Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathogenesis, Diagnosis, and Treatment of Diabetic Kidney Disease
edited by
submission deadline 31 Dec 2026 | Viewed by 305 | Submission Open
Keywords: diabetic kidney disease; pathogenesis; novel biomarkers; metabolic memory; SGLT2 inhibitors; fibrotic pathways; epigenetic modification; multi-target pharmacotherapy
AI-Driven Approaches to Neurodegeneration: From Disease Models to Therapeutic Strategies
edited by , Jianfu Li and Naeyma N. Islam
submission deadline 31 Dec 2026 | Viewed by 299 | Submission Open
Keywords: artificial intelligence (AI); neurodegeneration; disease modeling; therapeutic discovery; machine learning in biomedicine
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Experimental Validation and Computationally Driven Design of Protein–Protein Interaction Modulators
edited by
submission deadline 31 Dec 2026 | Viewed by 298 | Submission Open
Keywords: protein– protein interactions; peptide modulators; computational drug design; biophysical and cellular assays; molecular docking; molecular dynamics; AI in drug discovery; medicinal chemistry
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Biomolecules in Mycobacterial Pathogenesis, Host–Pathogen Interactions, and Antimicrobial and Therapeutic Approaches
edited by Cinzia Marianelli
submission deadline 31 Dec 2026 | Viewed by 298 | Submission Open
Keywords: mycobacterium; pathogenesis; host– pathogen interaction; antimicrobial action; therapeutic alternatives
(This special issue belongs to the Section Molecular Biology)
Cellular Regulation of Inflammatory Diseases
edited by
submission deadline 31 Dec 2026 | Viewed by 274 | Submission Open
Keywords: inflammatory diseases; inflammation; neutrophils; monocytes/macrophages; T cells; B cells; NK cells; dendritic cells
(This special issue belongs to the Section Cellular Biochemistry)
Multidrug-Resistant Microorganisms: Overcoming the Challenges in Antibiotic Treatment
edited by Eleni E. Mylona and
submission deadline 31 Dec 2026 | Viewed by 260 | Submission Open
Keywords: multidrug-resistant; antibiotic treatment; MDR pathogens; therapeutic strategies
Mechanisms of Chronic Diseases and Intervention Strategies: The Role of Bioactive Compounds in Foods and Herbal Extracts
edited by and Xiang Li
submission deadline 31 Dec 2026 | Viewed by 256 | Submission Open
Keywords: chronic diseases; multi-target intervention; bioactive compounds; medicine-food homology; herbal extracts; omics technologies; multi-target modulation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Human ABC Transporters in Drug Disposition and Resistance: 50 Years of Progress and Future Perspectives
edited by
submission deadline 31 Dec 2026 | Viewed by 254 | Submission Open
Keywords: ABC transporters; drug disposition; drug resistance; pharmacokinetics; pharmacodynamics; pharmacogenetics; single nucleotide polymorphisms (SNPs)
(This special issue belongs to the Section Chemical Biology)
Advances in Cardiometabolic Health, 2nd Edition
edited by Pamela Senesi and
submission deadline 31 Dec 2026 | Viewed by 241 | Submission Open
Keywords: obesity; cardiovascular diseases; biomarkers; lifestyle interventions; personalized medicine
(This special issue belongs to the Section Cellular Biochemistry)
Forces Driving Macromolecular Recognition: Role in Drug Design and Discovery
edited by David P. Remeta and
submission deadline 31 Dec 2026 | Viewed by 214 | Submission Open
Keywords: macromolecular recognition; drug design and discovery; biomolecular structure and dynamics; computational modeling; ligand– receptor binding energetics; drug-target interactions; thermodynamic forces; protein-ligand binding; drug discovery and optimization; protein-nucleic acid interactions; intrinsically disordered proteins; protein aggregation and disease
(This special issue belongs to the Section Chemical Biology)
Molecular and Cellular Mechanisms of Biomaterial–Tissue Interactions
edited by , Xin Xiong, Korzinskas Tadas and
submission deadline 31 Dec 2026 | Viewed by 196 | Submission Open
Keywords: biomaterials; cell– material interface; mechanotransduction; integrin signaling; protein corona; immune response; macrophage polarization; foreign body reaction; degradation; bioactive coatings; tissue regeneration; fibrosis; angiogenesis; multi-omics; quantitative histology
(This special issue belongs to the Section Bio-Engineered Materials)
Epigenetic Regulation of Metabolism and Inflammation in Health and Disease
edited by and Adhimoolam Karthikeyan
submission deadline 31 Dec 2026 | Viewed by 178 | Submission Open
Keywords: epigenetics; metabolism; inflammation; epigenetic biomarkers; metabolic disorders
(This special issue belongs to the Section Molecular Medicine)
