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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Biology of Neurodevelopment

edited by

David M. Feliciano

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3004 | Submission Open

Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Biology)

Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges

edited by

Atsushi Saito

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2874 | Submission Open

Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials

(This special issue belongs to the Section Bio-Engineered Materials)

Barrier Formation and Homeostasis in the Vertebrate Brain

edited by

Ramani Ramchandran

Karthikeyan Thirugnanam

and

Ankan Gupta

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2801 | Submission Open

Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia

(This special issue belongs to the Section Cellular Biochemistry)

Necrotic Cell Death Mechanisms and Therapies

edited by

Ilana Nathan

and

Boris Khalfin

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2794 | Submission Open

Keywords: necrosis; mitochondria; lysosomes; reactive oxygen species (ROS); calcium signalling; caspase-independent proteases: serine proteases like CELA; ELA; as well as cathepsin C and B etc.; heat shock proteins (HSPs); epigenetics; necrosis in diseases and therapeutic intervention; necroptosis; ferroptosis; paraptosis; pyroptosis

(This special issue belongs to the Section Cellular Biochemistry)

Non-Invasive Biomarkers in Saliva or Urine: Technical and Biological Variability

edited by

Peter Celec

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2521 | Submission Open

Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Signaling Pathways as Therapeutic Targets for Cancer

edited by Fabian Benencia

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2106 | Submission Open

Keywords: cancer signaling pathways; cancer metabolism; small molecules; anticancer antibodies; tumor models; combinatorial therapies

(This special issue belongs to the Section Molecular Biology)

Tumour Suppressor Genes: The Guardians of Cell Integrity

edited by

Nicola Manfrini

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1940 | Submission Open

Keywords: cell cycle; cell growth; cell integrity; cell proliferation; DNA damage; genome integrity; protein homeostasis; migration; invasion; metastasis; apoptosis; autophagy

(This special issue belongs to the Section Molecular Biology)

Novel Mechanisms of Bacterial Antibiotic Resistance

edited by

Dorothea K. Thompson

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1796 | Submission Open

Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches

(This special issue belongs to the Section Biological Factors)

Molecular Biomarkers in Cardiology 2025

edited by

Pietro Scicchitano

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1748 | Submission Open

Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart

(This special issue belongs to the Section Molecular Biomarkers)

New Insights into Molecular Mechanisms and Therapeutics for Malaria

edited by

Maria Isabel Veiga

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1745 | Submission Open

Keywords: antimalarial resistance; drug discovery; malaria epidemiology; diagnostic tools; malaria pathophysiology

(This special issue belongs to the Section Molecular Medicine)

Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials

edited by

Mire Zloh

and Rachael Dickman

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1578 | Submission Open

Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Calcium Signaling in Cell Function and Dysfunction

edited by

Giorgia Pallafacchina

and Sofia Zanin

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1409 | Submission Open

Keywords: calcium signaling; calcium regulation; cell function; human pathology

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications

edited by Yalin Qi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1320 | Submission Open

Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection

(This special issue belongs to the Section Chemical Biology)

Molecular Basis of Pathogenesis in Autoimmune Diseases

edited by

I-Tsu Chyuan

and

Chi-Jung Huang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1184 | Submission Open

Keywords: autoimmune diseases; molecular pathogenesis; genetic determinants; signaling pathways; immunopathology; therapeutic targets; novel molecular targets

(This special issue belongs to the Section Molecular Medicine)

Vertebrate Comparative Genomics

edited by Ya-Xiong Tao and

Shan He

submission deadline 31 Dec 2025 | 1 articles | Viewed by 932 | Submission Open

Keywords: vertebrate; comparative genomics; physiology; biochemistry; pathophysiology; protein structure-function; gene

(This special issue belongs to the Section Molecular Genetics)

Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition

edited by

Caterina Vicidomini

and

Giovanni N. Roviello

submission deadline 31 Dec 2025 | 1 articles | Viewed by 662 | Submission Open

Keywords: proteins; peptides; amyloid; Alzheimer disease; Parkinson’ s disease; neurodrugs; G-quadruplex nucleic acids; biotechnology; biomolecular targets; peptide aggregation; natural products; synthetic drugs; anti-amyloid therapeutics; machine learning

(This special issue belongs to the Section Chemical Biology)

Functional Peptides and Their Interactions (3rd Edition)

edited by

Mikhail Soloviev

and

Simon M. Cutting

submission deadline 31 Dec 2025 | 1 articles | Viewed by 610 | Submission Open

Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Phytohormones 2024–2025

edited by Guzel Kudoyarova

submission deadline 31 Dec 2025 | Viewed by 579 | Submission Open

Keywords: plant hormones; auxins; cytokinins; gibberellins; abscisic acid; ethylene; salicylic acid; jasmonates

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Basis of Mast Cells Activation and Medical Implications

edited by

Grzegorz Porebski

and

Matija Rijavec

submission deadline 31 Dec 2025 | Viewed by 423 | Submission Open

Keywords: mast cells; allergy; immediate hypersensitivity; molecular mechanisms

(This special issue belongs to the Section Biological Factors)

