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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Genetic and Epigenetic Gene Therapy for Diabetic Wound Healing

edited by

Kanhaiya Singh

submission deadline 21 Oct 2026 | 1 articles | Viewed by 1141 | Submission Open

Keywords: chronic wounds; DFU; wound healing; diet; diabetes; obesity; nutrition; genomics; epigenetics; DNA methylation; histone modifications

(This special issue belongs to the Section Molecular Genetics)

The Function of Stromal Cells in Gastrointestinal (GI) Diseases

edited by Li Chang

submission deadline 23 Oct 2026 | Viewed by 155 | Submission Open

Keywords: gastrointestinal (GI) diseases; intestinal stromal cells; intestinal homeostasis; cytokine; extracellular matrix; tissue repair

(This special issue belongs to the Section Molecular Medicine)

Advances in Inflammatory Bowel Disease: From Molecular Mechanisms to Therapies

edited by Mariangela Allocca

submission deadline 24 Oct 2026 | 1 articles | Viewed by 812 | Submission Open

Keywords: inflammatory bowel disease; Crohn's disease; ulcerative colitis; advanced therapies; treat-to-target; transmural healing; disease modification; personalized medicine

(This special issue belongs to the Section Molecular Medicine)

The Role of the Circadian Clock in Health and Disease

edited by Rajendram V. Rajnarayanan

submission deadline 24 Oct 2026 | Viewed by 153 | Submission Open

Keywords: circadian clock; chronobiology; clock genes; sleep; circadian misalignment; chronotherapy; metabolic disease; endocrine disruption; inflammation; neurodegeneration; biomarkers; multi-omics

(This special issue belongs to the Section Biological Factors)

Mechanism of Gene Modification Therapy for Cystic Fibrosis

edited by

Wolf-Michael Weber

and Joerg Grosse-Onnebrink

submission deadline 28 Oct 2026 | Viewed by 160 | Submission Open

Keywords: cystic fibrosis; CFTR; gene modification therapy; mRNA therapy; gene editing; CRISPR/Cas; airway epithelium; ion transport; nanoparticle delivery; precision medicine

(This special issue belongs to the Section Molecular Genetics)

Mitochondrial Calcium Signaling in Cardiac Health and Disease

edited by Enrique Balderas

submission deadline 29 Oct 2026 | 1 articles | Viewed by 1513 | Submission Open

Keywords: mitochondrial Ca2+; OXPHOS; H+ gradient; ATP-synthesis; NAD(H) balance; Ca2+-overload; mitochondrial permeability; apoptosis; mtDNA; ROS production-clearance

(This special issue belongs to the Section Cellular Biochemistry)

Computational Pharmacology: Advances in Computational Modeling of Drug–Receptor Interactions and Pharmacokinetics

edited by

Clement Agoni

and

Indrani Bera

submission deadline 30 Oct 2026 | Viewed by 365 | Submission Open

Keywords: computational pharmacology; drug– receptor interactions; pharmacokinetics modeling; molecular dynamics simulations; molecular docking; QSAR analysis; ADME prediction; AI in drug design; machine learning for drug discovery; protein– ligand binding; bioactive peptide– protein interactions; drug– enzyme interactions; drug– nucleic acid interactions; protein– lipid interactions; peptoid-target interactions; therapeutic optimization; pharmacodynamic modeling

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Research on Sarcoma: From Pathogenesis to Molecular Targets

edited by

Irene Faenza

submission deadline 30 Oct 2026 | Viewed by 316 | Submission Open

Keywords: sarcoma; molecular pathogenesis; genetic alterations; biomarkers; molecular targets; signal transduction

Novel Molecular Targets for Beta Cell Regeneration and Diabetes Therapy

edited by

Iraj Alipourfard

submission deadline 30 Oct 2026 | Viewed by 275 | Submission Open

Keywords: diabetes; pancreatic beta cells; regenerative therapy; molecular target

