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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Translation of Antioxidant Therapies to the Clinical Arena of Ischemic Stroke

edited by María Castelló-Ruiz, Juan B. Salom and Irene Escudero-Martínez

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5940 | Submission Open

Keywords: Ischemic stroke; endovascular treatment; reperfusion; oxidative stress; cerebroprotectants; antioxidant therapeutic approaches

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Systems in Plants

edited by

Francisco Espinosa Borreguero

, Ilda Jesús Casimiro Felicio and

Inmaculada Garrido Carballo

submission deadline 20 Jun 2025 | Viewed by 181 | Submission Open

Keywords: enzymatic antioxidants; non-enzymatic antioxidants; nitro-oxidative stress; reactive oxygen species; reactive nitrogen species; ROS and RNS signaling

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Role of Mitochondria and ROS in Health and Disease

edited by

Paola Venditti

Gaetana Napolitano

and

Gianluca Fasciolo

submission deadline 25 Jun 2025 | 6 articles | Viewed by 9082 | Submission Open

Keywords: ROS; mitochondria; antioxidant; oxidative stress; neurological diseases; metabolic diseases; retinal diseases; mitochondrial disfunctions; mitochondria endoplasmic reticulum communication; mitochondrial bioenergetics; ageing; physical activity

(This special issue belongs to the Section ROS, RNS and RSS)

Reactive Oxygen Species in Different Biological Processes—Second Edition

edited by

Fabiana Pizzolongo

and

Stefania Filosa

submission deadline 30 Jun 2025 | 7 articles | Viewed by 46923 | Submission Open

(This special issue belongs to the Section ROS, RNS and RSS)

The Use of Antioxidant-Rich Foods and Supplements in Disease Prevention

edited by

Abraham Wall Medrano

Escobar-Puentes Alberto A.

and

Gustavo Adolfo González-Águilar

submission deadline 30 Jun 2025 | 1 articles | Viewed by 6563 | Submission Open

Keywords: dietary antioxidants; bioactivity; metabolomics; human diet; xenobiotics; polyphenols; vitamins; health promotion

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Male Reproductive Health

edited by

Robert John Aitken

Joel R. Drevet

, Zamira Gibb and

Geoffry De Iuliis

submission deadline 30 Jun 2025 | 4 articles | Viewed by 4197 | Submission Open

Keywords: oxidative stress; antioxidant therapy; male reproductive health; male fertility; erectile dysfunction; prostatic disease; male ageing

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants and Age-Related Changes in Skeletal Muscle and Vascular Health

edited by

Thiago Silveira Álvares

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3635 | Submission Open

Keywords: phytochemicals; phenolic compounds; antioxidant supplementation; bioactivity; oxidative stress; reactive oxygen species; nitric oxide; endothelial function; microvascular reactivity; muscle oxygenation; muscle quality; fatigue resistance; sarcopenia; aging

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants and Their Oxidized Derivatives in Processed Food

edited by Concetta Condurso and Maria Merlino

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3530 | Submission Open

Keywords: natural antioxidants; oxidized derivatives; bioavailability/bioaccessibility; antioxidant activity; processed food; thermal treatment; non-thermal treatment; innovative processing technologies; mild processing technologies; active packaging; shelf-life; nutritional benefits; health benefits; sensory quality

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Multi-Target Profile of Antioxidant Compounds, Including Repurposing and Combination Strategies—2nd Edition

edited by

Roberta Rocca

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2919 | Submission Open

Keywords: polypharmacology; multi-target ligands; rational drug; design repurposing; off-target effects; computational techniques

Antioxidant Activity of Polyphenolic Extracts

edited by

Dimitrios Stagos

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2855 | Submission Open

Keywords: antioxidant activity; polyphenols; plant extracts; oxidative stress

Nitric Oxide (NO) and Hydrogen Sulfide (H₂S) in Biology, Illness, and Therapies—2nd Edition

edited by

Eizo Marutani

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2481 | Submission Open

Keywords: nitric oxide; hydrogen sulfide; persulfide/polysulfide; sulfur metabolism; redox reaction; interaction/crosstalk; antioxidants; disease; therapy; detection methods

(This special issue belongs to the Section ROS, RNS and RSS)

Recent Advances in Applications of Nanoantioxidants

edited by

Anna Calarco

and Raffaele Conte

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2375 | Submission Open

Keywords: nanoantioxidants; nanoscale engineering; medicine; cosmetics; functional foods; material characterization

