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9.4
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Biomolecules
Special Issues
Vertebrate Comparative Genomics
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Vertebrate Comparative Genomics

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 704

Special Issue Editors

Prof. Dr. Ya-Xiong Tao

E-Mail Website
Guest Editor
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
Interests: G protein-coupled receptor; melanocortin receptor; obesity; genomic medicine; diabetes mellitus
Special Issues, Collections and Topics in MDPI journals
Dr. Shan He

E-Mail Website
Guest Editor
Key Laboratory of Freshwater Animal Breeding, Wuhan, China
Interests: fish feeds; food intake; metabolism regulation; amino acids; glucose
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the explosive increase in genomic information, tremendous advances have been made into diverse questions in physiology and pathophysiology. For example, adaptation to diverse environments, including extreme conditions, different diet and feeding strategies, and unique properties of proteins in some species that can improve our understanding of physiology and biochemistry (protein structure-function), are all fruits derived from comparative genomic data analyses. This issue seeks to highlight some of these advances. Manuscripts covering comparative gene functions from fish to mammals, including humans, as well as evolution of genes in vertebrates, are welcomed for this Special Issue.

Prof. Dr. Ya-Xiong Tao
Dr. Shan He
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vertebrate
  • comparative genomics
  • physiology
  • biochemistry
  • pathophysiology
  • protein structure-function
  • gene

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Published Papers (1 paper)

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Research

19 pages, 3536 KiB  
Article
Molecular Characterization and Nutritional Regulation of Two Fatty Acid Elongase (elovl8) Genes in Chinese Perch (Siniperca chuatsi)
by Yu He, Zhengyong Wen, Luo Zhou, Wanhong Zeng, Panita Prathomya, Tilin Yi and Qiong Shi
Biomolecules 2025, 15(4), 567; https://doi.org/10.3390/biom15040567 - 11 Apr 2025
Viewed by 355
Abstract
Proteins for elongation of very long-chain fatty acids (ELOVLs) are critical for the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), and they are one group of the rate-limiting enzymes responsible for the initial condensation reaction within the fatty acid elongation. Elovl8 is a [...] Read more.
Proteins for elongation of very long-chain fatty acids (ELOVLs) are critical for the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), and they are one group of the rate-limiting enzymes responsible for the initial condensation reaction within the fatty acid elongation. Elovl8 is a newly identified member of the ELOVL protein family, and its evolutionary and functional characterizations are still rarely reported. Here, we identified two elovl8 paralogues (named Scelovl8 and Scelovl8b) from Chinese perch (Siniperca chuatsi), and then their molecular and evolutionary characteristics, as well as potential roles involved in LC-PUFA biosynthesis, were examined. The ORFs of both Scelovl8a and Scelovl8b genes were 810 bp and 789 bp in length, encoding proteins of 270 and 263 amino acids, respectively. Multiple protein sequence comparisons indicated that elovl8 genes were highly conserved in teleosts, showing similar structural function domains. Meanwhile, phylogenetic analysis showed that the elovl8 gene family was clustered into two subclades of elovl8a and elovl8b, and Scelovl8a and Scelovl8b shared close relationships with banded archerfish elovl8a and striped bass elovl8b, respectively. Genetic synteny and gene structure analyses further confirmed that elovl8b is more conserved in comparison to elovl8a in teleosts. In addition, Scelovl8a was found to be highly expressed in the liver, while Scelovl8b was most abundant in the gills. Long-term food deprivation and refeeding are verified to regulate the transcription of Scelovl8a and Scelovl8b, and intraperitoneal injection of fish oil (FO) and vegetable oil (VO) significantly modified their gene expression as well. In summary, our results in this study indicate that elovl8 genes were conservatively unique to teleosts, and both elovl8 genes might be involved in the endogenous biosynthesis of LC-PUFAs in Chinese perch. These findings not only expand our knowledge on the evolutionary and functional characteristics of both elovl8 genes but also lay a solid basis for investigating regulatory mechanisms of LC-PUFA biosynthesis in various teleosts. Full article
(This article belongs to the Special Issue Vertebrate Comparative Genomics)
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