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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanism and Regulation of Adipogenesis, Adipose Tissue Inflammation and Metabolism

edited by Udai P Singh

submission deadline 31 Oct 2025 | Viewed by 162 | Submission Open

Keywords: immunometabolism; obesity; adipogenesis; adipose tissue inflammation; adipose immune microenvironment; immune-adipose tissue cross-talk; hormones; high-fat diet; metabolic disease

(This special issue belongs to the Section Biological Factors)

Biochemistry and Molecular Biology of Vitamin D and Its Analog, 3rd Edition

edited by

Toshiyuki Sakaki

and Naoko Tsugawa

submission deadline 31 Oct 2025 | Viewed by 133 | Submission Open

Keywords: vitamin D; vitamin D receptor; vitamin D analog; genomic action; non-genomic action; bone formation; immune response; cancer; rickets; osteoporosis; psoriasis; drug discovery; disease prevention; nutrition improvement metabolism of vitamin D or its analogs cytochrome P450

Assembly of RNA and DNA

edited by

Roman Marks

and

Jürg Bähler

submission deadline 31 Oct 2025 | Viewed by 96 | Submission Open

Keywords: polymerization of RNA and DNA; electrical functioning of RNA/DNA; rotational– electric principles of replication; interactions between RNA/DNA and physical/chemical field; chirality in biomolecules

(This special issue belongs to the Section Molecular Genetics)

Advancing Innovations in Biomedical Research for Translational Applications

edited by Jianjie Ma, Ki Ho Park and

Zui Pan

submission deadline 31 Oct 2025 | Viewed by 61 | Submission Open

Keywords: nanoparticle drug delivery; precision medicine; stem cell; proteomic and lipidomic profiling; novel therapeutic strategies; regenerative medicine; biologic drug development; IND submission

Advances in Metabolomics in Health and Disease

edited by

Carmen Socaciu

submission deadline 31 Oct 2025 | Viewed by 55 | Submission Open

Keywords: metabolomics; disease biomarkers; metabolic phenotyping; metabolic pathways; mass spectrometry; NMR spectroscopy; metabolic databases; bioinformatics

(This special issue belongs to the Section Molecular Medicine)

Obesity, Hormones and Reproductive Health

edited by

Srinivas Nammi

submission deadline 31 Oct 2025 | Viewed by 53 | Submission Open

Keywords: obesity; leptin; insulin; estrogens; androgens; growth hormone; sexual dysfunction; reproductive health

(This special issue belongs to the Section Biological Factors)

Spotlight on Hot Cancer Biological Biomarkers

edited by

Dania Cioni

and

Salvatore Claudio Fanni

submission deadline 31 Oct 2025 | Viewed by 46 | Submission Open

Keywords: cancer biomarkers; precision medicine; liquid biopsy; imaging biomarkers; translational oncology

(This special issue belongs to the Section Molecular Biomarkers)

Soft Matter and Self-Assembly: From Biomaterials to Nanomaterials

edited by Caterina Ricci and

Maria Grazia Ortore

submission deadline 31 Oct 2025 | Viewed by 41 | Submission Open

Keywords: soft matter; self-assembly; biomaterials; nanomaterials; bioinspired materials; drug delivery; responsive materials; tissue engineering; nanotechnology; molecular organization

Molecular Mechanisms and Signaling Pathways in Autoimmune Diseases

edited by

Daniele Saverino

submission deadline 31 Oct 2025 | Viewed by 38 | Submission Open

Keywords: autoimmune diseases; molecular mechanisms; signaling pathways; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

Botanic Metabolites: From Extraction to Application

edited by

Carmen Formisano

submission deadline 31 Oct 2025 | Viewed by 26 | Submission Open

Keywords: medicinal plants; phytochemistry; antimicrobial activity; plant extracts; essential oils; synergism

The Role of Amyloid in Neurological Disorders: 2nd Edition

edited by

Marny Fedrigo

and Tamara Berno

submission deadline 31 Oct 2025 | Viewed by 20 | Submission Open

Keywords: amyloid-beta; neurodegenerative disorders; aducanumab; oligomers; cross-amyloid interaction

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome

edited by

Rosanna Squitti

submission deadline 31 Oct 2025 | Viewed by 20 | Submission Open

Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders

(This special issue belongs to the Section Molecular Medicine)

