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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Molecular Research on Protein Structure and Function

edited by

Sonani Ravi Raghav

submission deadline 15 Dec 2026 | 3 articles | Viewed by 3350 | Submission Open

Keywords: protein structure; protein function; molecular mechanisms; protein folding; structural biology

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapeutic Innovations in Musculoskeletal Disorders

edited by Fackson Mwale and Michael P. Grant

submission deadline 15 Dec 2026 | 1 articles | Viewed by 343 | Submission Open

Keywords: musculoskeletal; disorders; therapeutics; inflammation; degeneration

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Regulation of Kidney Disease

edited by

Syed J. Khundmiri

submission deadline 15 Dec 2026 | Viewed by 139 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; inflammation; renal repair and regeneration; gene expression; epigenetic mechanisms; systems biology; mathematical modeling

(This special issue belongs to the Section Biological Factors)

Neuromodulation of Hippocampal Circuits in Health and Disease

edited by Costas Papatheodoropoulos

submission deadline 15 Dec 2026 | Viewed by 136 | Submission Open

Keywords: neuromodulation; hippocampus; dopamine; serotonin; acetylcholine; norepinephrine; endocannabinoids; adenosine; oxytocin; opioids; brain rhythms; synaptic transmission; synaptic plasticity; behavior; neuropsychiatric disorders; neurological diseases

(This special issue belongs to the Section Biological Factors)

Adenosine and Its Receptors: Emerging Targets in Neurodegenerative Diseases

edited by

Soo-Ho Choi

submission deadline 15 Dec 2026 | Viewed by 135 | Submission Open

Keywords: adenosine; adenosine receptors; neuroinflammation; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

Innovative Approaches and New Directions in Drug Design and Chemical Biology

edited by Arshad Ansari and Avinash Gothwal

submission deadline 15 Dec 2026 | Viewed by 120 | Submission Open

Keywords: drug design; chemical biology; medicinal chemistry; protein– ligand interactions; chemical probes; target validation; computational drug discovery; drug discovery; structure-based design; novel therapeutics

(This special issue belongs to the Section Chemical Biology)

Ion Homeostasis and Metal Biology in Diseases

edited by

Yuting Wu

and Zhenglin Yang

submission deadline 17 Dec 2026 | Viewed by 90 | Submission Open

Keywords: metal ion homeostasis; metal biology; metalloproteins; metal-protein interactions; ion signaling and redox regulation; multi-metal crosstalk; bioinorganic mechanisms in metal biology; metal-targeted therapeutics; metal sensing methods; metals as medicines

(This special issue belongs to the Section Biological Factors)

Melanin Biosynthesis and Degradation: Molecular Mechanisms and Pathophysiological Roles

edited by Kazumasa Wakamatsu

submission deadline 18 Dec 2026 | Viewed by 77 | Submission Open

Keywords: melanogenesis; tyrosinase-related proteins (TRPs); melanosomal turnover; autophagy-mediated degradation; pigmentary homeostasis; molecular signalling pathways; pathophysiological dysregulation

(This special issue belongs to the Section Chemical Biology)

Inflammation and Immunity in Lung Disease

edited by

Xuexian Yang

submission deadline 20 Dec 2026 | 3 articles | Viewed by 2923 | Submission Open

Keywords: lung; infection; inflammation; host defense; cytokine release syndrome; genetic deficiency

(This special issue belongs to the Section Cellular Biochemistry)

Impact of Lifestyle Changes on Biomolecular Profiles Across the Lifespan

edited by

Sergio Maroto-Izquierdo

and

Kayvan Khoramipour

submission deadline 30 Dec 2026 | 1 articles | Viewed by 952 | Submission Open

Keywords: lifestyle; microRNAs; disease

(This special issue belongs to the Section Chemical Biology)

Linking Excess Adiposity to Cancer: Molecular and Cellular Perspectives

edited by Marion Korach-André and Amena Archer

submission deadline 30 Dec 2026 | Viewed by 173 | Submission Open

Keywords: obesity; cancer; tumor microenvironment; adipose tissue; liver; inflammation; microbiota; metabolic reprogramming; novel therapeutic; omics

(This special issue belongs to the Section Cellular Biochemistry)

