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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics

edited by

Tong-You Wei

submission deadline 28 Feb 2026 | Viewed by 134 | Submission Open

Keywords: cardiovascular diseases; NF-κ B signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics

(This special issue belongs to the Section Cellular Biochemistry)

Unveiling Protein Functions, Dynamics and Interactions in Health and Disease Using Experimental and Theoretical Approaches, 2nd Edition

edited by Alice Romagnoli,

Stefano Motta

and

Jesmina Rexha

submission deadline 28 Feb 2026 | Viewed by 107 | Submission Open

Keywords: protein structure and dynamics; protein– protein interactions; point mutations; molecular biology; molecular modeling; molecular dynamics; biochemistry; bioinformatics; protein– ligand interaction; protein– nucleic acid interaction; protein conformational changes

(This special issue belongs to the Section Chemical Biology)

Functional Analysis of Genes Related to DNA Damage

edited by Ryan P. Barnes and Amy M. Whitaker

submission deadline 28 Feb 2026 | Viewed by 82 | Submission Open

Keywords: DNA damage; DNA repair; genome stability; DNA replication stress

(This special issue belongs to the Section Molecular Biology)

Novel Insights and Applications of Pluripotent Stem Cells

edited by

Huseyin Sumer

and Ben Rollo

submission deadline 28 Feb 2026 | Viewed by 66 | Submission Open

Keywords: pluripotent stem cells; pluripotency; differentiation; stem cell transplant; regenerative medicine; disease modeling; organoids; therapeutic screening; cell therapies; drug discovery

(This special issue belongs to the Section Cellular Biochemistry)

Exploring Thermophilic Enzymes: From Structural Foundations to Functional Enhancement

edited by

Renjun Gao

submission deadline 28 Feb 2026 | Viewed by 52 | Submission Open

Keywords: thermostable enzymes; structural biology; protein engineering; functional enhancement; industrial applications; thermal stability mechanisms; biotechnology

(This special issue belongs to the Section Enzymology)

Molecular Mechanisms and Drug Research in Alzheimer’s Disease

edited by

Xudong Huang

submission deadline 28 Feb 2026 | Viewed by 45 | Submission Open

Keywords: Alzheimer's disease; molecular mechanisms; drug discovery; Aβ amyloid; tau protein; neuroinflammation; oxidative stress; metal homeostasis; blood– brain barrier; dysbiosis

(This special issue belongs to the Section Molecular Medicine)

Advances in the Pathology of Prostate Cancer: 2nd Edition

edited by

Piwen Wang

submission deadline 28 Feb 2026 | Viewed by 40 | Submission Open

Keywords: prostate cancer; molecular pathology; biomarker; chemoprevention; therapy

(This special issue belongs to the Section Chemical Biology)

Studies of Protein Dynamics, Interactions, and Concentration by Fluorescence Fluctuation Correlation Spectroscopy (FFCS)

edited by Jieqiong Lou and Elvis Pandžić

submission deadline 28 Feb 2026 | Viewed by 40 | Submission Open

Keywords: fluorescence fluctuation correlation spectroscopy (FFCS); fluorescence correlation spectroscopy (FCS); image correlation spectroscopy (ICS); pair correlation function (pCF) analysis; line-scan correlation; protein dynamics; molecular diffusion; molecular flow; confinement dynamics; protein– protein interactions; membrane organization; intracellular transport; molecular crowding; spatiotemporal fluctuations; concentration heterogeneity; live-cell imaging; single-molecule analysis; quantitative fluorescence microscopy; biophysics; super-resolution fluctuation analysis

VDAC1 as a Hub Protein–Modulation of VDAC1-Mediated Prograde Cell Death, Metabolism, Inflammation and Immunity via Interacting Proteins, Metabolites and Small Molecules

edited by Jay H. Chung and

Vito De Pinto

submission deadline 28 Feb 2026 | Viewed by 39 | Submission Open

Keywords: apoptosis; binding sites; ferroptosis; inflammation; metabolism; mitochondria; oxidative strass; pyroptosis; small molecules; VDAC

(This special issue belongs to the Section Cellular Biochemistry)

Molecular and Cellular Mechanisms of Aortic Diseases

edited by Maria Giovanna Scioli

submission deadline 28 Feb 2026 | Viewed by 37 | Submission Open

Keywords: aortic aneurysms; acute aortic syndromes; aortic dissection; intramural haematoma; penetrating atherosclerotic ulcer; traumatic aortic injury; pseudoaneurysm; aortic rupture; atherosclerotic; inflammatory affections; Marfan syndrome; congenital abnormalities; aortic diseases

(This special issue belongs to the Section Molecular Biology)