Molecular Genetics and Cell Biology in Neuroblastoma

edited by

Dirk Geerts

submission deadline 31 Oct 2025 | Viewed by 14 | Submission Open

Keywords: genetics; genomics; neuroblastoma; precision medicine; transcriptomics

(This special issue belongs to the Section Cellular Biochemistry)

Biomarkers in Neurodegenerative Diseases: Shaping the Future of Diagnosis and Treatment

edited by

Martine Tétreault

submission deadline 31 Oct 2025 | Viewed by 10 | Submission Open

Keywords: molecular diagnostics; lipidomics; genomics; proteomics; transcriptomics

(This special issue belongs to the Section Molecular Biomarkers)

Computational Design and Mechanistic Studies of Metal-Based Therapeutics

edited by

Iogann Tolbatov

and

Andrea Melchior

submission deadline 1 Nov 2025 | Viewed by 33 | Submission Open

Keywords: anticancer metal complexes; antitumor metallodrugs; antimicrobial agents; antiviral metallodrugs; medicinal inorganic chemistry; bioinorganic chemistry; computational design; mechanistic studies; rational drug development

Transcription Factors in Hematopoiesis and Immunity: From Development to Therapeutic Targeting

edited by Amiya Kumar Patra

submission deadline 1 Nov 2025 | Viewed by 21 | Submission Open

Keywords: transcription factors; immune regulation; epigenetics; cytokines and chemokines; molecular interaction; immunodeficiency; allergy; leukemia and lymphoma; small molecule inhibitors; hematopoietic disorders

Zebrafish Models in Cardiovascular and Metabolic Precision Medicine

edited by

Angom Ramcharan Singh

submission deadline 7 Nov 2025 | Viewed by 17 | Submission Open

Keywords: zebrafish models; cardiovascular disease; metabolic disorders; precision medicine; genetic screening; drug discovery; disease modeling; translational research; personalized therapy; high-throughput screening

Recent Advances in Mass Spectrometry-Based Proteomics

edited by

An Staes

and Simon Devos

submission deadline 15 Nov 2025 | Viewed by 36 | Submission Open

Keywords: LC-MS/MS proteomics; high-throughput; low input proteomics; clinical proteomics; spatial proteomics; immunopeptidomics; post-translational protein modifications; biomarker discovery; drug targets

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Structural Proteomics–Structural Biology Led by Advancements in Mass Spectrometry Techniques

edited by

Rohit Jain

, Corie Ralston and

Gang (Gary) Ren

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3995 | Submission Open

Keywords: hydroxyl radical protein footprinting MS (XFP; FPOP); hydrogen/deuterium exchange MS (HDX-MS); cross-linking MS (XL-MS); covalent labeling MS; top-down MS; native MS

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in the Structure and Function of Microtubule-Associated Motor Proteins

edited by Arne Gennerich

submission deadline 20 Nov 2025 | 1 articles | Viewed by 406 | Submission Open

Keywords: microtubules; kinesin; dynein; CryoEM; post-translational modifications

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

New Insights into Integrins

edited by

Yoshikazu Takada

submission deadline 30 Nov 2025 | 6 articles | Viewed by 8230 | Submission Open

Keywords: integrins; growth factors; ligands

(This special issue belongs to the Section Biological Factors)

Advances in p53 Research

edited by

Gabriella D’Orazi

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6287 | Submission Open

Keywords: p53; small molecules; tumor suppressor; apoptosis; tumor– host interaction; targeted therapies; tumor microenvironment (TME)

(This special issue belongs to the Section Molecular Biology)

Skeletal Muscle in Health, Exercise and Aging

edited by Barbara Munz

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5844 | Submission Open

Keywords: skeletal muscle; molecular mechanisms of exercise adaptation; aging; cachexia; sarcopenia

(This special issue belongs to the Section Molecular Biology)

Design and Synthesis of Bioactive Compounds for Therapeutic Applications

edited by

Gerald Guillaumet

and

Saïd El Kazzouli

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4508 | Submission Open

Keywords: drug design and discovery; synthesis of bioactive molecules; biological evaluations and applications; diagnostics; drug delivery