Molecular Basis and Oxidative Stress of Thyroid Diseases

edited by

Małgorzata Karbownik-Lewińska

and

Jan Stȩpniak

submission deadline 31 Dec 2025 | Viewed by 370 | Submission Open

Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease

(This special issue belongs to the Section Biological Factors)

The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication

edited by

Yuqian Yan

submission deadline 31 Dec 2025 | Viewed by 290 | Submission Open

Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis

(This special issue belongs to the Section Cellular Biochemistry)

Harnessing the Immune System Against Solid Cancer: New Targets and Novel Therapeutic Approaches

edited by

Milica Perišić Nanut

submission deadline 31 Dec 2025 | Viewed by 285 | Submission Open

Keywords: immune response in cancer; molecular mechanisms of immunosuppression; cysteine proteases and their inhibitors

(This special issue belongs to the Section Molecular Biology)

Ion Channels in Cardiovascular and Metabolic Diseases

edited by

Shang-Zhong Xu

submission deadline 31 Dec 2025 | Viewed by 285 | Submission Open

Keywords: Na+ channel; Ca2+ channel; K+ channel; TRP channel; store-operated channel; Cl− channel; cation channel; ryanodine receptor; mechanosenstive channels; piezo channels; SGLT-1 transporters; membrane transporters

(This special issue belongs to the Section Biological Factors)

Mechanosensitivity and Ion Channels

edited by Olivia García-Suarez and Yolanda García-Mesa

submission deadline 31 Dec 2025 | Viewed by 276 | Submission Open

Keywords: mechanosensation; piezo ion channels; mechanosensitivity ion channels; mechanotrasduction

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Immunofluorescent Techniques in Animal Stem Cell Research

edited by

Jaromír Vašíček

and Andrea Svoradová

submission deadline 31 Dec 2025 | Viewed by 275 | Submission Open

Keywords: animal stem cells; fluorescence/confocal microscopy; flow cytometry; fluorescence-activated cell sorting; fluorescent protein assay; stem cell markers; cell therapy; drug screening; exosomes; DNA analysis

(This special issue belongs to the Section Molecular Biology)

Advances in Computational Biology of Intrinsically Disordered Proteins

edited by

Paul Harrison

submission deadline 31 Dec 2025 | Viewed by 215 | Submission Open

Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Mechanisms Underlying Liver Diseases: 2nd Edition

edited by

Wei Zhong

submission deadline 31 Dec 2025 | Viewed by 203 | Submission Open

Keywords: pathogenesis of liver diseases; molecular mechanisms; organelle damages; genetic determinants; organ– organ interactions; biomarkers; in vivo models of liver diseases; therapeutic insights

(This special issue belongs to the Section Cellular Biochemistry)

Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications

edited by

Sara Missaglia

and Eleonora Martegani

submission deadline 31 Dec 2025 | Viewed by 192 | Submission Open

Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits

(This special issue belongs to the Section Molecular Biology)

State-of-the-Art Perspectives on tRNA and tRNA Aminoacylation

edited by

Tamara Hendrickson

submission deadline 31 Dec 2025 | Viewed by 186 | Submission Open

Keywords: tRNA; tRNA Aminoacylation; translation; tRNA processing and modification

(This special issue belongs to the Section Molecular Genetics)

Molecular and Cellular Mechanisms of Aortic Aneurysms

edited by Maria Giovanna Scioli

submission deadline 31 Dec 2025 | Viewed by 183 | Submission Open

Keywords: aorthopaties; thoracic and abdominal aneurysms; pathogenetic mechanisms; aortic wall degeneration; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Biology)

State-of-the-Art Molecular Structure and Dynamics and Biophysics in Asia

edited by

Xuanyu Meng

and

Ruhong Zhou

submission deadline 31 Dec 2025 | Viewed by 151 | Submission Open

Keywords: molecular modeling; molecular dynamics simulation; protein– protein interaction; protein folding; bioinformatics; molecular docking; drug design; machine learning

(This special issue belongs to the Section Chemical Biology)

Sjogren’s Syndrome: Recent Updates and Perspectives

edited by

Carlo Perricone

submission deadline 31 Dec 2025 | Viewed by 138 | Submission Open

Keywords: Sjogren’ s syndrome; autoimmune inflammatory disease; genetics; biomarkers; Toll-like receptors; inflammasome chemokines

Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism

edited by

Katsuhiko Suzuki

and

Kayvan Khoramipour

submission deadline 31 Dec 2025 | Viewed by 129 | Submission Open

Keywords: biomolecular signaling in exercise adaptation; exercise and immune cell metabolism; inflammatory pathways and exercise; mitochondrial bioenergetics and exercise; exercise and adaptive immunity; neuroimmunometabolism and brain health; exercise and cancer immunometabolism; metabolic biomarkers of exercise-induced immunomodulation

(This special issue belongs to the Section Molecular Biology)

Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies

edited by Takashi Onodera and

Akikazu Sakudo

submission deadline 31 Dec 2025 | Viewed by 107 | Submission Open

Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)

Function and Regulation of Hyaluronan and Hyalectins in Disease

edited by

Edward N. Harris

and

Michele T. Pritchard

submission deadline 31 Dec 2025 | Viewed by 102 | Submission Open

Keywords: hyaluonan; glycosaminoglycan; hyalectan; cancer; extracellular matrix; cellular signaling

(This special issue belongs to the Section Chemical Biology)

Ion Channels in Neurological and Psychological Disorders

edited by

Xiang-Ping Chu

submission deadline 31 Dec 2025 | Viewed by 100 | Submission Open

Keywords: ion channels; neurological disorders; psychological disorder; brain; therapeutic target

(This special issue belongs to the Section Molecular Biology)

Lung Cancer: From Molecular Basis to Therapy

edited by

Paolo Borghetti

submission deadline 31 Dec 2025 | Viewed by 92 | Submission Open

Keywords: biomarkers; prognostic factors; predictive factors; genetic mutations and oncogenes; tumor suppressor genes; immune checkpoints and PD-L1; proteomic; genomic; radiomic

(This special issue belongs to the Section Molecular Biology)

Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress

edited by

Hakim Manghwar

submission deadline 31 Dec 2025 | Viewed by 87 | Submission Open

Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research

(This special issue belongs to the Section Molecular Biology)

p53 Family: The Molecular Landscape in Cancer and Beyond

edited by

Paola Tucci

and Michele Pellegrino

submission deadline 31 Dec 2025 | Viewed by 79 | Submission Open

Keywords: p53 family; microRNA; tumorigenesis; aging; neurodegenerative diseases; immune regulation; biomarkers; therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions

edited by Yurong Xie and Hongbin Wei

submission deadline 31 Dec 2025 | Viewed by 78 | Submission Open

Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding

(This special issue belongs to the Section Molecular Genetics)

Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon: 2nd Edition

edited by

Eun-Woo Lee

and Jiho Yoo

submission deadline 31 Dec 2025 | Viewed by 77 | Submission Open

Keywords: biomolecules; cancer; angiogenesis; autophagy; GPCRs; translational applications; target identification; proximity-labeling; molecular docking; molecular probe; molecular pharmacology

(This special issue belongs to the Section Cellular Biochemistry)

The Value of Natural Compounds as Therapeutic Agents: 3rd Edition

edited by

Maria Beatrice Morelli

submission deadline 31 Dec 2025 | Viewed by 75 | Submission Open

Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products: 2nd Edition

edited by

Juei-Tang Cheng

submission deadline 31 Dec 2025 | Viewed by 65 | Submission Open

Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health

Biomaterial Innovations for Tissue Engineering and Regeneration

edited by

Maria Chatzinikolaidou

submission deadline 31 Dec 2025 | Viewed by 64 | Submission Open

Keywords: biomaterials; tissue engineering; regenerative medicine; cellular responses; 3D pathophysiological tissue models

(This special issue belongs to the Section Bio-Engineered Materials)

Antituberculous Drugs: Progress and Challenges

edited by

Ana Cristina Faria Ribeiro

and Ana Maria Telmo Dias Pereira Vicente Cabral

submission deadline 31 Dec 2025 | Viewed by 63 | Submission Open

Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems

(This special issue belongs to the Section Chemical Biology)

Molecular Insights into Retinal Biology: Focus on Inflammation, Metabolism, and Retinal Dysfunction

edited by

, Qiuhua Yang,

and

submission deadline 31 Dec 2025 | Viewed by 63 | Submission Open

Keywords: inflammation; metabolism; neovascularization; retinal degeneration; photoreceptors; Muller glia; RPE

(This special issue belongs to the Section Molecular Medicine)

Proteogenomics in Cancer Research

edited by

Chen Huang

submission deadline 31 Dec 2025 | Viewed by 58 | Submission Open

Keywords: bioinformatics; cancer research; proteogenomics; drug resistance; functional genomics

The Role of DNA Methylation, Histone Modifications and MicroRNA in Cancer

edited by

Joanna Szczepanek

submission deadline 31 Dec 2025 | Viewed by 55 | Submission Open

Keywords: epigenetic regulation; DNA methylation; histone modifications; microRNA; cancer progression; therapeutic resistance; tumor suppressor genes; oncogenic reprogramming; personalized cancer therapy; epigenetic therapy

(This special issue belongs to the Section Molecular Genetics)

Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies

edited by

Anat Galor

and Pragnya Rao Donthineni

submission deadline 31 Dec 2025 | Viewed by 51 | Submission Open

Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis

(This special issue belongs to the Section Cellular Biochemistry)

Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals

edited by

Monika Pitucha

and

Marta Rusek

submission deadline 31 Dec 2025 | Viewed by 47 | Submission Open

Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry

(This special issue belongs to the Section Chemical Biology)

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