Zebrafish: A Gateway to Understanding Human Disease

edited by

Gregory Kelly

and

Marc Ekker

submission deadline 28 Feb 2026 | Viewed by 36 | Submission Open

Keywords: zebrafish development; genetic pathways in zebrafish and humans; a better understanding of human disease conditions related to zebrafish

Exploring the Pathophysiology of Epilepsy: Metabolic Mechanisms and Therapeutic Potential

edited by

Halina Baran

and Christoph Baumgartner

submission deadline 28 Feb 2026 | Viewed by 35 | Submission Open

Keywords: epilepsy; metabolic regulation; signaling pathways; kynurenic acid; seizure detection; antiseizure drugs; innovative therapies

(This special issue belongs to the Section Molecular Medicine)

Modern Studies of Nucleic Acid Dynamics

edited by

Gary A. Meints

submission deadline 28 Feb 2026 | Viewed by 33 | Submission Open

Keywords: nucleic acid dynamics; DNA; RNA; nucleic acid energetics; dynamics of biomolecular recognition; timescales and magnitudes of dynamics

Membrane Clusters in Health and Neurodegenerative Disease

edited by Tayuan Chang and Catherine C. Y. Chang

submission deadline 28 Feb 2026 | Viewed by 31 | Submission Open

Keywords: membrane cluster; membrane lipids; membrane proteins; caveolin; lipid rafts; phospholipid; cholesterol; sphingolipids; cholesteryl esters

Advances in Drosophila Models for Amyloid and Neurodegenerative Diseases

edited by Ann Christin Brorsson

submission deadline 28 Feb 2026 | Viewed by 30 | Submission Open

Keywords: neurodegeneration; protein aggregation; amyloid structures; neurotoxicity; Drosophila melanogaster; model organism

Molecular Genetics of Parasitic Protozoa

edited by

Paştiu Anamaria Ioana

submission deadline 28 Feb 2026 | Viewed by 30 | Submission Open

Keywords: molecular genetics; parasitic protozoa; zoonosis; One Health

(This special issue belongs to the Section Molecular Genetics)

The Planarian Model in Pharmacology, Toxicology, and Neuroscience

edited by Oné R. Pagán

submission deadline 28 Feb 2026 | Viewed by 29 | Submission Open

Keywords: planarians; pharmacology; toxicology; neuroscience; neurotransmission; regeneration

(This special issue belongs to the Section Molecular Biology)

Biomarkers and Therapeutic Approaches in Melanoma: New Omics-Strategies

edited by

Italia Falcone

Fabio Valenti

and

Stefano Giuliani

submission deadline 28 Feb 2026 | Viewed by 28 | Submission Open

Keywords: melanoma; biomarkers; omics; precision oncology; drug resistance

(This special issue belongs to the Section Molecular Biomarkers)

Targeted Protein Degradation and Beyond: Integrated Biological, Chemical and Computational Approaches to Proximity-Based Modulation

edited by

Gabriele La Monica

and

Antonino Lauria

submission deadline 28 Feb 2026 | Viewed by 26 | Submission Open

Keywords: PROTACs; protein degradation; drug discovery; chemical biology; ternary complex; undruggable targets

Photosynthetic Adaptation and Photoprotection in Plants

edited by

Roland Valcke

submission deadline 28 Feb 2026 | Viewed by 16 | Submission Open

Keywords: pigment– protein complexes; excess energy; quenching; photoprotection; electron transport; reactive oxygen species

(This special issue belongs to the Section Natural and Bio-derived Molecules)

The N-Methyl-D-Aspartate (NMDA) Receptor: From Pathophysiology to Clinical Significance

edited by

Motohiro Okada

submission deadline 28 Feb 2026 | Submission Open

Keywords: L-glutamate; D-serine; ionotropic glutamate receptors; psychiatric disorders; neurodegeneration; synaptic plasticity; epilepsy; pathophysiology; signaling

Alcohol-Related Nervous System Damage and Disease: From Mechanisms to Therapies

edited by

Suzanne M. De La Monte

submission deadline 14 Mar 2026 | Viewed by 30 | Submission Open

Keywords: alcohol; brain; neurodegeneration; diagnostics; treatment; disease mechanisms; prevention; pathology; imaging; molecular and cellular studies; co-factor effects

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Bronchiolitis Obliterans

edited by Ralf Schubert and Silvija-Pera Jerkic

submission deadline 15 Mar 2026 | Submission Open

Keywords: bronchiolitis obliterans (BO); inflammation; fibrosis; molecular mechanisms

(This special issue belongs to the Section Molecular Medicine)

Molecular Effects of Environmental Pollutants on Health of Human, Animals and Plants, 2nd Edition

edited by

Marina Piscopo

submission deadline 20 Mar 2026 | Viewed by 567 | Submission Open

Keywords: health damage; reproductive health; environmental pollution; epigenetics; human; animals and plants