Lung Diseases: From Molecular Mechanisms to Therapeutics

edited by

Satoshi Kawakami

submission deadline 30 Dec 2026 | Viewed by 138 | Submission Open

Keywords: interstitial pneumonia; COPD; lung diseases; lung cancer; therapeutic targets; lifestyle factors; immunology; epigenetics; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Feature Papers in the Natural and Bio-Derived Molecules Section

edited by

Hang Fai (Henry) Kwok

submission deadline 31 Dec 2026 | 12 articles | Viewed by 83030 | Submission Open

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Insights from the Editorial Board Members

edited by

Peter E. Nielsen

submission deadline 31 Dec 2026 | 13 articles | Viewed by 42732 | Submission Open

Keywords: structure and function; bioactive and biogenic substances; molecular mechanisms; biomaterials

Cell Biology and Biomedical Application of Galectins

edited by

Alexander Timoshenko

submission deadline 31 Dec 2026 | 6 articles | Viewed by 20472 | Submission Open

Keywords: galectins; cell differentiation; stem cells; apoptosis; autophagy; cell adhesion; glycobiology; post-translational modifications; transmembrane signaling; protein trafficking; cancer; heart diseases; fibrosis; inflammation; targeted therapeutics; galectin inhibitors

(This special issue belongs to the Section Chemical Biology)

Antitumor Agents from Natural Sources 2026

edited by

Hang Fai (Henry) Kwok

submission deadline 31 Dec 2026 | 4 articles | Viewed by 16242 | Submission Open

Keywords: antitumor agents; natural sources; cancer prevention and therapy

(This special issue belongs to the Section Natural and Bio-derived Molecules)

State of the Art and Perspectives in Retinal Pigment Epithelium

edited by

Paola Secchiero

and

Elisabetta Melloni

submission deadline 31 Dec 2026 | 4 articles | Viewed by 14809 | Submission Open

Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy

(This special issue belongs to the Section Cellular Biochemistry)

Matrix Metalloproteinases: Mechanisms, Functions and Therapeutic Potential

edited by

Alireza Shoari

and Muhammad Faheem

submission deadline 31 Dec 2026 | 2 articles | Viewed by 12162 | Submission Open

Keywords: matrix metalloproteinases; endopeptidases; MMP inhibitor; tissue homeostasis; disease progression

(This special issue belongs to the Section Enzymology)

Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials

edited by

Mire Zloh

and

Rachael Dickman

submission deadline 31 Dec 2026 | 5 articles | Viewed by 11665 | Submission Open

Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Biomarkers in Cardiology 2026

edited by

Pietro Scicchitano

submission deadline 31 Dec 2026 | 4 articles | Viewed by 11044 | Submission Open

Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Advances in Rett Syndrome and Other Chromatin Related Disorders

edited by

Floriana Della Ragione

and Salvatore Fioriniello

submission deadline 31 Dec 2026 | 3 articles | Viewed by 8195 | Submission Open

Keywords: Rett syndrome and other chromatin disorders; epigenetic diseases; molecular alterations in Rett syndrome and other chromatin diseases; novel genes associated with chromatin disorders; MeCP2-mediated molecular mechanisms; roles of epigenetic modulators in chromatin-related diseases; preclinical studies for chromatin diseases; novel diagnostic; prognostic and therapeutic approaches for chromatin disorders

(This special issue belongs to the Section Molecular Medicine)

Advances in Galectins

edited by Anu Paul and Diyoly Ayona

submission deadline 31 Dec 2026 | 3 articles | Viewed by 7665 | Submission Open

Keywords: galectins; carbohydrate-binding proteins; galectin– microbe

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Unraveling the Complexity of Autoimmune and Autoinflammatory Skin Diseases: From Molecular Pathways to Targeted Therapies

edited by

Chiara Moltrasio

Angelo Valerio Marzano

and

Sergio Crovella

submission deadline 31 Dec 2026 | 1 articles | Viewed by 6613 | Submission Open

Keywords: autoimmune/autoinflammatory skin diseases; omics; bioinformatics; pathogenesis; tailored medicine

(This special issue belongs to the Section Molecular Genetics)

Industrial Microorganisms and Enzyme Technologies

edited by

Yunjun Yan

submission deadline 31 Dec 2026 | 4 articles | Viewed by 6053 | Submission Open

Keywords: enzyme engineering; enzyme kinetics and optimization; industrial biotechnology; industrial microbiology; microbial metabolism

(This special issue belongs to the Section Enzymology)

