Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Biology of Neurodevelopment
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2990 | Submission Open
Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders
(This special issue belongs to the Section Molecular Biology)
Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2858 | Submission Open
Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials
(This special issue belongs to the Section Bio-Engineered Materials)
Barrier Formation and Homeostasis in the Vertebrate Brain submission deadline 31 Dec 2025 | 2 articles | Viewed by 2795 | Submission Open
Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia
(This special issue belongs to the Section Cellular Biochemistry)
Necrotic Cell Death Mechanisms and Therapies
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2754 | Submission Open
Keywords: necrosis; mitochondria; lysosomes; reactive oxygen species (ROS); calcium signalling; caspase-independent proteases: serine proteases like CELA; ELA; as well as cathepsin C and B etc.; heat shock proteins (HSPs); epigenetics; necrosis in diseases and therapeutic intervention; necroptosis; ferroptosis; paraptosis; pyroptosis
(This special issue belongs to the Section Cellular Biochemistry)
Non-Invasive Biomarkers in Saliva or Urine: Technical and Biological Variability
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2513 | Submission Open
Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
Signaling Pathways as Therapeutic Targets for Cancer
edited by Fabian Benencia
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2100 | Submission Open
Keywords: cancer signaling pathways; cancer metabolism; small molecules; anticancer antibodies; tumor models; combinatorial therapies
(This special issue belongs to the Section Molecular Biology)
Tumour Suppressor Genes: The Guardians of Cell Integrity
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1938 | Submission Open
Keywords: cell cycle; cell growth; cell integrity; cell proliferation; DNA damage; genome integrity; protein homeostasis; migration; invasion; metastasis; apoptosis; autophagy
(This special issue belongs to the Section Molecular Biology)
Novel Mechanisms of Bacterial Antibiotic Resistance submission deadline 31 Dec 2025 | 1 articles | Viewed by 1792 | Submission Open
Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches
(This special issue belongs to the Section Biological Factors)
Molecular Biomarkers in Cardiology 2025
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1745 | Submission Open
Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart
(This special issue belongs to the Section Molecular Biomarkers)
New Insights into Molecular Mechanisms and Therapeutics for Malaria
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1743 | Submission Open
Keywords: antimalarial resistance; drug discovery; malaria epidemiology; diagnostic tools; malaria pathophysiology
(This special issue belongs to the Section Molecular Medicine)
Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials
edited by and Rachael Dickman
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1577 | Submission Open
Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Calcium Signaling in Cell Function and Dysfunction
edited by and Sofia Zanin
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1388 | Submission Open
Keywords: calcium signaling; calcium regulation; cell function; human pathology
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications
edited by Yalin Qi
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1318 | Submission Open
Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection
(This special issue belongs to the Section Chemical Biology)
Molecular Basis of Pathogenesis in Autoimmune Diseases submission deadline 31 Dec 2025 | 1 articles | Viewed by 1172 | Submission Open
Keywords: autoimmune diseases; molecular pathogenesis; genetic determinants; signaling pathways; immunopathology; therapeutic targets; novel molecular targets
(This special issue belongs to the Section Molecular Medicine)
Vertebrate Comparative Genomics
edited by Ya-Xiong Tao and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 931 | Submission Open
Keywords: vertebrate; comparative genomics; physiology; biochemistry; pathophysiology; protein structure-function; gene
(This special issue belongs to the Section Molecular Genetics)
Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 661 | Submission Open
Keywords: proteins; peptides; amyloid; Alzheimer disease; Parkinson’ s disease; neurodrugs; G-quadruplex nucleic acids; biotechnology; biomolecular targets; peptide aggregation; natural products; synthetic drugs; anti-amyloid therapeutics; machine learning
(This special issue belongs to the Section Chemical Biology)
Functional Peptides and Their Interactions (3rd Edition) submission deadline 31 Dec 2025 | 1 articles | Viewed by 607 | Submission Open
Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Phytohormones 2024–2025
edited by Guzel Kudoyarova