(This special issue belongs to the Section Natural and Bio-derived Molecules)

DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways

edited by

Renata Krupa

submission deadline 20 Mar 2026 | Viewed by 140 | Submission Open

Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy

(This special issue belongs to the Section Molecular Biology)

Future Innovation and Challenges in Bioactive Compounds from Plant Foods: Towards Sustainable Health

edited by

Giacomo Fais

and

Giorgia Sarais

submission deadline 20 Mar 2026 | Submission Open

Keywords: bioactive compounds; plant-based foods; functional phytochemicals; sustainable nutrition; nutraceuticals; eco-friendly extraction; agro-industrial byproducts; microalgae and cyanobacteria; food waste valorization; innovative food systems

The Kynurenine Pathway in Mood Disorders: From Mechanisms to Therapeutics

edited by Gregory F. Oxenkrug

submission deadline 27 Mar 2026 | Viewed by 15 | Submission Open

Keywords: kynurenine; tryptophan; mood disorders; stress; inflammation

(This special issue belongs to the Section Biological Factors)

Advances in Lysosomal Disorders: From Molecular Mechanisms to Diagnosis

edited by

Gianandrea Pasquinelli

and Irene Capelli

submission deadline 29 Mar 2026 | Viewed by 7 | Submission Open

Keywords: Fabry disease; lysosomal disorders; globotriaosylceramide (GB3); inherited disease; GLA-gene; nephropathy; hypertrophic cardiomyopathy; small fiber neuropathy

(This special issue belongs to the Section Molecular Medicine)

Research Progress on Anti-Aging with Natural Products

edited by

Sang-Han Lee

submission deadline 29 Mar 2026 | Viewed by 6 | Submission Open

Keywords: natural products; anti-aging signaling; autophagy; antioxidants; skin aging; bioactive compounds; molecular mechanisms; translational applications

(This special issue belongs to the Section Biological Factors)

Biogenic Amines, Their Receptors and Transporters in Health and Disease: Commemorative Issue in Honor of Professor Marc G. Caron (1946–2022)

edited by

Raul Gainetdinov

Bruno Giros

, Jean Martin Beaulieu and Stephen S.G. Ferguson

submission deadline 31 Mar 2026 | 16 articles | Viewed by 52069 | Submission Open

Keywords: dopamine; serotonin; norepinephrine; epinephrine; histamine; trace amines; beta-phenylethylamine; GPCR; TAAR

(This special issue belongs to the Section Biological Factors)

Novel Antimicrobial Strategies for Animal Health

edited by

Anna Aris

and

Elena Garcia-Fruitos

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4625 | Submission Open

Keywords: antimicrobial alternatives; antimicrobial resistance; animal health; infectious disease

(This special issue belongs to the Section Molecular Medicine)

Metabolic Pathways, COVID-19 and Other Viral Acute Respiratory Infections: Mechanisms and Clinical Implications: 2nd Edition

edited by

Simona Iftimie

and

Jordi Camps

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3147 | Submission Open

Keywords: COVID-19; respiratory syncytial virus; influenza; SARS-CoV-2; viral acute respiratory infections; metabolic pathways; herpes virus

(This special issue belongs to the Section Molecular Medicine)

Molecular Advances in Drug Resistance and Novel Therapies for Cancer

edited by

Agnieszka Wolnicka-Glubisz

and

Konrad Kleszczyński

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3117 | Submission Open

Keywords: cell signalling; cancer treatment; cancer metastasis; target validation; cancer and new molecules; cancer and cellular organelles

(This special issue belongs to the Section Biological Factors)

New Discoveries in the Field of Neuropharmacology

edited by

Beatrice Mihaela Radu

and Bogdan Amuzescu

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2136 | Submission Open

Keywords: neurologic and psychiatric diseases pharmacology; in silico drug screening; in vitro pharmacology assays; animal models; neuropharmacogenomics; drug safety; blood brain barrier; electrophysiology; patch-clamp

(This special issue belongs to the Section Molecular Medicine)

State of the Art and Perspectives in Retinal Pigment Epithelium

edited by

Paola Secchiero

and

Elisabetta Melloni

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1522 | Submission Open

Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy

(This special issue belongs to the Section Cellular Biochemistry)

Light as a Tool to Manipulate the Structure and Function of Membranes and Membrane Proteins

edited by

Peter Pohl

submission deadline 31 Mar 2026 | 1 articles | Viewed by 913 | Submission Open

Keywords: photopharmacology; optogenetics; membrane transport; light-gated channels; photoswitchable lipids

(This special issue belongs to the Section Chemical Biology)

The Role of Glycosaminoglycans and Proteoglycans in Human Disease

edited by

Umesh Desai

submission deadline 31 Mar 2026 | 1 articles | Viewed by 806 | Submission Open

Keywords: glycosaminoglycans (GAGs); proteoglycans (PGs); diseases; mechanisms; molecules