Pluripotent Stem Cells: From Basic Research to Therapeutic Applications

edited by

Claudia Spits

and

Diana Al Delbany

submission deadline 31 Dec 2026 | 2 articles | Viewed by 5782 | Submission Open

Keywords: pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells; organoids; differentiation; regenerative medicine; disease modeling; cell therapy; therapeutic applications

(This special issue belongs to the Section Molecular Biology)

Advances in Pharmacognosy and Phytochemistry: From Molecular to Pre-Clinical Insights

edited by

Hilal Zaid

Zipora Tietel

and

Akhilesh K. Tamrakar

submission deadline 31 Dec 2026 | 2 articles | Viewed by 5374 | Submission Open

Keywords: metabolomics; drug discovery; phytopharmacology; medicinal plants

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Basis of Pathogenesis in Autoimmune Diseases

edited by

I-Tsu Chyuan

and

Chi-Jung Huang

submission deadline 31 Dec 2026 | 1 articles | Viewed by 4771 | Submission Open

Keywords: autoimmune diseases; molecular pathogenesis; genetic determinants; signaling pathways; immunopathology; therapeutic targets; novel molecular targets

(This special issue belongs to the Section Molecular Medicine)

Feature Papers in "Molecular Biology" Section 2026

edited by

Claudia Tanja Mierke

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3908 | Submission Open

Keywords: mechanobiology; cellular processes including metabolism; proliferation and motility; molecular motors and forces; molecular and biophysical techniques; organelle and membrane transport; exo- and endosomal trafficking; cell and biophysical signal transduction; the biomolecular synthesis of proteins; protein folding and post-translational modification of proteins and macromolecular assemblies

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications

edited by Yalin Qi

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3762 | Submission Open

Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection

(This special issue belongs to the Section Chemical Biology)

Epigenetic Regulation of Cell Differentiation During Development and Disease: From Vascular Plasticity to Immune Signaling

edited by

Melina M. Musri

and

Victor I. Peinado

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3723 | Submission Open

Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation

(This special issue belongs to the Section Molecular Biology)

Advances in Membrane Proteins: From Structure to Function and Molecular Engineering

edited by

Ximin Chi

and Renhong Yan

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3500 | Submission Open

Keywords: membrane transport; transmembrane signaling; membrane protein complex; membrane-based reactions; membrane and protein interaction; regulation of membrane proteins; membrane protein design; membrane protein engineering

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

DNA Damage Repair and Cancer Therapeutics

edited by

Wenjing Li

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3432 | Submission Open

Keywords: DNA damage repair; cancer therapy; genomic stability; targeted therapy; biomarkers

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Studies of Protein Dynamics, Interactions, and Concentration by Fluorescence Fluctuation Correlation Spectroscopy (FFCS)

edited by Jieqiong Lou and Elvis Pandžić

submission deadline 31 Dec 2026 | 4 articles | Viewed by 3323 | Submission Open

Keywords: fluorescence fluctuation correlation spectroscopy (FFCS); fluorescence correlation spectroscopy (FCS); image correlation spectroscopy (ICS); pair correlation function (pCF) analysis; line-scan correlation; protein dynamics; molecular diffusion; molecular flow; confinement dynamics; protein– protein interactions; membrane organization; intracellular transport; molecular crowding; spatiotemporal fluctuations; concentration heterogeneity; live-cell imaging; single-molecule analysis; quantitative fluorescence microscopy; biophysics; super-resolution fluctuation analysis

Metal-Based Complexes in Medicine: From Therapeutics to Diagnostics and Theranostics

edited by

Iogann Tolbatov

and

Andrea Melchior

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3040 | Submission Open

Keywords: anticancer metal complexes; antitumor metallodrugs; antimicrobial agents; antiviral metallodrugs; medicinal inorganic chemistry; bioinorganic chemistry; computational design; molecular dynamics; docking; spectroscopic methods; NMR; mechanistic studies; rational drug development; synthesis; biological evaluation; drug delivery; experimental; in vitro; in vivo; theranostics; medicinal imaging

Vertebrate Comparative Genomics

edited by Ya-Xiong Tao and

Shan He

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2981 | Submission Open

Keywords: vertebrate; comparative genomics; physiology; biochemistry; pathophysiology; protein structure-function; gene

(This special issue belongs to the Section Molecular Genetics)

Biomolecular Sciences and Precision Medicine in Vascular Disease

edited by

Raffaele Serra

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2262 | Submission Open

Keywords: precision medicine; vascular disease; vascular surgery

(This special issue belongs to the Section Molecular Medicine)

