Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Targeting Protein Misfolding: From Alzheimer's Amyloids to Therapeutic Peptides submission deadline 16 Feb 2026 | Viewed by 9 | Submission Open
Keywords: amyloidogenesis; amyloidosis; amyloid fibrils; dissolution of amyloid fibrils; beta-sheet breakers; peptide inhibitors; small molecule inhibitors
Evolutionary Genomics of Bacterial Endosymbionts: From Mutualism to Parasitism
edited by
submission deadline 20 Feb 2026 | Viewed by 11 | Submission Open
Keywords: host– symbiont coevolution; metabolic pathways; horizontal DNA transfer; phylogenetics
Molecular Mechanisms of Traumatic Brain Injury
edited by Xiang Gao
submission deadline 22 Feb 2026 | Viewed by 52 | Submission Open
Keywords: traumatic brain injury; cell death; neural degeneration/regeneration; genetic modification; neuroprotection
Role of Oxidative Stress in Vascular Diseases submission deadline 26 Feb 2026 | Viewed by 26 | Submission Open
Keywords: oxidative stress; vascular disease; endothelial dysfunction; NADPH oxidase/NOX2; platelet activation; autophagy; gut microbiota; inflammation; reactive oxygen species (ROS); cardiovascular risk
Molecular Advances in Wound Healing and Skin Regeneration
edited by and Muhammad Shafiq
submission deadline 28 Feb 2026 | 2 articles | Viewed by 9458 | Submission Open
Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair
(This special issue belongs to the Section Biological Factors)
Innovative Biomolecular Structure Analysis Techniques
edited by Tzanko I. Doukov
submission deadline 28 Feb 2026 | 4 articles | Viewed by 4374 | Submission Open
Keywords: macromolecular crystallography; room temperature crystallography; protein ensembles; NMR; MD simulations
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Novel Molecules for Cancer Treatment (3rd Edition) submission deadline 28 Feb 2026 | 3 articles | Viewed by 2777 | Submission Open
Keywords: cancer; small molecules; antibody-drug-conjugated; tyrosine kinase inhibitors; target therapy; monoclonal antibodies; immunotherapy; natural compounds
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Biomarkers and Molecular Basis of Psychiatry
edited by
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1579 | Submission Open
Keywords: mental health; bipolar disorders; mood; anxiety; psychosis; schizophrenia; biomarkers
(This special issue belongs to the Section Biological Factors)
Molecular and Cellular Mechanisms in Anti-Thrombosis submission deadline 28 Feb 2026 | 2 articles | Viewed by 1570 | Submission Open
Keywords: platelet activation and thrombosis; neuroprotection; antithrombotic mechanisms
(This special issue belongs to the Section Molecular Medicine)
Unveiling Protein Functions, Dynamics and Interactions in Health and Disease Using Experimental and Theoretical Approaches, 2nd Edition
edited by Alice Romagnoli, and
submission deadline 28 Feb 2026 | Viewed by 79 | Submission Open
Keywords: protein structure and dynamics; protein– protein interactions; point mutations; molecular biology; molecular modeling; molecular dynamics; biochemistry; bioinformatics; protein– ligand interaction; protein– nucleic acid interaction; protein conformational changes
(This special issue belongs to the Section Chemical Biology)
Polyphosphate (PolyP) in Health and Disease
edited by
submission deadline 28 Feb 2026 | Viewed by 28 | Submission Open
Keywords: polyphosphate; polyP; biomarker and therapeutic target
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Novel Insights and Applications of Pluripotent Stem Cells
edited by and Ben Rollo
submission deadline 28 Feb 2026 | Viewed by 18 | Submission Open
Keywords: pluripotent stem cells; pluripotency; differentiation; stem cell transplant; regenerative medicine; disease modeling; organoids; therapeutic screening; cell therapies; drug discovery
(This special issue belongs to the Section Cellular Biochemistry)
Advances in Drosophila Models for Amyloid and Neurodegenerative Diseases
edited by Ann Christin Brorsson
submission deadline 28 Feb 2026 | Viewed by 15 | Submission Open
Keywords: neurodegeneration; protein aggregation; amyloid structures; neurotoxicity; Drosophila melanogaster; model organism
Advances in the Pathology of Prostate Cancer: 2nd Edition
edited by
submission deadline 28 Feb 2026 | Viewed by 10 | Submission Open
Keywords: prostate cancer; molecular pathology; biomarker; chemoprevention; therapy
(This special issue belongs to the Section Chemical Biology)
Exploring Thermophilic Enzymes: From Structural Foundations to Functional Enhancement
edited by
submission deadline 28 Feb 2026 | Viewed by 1 | Submission Open
Keywords: thermostable enzymes; structural biology; protein engineering; functional enhancement; industrial applications; thermal stability mechanisms; biotechnology
(This special issue belongs to the Section Enzymology)
Studies of Protein Dynamics, Interactions, and Concentration by Fluorescence Fluctuation Correlation Spectroscopy (FFCS)
edited by Jieqiong Lou and Elvis Pandžić
submission deadline 28 Feb 2026 | Submission Open
Keywords: fluorescence fluctuation correlation spectroscopy (FFCS); fluorescence correlation spectroscopy (FCS); image correlation spectroscopy (ICS); pair correlation function (pCF) analysis; line-scan correlation; protein dynamics; molecular diffusion; molecular flow; confinement dynamics; protein– protein interactions; membrane organization; intracellular transport; molecular crowding; spatiotemporal fluctuations; concentration heterogeneity; live-cell imaging; single-molecule analysis; quantitative fluorescence microscopy; biophysics; super-resolution fluctuation analysis