(This special issue belongs to the Section Molecular Medicine)

Serotonin Signaling in Cancer Development and Progression

edited by

Iván P. Uray

submission deadline 30 Oct 2026 | Viewed by 156 | Submission Open

Keywords: serotonin; 5-HT; cancer; carcinogenesis; invasion; tumor microenvironment; serotonylation; mechanotransduction

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases

edited by

Zhidong Zhou

submission deadline 31 Oct 2026 | 7 articles | Viewed by 17805 | Submission Open

Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy

(This special issue belongs to the Section Biological Factors)

Molecular Advances in Drug Resistance and Novel Therapies for Cancer

edited by

Agnieszka Wolnicka-Glubisz

and

Konrad Kleszczyński

submission deadline 31 Oct 2026 | 6 articles | Viewed by 11690 | Submission Open

Keywords: cell signalling; cancer treatment; cancer metastasis; target validation; cancer and new molecules; cancer and cellular organelles

(This special issue belongs to the Section Biological Factors)

The Value of Natural Compounds as Therapeutic Agents: 3rd Edition

edited by

Maria Beatrice Morelli

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4312 | Submission Open

Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Updates on Molecular Mechanisms of Lysosomal Storage Disease

edited by

Anna Tylki-Szymanska

and

Patryk Lipiński

submission deadline 31 Oct 2026 | 1 articles | Viewed by 3423 | Submission Open

Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD

(This special issue belongs to the Section Biological Factors)

The Immune Response to Severe Trauma

edited by

Jon Hazeldine

and David N Naumann

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2430 | Submission Open

Keywords: trauma-induced immune response; systemic inflammation; immune suppression; immune dysregulation; critical care

(This special issue belongs to the Section Molecular Medicine)

Multifunctional Enzymes and Proteins: New Insights into Structure and Function

edited by

Martina Buonanno

Paola Imbimbo

and

Fabiola Mascanzoni

submission deadline 31 Oct 2026 | Viewed by 2207 | Submission Open

Keywords: multifunctional enzymes; protein structure; protein function; catalytic activity; conformational dynamics; biochemistry; biophysics; drug discovery

(This special issue belongs to the Section Molecular Biology)

Obesity-Related Diseases: Molecular Basis and Therapeutic Approaches

edited by

Dénes Molnár

and

Szilvia Bokor

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1316 | Submission Open

Keywords: obesity; causes; therapy; epigenetics; biomolecules

Prebiotics and Probiotics in Health and Disease: Precision Delivery and Microbiota-Informed Therapeutics

edited by

Virginia Fuochi

and

Pio Maria Furneri

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1164 | Submission Open

Keywords: prebiotics; probiotics; postbiotics; drug delivery systems; nanocarriers; microbiota-targeted therapies; gut microbiota; precision biotics

(This special issue belongs to the Section Molecular Biology)

Cell Death and Clearance

edited by

Ivan Poon

and Jascinta Santavanond

submission deadline 31 Oct 2026 | Viewed by 368 | Submission Open

Keywords: cell death; apoptosis; efferocytosis; cell clearance

(This special issue belongs to the Section Molecular Medicine)

LDL Receptor Family in Metabolic Homeostasis, Neurodevelopmental Disorders, and Signaling Pathways

edited by

María-Paz Marzolo

submission deadline 31 Oct 2026 | Viewed by 323 | Submission Open

Keywords: LDL receptor family; lipid metabolism; cholesterol homeostasis; neurodevelopmental and neuropsychiatric disorders; neurodegeneration; receptor-mediated endocytosis; Wnt and reelin signaling pathways; apolipoproteins; Alzheimer's disease; Parkinson's disease

Feature Papers in Section "Biological Factors", 2nd Edition

edited by

Tracey A. Martin

submission deadline 31 Oct 2026 | Viewed by 319 | Submission Open

Keywords: neurotransmitters; cytokines; chemokines; hormones; connexins; androgen; estrogens; coagulation factors; hypoxia-inducible factors; transcription factors; signaling; receptors; interferon