Molecular Genetics and Molecular Diagnosis in Precision Oncology
edited by Andrea Ferreira-Gonzalez
submission deadline 31 Dec 2026 | Viewed by 176 | Submission Open
Keywords: cancer; genetics; molecular therapy; immunotherapy; molecular genetics; molecular diagnostics; NGS; liquid biopsy
(This special issue belongs to the Section Molecular Genetics)
Bone Tissue Morphology: From Pathophysiological Mechanisms to Regenerative Strategies
edited by
submission deadline 31 Dec 2026 | Viewed by 172 | Submission Open
Keywords: osteoporosis; bone cancer; fracture repair; regenerative biomaterials; bone remodeling; molecular mechanisms; biomechanical mechanisms; bone imaging techniques
(This special issue belongs to the Section Molecular Medicine)
Harnessing DNA Amplification for Biosensing: From Molecular Mechanisms to Diagnostic Platforms
edited by Mariarosaria De Falco and
submission deadline 31 Dec 2026 | Viewed by 158 | Submission Open
Keywords: infectious diseases; isothermal DNA/RNA amplification; molecular biology– based diagnostic technologies; point-of-care (POC) diagnostics; rapid pathogen detection
(This special issue belongs to the Section Molecular Biology)
The Role of Non-Coding RNAs in Female and Male Reproduction: Molecular Mechanisms and Clinical Implications
edited by , Rosalia Battaglia and
submission deadline 31 Dec 2026 | Viewed by 152 | Submission Open
Keywords: female and male fertility; non-coding RNA; epigenetic fertility regulation; epigenetic biomarkers; reproductive dysfunctions
(This special issue belongs to the Section Molecular Genetics)
Molecular Genetics of Psychiatric Disorders submission deadline 31 Dec 2026 | Viewed by 151 | Submission Open
Keywords: molecular psychiatry; functional genomics; candidate gene studies; genome-wide association studies (GWAS); epigenetics
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms of Cell Reprogramming and Differentiation
edited by and Stefano Ciaurelli
submission deadline 31 Dec 2026 | Viewed by 141 | Submission Open
Keywords: stem cell differentiating stage factors; cell reprogramming; cell differentiation; stem cells; epigenetic regulation; cellular plasticity
(This special issue belongs to the Section Cellular Biochemistry)
New Insights into the Molecular Genetics of Neurodevelopmental Disorders: 2nd Edition
edited by and Flavio Faletra
submission deadline 31 Dec 2026 | Viewed by 137 | Submission Open
Keywords: neurodevelopmental disorders; NGS analysis and reanalysis; pathomechanisms; phenotypic spectra; phenotype– genotype correlation
(This special issue belongs to the Section Molecular Genetics)
The Future of Protein Research: New Paradigms and Transformative Technologies
edited by
submission deadline 31 Dec 2026 | Viewed by 137 | Submission Open
Keywords: protein science; proteomics; cryo-electron microscopy; AI-driven approaches; interactomes; drug discovery; synthetic biology; protein structure and function; protein engineering; biophysics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Bridging Molecular Biology and Machine Learning to Understand Brain Network Function and Plasticity
edited by
submission deadline 31 Dec 2026 | Viewed by 135 | Submission Open
Keywords: brain network plasticity; molecular neuroscience; machine learning in neuroscience; multimodal data integration; translational neuroscience
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Advanced Biomaterials for Targeted Drug Delivery and Microbiome Modulation
edited by
submission deadline 31 Dec 2026 | Viewed by 128 | Submission Open
Keywords: biomaterials; immunomodulation; microbiome; drug delivery; precision medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Molecular Genomics for Plant Stress Resilience and Improvement
edited by and Moxian Chen
submission deadline 31 Dec 2026 | Viewed by 121 | Submission Open
Keywords: plant stress resilience; molecular genomics; abiotic stress; transcriptomics; proteomics; epigenetics; gene regulation; crop improvement; climate-smart agriculture
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms of Nano-Rare Diseases, Interventions and Lessons Learned from ASO Treatments
edited by Stanley T. Crooke
submission deadline 31 Dec 2026 | Viewed by 120 | Submission Open
Keywords: nano-rare mutations; antisense oligonucleotides (ASOs); individualized medicine; FDA guidance; patient community
(This special issue belongs to the Section Molecular Medicine)
Biomolecular Basis in Mycobacterium Tuberculosis (Mtb) Infection: Disease Development and Control
edited by
submission deadline 31 Dec 2026 | Viewed by 117 | Submission Open
Keywords: Mycobacterium tuberculosis; biomolecules; host immunity; vaccine development; drug resistance; biomarkers; vaccine; diagnosis; therapeutic