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Aspects of Female Infertility

edited by

Mara Marongiu

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4334 | Submission Open

Keywords: female infertility; reproduction; ovary; reproductive aging; genetic disorders

(This special issue belongs to the Section Molecular Biology)

Tumor Microenvironment, Immunology and Precision Medicine of Liver Cancer

edited by Lynn Jeanette Savic

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2229 | Submission Open

Keywords: hepatocellular carcinoma; hypoxia; tumor microenvironment; immunometabolic crosstalk; tumor-associated macrophages

(This special issue belongs to the Section Biological Factors)

Properties and Functions of Endometrial Stromal Cells

edited by

Toshihiro Sakurai

and

Mikihiro Yoshie

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2036 | Submission Open

Keywords: endometrium; endometriosis; molecular reproduction; implantation; decidualization; placentation; inflammation; reproductive endocrinology; assisted reproductive technology; molecular reproductive biology

(This special issue belongs to the Section Molecular Reproduction)

The Role of Mechanotransduction in Cellular Biology

edited by

Frederick H. Silver

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1684 | Submission Open

Keywords: cell membrane; cytosol; nuclear membrane; integrin; mechanotransduction; map kinase pathway; ERKs; JNKs; p38/SAPKs; YAP/TAZ; Hippo pathway

(This special issue belongs to the Section Cellular Biochemistry)

Recent Developments in the Biology of Extracellular or Cell-Free DNA, 2nd Edition

edited by

Peter Celec

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1139 | Submission Open

Keywords: neutrophil extracellular traps; DNase; toll-like receptor 9; exosomes; autoimmunity

(This special issue belongs to the Section Molecular Biology)

Pluripotent Stem Cell Models of Human Disease

edited by Satish Kumar

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1129 | Submission Open

Keywords: pluripotent stem cells; cellular reprogramming; cellular differentiation; 2D and 3D cell models of human disease; cellular phenotypes; biomarkers; disease gene; multi-omics approaches; genome editing; drug screening and discovery

(This special issue belongs to the Section Cellular Biochemistry)

Biomolecules and Materials from Agro-Industrial Wastes, 2nd Edition

edited by

Valdir Florencio Da Veiga Junior

submission deadline 30 Nov 2025 | 1 articles | Viewed by 814 | Submission Open

Keywords: bioactive molecules from discarded plant parts; new extraction methodologies; green solvents; green chemistry; bioenergy; biorefinery; biofibres

(This special issue belongs to the Section Bio-Engineered Materials)

Mechanisms of Kidney Injury and Treatment Modalities

edited by Utpal Sen

submission deadline 30 Nov 2025 | 1 articles | Viewed by 609 | Submission Open

Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics; mitochondrial damage; and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation; histone modification; and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences; aging; and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut– kidney axis and health; hypertensive; diabetic; and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein; metalloproteinases; and their inhibitors; necrosis; necroptosis; apoptosis; pyroptosis; and ferroptosis; renal repair and regeneration

(This special issue belongs to the Section Molecular Biology)

Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases

edited by Aurora Daniele and

Ersilia Nigro

submission deadline 30 Nov 2025 | Viewed by 338 | Submission Open

Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease

(This special issue belongs to the Section Biological Factors)

Thyroid Cancer: Molecular Mechanisms and Targeted Therapies

edited by

Cristina Alina Silaghi

Carmen Emanuela Georgescu

and

Horaţiu Silaghi

submission deadline 30 Nov 2025 | Viewed by 250 | Submission Open

Keywords: differentiated thyroid cancer; medullary thyroid cancer; anaplastic thyroid carcinoma; advanced/metastatic thyroid cancer; refractory thyroid cancer; molecular biomarkers; oncogenic signaling pathways; thyroid cytology; targeted therapy; tyrosine kinase inhibitors; immune checkpoint inhibitors; therapeutic strategies; thyroid cancer prognosis; epigenomics in thyroid cancer

(This special issue belongs to the Section Molecular Medicine)

