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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolic Dysfunction and Mitochondrial Pathophysiology: From Mechanisms to Therapeutic Insights

edited by

Yana Sandlers

submission deadline 15 Oct 2026 | Viewed by 135 | Submission Open

Keywords: mitochondrial dysfunction; mitochondrial respiration; mitophagy; Krebs cycle; oxidative stress

(This special issue belongs to the Section Molecular Medicine)

Alcohol-Related Nervous System Damage and Disease: From Mechanisms to Therapies

edited by

Suzanne M. De La Monte

submission deadline 16 Oct 2026 | 2 articles | Viewed by 1933 | Submission Open

Keywords: alcohol; brain; neurodegeneration; diagnostics; treatment; disease mechanisms; prevention; pathology; imaging; molecular and cellular studies; co-factor effects

(This special issue belongs to the Section Molecular Medicine)

Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition

edited by

Michele Scuruchi

submission deadline 20 Oct 2026 | 2 articles | Viewed by 5069 | Submission Open

Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System, 2nd Edition

edited by Peng Yao and

Wei Guo

submission deadline 20 Oct 2026 | Viewed by 276 | Submission Open

Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA

(This special issue belongs to the Section Molecular Genetics)

Nutrition, Obesity and Metabolic Disorders: Molecular Bases, Biological Mechanisms, Related Diseases and Translational Research

edited by

Nuria De Castro

and

Jaime Ruiz-Tovar

submission deadline 20 Oct 2026 | Viewed by 202 | Submission Open

Keywords: obesity; metabolic disorders; molecular bases; metabolomics; genomics; biological mechanisms; inflammation and oxidation; neuroimmunoendocrine modulation and aging; nutritional interventions; therapeutic strategies

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Novel Treatments of Stroke, 2nd Edition

edited by

Saif Ahmad

and Naseem Akhter

submission deadline 20 Oct 2026 | Viewed by 188 | Submission Open

Keywords: ischemic stroke; molecular mechanisms; neuroinflammation; signaling pathways; therapeutic approaches

(This special issue belongs to the Section Molecular Biology)

Molecular Regulation of Blood Biomarkers in Inflammation

edited by

René Huber

submission deadline 20 Oct 2026 | Viewed by 153 | Submission Open

Keywords: inflammation; inflammatory diseases; blood; biomarker; molecular regulation

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Mechanisms Regulating Cardiomyocyte Proliferation and Cell Cycle Re-Entry

edited by Jianyi Zhang,

Yuji Nakada

and Thanh Nguyen

submission deadline 20 Oct 2026 | Viewed by 118 | Submission Open

Keywords: cardiomyocyte proliferation; cardiomyocyte regeneration; cardiomyocyte dedifferentiation; cell-cycle; transcription factor; cardiac disease; epigenetic regulation; hiPSC-CMs; transcriptomics

(This special issue belongs to the Section Molecular Genetics)

Advances in Genetic and Epigenetic Gene Therapy for Diabetic Wound Healing

edited by

Kanhaiya Singh

submission deadline 21 Oct 2026 | 1 articles | Viewed by 1127 | Submission Open

Keywords: chronic wounds; DFU; wound healing; diet; diabetes; obesity; nutrition; genomics; epigenetics; DNA methylation; histone modifications

(This special issue belongs to the Section Molecular Genetics)

The Function of Stromal Cells in Gastrointestinal (GI) Diseases

edited by Li Chang

submission deadline 23 Oct 2026 | Viewed by 150 | Submission Open

Keywords: gastrointestinal (GI) diseases; intestinal stromal cells; intestinal homeostasis; cytokine; extracellular matrix; tissue repair

(This special issue belongs to the Section Molecular Medicine)

Advances in Inflammatory Bowel Disease: From Molecular Mechanisms to Therapies

edited by Mariangela Allocca

submission deadline 24 Oct 2026 | 1 articles | Viewed by 754 | Submission Open

Keywords: inflammatory bowel disease; Crohn's disease; ulcerative colitis; advanced therapies; treat-to-target; transmural healing; disease modification; personalized medicine

(This special issue belongs to the Section Molecular Medicine)

The Role of the Circadian Clock in Health and Disease

edited by Rajendram V. Rajnarayanan

submission deadline 24 Oct 2026 | Viewed by 151 | Submission Open

Keywords: circadian clock; chronobiology; clock genes; sleep; circadian misalignment; chronotherapy; metabolic disease; endocrine disruption; inflammation; neurodegeneration; biomarkers; multi-omics

(This special issue belongs to the Section Biological Factors)

Mechanism of Gene Modification Therapy for Cystic Fibrosis

edited by

Wolf-Michael Weber

and Joerg Grosse-Onnebrink

submission deadline 28 Oct 2026 | Viewed by 155 | Submission Open

Keywords: cystic fibrosis; CFTR; gene modification therapy; mRNA therapy; gene editing; CRISPR/Cas; airway epithelium; ion transport; nanoparticle delivery; precision medicine

