Studies of Protein Dynamics, Interactions, and Concentration by Fluorescence Fluctuation Correlation Spectroscopy (FFCS)
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 28 February 2026 | Viewed by 1
Special Issue Editors
Interests: chromatin organization; light microscopy; biochemistry and cell biology; medical biochemistry and metabolomics; fluorescence microscopy; cell biology; protein dynamics; membrane protein signaling and trafficking
Special Issues, Collections and Topics in MDPI journals
Interests: fluorescence fluctuation correlation spectroscopy; membrane biophysics; mechanobiology; super-resolution microscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Biomolecules will publish a Special Issue, entitled “Studies of Protein Dynamics, Interactions, and Concentration by Fluorescence Fluctuation Correlation Spectroscopy (FFCS)”, highlighting the power and versatility of FFCS techniques in terms of exploring molecular dynamics in live cells and complex biological environments. This Issue aims to showcase advances in both the methodology and application of FFCS, including but not limited to fluorescence correlation spectroscopy (FCS), image correlation spectroscopy (ICS), pair correlation function analysis, line-scan confocal fluctuation analysis, and related extensions.
We welcome contributions that explore the development of new imaging protocols, experimental designs, and analysis tools, as well as those applying FFCS-based approaches to reveal critical insights into biomolecular behavior in living systems.
Topics of interest:
- The evaluation of commercial and custom-built microscope systems for FFCS and related techniques.
- The development of novel acquisition strategies, analysis software, and plugins for FFCS-based methods.
- The applications of FFCS techniques to study protein diffusion, flow, confinement, kinetics, interactions, and concentration heterogeneity in biological systems.
This Special Issue is intended to serve both the biophysics and cell biology communities, and we invite scholars to contribute high-quality, relevant submissions. Please contact the Guest Editors if you have any questions regarding scope or suitability.
We are pleased to announce that the following leading experts in the field will be contributing to this Special Issue:
Prof. Wiseman—"Measurement of membrane proteins transport and confinement by lipidic and protein complexes using k-space Image Correlation Spectroscopy";
Prof. Clayton—"Polarized phase-sensitive fluorescence image correlation microscopy";
Prof. Wohland—"ImFCS study of membrane-associated Myosin Light Chain in focal adhesion formation";
Prof. Maiti—"TBC";
A. Prof. Lanzanò—"TBC";
A. Prof. Hinde—"Using Fluorescence Correlation Spectroscopy to Study Protein Dynamics from the Plasma Membrane to the Nucleus".
Dr. Jieqiong Lou
Dr. Elvis Pandžić
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- fluorescence fluctuation correlation spectroscopy (FFCS)
- fluorescence correlation spectroscopy (FCS)
- image correlation spectroscopy (ICS)
- pair correlation function (pCF) analysis
- line-scan correlation
- protein dynamics
- molecular diffusion
- molecular flow
- confinement dynamics
- protein–protein interactions
- membrane organization
- intracellular transport
- molecular crowding
- spatiotemporal fluctuations
- concentration heterogeneity
- live-cell imaging
- single-molecule analysis
- quantitative fluorescence microscopy
- biophysics
- super-resolution fluctuation analysis
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