(This special issue belongs to the Section Biological Factors)

Synthetic Biology's Potential to Address Undruggable Targets and Difficult-to-Treat Diseases

edited by

Dario Mizrachi

submission deadline 31 Oct 2026 | Viewed by 270 | Submission Open

Keywords: synthetic biology; protein engineering; drug development; biologics; undruggable targets

(This special issue belongs to the Section Molecular Medicine)

SAM Domains in Health and Diseases: Structural and Functional Insights

edited by

Flavia Anna Mercurio

and

Marilisa Leone

submission deadline 31 Oct 2026 | Viewed by 266 | Submission Open

Keywords: SAM domains; oligomer- and polymer-forming SAM; mid-loop/end-helix architecture of binding; SAM physiological and pathological signaling pathways; SAM domains as drug targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Fibronectin, Integrins and Related Molecules in Health and Diseases

edited by

Yoshikazu Takada

submission deadline 31 Oct 2026 | Viewed by 256 | Submission Open

Keywords: integrin; fibronectin; cytokines

(This special issue belongs to the Section Chemical Biology)

Modern Studies of Nucleic Acid Dynamics

edited by

Gary A. Meints

submission deadline 31 Oct 2026 | Viewed by 250 | Submission Open

Keywords: nucleic acid dynamics; DNA; RNA; nucleic acid energetics; dynamics of biomolecular recognition; timescales and magnitudes of dynamics

Calcium Signaling: Molecular Mechanisms and Therapeutic Targets in Cardiovascular Diseases

edited by Jianjie Ma and

Yuchen Chen

submission deadline 31 Oct 2026 | Viewed by 248 | Submission Open

Keywords: calcium signaling; excitation– contraction coupling; cardiovascular disease; ryanodine receptor and ion channelopathies; gene therapy and precision medicine

(This special issue belongs to the Section Chemical Biology)

Pathophysiological Insights into Congenital Myasthenic Syndromes

edited by Xin-Ming Shen, Kinji Ohno and Duygu Selcen

submission deadline 31 Oct 2026 | Viewed by 231 | Submission Open

Keywords: neuromuscular junction; neurotransmission; developmental biology; myasthenia; congenital myasthenic syndrome; human genetics; variant; mutation; animal model

(This special issue belongs to the Section Molecular Medicine)

Application of Spectral Analysis in Disease Diagnosis and Treatment

edited by

Entesar Al-Hetlani

and

Igor Lednev

submission deadline 31 Oct 2026 | Viewed by 226 | Submission Open

Keywords: molecular spectroscopy; mass spectrometry; medical diagnostics; disease treatment/treatment monitoring; lipidomics/proteomics/metabolomics; biofluids; machine learning

(This special issue belongs to the Section Molecular Medicine)

Supramolecular Peptide Materials for Biomedical Applications

edited by

Anna Mitraki

and

Dhwanit R. Dave

submission deadline 31 Oct 2026 | Viewed by 192 | Submission Open

Keywords: supramolecular peptides; peptide self-assembly; peptide-based biomaterials; biomedical applications; drug delivery; tissue engineering

(This special issue belongs to the Section Bio-Engineered Materials)

Molecular Advances in Multiple Sclerosis

edited by

Felix Javier Jiménez Jiménez

submission deadline 31 Oct 2026 | Viewed by 189 | Submission Open

Keywords: multiple sclerosis; molecular pathogenesis; neuroinflammation; demyelination; neurodegeneration; genetic susceptibility; GWAS; therapeutic strategies

(This special issue belongs to the Section Molecular Biology)

Cancer and Chronic Disease: Molecular Mechanisms and Translational Oncology in Multimorbidity

edited by Kiven Erique Lukong,

and

submission deadline 31 Oct 2026 | Viewed by 184 | Submission Open

Keywords: cancer; chronic diseases; multimorbidity; molecular mechanisms; epigenetics; chronic inflammation; molecular aberrations; translational oncology