(This special issue belongs to the Section Molecular Medicine)
Circadian Signaling in Regulation of Immune Response: New Insights into the Interaction of the Clock with Inflammatory Signaling
edited by and Tobias Eckle
submission deadline 31 Dec 2026 | Viewed by 113 | Submission Open
Keywords: circadian rhythms; BMAL1; CLOCK; PER; and CRY; zeitgebers; suprachiasmatic nucleus; inflammation signaling; NLRP3 inflammasome; reactive oxygen species; immune responses; sleep apnea; chronotherapy; dark light cycle; circadian synchronization; chronobiology
(This special issue belongs to the Section Cellular Biochemistry)
Feature Papers in “Bio-Engineered Materials” Section
edited by
submission deadline 31 Dec 2026 | Viewed by 97 | Submission Open
Keywords: bio-engineered materials; functional biomaterials; biofabrication; hydrogels; biointerfaces; tissue engineering; regenerative medicine; polymers; polysaccharides; proteins
(This special issue belongs to the Section Bio-Engineered Materials)
Kinases Signaling in Cancer 2026
edited by
submission deadline 31 Dec 2026 | Viewed by 85 | Submission Open
Keywords: kinases signaling; cancer; signaling pathways
(This special issue belongs to the Section Cellular Biochemistry)
Research Progress in Pediatric Oncology
edited by Emmanouel Hatzipantelis and
submission deadline 31 Dec 2026 | Viewed by 75 | Submission Open
Keywords: pediatric oncology; childhood cancer; targeted therapy; immunotherapy; precision medicine; supportive care; infection; survivorship; global health
(This special issue belongs to the Section Molecular Medicine)
Amyloid-Beta and Alzheimer’s Disease, 2nd Edition
edited by
submission deadline 31 Dec 2026 | Viewed by 24 | Submission Open
Keywords: Alzheimer's disease (AD)  ; amyloid-beta (Aβ )  ; neurotoxicity of Aβ   ; Aβ phagocytosis  ; Aβ clearance  ; neuroinflammation in AD  ; glial cells in AD  ; tau protein  ; anti-Aβ monoclonal antibodies; CAR-A therapy
(This special issue belongs to the Section Cellular Biochemistry)
Inflammasome and Inflammasome Inhibitors
edited by
submission deadline 8 Jan 2027 | Viewed by 145 | Submission Open
Keywords: inflammasomes; pyroptosis; innate immunity; inflammasome modulators; inhibitors; inflammatory diseases; drug discovery; translational research
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Signaling Networks and Novel Biomarkers for Precision Cancer Medicine
edited by
submission deadline 8 Jan 2027 | Viewed by 60 | Submission Open
Keywords: biomarkers; cancer signaling networks; ctDNA; ctRNA; extracellular vesicles; liquid biopsy; multi-omics; precision oncology; proteomics; TME; therapy resistance
(This special issue belongs to the Section Molecular Medicine)
Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair and Regeneration
edited by and
submission deadline 10 Jan 2027 | 2 articles | Viewed by 2473 | Submission Open
Keywords: MSC; vesicles; exosomes; tissue repair and regeneration
Discovery of Therapeutic Target Genes in Oral and Craniofacial Cancers: From Molecular Signatures to Precision Dentistry
edited by
submission deadline 15 Jan 2027 | Viewed by 168 | Submission Open
Keywords: oral squamous cell carcinoma; head and neck cancer; therapeutic targets; target genes; biomarkers; saliva diagnostics; oral potentially malignant disorders; epigenetics; transcriptomics; single-cell; microbiome; precision dentistry
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms of the Epidermal Microenvironment in Pigmentation Disorders
edited by
submission deadline 15 Jan 2027 | Viewed by 119 | Submission Open
Keywords: epidermal microenvironment; melanocyte homeostasis; intercellular signaling networks; epidermal cell– cell crosstalk; pigmentation disorders
(This special issue belongs to the Section Molecular Medicine)
Albumin in Health and Disease: Physiological Roles, Pathogenic Mechanisms, and Biomedical Applications
edited by
submission deadline 15 Jan 2027 | Viewed by 104 | Submission Open
Keywords: albumin; antioxidant; biomarker; drug delivery system; biomaterials
(This special issue belongs to the Section Molecular Medicine)
Amino Acids and Their Metabolism in Disease
edited by
submission deadline 20 Jan 2027 | 2 articles | Viewed by 1750 | Submission Open
Keywords: amino acid metabolism; disease pathophysiology; cancer metabolism; immunometabolism; metabolic reprogramming; amino acid transporters; therapeutic targeting; biomarkers; nutrient sensing; systems biology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Role of Oxidative Stress in Vascular Diseases submission deadline 20 Jan 2027 | 1 articles | Viewed by 820 | Submission Open
