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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antioxidant Activities of Phytochemicals in Fruits and Vegetables

edited by

Wen Qin

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5239 | Submission Open

Keywords: ROS and oxidative stress; green and efficient extraction technology of phytochemicals; antioxidant activity of phytochemicals in fruits and vegetables; polyphenols and polysaccharides in fruits and vegetables; phytochemicals and inflammation

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Heme Oxygenase in Health and Disease: New Insights and Future Directions

edited by

J. Catharina Duvigneau

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4296 | Submission Open

Keywords: enzyme activity; ferroptosis; carbon monoxide; oxidative stress; reactive oxygen and nitrogen species; heme proteins; heme degradation; heme responsive elements; heme regulation

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Cellular ROS and Antioxidants: Physiological and Pathological Role—2nd Edition

edited by

Andrey V. Kozlov

Mihály Boros

and

Salvatore Nesci

submission deadline 31 Oct 2025 | 4 articles | Viewed by 3605 | Submission Open

Keywords: reactive oxygen and nitrogen species; intracellular signaling; oxidative stress; iron metabolism; mitochondrial dysfunction; hypoxia; inflammation; targeted and untargeted antioxidants; gas messengers natural and artificial sources of reactive oxygen species; antioxidant defense systems; small signaling molecules; oxidative stress-driven processes

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress Induced by Micro(Nano)plastics

edited by

Lavinia Casati

Alessandro Villa

and

Marco Parolini

submission deadline 31 Oct 2025 | 1 articles | Viewed by 3503 | Submission Open

Keywords: micro(nano)plastics; oxidative stress; One Health; in vitro and in vivo models; organisms; cellular microenvironment

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

From Waste to Health: Upcycling Agrifood By-Products into Functional Antioxidant-Rich Ingredients and Products

edited by

Ítala Marx

and

Feliciano Priego-Capote

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2716 | Submission Open

Keywords: antioxidant activity; oxidative stress; reactive oxygen species; polyphenols; bioactive compounds; functional ingredients; health-promoting formulations; agrifood waste; green extraction technologies; emerging analytical methods

Phytochemicals Against Oxidative Stress: Polypharmacological Strategies for Aging-Related Disease

edited by

and

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2354 | Submission Open

Keywords: phytochemicals; antioxidants; systems biology; oxidative stress; hair loss; skin aging

Olive Antioxidants: Extraction, Biological Activity and Practical Applications—3rd Edition

edited by

Juan Fernández-Bolaños

and

Alejandra Bermudez-Oria

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2039 | Submission Open

Keywords: antioxidant effect; olive oil; olive by-products; olive leaves; polyphenols; carotenoids; polysaccharide– polyphenol complexes; vitamin E; health; Mediterranean diet

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Plants and Plant-Based By-Products as Valuable Sources of Antioxidants: Current Tendencies and Achievements in Their Exploitation

edited by Svetlana Momchilova and

Adriana Slavova-Kazakova

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1800 | Submission Open

Keywords: antioxidants; oxidative stability; antioxidant activity; lipid oxidation; green chemistry; biomass; plants and by-products; herbs; utilization

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Unveiling the Essential Role of Coenzyme Q in Health

edited by

Guillermo López Lluch

and

Steen Larsen

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1427 | Submission Open

Keywords: coenzyme Q10; CoQ biosynthesis; ROS; cognitive deficiency; cardiovascular disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Regulation in COPD: Therapeutic Implications of Antioxidants

edited by

Samuel Santos Valença

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1045 | Submission Open

Keywords: COPD; oxidative stress; antioxidants; pulmonary diseases; therapeutics

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants in Cardiovascular Medicine: Emerging Trends and Future Perspectives

edited by

Matteo Becatti

and

Claudia Fiorillo

submission deadline 31 Oct 2025 | 1 articles | Viewed by 880 | Submission Open

Keywords: cardiovascular disease; CVD; atherosclerosis; hypertension; heart failure; ischemic heart disease; vascular aging; myocardial remodeling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Sperm: Technical, Biological and Clinical Aspects—2nd Edition

edited by

Monica Muratori

submission deadline 31 Oct 2025 | 1 articles | Viewed by 864 | Submission Open

Keywords: male infertility; ROS; oxidative sperm DNA damage; sperm DNA fragmentation; sperm epigenetic damage; assisted reproductive techniques; in vitro sperm manipulation; antioxidants; embryo development; pregnancy