(This special issue belongs to the Section Molecular Medicine)

Advancing Health, Industrial, and Husbandry Sciences Through Bioinformatics and Biomaterials

edited by Xian-Ze Meng and

Dongqing Wei

submission deadline 31 Oct 2026 | Viewed by 172 | Submission Open

Keywords: molecular evolution; epidemiology; computational virology; genomics; material protection

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Genetic and Epigenetic Mechanisms in Craniofacial Development and Disease

edited by

Zhaoming Wu

and

Timothy C. Cox

submission deadline 31 Oct 2026 | Viewed by 169 | Submission Open

(This special issue belongs to the Section Molecular Genetics)

Recent Advances in the Enzymatic Synthesis of Bioactive Compounds—2nd Edition

edited by

Bartłomiej Zieniuk

submission deadline 31 Oct 2026 | Viewed by 169 | Submission Open

Keywords: biocatalysis; biotransformation; enzyme-catalyzed reactions; whole-cell catalysis; green chemistry; enzymes; phenolic compounds; polyphenols; lipases; lipophilization; enzymatic synthesis; esterification; transesterification; green and sustainable chemistry approaches; lipid modification

(This special issue belongs to the Section Enzymology)

Novel Insights into Endocannabinoidome and Cannabis

edited by

Emmanuel Onaivi

submission deadline 31 Oct 2026 | Viewed by 151 | Submission Open

Keywords: cannabinoids; endocannabinoids; cannabis; marijuana; inflammation; neuroimmune crosstalk; alcohol; opioids; addiction; mental disorders; gut– brain axis

(This special issue belongs to the Section Natural and Bio-derived Molecules)

DMSO as a Biomolecule to Treat Various Health Conditions

edited by

Frank Krause

submission deadline 31 Oct 2026 | Viewed by 138 | Submission Open

Keywords: pain killer; stroke; spinal cord injuries; autoimmune diseases; cancer

(This special issue belongs to the Section Chemical Biology)

Molecular and Cellular Mechanisms of Aortic Diseases: From Biomarkers to Therapeutic Strategies

edited by Maria Giovanna Scioli

submission deadline 31 Oct 2026 | Viewed by 132 | Submission Open

Keywords: aortic diseases; vascular remodeling; extracellular matrix degradation; vascular smooth muscle cells; endothelial dysfunction; inflammation and cytokines; signal transduction pathways; molecular biomarkers; prognostic markers; targeted therapies; precision medicine; translational research; pharmacological interventions

(This special issue belongs to the Section Molecular Biomarkers)

Properties and Functions of Endometrial Stromal Cells—2nd Edition

edited by

Toshihiro Sakurai

and

Mikihiro Yoshie

submission deadline 31 Oct 2026 | Viewed by 131 | Submission Open

Keywords: endometrium; endometriosis; molecular reproduction; implantation; decidualization; placentation; inflammation; reproductive endocrinology; assisted reproductive technology; molecular reproductive biology

(This special issue belongs to the Section Molecular Reproduction)

Molecular Pathogenesis and Genetic Adaptation of Bacterial Pathogens

edited by

David Roy

submission deadline 31 Oct 2026 | Viewed by 127 | Submission Open

Keywords: host– pathogen interactions; virulence; proteins; enzymes; toxins; nucleic acids; metabolites; antibiotic resistance; biomolecules

(This special issue belongs to the Section Molecular Biology)

High-Field MRI-Guided Boron Neutron Capture Therapy (BNCT): Targeted Delivery and Efficacy Monitoring in Glioma

edited by

Silvia Capuani

and Paola Porcari

submission deadline 31 Oct 2026 | Viewed by 124 | Submission Open

Keywords: boron neutron capture therapy (BNCT); accelerator-based neutron sources; glioma MRI; 19F MRI and MRS; boronophenylalanine (BPA); fluorinated boron agents; glioblastoma; quantitative treatment monitoring; precision radiotherapy; tanslational neuro-oncology