Light as a Tool to Manipulate the Structure and Function of Membranes and Membrane Proteins

edited by

Peter Pohl

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2134 | Submission Open

Keywords: photopharmacology; optogenetics; membrane transport; light-gated channels; photoswitchable lipids

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular, Cellular, and Blood Biomarkers in Diagnosis, Prognosis, Monitoring, and Treatment: 2nd Edition

edited by

Jordi Camps

Isabel Fort Gallifa

and Xavier Gabaldó Barrios

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2020 | Submission Open

Keywords: biomarkers; infectious diseases; laboratory medicine; non-communicable diseases

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Basis of Parasite Infection

edited by

Adekunle Sanyaolu

and

Ricardo Izurieta

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1638 | Submission Open

Keywords: parasite infection; host– parasite interaction; cellular invasion; molecular mechanisms; immune evasion

(This special issue belongs to the Section Molecular Medicine)

Current and Future Molecular Insights into Hematological Diseases: From Diagnosis to Therapy

edited by Miguel Piris-Villaespesa,

Javier Leon

and

Fernando Martín-Moro

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1591 | Submission Open

Keywords: hematological diseases; diagnostic assessment; molecular biology; targeted therapies; lymphoid neoplasm; myeloid neoplasm

(This special issue belongs to the Section Molecular Medicine)

Phytohormones 2026

edited by Guzel Kudoyarova

submission deadline 31 Dec 2026 | Viewed by 1286 | Submission Open

Keywords: plant hormones; auxins; cytokinins; gibberellins; abscisic acid; ethylene; salicylic acid; jasmonates

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Mechanisms, Pathogenesis, and Treatment of Cardiovascular Diseases

edited by

Mahavir Singh

and

Zsuzsa Bagoly

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1214 | Submission Open

Keywords: cardiovascular diseases; molecular pathogenesis; genomics and metabolomics; AI/ML diagnostics; precision medicine; translational research

(This special issue belongs to the Section Molecular Medicine)

Lung Cancer: From Molecular Basis to Therapy

edited by

Paolo Borghetti

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1099 | Submission Open

Keywords: biomarkers; prognostic factors; predictive factors; genetic mutations and oncogenes; tumor suppressor genes; immune checkpoints and PD-L1; proteomic; genomic; radiomic

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Stress Response, Growth, Development, and Breeding of Horticultural Crops

edited by

Bo Sun

Xin Li

and Jian Lyu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1076 | Submission Open

Keywords: horticultural crops; multi-omics integration; genome editing; molecular plant breeding; abiotic and biotic stress; quality; metabolic pathways; plant hormones; transcriptional and epigenetic regulation; protein interaction networks

(This special issue belongs to the Section Biological Factors)

Sjogren’s Syndrome: Recent Updates and Perspectives

edited by

Carlo Perricone

submission deadline 31 Dec 2026 | Viewed by 585 | Submission Open

Keywords: Sjogren’ s syndrome; autoimmune inflammatory disease; genetics; biomarkers; Toll-like receptors; inflammasome chemokines

Skin Diseases: Molecular Pathogenesis and Therapeutic Approaches

edited by Georgios Gaitanis,

Ioannis D. Bassukas

and Achilleas Floudas

submission deadline 31 Dec 2026 | 1 articles | Viewed by 511 | Submission Open

Keywords: skin; pathophysiology; immunology; biochemistry; omics

(This special issue belongs to the Section Molecular Medicine)

Molecular Docking and Dynamics in Drug Discovery

edited by

Črtomir Podlipnik

submission deadline 31 Dec 2026 | Viewed by 468 | Submission Open

Keywords: molecular docking; molecular dynamics (MD); structure-based drug design (SBDD); computational drug discovery; open science

(This special issue belongs to the Section Chemical Biology)

Molecular Insights into Quantum Biology

edited by Daniel R. Kattnig

submission deadline 31 Dec 2026 | Viewed by 382 | Submission Open

Keywords: quantum biology; molecular mechanisms; quantum coherence; quantum entanglement; magnetoreception; quantum cognition; photosynthetic energy transfer; biological qubits; quantum sensing; environment-assisted quantum effects

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Microbiome–Gut–Brain Axis in Neurodevelopmental Disorders

edited by Katerina Karaivazoglou and