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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Carotenoids in Health and Disease

edited by Kazutoshi Shindo

submission deadline 31 Dec 2025 | 3 articles | Viewed by 11163 | Submission Open

Keywords: antioxidant activities of carotenoids; analytical chemistry on carotenoids; reactive oxygen species (ROS) and disease; production of carotenoids

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Multi-Target Profile of Antioxidant Compounds, Including Repurposing and Combination Strategies—2nd Edition

edited by

Roberta Rocca

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9495 | Submission Open

Keywords: polypharmacology; multi-target ligands; rational drug; design repurposing; off-target effects; computational techniques

Agri-Food Wastes as Natural Source of Bioactive Antioxidants: Fourth Edition

edited by

Silvana Hrelia

Cristina Angeloni

and

Maria Cristina Barbalace

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9402 | Submission Open

Keywords: agri-food by-products; agri-food waste; nutraceuticals; functional foods; cosmeceutical products; sustainable practices; bioactive compounds; health effects

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Redox Regulation in Cardiovascular Diseases

edited by

Yiliang Chen

and

Jacek Zielonka

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8960 | Submission Open

Keywords: oxidative stress; mitochondria; metabolism; chronic inflammation; atherosclerosis; CVD; ROS

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Selected Papers from the 2nd International Electronic Conference on Antioxidants (IECAN2025)

edited by

Alessandra Napolitano

and

Mario Allegra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6795 | Submission Open

Keywords: obesity; cardiovascular diseases; chronic disease; dietary prevention; antioxidants intake; gut microbiome; natural and synthetic antioxidants; antioxidant enzyme systems; antioxidant extraction

Oxidative Stress, Antioxidants, and Mechanisms in FLASH Radiotherapy

edited by

Jean Paul Jay-Gerin

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6674 | Submission Open

Keywords: radiobiology and radiotherapy; ultra-high dose rate irradiation and the FLASH effect; molecular and cellular mechanisms; radiation-induced oxidative stress; reactive oxygen and nitrogen species; inflammatory processes; antioxidants and radioprotectors; pulse radiolysis; kinetics; physicochemical and biological processes; DNA damage; role of oxygen and the oxygen depletion hypothesis; modeling and experimental; FLASH particle therapy

Role of Reactive Oxygen Species (ROS) in Tumor Microenvironment Modulation

edited by

Antonis Giakountis

and

Dimitrios Kouretas

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6461 | Submission Open

Keywords: reactive oxygen species; tumor microenvironment; stroma cells; functional genomics; spatial transcriptomics; single-cell sequencing; RNA-seq; cancer; diagnosis and prognosis; biomarkers

Antioxidant Activity of Polyphenolic Extracts

edited by

Dimitrios Stagos

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6417 | Submission Open

Keywords: antioxidant activity; polyphenols; plant extracts; oxidative stress

Oxidative Stress in Rare Diseases: Mechanisms, Implications, and Therapeutic Opportunities

edited by

Christophe Desterke

and

Jorge Mata-Garrido

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5413 | Submission Open

Keywords: rare diseases; oxidative stress; free radicals; biomedicine; redox biomarkers; redox epigenetics; redox metabolism; redox control of protein function; ferroptosis

Natural Antioxidants in Animal Nutrition

edited by

Lili Zhang

Xiang Zhong

, Chao Wang, Hao Zhang and Jingfei Zhang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4932 | Submission Open

Keywords: antioxidants; animal; growth; metabolism; nutrition; oxidative stress; plant extracts

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Biology and Genomic Integrity

edited by

Viktor Stolc

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4884 | Submission Open

Keywords: redox biology; reactive oxygen species (ROS); oxidative stress; oxidative DNA damage; genome stability; DNA repair; hypermutation; antioxidant defense mechanisms; mitochondrial dysfunction; Saccharomyces cerevisiae; cellular adaptation; epigenetics; telomeres

From Field to Cell: Redox Mechanisms of Chemical Stressor Toxicity in Biological Systems

edited by

Marco G. Alves

and

Ariane Zamoner

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3232 | Submission Open

Keywords: redox biology; environmental toxicology; chemical stressors; pesticides; redox signaling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Metabolic Dysfunction and Oxidative Stress

edited by

Vinood B. Patel

and

Mohammed Gulrez Zariwala

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2691 | Submission Open

Keywords: iron; mitochondria; oxidative stress; inflammation; metabolism; free radicals