(This special issue belongs to the Section Chemical Biology)

Microtubule-Based Motor Proteins in Health and Disease: Mechanisms, Regulation and Cellular Functions

edited by Weihong Qiu

submission deadline 31 Oct 2026 | Viewed by 112 | Submission Open

Keywords: motor proteins; kinesins; dyneins; microtubule

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Advances in Porphyria and Liver Disease Research

edited by Andrew G. Smith

submission deadline 31 Oct 2026 | Viewed by 65 | Submission Open

Keywords: porphyria; liver disease; heme; mechanisms; susceptibilities

(This special issue belongs to the Section Molecular Medicine)

Advances in the Molecular Mechanisms of Inflammatory Arthritis and Inflammation-Related Bone Changes: 2nd Edition

edited by

Carlo Perricone

submission deadline 1 Nov 2026 | 1 articles | Viewed by 1057 | Submission Open

Keywords: inflammatory arthritis; molecular mechanisms; bone changes; osteoimmunology; autoimmunity

(This special issue belongs to the Section Molecular Medicine)

Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications

edited by

Hawraz Ibrahim M. Amin

submission deadline 7 Nov 2026 | 3 articles | Viewed by 5281 | Submission Open

Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation

(This special issue belongs to the Section Chemical Biology)

Research Progress on Anti-Aging with Natural Products

edited by

Sang-Han Lee

submission deadline 10 Nov 2026 | 2 articles | Viewed by 5785 | Submission Open

Keywords: natural products; anti-aging signaling; autophagy; antioxidants; skin aging; bioactive compounds; molecular mechanisms; translational applications

(This special issue belongs to the Section Biological Factors)

The Mechanisms of Nervous System Injury

edited by

Krisztián Pajer

and Antal Nógrádi

submission deadline 10 Nov 2026 | Viewed by 73 | Submission Open

Keywords: nervous system injury; neuroprotection; stem cell secretome; inflammasome; extracellular vesicles; neuroinflammation; regenerative medicine; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

The Kynurenine Pathway in Mood Disorders: From Mechanisms to Therapeutics

edited by Gregory F. Oxenkrug

submission deadline 17 Nov 2026 | 1 articles | Viewed by 959 | Submission Open

Keywords: kynurenine; tryptophan; mood disorders; stress; inflammation

(This special issue belongs to the Section Biological Factors)

Advances in the Structure and Function of Microtubule-Associated Motor Proteins

edited by Arne Gennerich

submission deadline 20 Nov 2026 | 4 articles | Viewed by 6003 | Submission Open

Keywords: microtubules; kinesin; dynein; CryoEM; post-translational modifications

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Advances in S-Triazine-Based Therapeutics: From Antimicrobials to Neurodegenerative Disease Modulators

edited by

Danuta Drozdowska

submission deadline 20 Nov 2026 | 1 articles | Viewed by 2097 | Submission Open

Keywords: 1; 3; 5-triazine; s-triazine; biological activity; drug discovery; antibacterial agent; antifungal agent; anticancer activity; antiviral agents; antimalarial activity; anti-Alzheimer’ s activity; anti-Alzheimer’ s agents; cholinesterase inhibitors; BACE1 inhibitors; anti-neurodegenerative effects; anti-inflammatory activity; molecular mechanisms of s-triazine activity

(This special issue belongs to the Section Chemical Biology)

Translational Insights from Insect Immunity: Antimicrobial Strategies and Infection Models

edited by

Sylwia Stączek

and

Agnieszka Zdybicka-Barabas

submission deadline 20 Nov 2026 | Viewed by 100 | Submission Open

Keywords: insect immunity; antimicrobial peptides; host-pathogen interaction; innate immune response; infection models

(This special issue belongs to the Section Molecular Medicine)

Displaying special issue 301-350 on page 7 of 11.