(This special issue belongs to the Section Molecular Biology)

Advances in Glycosaminoglycans (GAGs) and Mimetics

edited by

Daniel Afosah

and

Rami A. Al-Horani

submission deadline 31 Mar 2026 | 1 articles | Viewed by 766 | Submission Open

Keywords: glycosaminoglycans (GAGs); hyaluronan; heparin; chondroitin sulfate; keratan sulfate; dermatan sulfate; sulfation; GAG mimetics; GAG-binding proteins

(This special issue belongs to the Section Chemical Biology)

Tissue-Specific Organelle Dynamics

edited by

Agnese De Mario

and

Marta Giacomello

submission deadline 31 Mar 2026 | Viewed by 261 | Submission Open

Keywords: organelles crosstalk; organelles contact sites; organelle dynamics

(This special issue belongs to the Section Cellular Biochemistry)

Fibrinogen and Fibrin in Human Diseases

edited by

Abha Sahni

submission deadline 31 Mar 2026 | Viewed by 183 | Submission Open

Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis

(This special issue belongs to the Section Molecular Biology)

Advanced Therapeutic Strategies for Hormone-Dependent Cancers

edited by

Athanasios A. Panagiotopoulos

submission deadline 31 Mar 2026 | 1 articles | Viewed by 172 | Submission Open

Keywords: hormone-dependent cancers; endocrine therapy resistance; targeted therapy; combination treatment strategies; cancer biomarkers

(This special issue belongs to the Section Molecular Medicine)

Genetics and Molecular Mechanisms of Parkinson's Disease

edited by

Hugo Fernandes

submission deadline 31 Mar 2026 | Viewed by 103 | Submission Open

Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration

(This special issue belongs to the Section Molecular Genetics)

Protein Arginine Methylation: Functions, Mechanisms, and Therapeutic Implications

edited by Yanzhong Yang

submission deadline 31 Mar 2026 | Viewed by 98 | Submission Open

Keywords: protein arginine methyltransferases; transcription; RNA splicing; signaling transduction; DNA repair; cancer; development; small molecule inhibitor

(This special issue belongs to the Section Molecular Genetics)

Molecular Chaperones in Neurodegenerative Diseases: Mechanistic Role and Therapeutic Potential

edited by Umesh Kumar Jinwal

submission deadline 31 Mar 2026 | Viewed by 77 | Submission Open

Keywords: molecular chaperones; neurodegenerative diseases; Hsp90; Hsp70; Alzheimer's Disease; Parkinson’ s Disease; Huntington's disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Unraveling the Complexity of Autoimmune and Autoinflammatory Skin Diseases: From Molecular Pathways to Targeted Therapies

edited by

Chiara Moltrasio

Angelo Valerio Marzano

and

Sergio Crovella

submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open

Keywords: autoimmune/autoinflammatory skin diseases; omics; bioinformatics; pathogenesis; tailored medicine

(This special issue belongs to the Section Molecular Genetics)

Nutritional Immunity and Inflammation: Decoding Mechanisms for Therapeutic Advancement

edited by

Franziska Roth-Walter

and

Carolina Frizzo-Ramos

submission deadline 31 Mar 2026 | Viewed by 57 | Submission Open

Keywords: nutritional deficiencies; antioxidants; minerals; vitamins; mucosal block; cross feeding; microbes; inflammation; tolerance

Zebrafish: A Powerful Model in Neuroscience to Investigate Genes, Brain Mechanisms, and Behavior

edited by

Marco Dal Maschio

Nicola Facchinello

and

Maria Elena Miletto Petrazzini

submission deadline 31 Mar 2026 | Viewed by 30 | Submission Open

Keywords: zebrafish; behavioural neuroscience; neurodevelopment; neurodegeneration

(This special issue belongs to the Section Chemical Biology)

Exploring the Molecular and Cellular Mechanisms of Pulmonary Arterial Hypertension

edited by

Fabrice Antigny

and Grégoire Ruffenach

submission deadline 31 Mar 2026 | Viewed by 27 | Submission Open

Keywords: pulmonary arterial hypertension; PAH predisposing genes; ion channels; transcription factors; RNA-binding protein; omics approaches

(This special issue belongs to the Section Molecular Medicine)

SAM Domains in Health and Diseases: Structural and Functional Insights

edited by

Flavia Anna Mercurio

and

Marilisa Leone

submission deadline 31 Mar 2026 | Viewed by 26 | Submission Open

Keywords: SAM domains; oligomer- and polymer-forming SAM; mid-loop/end-helix architecture of binding; SAM physiological and pathological signaling pathways; SAM domains as drug targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Obesity-Related Diseases: Molecular Basis and Therapeutic Approaches

edited by