(This special issue belongs to the Section Molecular Genetics)

Mitochondrial Calcium Signaling in Cardiac Health and Disease

edited by Enrique Balderas

submission deadline 29 Oct 2026 | 1 articles | Viewed by 1483 | Submission Open

Keywords: mitochondrial Ca2+; OXPHOS; H+ gradient; ATP-synthesis; NAD(H) balance; Ca2+-overload; mitochondrial permeability; apoptosis; mtDNA; ROS production-clearance

(This special issue belongs to the Section Cellular Biochemistry)

Computational Pharmacology: Advances in Computational Modeling of Drug–Receptor Interactions and Pharmacokinetics

edited by

Clement Agoni

and

Indrani Bera

submission deadline 30 Oct 2026 | Viewed by 358 | Submission Open

Keywords: computational pharmacology; drug– receptor interactions; pharmacokinetics modeling; molecular dynamics simulations; molecular docking; QSAR analysis; ADME prediction; AI in drug design; machine learning for drug discovery; protein– ligand binding; bioactive peptide– protein interactions; drug– enzyme interactions; drug– nucleic acid interactions; protein– lipid interactions; peptoid-target interactions; therapeutic optimization; pharmacodynamic modeling

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Research on Sarcoma: From Pathogenesis to Molecular Targets

edited by

Irene Faenza

submission deadline 30 Oct 2026 | Viewed by 309 | Submission Open

Keywords: sarcoma; molecular pathogenesis; genetic alterations; biomarkers; molecular targets; signal transduction

Novel Molecular Targets for Beta Cell Regeneration and Diabetes Therapy

edited by

Iraj Alipourfard

submission deadline 30 Oct 2026 | Viewed by 274 | Submission Open

Keywords: diabetes; pancreatic beta cells; regenerative therapy; molecular target

(This special issue belongs to the Section Molecular Medicine)

Serotonin Signaling in Cancer Development and Progression

edited by

Iván P. Uray

submission deadline 30 Oct 2026 | Viewed by 154 | Submission Open

Keywords: serotonin; 5-HT; cancer; carcinogenesis; invasion; tumor microenvironment; serotonylation; mechanotransduction

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases

edited by

Zhidong Zhou

submission deadline 31 Oct 2026 | 7 articles | Viewed by 17649 | Submission Open

Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy

(This special issue belongs to the Section Biological Factors)

Molecular Advances in Drug Resistance and Novel Therapies for Cancer

edited by

Agnieszka Wolnicka-Glubisz

and

Konrad Kleszczyński

submission deadline 31 Oct 2026 | 6 articles | Viewed by 11554 | Submission Open

Keywords: cell signalling; cancer treatment; cancer metastasis; target validation; cancer and new molecules; cancer and cellular organelles

(This special issue belongs to the Section Biological Factors)

The Value of Natural Compounds as Therapeutic Agents: 3rd Edition

edited by

Maria Beatrice Morelli

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4253 | Submission Open

Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Updates on Molecular Mechanisms of Lysosomal Storage Disease

edited by

Anna Tylki-Szymanska

and

Patryk Lipiński

submission deadline 31 Oct 2026 | 1 articles | Viewed by 3382 | Submission Open

Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD

(This special issue belongs to the Section Biological Factors)

The Immune Response to Severe Trauma

edited by

Jon Hazeldine

and David N Naumann

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2232 | Submission Open

Keywords: trauma-induced immune response; systemic inflammation; immune suppression; immune dysregulation; critical care

(This special issue belongs to the Section Molecular Medicine)

Multifunctional Enzymes and Proteins: New Insights into Structure and Function

edited by

Martina Buonanno

Paola Imbimbo

and

Fabiola Mascanzoni

submission deadline 31 Oct 2026 | Viewed by 2204 | Submission Open

Keywords: multifunctional enzymes; protein structure; protein function; catalytic activity; conformational dynamics; biochemistry; biophysics; drug discovery

(This special issue belongs to the Section Molecular Biology)

Obesity-Related Diseases: Molecular Basis and Therapeutic Approaches

edited by

Dénes Molnár

and

Szilvia Bokor

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1293 | Submission Open

Keywords: obesity; causes; therapy; epigenetics; biomolecules

Prebiotics and Probiotics in Health and Disease: Precision Delivery and Microbiota-Informed Therapeutics

edited by

Virginia Fuochi

and

Pio Maria Furneri

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1142 | Submission Open

Keywords: prebiotics; probiotics; postbiotics; drug delivery systems; nanocarriers; microbiota-targeted therapies; gut microbiota; precision biotics

(This special issue belongs to the Section Molecular Biology)