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in the Astonishing World of Phytochemicals: State-of-the-Art for Antioxidants—3rd Edition

edited by

Antonella D'Anneo

and

Marianna Lauricella

submission deadline 31 Oct 2025 | 1 articles | Viewed by 794 | Submission Open

Keywords: bioactive compounds; phytochemicals; antioxidant properties; oxidative and nitrosative stress; anticancer action; antimicrobial properties; anti-inflammatory actions

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress in Respiratory Diseases—Second Edition

edited by

Sabina Galiniak

and

Stephen M. Black

submission deadline 31 Oct 2025 | Viewed by 248 | Submission Open

Keywords: reactive oxygen species; inflammation; antioxidant therapy; chronic obstructive pulmonary disease; asthma; cystic fibrosis; nitrosative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Applications and Health Benefits of Novel Antioxidant Biomaterials—2nd Edition

edited by

Washington Luiz Esteves Magalhães

and Tielidy Lima

submission deadline 31 Oct 2025 | Viewed by 241 | Submission Open

Keywords: antioxidant biomaterials; tissue regeneration; biocompatibility; controlled release; premature aging

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Chronic Pain and Oxidative Stress

edited by

Olga Pol

submission deadline 31 Oct 2025 | Viewed by 180 | Submission Open

Keywords: analgesia; antioxidants; chemotherapy; heme oxygenase 1; neuropathy; nociception; Nrf2 transcription factor; oxidative stress; pain

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Bioactive Compounds from Natural Sources with Antioxidant and Anti-Inflammatory Potential

edited by

Chun Guang Li

submission deadline 31 Oct 2025 | Viewed by 166 | Submission Open

Keywords: antioxidant; anti-inflammatory; natural compounds; isolation; extraction; molecular mechanism; synergistic effect; clinical trial; bioavailability; analytical method; pharmacodynamics; pharmacokinetics

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Vitamins, Antioxidants, and Neurodegeneration: Exploring Protective Strategies in Brain Health

edited by

Maria Morello

submission deadline 31 Oct 2025 | Viewed by 139 | Submission Open

Keywords: neurodegenerative diseases; alzheimer's disease; parkinson's disease; amyotrophic lateral sclerosis (ALS); aging populations; vitamins; antioxidants; oxidative stress; neuroinflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Role of Oxidative Stress in Cardiac Remodeling and Heart Failure—3rd Edition

edited by

Marina Politi Okoshi

Elida Paula Benquique Ojopi

and

Luana Urbano Pagan

submission deadline 31 Oct 2025 | Viewed by 118 | Submission Open

Keywords: oxidative stress; heart disease; cardiac remodeling; signaling pathways; remodeling; left ventricular dysfunction; heart failure; cardiovascular disease; myocardial damage

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

NADPH Oxidases (NOXs)

edited by David W. Stepp

submission deadline 10 Nov 2025 | 7 articles | Viewed by 11073 | Submission Open

Keywords: NADPH oxidases; reactive oxygen species; redox signaling; cardiovascular diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Roles of NADPH Oxidase in Modulation of Signal Transduction and Cellular Metabolism—2nd Edition

edited by

Rosario Ammendola

and

Fabio Cattaneo

submission deadline 10 Nov 2025 | 3 articles | Viewed by 5368 | Submission Open

Keywords: redox signaling; inflammation; NADPH oxidase; ROS; cell metabolism; redox-state; Warburg effect; metabolic reprogramming; tumor microenvironment; cell proliferation

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Oxidative Stress and NRF2 in Health and Disease—2nd Edition

edited by

Lidija Milković

submission deadline 20 Nov 2025 | 7 articles | Viewed by 10574 | Submission Open

Keywords: oxidative stress; redox signaling; NRF2 and its regulation; redox-modifying therapeutic approach; omics approach; physiology; non-communicable diseases; metabolism; aging

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Alcohol-Induced Oxidative Stress in Health and Disease, 2nd Edition

edited by

Marco Fiore

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2367 | Submission Open

Keywords: alcohol; alcohol use disorder; reactive oxygen species; antioxidant defense

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress from Environmental Exposures

edited by

Giulia Squillacioti

Valeria Bellisario

and

Federica Ghelli

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1300 | Submission Open

Keywords: environmental exposures; human health; air pollution; lifestyle; oxidative stress; particulate matter; environmental stressors