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Editorial Board Members’ Collection Series: Advances in Redox-Tools and Therapies in Cardiovascular Disease

edited by

Andreas Daiber

Albino Carrizzo

and

Moo-Yeol Lee

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2554 | Submission Open

Keywords: cardiovascular disease; oxidative stress; inflammation; reactive oxygen species; redox signalling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Respiratory Disorders

edited by

Daniela Mokra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2310 | Submission Open

Keywords: oxidative stress; lung; reactive oxygen species; reactive nitrogen species; acute lung injury; asthma; COPD; lung fibrosis; pulmonary silicosis; premature neonate

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Novel Strategies for Oxidative Stress Management: Dietary Interventions for Liver and Gut Health

edited by

Antonio Cilla

and

Mussa Makran

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1812 | Submission Open

Keywords: antioxidant compounds; phytochemicals; dietary interventions; hepatic disease; intestinal disease; redox homeostasis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Super Oxide Dismutase (SOD) Isoenzymes and Reactive Oxygen Species (ROS) in Immuno-Pathophysiology

edited by Giuseppina Ruggiero and

Paolo Mondola

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1458 | Submission Open

Keywords: superoxide dismutase (SOD) isoenzymes; superoxide dismutase (SOD)1; cell signalling; cell metabolism; cell functions; cellular stress; disease pathogenesis

Natural Antioxidants in Functional Foods

edited by

Angela Cardinali

, Palmira De Bellis and

Anna Rita Bavaro

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1292 | Submission Open

Keywords: polyphenols; functional foods; fermentation; antioxidant activity; anti-inflammatory activity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Modulation of Biochemical, Cellular and Physiological Mechanisms in Response to Oxidative Stress in Animals

edited by

Konstantinos Feidantsis

and

Vasiliki Sapanidou

submission deadline 31 Dec 2025 | 1 articles | Viewed by 969 | Submission Open

Keywords: animals; cell signaling; metabolism; cell death responses; oxidative damage

Radiation Exposure and Health: The Role of Oxidative Stress and Inflammatory Response

edited by

Siamak Haghdoost

and

Benjamin Frey

submission deadline 31 Dec 2025 | 1 articles | Viewed by 957 | Submission Open

Keywords: radiation; inflammatory response; oxidative stress

Algal Antioxidants: Physiology, Metabolism, and Evolution

edited by

Shan Lu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 750 | Submission Open

Keywords: algae; antioxidant; oxidative stresses; algal physiology

Phenolic Antioxidants in Functional Foods and Nutraceuticals

edited by

Diana Andreia Tavares Pinto

and

Francisca Rodrigues

submission deadline 31 Dec 2025 | Viewed by 490 | Submission Open

Keywords: bioactive compounds; agri-food byproducts; in vitro assays; in vivo studies; green extraction; biological activities; safety assessment; industrial application

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Antioxidants and Dietary Nutrition: Emerging Trends, and Clinical Applications

edited by

Sofia Lotti

and

Raúl Zamora-Ros

submission deadline 31 Dec 2025 | Viewed by 431 | Submission Open

Keywords: antioxidants; oxidative stress; chronic disease prevention; dietary strategies; bioavailability

Antioxidant Properties of Functional Foods

edited by Konstantinos G. Adamopoulos and

Patroklos Vareltzis

submission deadline 31 Dec 2025 | Viewed by 422 | Submission Open

Keywords: antioxidant; extraction; bioavailability; processing; optimization; functional food; phytochemicals

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Emerging Trends in Antioxidant Nutraceuticals

edited by

Andrei Mocan

and

Oleg Frumuzachi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 419 | Submission Open

Keywords: nutraceuticals; diabetes; cancer; oxidative stress; inflammation; antioxidant

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Metabolism and Epigenetics: A Potential Dual Interaction in the Microenvironment of Solid Tumors

edited by

Federico Pio Fabrizio

Lucia Anna Muscarella

Filippo Torrisi

and Sebastiano Giallongo

submission deadline 31 Dec 2025 | Viewed by 310 | Submission Open

Keywords: metabolomics; tumor cell metabolism; tumor microenvironment; cell communication; cell signaling; epigenetics; post-translational modifications; cancer therapy

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Development and Application of Detection Methods for Reactive Oxygen Species and Antioxidants

edited by

Naoya Kishikawa

and

Mahmoud El-Maghrabey

submission deadline 31 Dec 2025 | Viewed by 293 | Submission Open

Keywords: antioxidant extraction; antioxidant assay; sensors for reactive oxygen species (ROS); ROS scavenger assays; biological samples; oxidative stress status; nutritional value; food analysis; bioassays; enzymatic assays; redox cycle; cell imaging