submission deadline 31 Dec 2025 | Viewed by 578 | Submission Open
Keywords: plant hormones; auxins; cytokinins; gibberellins; abscisic acid; ethylene; salicylic acid; jasmonates
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Basis of Mast Cells Activation and Medical Implications submission deadline 31 Dec 2025 | Viewed by 423 | Submission Open
Keywords: mast cells; allergy; immediate hypersensitivity; molecular mechanisms
(This special issue belongs to the Section Biological Factors)
Molecular Basis and Oxidative Stress of Thyroid Diseases submission deadline 31 Dec 2025 | Viewed by 369 | Submission Open
Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease
(This special issue belongs to the Section Biological Factors)
The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication
edited by
submission deadline 31 Dec 2025 | Viewed by 290 | Submission Open
Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis
(This special issue belongs to the Section Cellular Biochemistry)
Harnessing the Immune System Against Solid Cancer: New Targets and Novel Therapeutic Approaches submission deadline 31 Dec 2025 | Viewed by 285 | Submission Open
Keywords: immune response in cancer; molecular mechanisms of immunosuppression; cysteine proteases and their inhibitors
(This special issue belongs to the Section Molecular Biology)
Ion Channels in Cardiovascular and Metabolic Diseases
edited by
submission deadline 31 Dec 2025 | Viewed by 285 | Submission Open
Keywords: Na+ channel; Ca2+ channel; K+ channel; TRP channel; store-operated channel; Cl− channel; cation channel; ryanodine receptor; mechanosenstive channels; piezo channels; SGLT-1 transporters; membrane transporters
(This special issue belongs to the Section Biological Factors)
Mechanosensitivity and Ion Channels
edited by Olivia García-Suarez and Yolanda García-Mesa
submission deadline 31 Dec 2025 | Viewed by 276 | Submission Open
Keywords: mechanosensation; piezo ion channels; mechanosensitivity ion channels; mechanotrasduction
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Immunofluorescent Techniques in Animal Stem Cell Research
edited by and Andrea Svoradová
submission deadline 31 Dec 2025 | Viewed by 275 | Submission Open
Keywords: animal stem cells; fluorescence/confocal microscopy; flow cytometry; fluorescence-activated cell sorting; fluorescent protein assay; stem cell markers; cell therapy; drug screening; exosomes; DNA analysis
(This special issue belongs to the Section Molecular Biology)
Advances in Computational Biology of Intrinsically Disordered Proteins
edited by
submission deadline 31 Dec 2025 | Viewed by 215 | Submission Open
Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Molecular Mechanisms Underlying Liver Diseases: 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 203 | Submission Open
Keywords: pathogenesis of liver diseases; molecular mechanisms; organelle damages; genetic determinants; organ– organ interactions; biomarkers; in vivo models of liver diseases; therapeutic insights
(This special issue belongs to the Section Cellular Biochemistry)
Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications
edited by and Eleonora Martegani
submission deadline 31 Dec 2025 | Viewed by 192 | Submission Open
Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits
(This special issue belongs to the Section Molecular Biology)
State-of-the-Art Perspectives on tRNA and tRNA Aminoacylation
edited by
submission deadline 31 Dec 2025 | Viewed by 186 | Submission Open
Keywords: tRNA; tRNA Aminoacylation; translation; tRNA processing and modification
(This special issue belongs to the Section Molecular Genetics)
Molecular and Cellular Mechanisms of Aortic Aneurysms
edited by Maria Giovanna Scioli
submission deadline 31 Dec 2025 | Viewed by 183 | Submission Open
Keywords: aorthopaties; thoracic and abdominal aneurysms; pathogenetic mechanisms; aortic wall degeneration; biomarkers; targeted therapies
(This special issue belongs to the Section Molecular Biology)
State-of-the-Art Molecular Structure and Dynamics and Biophysics in Asia
edited by and
submission deadline 31 Dec 2025 | Viewed by 151 | Submission Open
Keywords: molecular modeling; molecular dynamics simulation; protein– protein interaction; protein folding; bioinformatics; molecular docking; drug design; machine learning
(This special issue belongs to the Section Chemical Biology)
Sjogren’s Syndrome: Recent Updates and Perspectives
edited by
submission deadline 31 Dec 2025 | Viewed by 138 | Submission Open
Keywords: Sjogren’ s syndrome; autoimmune inflammatory disease; genetics; biomarkers; Toll-like receptors; inflammasome chemokines
Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism submission deadline 31 Dec 2025 | Viewed by 129 | Submission Open
Keywords: biomolecular signaling in exercise adaptation; exercise and immune cell metabolism; inflammatory pathways and exercise; mitochondrial bioenergetics and exercise; exercise and adaptive immunity; neuroimmunometabolism and brain health; exercise and cancer immunometabolism; metabolic biomarkers of exercise-induced immunomodulation