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidants and Food Supplements

edited by

Mariano Stornaiuolo

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2242 | Submission Open

Keywords: food supplements; natural bioactive compound; antioxidants; oxidative stress; cellular pathways; nutraceuticals; free radicals; health outcomes; disease prevention

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Striated Muscle and Other Tissues

edited by

Enrique Jaimovich

submission deadline 30 Jun 2025 | 1 articles | Viewed by 923 | Submission Open

Keywords: ROS/RNS production; mitochondria ROS; NADPH oxidase; metabolic regulation; cardiac oxidative stress; ROS sources; exercise-induced ROS/RNS; antioxidants; ROS/RNS in disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Biology and Genomic Integrity

edited by

Viktor Stolc

submission deadline 30 Jun 2025 | 1 articles | Viewed by 772 | Submission Open

Keywords: redox biology; reactive oxygen species (ROS); oxidative stress; oxidative DNA damage; genome stability; DNA repair; hypermutation; antioxidant defense mechanisms; mitochondrial dysfunction; Saccharomyces cerevisiae; cellular adaptation; epigenetics; telomeres

Polyphenolic Antioxidants in Food

edited by

Avi Shpigelman

and

Jelena Popović-Djordjević

submission deadline 30 Jun 2025 | 1 articles | Viewed by 579 | Submission Open

Keywords: polyphenols; antioxidant activity; bio-functionality; food sources; health benefits; polyphenol analytics

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Role of Antioxidants and Oxidative Stress in Neurodegenerative Diseases

edited by

Barbara Sottero

submission deadline 30 Jun 2025 | 1 articles | Viewed by 531 | Submission Open

Keywords: neurodegenerative diseases; antioxidants; oxidative stress; Parkinson’ s disease; Alzheimer’ s disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Activity of Olive Extracts and Their Applications

edited by

Alejandra Bermudez-Oria

and Fátima Rubio-Senent

submission deadline 30 Jun 2025 | Viewed by 484 | Submission Open

Keywords: olive extracts; antioxidant activity; polyphenols; carotenoids; chlorophylls; tocopherol; oxidative stress; cellular damage prevention; health benefits; extraction methods; green extraction techniques; nutritional applications; cosmetic applications

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

H₂S, Polysulfides and Antioxidases in Supporting Life: From Bacteria to Humans

edited by

Noriyuki Nagahara

submission deadline 30 Jun 2025 | Viewed by 451 | Submission Open

Keywords: H2S; polysulfides; antioxidases; bacteria; human

Oxidative Stress to DNA: Pathogenic Mechanism and Therapeutic Opportunity

edited by

Marco Giorgio

submission deadline 30 Jun 2025 | Viewed by 335 | Submission Open

Keywords: DNA damage; oxidative stress; antioxidants; epigenetics; aging

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

High-Fat Diet-Induced Oxidative Stress

edited by

María Teresa Llinas Más

and

Isabel Hernández

submission deadline 30 Jun 2025 | Viewed by 300 | Submission Open

Keywords: saturated fats; fats; high-fat diet; obesity; cardiovascular disease; non-alcoholic fatty liver disease; oxidative stress; antioxidants; cancer; neurodegenerative diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants from the Sea and Their Application

edited by

Daniela Giordano

and

Chiara Lauritano

submission deadline 30 Jun 2025 | Viewed by 234 | Submission Open

Keywords: marine natural products; marine enzymes; marine nutraceuticals; marine cosmeceuticals; food supplements; antioxidant mechanisms of action; structure– function relationship; antioxidant capacity; biotechnological application; biotechnological production

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Super Oxide Dismutase (SOD) Isoenzymes and Reactive Oxygen Species (ROS) in Immuno-Pathophysiology

edited by Giuseppina Ruggiero and

Paolo Mondola

submission deadline 30 Jun 2025 | Viewed by 216 | Submission Open

Keywords: superoxide dismutase (SOD) isoenzymes; superoxide dismutase (SOD)1; cell signalling; cell metabolism; cell functions; cellular stress; disease pathogenesis

Exploring the Role of Polyphenols in Oxidative Stress and Cellular Protection

edited by

Lucia Gimeno-Mallench

submission deadline 30 Jun 2025 | Viewed by 212 | Submission Open

Keywords: polyphenol; oxidative stress; cellular signaling; metabolic pathways

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Carotenoids in Health and Disease

edited by Kazutoshi Shindo

submission deadline 30 Jun 2025 | Viewed by 189 | Submission Open

Keywords: antioxidant activities of carotenoids; analytical chemistry on carotenoids; reactive oxygen species (ROS) and disease; production of carotenoids