(This special issue belongs to the Section Methods for Antioxidants Evaluation/Measurement)

The Role of Dietary Antioxidants in Alleviating Oxidative Stress and Inflammation for Enhanced Immunity in Animals

edited by Yanka D. Karamalakova and

Jie Yin

submission deadline 31 Dec 2025 | Viewed by 284 | Submission Open

Keywords: antioxidants; antioxidant feeding; insect meal; growth performance; digestible energy; nutrient digestibility; blood biochemistry; oxidative stress (OS); lipid peroxidation (MDA); ROS/RNS; superoxide dismutase (SOD); catalase (CAT); glutathione (GSH); glutathione peroxidase (GPx); inflammation markers; total antioxidant capacity (TAC); meat; milk; eggs quality

Oxidative Stress and Mitochondrial Dysfunction in Metabolic Disorders

edited by

Pablo M. García-Rovés

Steen Larsen

and Hugo J Alves-Figueiredo

submission deadline 31 Dec 2025 | Viewed by 245 | Submission Open

Keywords: metabolic diseases; oxidative stress; mitochondrial dysfunction; antioxidant therapies; lifestyle interventions; gene therapies; mitochondrial transfer therapies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Natural Products and Peptides in Cosmetics

edited by

Fotini Lamari

Vassiliki Magafa

and

Sophia Hatziantoniou

submission deadline 31 Dec 2025 | Viewed by 240 | Submission Open

Keywords: cosmetics; herbal extracts; natural products; peptides; synthesis; isolation; oxidative stress; emulsions; nanoparticles; fibroblasts; ageing

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Sustainable Strategies for Natural Antioxidant Utilization

edited by

Vlasios Goulas

and Atalanti Christou

submission deadline 31 Dec 2025 | Viewed by 220 | Submission Open

Keywords: extraction; antioxidants; polyphenols; phytochemicals; green chemistry; sustainable process; natural products; drug discovery; formulation; natural product analysis

Antioxidants for Skin Health—2nd Edition

edited by Rubia Casagrande

submission deadline 31 Dec 2025 | Viewed by 213 | Submission Open

Keywords: skin inflammation; cytokine; skin oxidative stress; Nrf2; reduced glutathione; ultraviolet irradiation; drug delivery; flavonoid; terpenes; specialized pro-resolution lipid mediators

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Bioavailability of Antioxidants: From Omics Insights to Health Outcomes

edited by

Pascual García-Pérez

submission deadline 31 Dec 2025 | Viewed by 208 | Submission Open

Keywords: bioavailability; nutrigenomics; metabolomics; gut microbiota; dietary polyphenols; functional foods; biotransformation; systems biology; antioxidants; bioactivity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Studies on Antioxidants and Anti-Aging Substances Using Model Organisms and Cell Cultures

edited by

Yoshihiro H. Inoue

submission deadline 31 Dec 2025 | Viewed by 204 | Submission Open

Keywords: antioxidants; anti-aging substances and natural products; experimental animals; 3D cell culture models; organoids; acting mechanisms; antioxidant genes; autophagy; proteasome

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Regulation of Plant Growth and Development

edited by Judit Dobránszki and

Judit Remenyik

submission deadline 31 Dec 2025 | Viewed by 146 | Submission Open

Keywords: plant biology; ascorbate; free-radical scavenging; glutathione; heat shock proteins; melatonin; oxidative stress; plant growth and development; redox homeostasis; RNP; ROS; plant stress mitigation; plant stress adaptation; transcription factors

(This special issue belongs to the Section ROS, RNS and RSS)

Hydrogen Sulfide and Its Role in Inflammatory and Degenerative Joint Diseases

edited by Guenter Steiner and Burkhard Klösch

submission deadline 31 Dec 2025 | Viewed by 145 | Submission Open

Keywords: hydrogen sulfide; inflammation; antioxidant; osteoarthritis; rheumatoid arthritis; degeneration; chondrocyte; monocyte; fibroblast; drug development

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Biomarkers of Oxidative Stress in Lung Disease

edited by

Rafał Pawliczak

submission deadline 31 Dec 2025 | Viewed by 119 | Submission Open

Keywords: oxidative stress; reactive oxygen species; reactive nitrogen species; antioxidants; lung inflammation; bronchial inflammation; COPD; asthma; lung fibrosis; mitochondria