Keywords: oxidative stress; vascular disease; endothelial dysfunction; NADPH oxidase/NOX2; platelet activation; autophagy; gut microbiota; inflammation; reactive oxygen species (ROS); cardiovascular risk
Role of Oxidative Stress and Redox Signaling in Inner Ear Dysfunction submission deadline 20 Jan 2027 | Viewed by 247 | Submission Open
Keywords: inner ear; cochlea; stria vascularis; auditory pathways; ion channels; ion transporters; molecular targets; oxidative stress; antioxidants; hearing loss; vestibular dysfunction; tinnitus
(This special issue belongs to the Section Molecular Biology)
Protein Structure–Function and Proteomics in Health and Environment
edited by and Tharusha Jayasena
submission deadline 20 Jan 2027 | Viewed by 166 | Submission Open
Keywords: proteins; proteomics; mass spectrometry; enzymes; health and disease; environment; bioinformatics; computational; evolution; artificial intelligence; ai
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Polyamine Metabolism and Targets: Glial Cell Function in Neural Health, Aging, and Disease
edited by , Rüdiger W. Veh and Christian J. Malpica-Nieves
submission deadline 20 Jan 2027 | Viewed by 151 | Submission Open
Keywords: neuroglia; polyamines; neurophysiology; ion channels; gap junctions; transporters; neurogliovascular ensembles; gliotransmission; diseases; syndromes
The Role of Amyloid in Neurological Disorders: 2nd Edition
edited by and Tamara Berno
submission deadline 25 Jan 2027 | 1 articles | Viewed by 1018 | Submission Open
Keywords: amyloid-beta; neurodegenerative disorders; aducanumab; oligomers; cross-amyloid interaction
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Cellular and Molecular Mechanisms Underlying Neuromuscular System Disorders
edited by Laura Cristina Ceafalan and
submission deadline 29 Jan 2027 | Viewed by 80 | Submission Open
Keywords: neuromuscular disorders; skeletal muscle; motor neurons; neuromuscular junction; neurodegeneration; muscle atrophy; sarcopenia; cachexia; α -synuclein; mitochondrial dysfunction; oxidative stress; inflammation; proteostasis; ubiquitin– proteasome system; autophagy; mitophagy; calcium homeostasis; epigenetics; myokines; extracellular vesicles; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms of Brain Injury and Repair in the Developing Neonate
edited by and Robin K. Ohls
submission deadline 30 Jan 2027 | Viewed by 103 | Submission Open
Keywords: neonatal brain injury; microglial polarization; neuroinflammation; hypoxic-ischemic encephalopathy (HIE); translational research
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms and Pathophysiology of Gliomas
edited by Fengchao Lang
submission deadline 31 Jan 2027 | 1 articles | Viewed by 4609 | Submission Open
Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies
(This special issue belongs to the Section Molecular Biology)
Ovarian Cancer and Breast Cancer: Molecular Mechanisms, and Therapeutic Targets submission deadline 31 Jan 2027 | 2 articles | Viewed by 3862 | Submission Open
Keywords: breast neoplasms; ovarian neoplasms; cancers; molecular subtyping; genomic instability; tumour heterogeneity; precision medicine; targeted therapy; PARP inhibitors; immunotherapy; chemotherapy resistance; triple negative breast neoplasms; HER2-positive breast cancer; high-grade serous ovarian cancer; low-grade serous ovarian cancer; rare cancer subtypes; next-generation sequencing
Redox Dysregulation and Mitochondrial Adaptation in Kidney Disease
edited by
submission deadline 31 Jan 2027 | 2 articles | Viewed by 1506 | Submission Open
Keywords: acute kidney injury; chronic kidney disease; diabetic nephropathy; diabetic kidney disease; redox imbalance; reductive stress; reactive oxygen species; oxidative stress; mitochondrial stress response and adaptation; mitochondrial abnormalities; mitochondrial homeostasis; mitophagy; unfolded protein response
Pain and Therapy: Molecular Perspectives and Future Directions submission deadline 31 Jan 2027 | Viewed by 363 | Submission Open
Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment
(This special issue belongs to the Section Molecular Biology)
Melatonin Functions and Stress Adaptation in Plants
edited by
submission deadline 31 Jan 2027 | Viewed by 201 | Submission Open
Keywords: melatonin biosynthesis; melatonin metabolites; biotic stresses; abiotic stresses; plant growth and development
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Immunometabolism and Signaling Networks in Autoimmune Rheumatic Diseases
edited by Ryu Watanabe and
submission deadline 31 Jan 2027 | Viewed by 187 | Submission Open
Keywords: immunometabolism; intracellular signaling pathways; T-cell and B-cell metabolism; metabolic– signaling crosstalk; innate immune cell signaling
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