Antioxidant and Anti-Inflammatory Activities of Phytochemicals

edited by

Peter Rose

and

Yi Zhun Zhu

submission deadline 30 Nov 2025 | Viewed by 167 | Submission Open

Keywords: antioxidants; plant bioactives; inflammation; free radicals

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Genetic Insights into Biological Mechanisms Governing Aging

edited by

Zhihong Yang

and Duilio Michele Potenza

submission deadline 30 Nov 2025 | Viewed by 125 | Submission Open

Keywords: aging; genetics; cellular senescence; oxidative stress; inflammation; mitochondrial function

(This special issue belongs to the Section Molecular Genetics)

Novel Evidence About Hydrogen Sulfide (H₂S)-Donor Molecules as Innovative Therapeutical Tools 2025

edited by

Alma Martelli

submission deadline 30 Nov 2025 | Viewed by 115 | Submission Open

Keywords: hydrogen sulfide (H2S)-donor; H2S-releasing molecule; H2S-hybrid drug; hydrogen sulfide; therapeutical tool

Advances in Molecular Mechanisms in Chronic Kidney Disease

edited by

Francisco Herrera-Gómez

and María J. Izquierdo

submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open

Keywords: chronic kidney disease; end-stage kidney disease; etiological diagnosis; biomarkers; personalized medicine; humans

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Advances in Platelet Disease, Thrombosis and Hemostasis

edited by

José Rivera

submission deadline 30 Nov 2025 | Viewed by 85 | Submission Open

Keywords: platelets; hemostasis and thrombosis; inherited platelet disorders; coagulation; immunothrombosis; miRNA; GPVI; Runx1; antiplatelet therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Olfactory and Gustatory System

edited by

Andrea Mazzatenta

submission deadline 30 Nov 2025 | Viewed by 84 | Submission Open

Keywords: olfaction; smell; taste; chemical stimuli; sensation; perception; Volabolome; advanced diagnostic techniques

(This special issue belongs to the Section Molecular Biology)

Defects in the Transport Mechanism of Membrane Proteins and Related Diseases, 2nd Edition

edited by Daniela Valeria Miniero

submission deadline 30 Nov 2025 | Viewed by 63 | Submission Open

Keywords: function; structure and folding of membrane transport proteins; pathological mutations; mechanism of transport; neurological and metabolic disease; transport of nanoparticles; organelle membranes; cellular function and signaling; bioenergetics; neuroinflammation; nanoformulations for drug targets

New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles

edited by

Massimo Tusconi

, Serdar Dursun and

Germano Orru

submission deadline 30 Nov 2025 | Viewed by 48 | Submission Open

Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD

Deciphering Biomolecular Multimeric Systems: Computational Advances in Structure, Dynamics, and Function

edited by

Zhaoxi Sun

, Jinping Lei and Hui Wang

submission deadline 30 Nov 2025 | Viewed by 42 | Submission Open

Keywords: molecular glue; molecular simulations; PROTAC; binding affinity; binding mode; MSM; membrane

Current Advances of Metal Complexes for Biomedical Applications

edited by

Marcelino Maneiro

and Sandra Fernández-Fariña

submission deadline 30 Nov 2025 | Viewed by 41 | Submission Open

Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications

Acute Kidney Injury and Mitochondrial Involvement

edited by Iva Suman

submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open

Keywords: acute kidney injury; mitochondrial dysfunction; mitochondrial dynamics; mitophagy; biomarkers

Recent Advances in Retroviruses and Endogenous Retroviruses (ERVs) in Mammalian Placenta and Beyond 2025

edited by

Kazuhiko Imakawa

and

Jun Sugimoto

submission deadline 30 Nov 2025 | Viewed by 17 | Submission Open

Keywords: retroviruses; ERVs (endogenous retroviruses); placental diversity; organ development (stem cells); immunoregulation

(This special issue belongs to the Section Biomacromolecules: Nucleic Acids)

New Insight into the Structures and Host Cell Interactions of Emerging Viruses

edited by

Wei Zhang

and

Qibin Geng

submission deadline 30 Nov 2025 | Viewed by 14 | Submission Open

Keywords: emerging viruses; virus structure; structural biology; Cryo-EM/Cryo-ET/CLEM; virus– host interactions; viral receptor binding and entry; viral assembly; maturation; and egress; immune evasion; molecular dynamics simulation; antiviral targets

(This special issue belongs to the Section Molecular Structure and Dynamics)

Functional Structures in RNA Viruses

edited by Riccardo Delli Ponti,