Metal-Based Complexes in Medicine: From Therapeutics to Diagnostics and Theranostics

Dear Colleagues,

The pivotal role of metal complexes in contemporary medicinal chemistry necessitates continued investigation, particularly through the lens of rational design, synthesis, and mechanistic elucidation. Moreover, the inherent physicochemical diversity of metal ions provides a rich chemical space for targeted drug development. Indeed, the considerable therapeutic promise of metal-based pharmaceuticals is evident in the extensive array of both platinum and non-platinum metallodrugs that exhibit a spectrum of biological activities. For instance, gold complexes demonstrate notable cytotoxicity, while ruthenium compounds display anti-metastatic effects. The clinical progress of gallium, germanium, gadolinium, and titanium complexes further underscores the translational significance of metal-based interventions. We welcome high-quality research on both therapeutic and diagnostic applications of metal complexes, including theranostics, where agents combine both functions.

Mechanistically, the inherent chemical versatility of metal ions facilitates diverse interactions with biomolecular targets, encompassing DNA binding, enzymatic inhibition, the modulation of cellular redox states, and interference with signaling cascades. This intrinsic tunability renders metal centers and metalloids as highly adaptable platforms for the rational design of therapeutic agents across a broad spectrum of medical applications, extending significantly beyond oncology to include antimicrobial, antiparasitic, and antiviral therapies.

Modern spectroscopic techniques and computational methodologies are increasingly crucial in the rational design of metal-based therapeutics, enabling the precise manipulation of structural features to achieve desired biological outcomes. Simultaneously, advanced synthetic techniques and comprehensive in vitro and in vivo studies are essential steps for advancing this field.

This Special Issue aims to consolidate cutting-edge research focused on the advancements in metal-based medicinal complexes, with particular focus on how their properties and reactivity influence their mechanisms of action. We strongly encourage the submission of high-quality articles and reviews focused on the rational development and mechanistic actions of a diverse range of metal-based compounds where experimental and computational methodologies are applied, also in combination. This is an opportunity to highlight the extensive therapeutic potential inherent in coordination compounds and organometallic species.

Dr. Iogann Tolbatov
Dr. Andrea Melchior
Guest Editors

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