Cell Death and Clearance

edited by

Ivan Poon

and Jascinta Santavanond

submission deadline 31 Oct 2026 | Viewed by 366 | Submission Open

Keywords: cell death; apoptosis; efferocytosis; cell clearance

(This special issue belongs to the Section Molecular Medicine)

LDL Receptor Family in Metabolic Homeostasis, Neurodevelopmental Disorders, and Signaling Pathways

edited by

María-Paz Marzolo

submission deadline 31 Oct 2026 | Viewed by 320 | Submission Open

Keywords: LDL receptor family; lipid metabolism; cholesterol homeostasis; neurodevelopmental and neuropsychiatric disorders; neurodegeneration; receptor-mediated endocytosis; Wnt and reelin signaling pathways; apolipoproteins; Alzheimer's disease; Parkinson's disease

Feature Papers in Section "Biological Factors", 2nd Edition

edited by

Tracey A. Martin

submission deadline 31 Oct 2026 | Viewed by 307 | Submission Open

Keywords: neurotransmitters; cytokines; chemokines; hormones; connexins; androgen; estrogens; coagulation factors; hypoxia-inducible factors; transcription factors; signaling; receptors; interferon

(This special issue belongs to the Section Biological Factors)

Synthetic Biology's Potential to Address Undruggable Targets and Difficult-to-Treat Diseases

edited by

Dario Mizrachi

submission deadline 31 Oct 2026 | Viewed by 268 | Submission Open

Keywords: synthetic biology; protein engineering; drug development; biologics; undruggable targets

(This special issue belongs to the Section Molecular Medicine)

SAM Domains in Health and Diseases: Structural and Functional Insights

edited by

Flavia Anna Mercurio

and

Marilisa Leone

submission deadline 31 Oct 2026 | Viewed by 264 | Submission Open

Keywords: SAM domains; oligomer- and polymer-forming SAM; mid-loop/end-helix architecture of binding; SAM physiological and pathological signaling pathways; SAM domains as drug targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Fibronectin, Integrins and Related Molecules in Health and Diseases

edited by

Yoshikazu Takada

submission deadline 31 Oct 2026 | Viewed by 253 | Submission Open

Keywords: integrin; fibronectin; cytokines

(This special issue belongs to the Section Chemical Biology)

Modern Studies of Nucleic Acid Dynamics

edited by

Gary A. Meints

submission deadline 31 Oct 2026 | Viewed by 247 | Submission Open

Keywords: nucleic acid dynamics; DNA; RNA; nucleic acid energetics; dynamics of biomolecular recognition; timescales and magnitudes of dynamics

Calcium Signaling: Molecular Mechanisms and Therapeutic Targets in Cardiovascular Diseases

edited by Jianjie Ma and

Yuchen Chen

submission deadline 31 Oct 2026 | Viewed by 245 | Submission Open

Keywords: calcium signaling; excitation– contraction coupling; cardiovascular disease; ryanodine receptor and ion channelopathies; gene therapy and precision medicine

(This special issue belongs to the Section Chemical Biology)

Pathophysiological Insights into Congenital Myasthenic Syndromes

edited by Xin-Ming Shen, Kinji Ohno and Duygu Selcen

submission deadline 31 Oct 2026 | Viewed by 229 | Submission Open

Keywords: neuromuscular junction; neurotransmission; developmental biology; myasthenia; congenital myasthenic syndrome; human genetics; variant; mutation; animal model

(This special issue belongs to the Section Molecular Medicine)

Application of Spectral Analysis in Disease Diagnosis and Treatment

edited by

Entesar Al-Hetlani

and

Igor Lednev

submission deadline 31 Oct 2026 | Viewed by 223 | Submission Open

Keywords: molecular spectroscopy; mass spectrometry; medical diagnostics; disease treatment/treatment monitoring; lipidomics/proteomics/metabolomics; biofluids; machine learning

(This special issue belongs to the Section Molecular Medicine)

Supramolecular Peptide Materials for Biomedical Applications

edited by

Anna Mitraki

and

Dhwanit R. Dave

submission deadline 31 Oct 2026 | Viewed by 188 | Submission Open

Keywords: supramolecular peptides; peptide self-assembly; peptide-based biomaterials; biomedical applications; drug delivery; tissue engineering

(This special issue belongs to the Section Bio-Engineered Materials)

Molecular Advances in Multiple Sclerosis

edited by

Felix Javier Jiménez Jiménez

submission deadline 31 Oct 2026 | Viewed by 185 | Submission Open

Keywords: multiple sclerosis; molecular pathogenesis; neuroinflammation; demyelination; neurodegeneration; genetic susceptibility; GWAS; therapeutic strategies

(This special issue belongs to the Section Molecular Biology)

