 75
Special Issue Editors
Interests: epigenetics; cardiovascular research; smooth muscle cells
2. Biomedical Research Networking Center in Respiratory Diseases (CIBERES), Madrid, Spain
Interests: COPD; pulmonary hypertension; pulmonary fibrosis; ARDS; ALI; OSAS
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Vascular smooth muscle cells (vSMCs) form the tunica media of arteries and veins and play a key role in establishing and stabilizing blood vessels during development and the regulation of vascular tone and tissue perfusion in adulthood. It is well known that vSMCs display a high degree of plasticity during disease progression, switching from a differentiated and contractile phenotype to a proliferative and migratory phenotype, known as vSMC de-differentiation. Recent reports using cell lineage tracing and single-cell RNA sequencing have revealed that vSMCs possess multiple differentiation potentials and acquire a variety of phenotypes, including osteoblast-like, macrophage-like, and mesenchymal-like characteristics. In recent years, epigenetics has become the most prominent mechanism used to study the regulation of gene expression both during development and disease states. In this Special Issue, we invite manuscripts on the epigenetic regulation of the vSMC phenotype during development and disease.
Dr. Melina M. Musri
Dr. Victor I. Peinado
Guest Editors
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Keywords
- vascular smooth muscle cells
- cell phenotypic change
- epigenetics
- gene expression regulation
- cell differentiation
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