Advances in Pharmacognosy and Phytochemistry: From Molecular to Pre-Clinical Insights

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-derived Molecules".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2305

Special Issue Editors


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Guest Editor
1. Faculty of Sciences, Arab American University, Jenin P.O. Box 240, Palestine
2. Al-Qasemi Research Center, Al-Qasemi Academic College, Baqa-El-Gharbia P.O. Box 124, Israel
Interests: drug resistance; novel compounds and drug discovery; secondary metabolites; advanced extraction and fractionation strategies; phytochemical screening and composition; computer-aided drug design; non-communicable diseases
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Guest Editor
Food Science, Agricultural Research Organization, Volcani Institute, Negev 8531100, Israel
Interests: foodomics; metabolomics; volatilomics; functional food; health-related phytochemistry
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Guest Editor
Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India
Interests: insulin resistance; metabolic syndrome; diabetic complications; immunometabolism
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Special Issue Information

Dear Colleagues,

We are delighted to announce a Special Issue on recent advances in pharmacognosy and phytochemistry contributing towards bridging the gap between molecular and pre-clinical research. With natural products providing a vast array of bioactive substances, new technologies can enable the investigation of natural products while providing required insight into the mechanisms of action of these agents and determining their therapeutic and safety profiles.

This Special Issue requests original research and review articles on topics including, but not limited to, the following:

  • Bioactive natural products: Isolation, structural elucidation, and biosynthetic pathways;
  • Phytochemical innovations: Metabolomics, analytical techniques, and novel extraction methods;
  • Pharmacological evaluations: In vitro and in vivo studies of natural compounds;
  • Molecular mechanisms of action: Target identification and signaling pathways;
  • Pre-clinical advancements: Toxicological assessments and formulation studies.

We request contributions from innovative natural product science researchers. Manuscripts should present novel insights that contribute to this field’s development.

Prof. Dr. Hilal Zaid
Dr. Zipora Tietel
Dr. Akhilesh K. Tamrakar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • drug discovery
  • phytopharmacology
  • medicinal plants

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Published Papers (1 paper)

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Research

31 pages, 18432 KB  
Article
Elderberry-Based Multifunctional Prebiotic Systems Prepared via Spray Drying
by Anna Gościniak, Lidia Tajber, Piotr Szulc, Andrzej Miklaszewski, Tomasz M. Karpiński and Judyta Cielecka-Piontek
Biomolecules 2025, 15(9), 1289; https://doi.org/10.3390/biom15091289 - 7 Sep 2025
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Abstract
Elderberry (Sambucus nigra L.) is recognized as a rich source of anthocyanins and other bioactives with antioxidant and antidiabetic potential, and is increasingly explored as a functional ingredient in nutraceuticals. However, cultivar-dependent variability can strongly influence chemical composition and bioactivity, underscoring the [...] Read more.
Elderberry (Sambucus nigra L.) is recognized as a rich source of anthocyanins and other bioactives with antioxidant and antidiabetic potential, and is increasingly explored as a functional ingredient in nutraceuticals. However, cultivar-dependent variability can strongly influence chemical composition and bioactivity, underscoring the need for careful selection of plant material prior to formulation. In the present study, twelve genotypes of elderberry were compared in terms of total polyphenols, antioxidant activity, and antiglycation potential. Based on the overall profile, ‘Samyl 1’ was advanced to formulation trials. Spray-dried carrier systems were produced using galactooligosaccharides (GOS) or chitooligosaccharides (COS), with or without colloidal silica. GOS-based powders retained anthocyanins at levels approaching theoretical values and exhibited superior thermal stability, as evidenced by differential scanning calorimetry, thermogravimetric analysis, and degradation-kinetic modeling, whereas COS matrices provided less effective stabilization. Incorporation of silica significantly enhanced technological properties, improving recovery, reducing agglomeration, and increasing flowability, without compromising anthocyanin content. All powders displayed low moisture (2.5–7.1%), favorable morphology, and preserved functional activity, aligning with stability requirements for shelf-stable plant extracts. Overall, the study demonstrates that strategic cultivar selection combined with GOS–silica carrier systems enables the production of stable elderberry powders that maintain high anthocyanin content and bioactivity. Such multifunctional ingredients couple prebiotic functionality with efficient delivery of polyphenols, highlighting their potential in nutraceutical and pharmaceutical formulations. Full article
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