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Hepatic Diseases

edited by

Miquel Mulero

submission deadline 21 Nov 2025 | 3 articles | Viewed by 4301 | Submission Open

Keywords: oxidative stress; hepatic diseases; liver fibrosis; reactive oxygen species (ROS); mitochondrial dysfunction; lipid peroxidation; antioxidant defense; non-alcoholic fatty liver disease (NAFLD); alcoholic liver disease; hepatoprotective strategies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants from Food and Food Wastes for Nutraceutical, Pharmaceutical and Cosmetic Fields

edited by Monica Locatelli and

Vincenzo Disca

submission deadline 25 Nov 2025 | 7 articles | Viewed by 11049 | Submission Open

Keywords: phenolic compounds; analytical methods; bioactivities; green extraction; functional ingredients; food supplements; by-products and up-cycled ingredients; nutraceutical; cosmetics; bioaccessibility

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Antioxidant Compounds and Health Benefits of Mediterranean Functional Food

edited by

Stefania D'Angelo

submission deadline 25 Nov 2025 | 2 articles | Viewed by 3394 | Submission Open

Keywords: antioxidants; anti-inflammatory; anti-obesity; functional food; human health; Mediterranean diet; nutraceuticals; nutrition; oxidative stress; phytochemicals; polyphenols

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress in Animal Reproduction and Nutrition

edited by

Fang Chen

and

Jun Chen

submission deadline 28 Nov 2025 | 3 articles | Viewed by 2720 | Submission Open

Keywords: oxidative stress; antioxidants; animal reproduction; nutritional regulation; livestock and poultry; mouse or rat model; antioxidant mechanisms; oxidative stress mechanisms

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants in Meat and Meat Products

edited by

Rubén Domínguez-Valencia

and

Mirian Pateiro

submission deadline 28 Nov 2025 | Viewed by 187 | Submission Open

Keywords: natural antioxidants; oxidative degradation; meat shelf-life; food quality; functional food; bioactive compounds; antioxidant active packaging

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Antioxidants and Retinal Diseases—2nd Edition

edited by

Francisco J. Romero

and Jorge M. Barcia

submission deadline 30 Nov 2025 | 8 articles | Viewed by 22668 | Submission Open

Keywords: retinal diseases; antioxidants; oxygen species; extracellular vesicles; miRNA

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Therapy for Obesity-Related Diseases

edited by

Seyed Khosrow Tayebati

submission deadline 30 Nov 2025 | 8 articles | Viewed by 15228 | Submission Open

Keywords: obesity; inflammation; oxidative stress; organ damage; natural antioxidants; synthetic antioxidants; mechanisms of action; therapeutical approaches

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Cancer

edited by

and

submission deadline 30 Nov 2025 | 4 articles | Viewed by 11053 | Submission Open

Keywords: ascorbate; vitamin C; cancer therapy; cancer prevention; antioxidants; prooxidants; oxidative stress; epigenetic activity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Free Radicals, Antioxidants, and Oxidative Stress in Aging and Age-Related Diseases—2nd Edition

edited by

Abdelouahed Khalil

and

Tamas Fulop

submission deadline 30 Nov 2025 | 5 articles | Viewed by 11021 | Submission Open

Keywords: aging; oxidative stress; age-related diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Novel Antioxidants for Animal Nutrition—2nd Edition

edited by

Matteo Dell'Anno

and

Luciana Rossi

submission deadline 30 Nov 2025 | 6 articles | Viewed by 9996 | Submission Open

Keywords: nutrition; functional diets; innovative antioxidants; feed additives; natural extracts; disease prevention; oxidative stress; one health

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Products: Biological, Antioxidant Properties and Health Effects—4th Edition

edited by

Evangelos Zoidis

submission deadline 30 Nov 2025 | 7 articles | Viewed by 9837 | Submission Open

Keywords: algal antioxidants; agricultural by-products; algae; bioactive compounds; cancer; cardiovascular diseases; essential oils; inflammatory diseases; marine organisms; metabolic diseases; oxidative stress; phytochemicals; polyphenols; radical scavenging; shelf life; waste products

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection—2nd Edition

edited by

Maja Jazvinšćak Jembrek

and

Josipa Vlainić

submission deadline 30 Nov 2025 | 5 articles | Viewed by 7847 | Submission Open

Keywords: neuroprotection; neurotoxicity; antioxidative vs. proxidative; oxidative stress; signaling pathways; redox metals