(This special issue belongs to the Section Molecular Biology)
Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies
edited by Takashi Onodera and
submission deadline 31 Dec 2025 | Viewed by 107 | Submission Open
Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)
Function and Regulation of Hyaluronan and Hyalectins in Disease submission deadline 31 Dec 2025 | Viewed by 102 | Submission Open
Keywords: hyaluonan; glycosaminoglycan; hyalectan; cancer; extracellular matrix; cellular signaling
(This special issue belongs to the Section Chemical Biology)
Ion Channels in Neurological and Psychological Disorders
edited by
submission deadline 31 Dec 2025 | Viewed by 100 | Submission Open
Keywords: ion channels; neurological disorders; psychological disorder; brain; therapeutic target
(This special issue belongs to the Section Molecular Biology)
Lung Cancer: From Molecular Basis to Therapy
edited by
submission deadline 31 Dec 2025 | Viewed by 91 | Submission Open
Keywords: biomarkers; prognostic factors; predictive factors; genetic mutations and oncogenes; tumor suppressor genes; immune checkpoints and PD-L1; proteomic; genomic; radiomic
(This special issue belongs to the Section Molecular Biology)
Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress
edited by
submission deadline 31 Dec 2025 | Viewed by 87 | Submission Open
Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research
(This special issue belongs to the Section Molecular Biology)
p53 Family: The Molecular Landscape in Cancer and Beyond
edited by and Michele Pellegrino
submission deadline 31 Dec 2025 | Viewed by 79 | Submission Open
Keywords: p53 family; microRNA; tumorigenesis; aging; neurodegenerative diseases; immune regulation; biomarkers; therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions
edited by Yurong Xie and Hongbin Wei
submission deadline 31 Dec 2025 | Viewed by 78 | Submission Open
Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding
(This special issue belongs to the Section Molecular Genetics)
Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon: 2nd Edition
edited by and Jiho Yoo
submission deadline 31 Dec 2025 | Viewed by 77 | Submission Open
Keywords: biomolecules; cancer; angiogenesis; autophagy; GPCRs; translational applications; target identification; proximity-labeling; molecular docking; molecular probe; molecular pharmacology
(This special issue belongs to the Section Cellular Biochemistry)
The Value of Natural Compounds as Therapeutic Agents: 3rd Edition submission deadline 31 Dec 2025 | Viewed by 75 | Submission Open
Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products: 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 65 | Submission Open
Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health
Biomaterial Innovations for Tissue Engineering and Regeneration submission deadline 31 Dec 2025 | Viewed by 63 | Submission Open
Keywords: biomaterials; tissue engineering; regenerative medicine; cellular responses; 3D pathophysiological tissue models
(This special issue belongs to the Section Bio-Engineered Materials)
Antituberculous Drugs: Progress and Challenges
edited by and Ana Maria Telmo Dias Pereira Vicente Cabral
submission deadline 31 Dec 2025 | Viewed by 63 | Submission Open
Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems
(This special issue belongs to the Section Chemical Biology)
Molecular Insights into Retinal Biology: Focus on Inflammation, Metabolism, and Retinal Dysfunction
edited by , Qiuhua Yang, , and
submission deadline 31 Dec 2025 | Viewed by 61 | Submission Open
Keywords: inflammation; metabolism; neovascularization; retinal degeneration; photoreceptors; Muller glia; RPE
(This special issue belongs to the Section Molecular Medicine)
Proteogenomics in Cancer Research
edited by
submission deadline 31 Dec 2025 | Viewed by 58 | Submission Open
Keywords: bioinformatics; cancer research; proteogenomics; drug resistance; functional genomics
The Role of DNA Methylation, Histone Modifications and MicroRNA in Cancer
edited by
submission deadline 31 Dec 2025 | Viewed by 55 | Submission Open
Keywords: epigenetic regulation; DNA methylation; histone modifications; microRNA; cancer progression; therapeutic resistance; tumor suppressor genes; oncogenic reprogramming; personalized cancer therapy; epigenetic therapy
(This special issue belongs to the Section Molecular Genetics)
Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies
edited by and Pragnya Rao Donthineni
submission deadline 31 Dec 2025 | Viewed by 51 | Submission Open
Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis
(This special issue belongs to the Section Cellular Biochemistry)
Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals
edited by and
submission deadline 31 Dec 2025 | Viewed by 47 | Submission Open
Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry
(This special issue belongs to the Section Chemical Biology)
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