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Adaptive Responses in Space Medicine and Physiology

edited by

Dawon Kang

submission deadline 31 Dec 2025 | Viewed by 111 | Submission Open

Keywords: antioxidant defense ; microgravity ; oxidative stress ; radiation ; space medicine ; space physiology

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Phytochemicals for Promoting Human Health and Well-Being

edited by

Teresa Mencherini

Francesca Sansone

and

Tiziana Esposito

submission deadline 10 Jan 2026 | 6 articles | Viewed by 7881 | Submission Open

Keywords: antioxidant phytochemicals; oxidative stress; health promotion; chronic disease; functional foods; nutraceuticals

Antioxidant Effects of Natural Compounds on Cell Metabolism

edited by Ester Tellone and Annamaria Russo

submission deadline 12 Jan 2026 | 3 articles | Viewed by 5444 | Submission Open

Keywords: antioxidants; metabolic pathways; dietary intake; blood cells; bioactive compounds

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Mitochondrial Oxidative Stress in Aging and Disease—2nd Edition

edited by

Angela Maria Serena Lezza

and

Vito Pesce

submission deadline 15 Jan 2026 | 7 articles | Viewed by 18509 | Submission Open

Keywords: mitochondrial oxidative stress in aging; mitochondrial oxidative stress in age-related or metabolic diseases; mitochondrial signaling via ROS in diseases; mitochondrial oxidative stress and genomic instability; mitochondrial oxidative stress and inflammation; antioxidants as novel therapeutic approaches; mitochondrial pathologies; aging; mitochondrial

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hydrophilic and Lipophilic Antioxidants in Foods and Food Processing

edited by

Volker Böhm

submission deadline 15 Jan 2026 | Viewed by 179 | Submission Open

Keywords: antioxidant activity; antioxidant capacity; antioxidant mechanisms; carotenoids; polyphenols; vitamin C; vitamin E; impact of food processing

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidant Systems in Plants

edited by

Francisco Espinosa Borreguero

, Ilda Jesús Casimiro Felicio and

Inmaculada Garrido Carballo

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2035 | Submission Open

Keywords: enzymatic antioxidants; non-enzymatic antioxidants; nitro-oxidative stress; reactive oxygen species; reactive nitrogen species; ROS and RNS signaling

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Exploring the Role of Polyphenols in Oxidative Stress and Cellular Protection

edited by

Lucia Gimeno-Mallench

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1960 | Submission Open

Keywords: polyphenol; oxidative stress; cellular signaling; metabolic pathways

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants and Multifunction Photoprotection—2nd Edition

edited by

André Rolim Baby

and

Catarina Rosado

submission deadline 20 Jan 2026 | 1 articles | Viewed by 178 | Submission Open

Keywords: natural and synthetic antioxidants; sunscreens; multifunctional products; safety and efficacy establishment; product technologies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Peroxiredoxin Biology

edited by Mikael Molin and Cecilia Picazo

submission deadline 23 Jan 2026 | 1 articles | Viewed by 159 | Submission Open

Keywords: oxidative stress; aging; age-related diseases; H2O2 signaling; redox regulation

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Interplay Between Gut Microbiota and Oxidative Stress

edited by

Sunmin Park

submission deadline 25 Jan 2026 | Viewed by 264 | Submission Open

Keywords: gut microbiota; redox; human health; gut homeostasis

Redox Balance and Autophagy in Neuroinflammation

edited by

Anna Colell

and

Vicente Roca-Agujetas

submission deadline 26 Jan 2026 | Viewed by 261 | Submission Open

Keywords: oxidative stress/oxidative damage ; reactive oxygen species (ROS) ; redox homeostasis ; autophagy ; lysosomal clearance ; proteinopathies ; neuroinflammation ; neurological disorders ; cellular homeostasis ; neuroprotection

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Effect of Oxidative Stress on Reproduction and Development—3rd Edition

edited by

Giulia Guerriero

and

Gerardino D’Errico

submission deadline 30 Jan 2026 | 5 articles | Viewed by 6917 | Submission Open

Keywords: free radicals and antioxidants; oxidative stress in male and female reproduction; mitochondria; gametogenesis; assisted reproduction; thermal fertility limit (TFL); climate change; one-health; biodiversity conservation and sustainability; reproduction; development and nutrigenomics; methods for reactive oxygen species detection and antioxidant property determination.

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Diabetic Retinopathy

edited by Tatsuya Mimura

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1862 | Submission Open

Keywords: diabetic retinopaty; oxidative stress; antioxidants; inflammation; environmental factor

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

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