Cancer and Chronic Disease: Molecular Mechanisms and Translational Oncology in Multimorbidity

edited by Kiven Erique Lukong,

and

submission deadline 31 Oct 2026 | Viewed by 179 | Submission Open

Keywords: cancer; chronic diseases; multimorbidity; molecular mechanisms; epigenetics; chronic inflammation; molecular aberrations; translational oncology

(This special issue belongs to the Section Molecular Medicine)

Advancing Health, Industrial, and Husbandry Sciences Through Bioinformatics and Biomaterials

edited by Xian-Ze Meng and

Dongqing Wei

submission deadline 31 Oct 2026 | Viewed by 171 | Submission Open

Keywords: molecular evolution; epidemiology; computational virology; genomics; material protection

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Recent Advances in the Enzymatic Synthesis of Bioactive Compounds—2nd Edition

edited by

Bartłomiej Zieniuk

submission deadline 31 Oct 2026 | Viewed by 166 | Submission Open

Keywords: biocatalysis; biotransformation; enzyme-catalyzed reactions; whole-cell catalysis; green chemistry; enzymes; phenolic compounds; polyphenols; lipases; lipophilization; enzymatic synthesis; esterification; transesterification; green and sustainable chemistry approaches; lipid modification

(This special issue belongs to the Section Enzymology)

Genetic and Epigenetic Mechanisms in Craniofacial Development and Disease

edited by

Zhaoming Wu

and

Timothy C. Cox

submission deadline 31 Oct 2026 | Viewed by 158 | Submission Open

(This special issue belongs to the Section Molecular Genetics)

Novel Insights into Endocannabinoidome and Cannabis

edited by

Emmanuel Onaivi

submission deadline 31 Oct 2026 | Viewed by 144 | Submission Open

Keywords: cannabinoids; endocannabinoids; cannabis; marijuana; inflammation; neuroimmune crosstalk; alcohol; opioids; addiction; mental disorders; gut– brain axis

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular and Cellular Mechanisms of Aortic Diseases: From Biomarkers to Therapeutic Strategies

edited by Maria Giovanna Scioli

submission deadline 31 Oct 2026 | Viewed by 131 | Submission Open

Keywords: aortic diseases; vascular remodeling; extracellular matrix degradation; vascular smooth muscle cells; endothelial dysfunction; inflammation and cytokines; signal transduction pathways; molecular biomarkers; prognostic markers; targeted therapies; precision medicine; translational research; pharmacological interventions

(This special issue belongs to the Section Molecular Biomarkers)

Properties and Functions of Endometrial Stromal Cells—2nd Edition

edited by

Toshihiro Sakurai

and

Mikihiro Yoshie

submission deadline 31 Oct 2026 | Viewed by 130 | Submission Open

Keywords: endometrium; endometriosis; molecular reproduction; implantation; decidualization; placentation; inflammation; reproductive endocrinology; assisted reproductive technology; molecular reproductive biology

(This special issue belongs to the Section Molecular Reproduction)

DMSO as a Biomolecule to Treat Various Health Conditions

edited by

Frank Krause

submission deadline 31 Oct 2026 | Viewed by 128 | Submission Open

Keywords: pain killer; stroke; spinal cord injuries; autoimmune diseases; cancer

(This special issue belongs to the Section Chemical Biology)

High-Field MRI-Guided Boron Neutron Capture Therapy (BNCT): Targeted Delivery and Efficacy Monitoring in Glioma

edited by

Silvia Capuani

and Paola Porcari

submission deadline 31 Oct 2026 | Viewed by 123 | Submission Open

Keywords: boron neutron capture therapy (BNCT); accelerator-based neutron sources; glioma MRI; 19F MRI and MRS; boronophenylalanine (BPA); fluorinated boron agents; glioblastoma; quantitative treatment monitoring; precision radiotherapy; tanslational neuro-oncology

(This special issue belongs to the Section Chemical Biology)

Molecular Pathogenesis and Genetic Adaptation of Bacterial Pathogens

edited by

David Roy

submission deadline 31 Oct 2026 | Viewed by 121 | Submission Open

Keywords: host– pathogen interactions; virulence; proteins; enzymes; toxins; nucleic acids; metabolites; antibiotic resistance; biomolecules

(This special issue belongs to the Section Molecular Biology)

Microtubule-Based Motor Proteins in Health and Disease: Mechanisms, Regulation and Cellular Functions

edited by Weihong Qiu

submission deadline 31 Oct 2026 | Viewed by 110 | Submission Open

Keywords: motor proteins; kinesins; dyneins; microtubule

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Advances in Porphyria and Liver Disease Research

edited by Andrew G. Smith

submission deadline 31 Oct 2026 | Viewed by 61 | Submission Open

Keywords: porphyria; liver disease; heme; mechanisms; susceptibilities

(This special issue belongs to the Section Molecular Medicine)

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