Pluripotent Stem Cells: From Basic Research to Therapeutic Applications
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 775
Special Issue Editors
Interests: human pluripotent stem cells; genome instability; aneuploidy; differentiation capacity; tumorigenesis
Special Issues, Collections and Topics in MDPI journals
Interests: human pluripotent stem cells; aneuploidy; organoid; tumorigenesis
Special Issue Information
Dear Colleagues,
Pluripotent stem cells (PSCs) are remarkable cells that can differentiate into any cell of the embryonic lineage, and depending on their state of pluripotency and species, they can also generate extraembryonic cell types. PSCs can be derived from early-stage embryos as embryonic stem cells (ESCs) or from adult somatic cells through reprogramming, creating induced pluripotent stem cells (iPSCs). These cells have revolutionized medical research and clinical applications due to their unique potential for therapy and regenerative medicine. They can be used to repair or replace damaged tissues, potentially overcoming donor scarcity and immune rejection. Up to now, there are over 1,800 ongoing clinical trials worldwide that are testing stem cell therapies across various phases of development, covering a wide range of applications from treating neurological disorders and blindness to regenerative therapies for cardiovascular diseases and beyond. Moreover, PSCs can serve as invaluable tools for studying developmental biology and cellular differentiation, allowing researchers to investigate the mechanisms that regulate cell fate and provide insights into normal development and the underlying causes of various diseases. This Special Issue aims to explore the recent advances in PSC research, covering the molecular mechanisms of pluripotency, genetic modification, tissue engineering, disease modeling, drug discovery, and early-stage clinical trials.
Prof. Dr. Claudia Spits
Guest Editor
Dr. Diana Al Delbany
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- pluripotent stem cells
- embryonic stem cells
- induced pluripotent stem cells
- organoids
- differentiation
- regenerative medicine
- disease modeling
- cell therapy
- therapeutic applications
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