Novel Antimicrobial Strategies for Animal Health submission deadline 31 Mar 2026 | 2 articles | Viewed by 3377 | Submission Open
Keywords: antimicrobial alternatives; antimicrobial resistance; animal health; infectious disease
(This special issue belongs to the Section Molecular Medicine)
Light as a Tool to Manipulate the Structure and Function of Membranes and Membrane Proteins
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 678 | Submission Open
Keywords: photopharmacology; optogenetics; membrane transport; light-gated channels; photoswitchable lipids
(This special issue belongs to the Section Chemical Biology)
Fibrinogen and Fibrin in Human Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 167 | Submission Open
Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis
(This special issue belongs to the Section Molecular Biology)
Protein Arginine Methylation: Functions, Mechanisms, and Therapeutic Implications
edited by Yanzhong Yang
submission deadline 31 Mar 2026 | Viewed by 74 | Submission Open
Keywords: protein arginine methyltransferases; transcription; RNA splicing; signaling transduction; DNA repair; cancer; development; small molecule inhibitor
(This special issue belongs to the Section Molecular Genetics)
Advanced Therapeutic Strategies for Hormone-Dependent Cancers submission deadline 31 Mar 2026 | Viewed by 49 | Submission Open
Keywords: hormone-dependent cancers; endocrine therapy resistance; targeted therapy; combination treatment strategies; cancer biomarkers
Unraveling the Complexity of Autoimmune and Autoinflammatory Skin Diseases: From Molecular Pathways to Targeted Therapies submission deadline 31 Mar 2026 | Viewed by 39 | Submission Open
Keywords: autoimmune/autoinflammatory skin diseases; omics; bioinformatics; pathogenesis; tailored medicine
(This special issue belongs to the Section Molecular Genetics)
Molecular Chaperones in Neurodegenerative Diseases: Mechanistic Role and Therapeutic Potential
edited by Umesh Kumar Jinwal
submission deadline 31 Mar 2026 | Viewed by 37 | Submission Open
Keywords: molecular chaperones; neurodegenerative diseases; Hsp90; Hsp70; Alzheimer's Disease; Parkinson’ s Disease; Huntington's disease; amyotrophic lateral sclerosis
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Nutritional Immunity and Inflammation: Decoding Mechanisms for Therapeutic Advancement submission deadline 31 Mar 2026 | Viewed by 18 | Submission Open
Keywords: nutritional deficiencies; antioxidants; minerals; vitamins; mucosal block; cross feeding; microbes; inflammation; tolerance
Advances in Glycosaminoglycans (GAGs) and Mimetics submission deadline 31 Mar 2026 | Viewed by 12 | Submission Open
Keywords: glycosaminoglycans (GAGs); hyaluronan; heparin; chondroitin sulfate; keratan sulfate; dermatan sulfate; sulfation; GAG mimetics; GAG-binding proteins
(This special issue belongs to the Section Chemical Biology)
Advances in Antimicrobial Peptides (AMPs)
edited by
submission deadline 30 Apr 2026 | Viewed by 1 | Submission Open
Keywords: antimicrobial peptides (AMPs); host defense peptides (HDPs); peptidomimetics; antimicrobial resistance (AMR); membrane interaction; cryptides; immunomodulation; peptide design and synthesis; biofilm inhibition; drug delivery systems
Bench and Bedside: Molecular Insights and Neuroprotective Strategies for Stroke
edited by
submission deadline 31 May 2026 | Viewed by 255 | Submission Open
Keywords: neuroprotection; neurorehabilitation; conditioning medicine; ischemia and reperfusion injury; cerebral hemor-rhages; stress; vascular diseases
(This special issue belongs to the Section Molecular Medicine)
Molecular Basis and Translational Research in Metabolic Myopathies: A Themed Issue in Honor of Professor Corrado Angelini, 2nd Edition submission deadline 31 May 2026 | Viewed by 71 | Submission Open
Keywords: metabolic myopathies; lipid metabolism; glycogen metabolism; genetic diseases; treatments; lipid storage myopathies; glycogen storage myopathies; lysosomal storage myopathies
(This special issue belongs to the Section Molecular Biology)
Molecular Pathways Controlling Platelet and Megakaryocyte Activity
edited by Ana Kasirer-Friede
submission deadline 31 May 2026 | Viewed by 57 | Submission Open
Keywords: platelet; megakaryocyte; signaling; omics; immune
(This special issue belongs to the Section Molecular Biology)
Protein Biophysics submission deadline 31 May 2026 | Viewed by 3 | Submission Open
Keywords: protein function; protein folding; protein misfolding; protein structure; protein dynamics; protein stability; protein and peptide aggregation; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Advances in Membrane Proteins: From Structure to Function and Molecular Engineering
edited by and Renhong Yan
submission deadline 31 May 2026 | Viewed by 2 | Submission Open
Keywords: membrane transport; transmembrane signaling; membrane protein complex; membrane-based reactions; membrane and protein interaction; regulation of membrane proteins; membrane protein design; membrane protein engineering
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Advances in Pharmacognosy and Phytochemistry: From Molecular to Pre-Clinical Insights submission deadline 30 Jun 2026 | Viewed by 924 | Submission Open
Keywords: metabolomics; drug discovery; phytopharmacology; medicinal plants
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Pathology, Diagnostics, and Therapeutics of Lung Disease
edited by
submission deadline 30 Jun 2026 | Viewed by 56 | Submission Open
Keywords: pulmonary diseases; diagnostics; therapeutics
(This special issue belongs to the Section Molecular Medicine)
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