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Reactive Oxygen and Nitrogen Species in Plants―2nd Edition

edited by

Francisco J. Corpas

Rosa M. Rivero

and

José M. Palma

submission deadline 30 Nov 2025 | 4 articles | Viewed by 7028 | Submission Open

Keywords: antioxidants; hydrogen peroxide; nitric oxide; nitro-oxidative stress; ROS; RNS; hydrogen sulfide; melatonin

(This special issue belongs to the Section ROS, RNS and RSS)

Oxidative Stress in Eye Diseases

edited by

Dhirendra Pratap Singh

and

Eri Kubo

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6680 | Submission Open

Keywords: oxidative stress; antioxidants; reactive oxygen species; redox signaling; inflammatory cell death; age-related blinding diseases; glaucoma; cataract; age-related macular degeneration; gene regulation; retinal disorder; dry eye disorder; corneal diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Interaction Between Gut Microbiota and Host Oxidative Stress

edited by

Jie Yin

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5358 | Submission Open

Keywords: oxidative stress; antioxidants; gut microbiome; immunity

Innovative Technologies for Detecting Antioxidant Properties and Oxidative Stabilization of Agri-Food Products and Plant Extracts

edited by

Chao Hui Feng

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5115 | Submission Open

Keywords: green extraction; plant extracts; bioactive compounds; flavonoids; polyphenols; detection technologies; antioxidant activity

(This special issue belongs to the Section Methods for Antioxidants Evaluation/Measurement)

Developmental Origins of Health and Disease: Antioxidants as Strategy for Prevention and Treatment

edited by

Silvia M. Arribas

and

David Ramiro-Cortijo

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4312 | Submission Open

Keywords: oxidative stress; pregnancy; germline damage; obstetric complications; fetal programming

Glutathione and Health: From Development to Disease

edited by

Ying Chen

and Vasilis K. Vasiliou

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4118 | Submission Open

Keywords: glutathione; antioxidants; antioxidant enzymes; oxidative stress; redox biology; molecular biology; cellular biology; biochemistry; development; disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Antioxidants in Hypoxia and Human Pathophysiology Settings, 2nd Edition

edited by

Rodrigo L. Castillo

and Alejandro Gonzalez-Candia

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3358 | Submission Open

Keywords: tissue hypoxia; reperfusion injury; hypoxic preconditioning; oxidative stress; antioxidants; hypoxic programing; microRNA; clinical hypoxic settings

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants from Plant-Based By-Products: Mechanisms and Applications in Food Systems

edited by

María Jesús Petrón Testón

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2218 | Submission Open

Keywords: natural antioxidants; plant-based by-products; phenolic compounds; food preservation; shelf life extension; sustainable food systems; extraction techniques

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress and Inflammation in Neurologic Diseases

edited by

Adriana Bulboaca

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1986 | Submission Open

Keywords: oxidative stress; nitrosative stress; neuroinflammation; neurodegeneration; neuronal apoptosis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Plant Stress and Plant Physiology

edited by

Mohsin Tanveer

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1709 | Submission Open

Keywords: ROS signaling; stress adaptive responses; halophyte vs glycophyte; redox homeostasis; molecular crosstalk with ROS signaling; biotic; abiotic; soil borne; and air pollutants

(This special issue belongs to the Section ROS, RNS and RSS)

Oxidative Stress in Cell Senescence

edited by

Sara Cruciani

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1683 | Submission Open

Keywords: stem cells; cell senescence; regenerative medicine; antioxidant strategies; age-related diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Signaling in Cancer: Mechanisms and Therapeutic Opportunities

edited by

Myoung Ok Kim

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1150 | Submission Open

Keywords: oxidative stress; cancer; reactive oxygen species (ROS); redox signaling; natural compounds; ferroptosis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hydrogen Sulfide, Reactive Sulfur Species, and Donor Compounds: Natural and Synthetic Tools for Physiology and Disease

edited by

Giuseppe Caliendo

and

Angela Corvino

submission deadline 30 Nov 2025 | 1 articles | Viewed by 771 | Submission Open

Keywords: hydrogen sulfide; H2S donors; H2S hybrid compounds; H2S sources; pharmacological tools; H2S signaling

Oxidative Metabolism and Mitochondrial Dysfunction in Metabolic Diseases—3rd Edition

edited by

Gina Cavaliere

and

Giovanna Trinchese

submission deadline 30 Nov 2025 | Viewed by 218 | Submission Open

Keywords: mitochondria function; oxidative processes; metabolic diseases; reactive oxygen species; therapeutic approaches; mitochondrial integrity; energy production; mitochondrial bioenergetic; metabolism; mitochondrial dynamic

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

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