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidants in Drugs and Health Products

edited by

Maria N. Modica

submission deadline 30 Jun 2025 | Viewed by 160 | Submission Open

Keywords: antioxidants; human diseases; polyphenols; hybrid compounds; drugs

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Sleep Disorders

edited by

Agata Gabryelska

submission deadline 30 Jun 2025 | Viewed by 136 | Submission Open

Keywords: sleep disorders; sleep apnea; insomnia; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Role of Redox in Pulmonary Vascular Diseases

edited by

Michael S. Wolin

and Sachin Gupte

submission deadline 1 Jul 2025 | 2 articles | Viewed by 2554 | Submission Open

Keywords: hypoxic pulmonary vasoconstriction; metabolic redox regulation; pulmonary circulation; pulmonary hypertension; pulmonary vascular disease; redox signaling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

New Strategies in Preventing Inflammatory and/or Oxidative Stress-Induced Damages in Ischemia-Reperfusion Injury, 2nd Edition

edited by

Borja Herrero de la Parte

Ignacio García-Alonso

and

Ana Alonso-Varona

submission deadline 10 Jul 2025 | 6 articles | Viewed by 6828 | Submission Open

Keywords: ischemia– reperfusion injury; reactive oxygen species; hypoxia; antioxidants; therapeutic management

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant and Antimicrobial Activity of Plant Extracts and Their Pharmacological Applications

edited by

Andrea Bunea

Sanda Andrei

and

Mihai Cosmin Cenariu

submission deadline 15 Jul 2025 | 4 articles | Viewed by 6424 | Submission Open

Keywords: plant extracts; polyphenols; carotenoids; antioxidants; antimicrobials; oxidative stress; microbial infections; herbal remedies; synergistic effects; therapeutic efficacy; safety profiles; natural alternatives

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Reactive Oxygen and Nitrogen Species in Plants―2nd Edition

edited by

Francisco J. Corpas

Rosa M. Rivero

and

José M. Palma

submission deadline 15 Jul 2025 | 3 articles | Viewed by 4942 | Submission Open

Keywords: antioxidants; hydrogen peroxide; nitric oxide; nitro-oxidative stress; ROS; RNS; hydrogen sulfide; melatonin

(This special issue belongs to the Section ROS, RNS and RSS)

Oxidative Stress and Neuroinflammation in Neurodegenerative Diseases: Mechanisms and Therapies

edited by Ana M. Munoz and

Jannette Rodríguez-Pallares

submission deadline 20 Jul 2025 | 10 articles | Viewed by 18732 | Submission Open

Keywords: neurodegeneration; aging; neuroprotection; mitochondrial dysfunction; cytokines; apoptosis; autophagy; microglia; astroglia; antioxidants; free radicals

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Phenolic Antioxidants—2nd Edition

edited by

Adriano Costa de Camargo

and

Fereidoon Shahidi

submission deadline 20 Jul 2025 | 1 articles | Viewed by 782 | Submission Open

Keywords: phenolics; phenolic compounds; antioxidants

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Something Is Rotten in the State of Redox—2nd Edition

edited by

Claus Jacob

Muhammad Jawad Nasim

and

Ahmad Yaman Abdin

submission deadline 20 Jul 2025 | Viewed by 232 | Submission Open

Keywords: antioxidants; antioxidant mechanisms; ageing and age-related diseases; oxidative stress; redox biology

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Effect of Oxidative Stress on Reproduction and Development—3rd Edition

edited by

Giulia Guerriero

and

Gerardino D’Errico

submission deadline 20 Jul 2025 | Viewed by 181 | Submission Open

Keywords: free radicals and antioxidants; oxidative stress in male and female reproduction; mitochondria; gametogenesis; assisted reproduction; thermal fertility limit (TFL); climate change; one-health; biodiversity conservation and sustainability; reproduction; development and nutrigenomics; methods for reactive oxygen species detection and antioxidant property determination.

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Brain Function—2nd Edition

edited by

Waldo Cerpa

submission deadline 21 Jul 2025 | 4 articles | Viewed by 3823 | Submission Open

Keywords: pathophysiological brain regulation; brain function; oxidative stress; brain damage; neurodegeneration; cellular signaling; neurotoxicity; excitotoxicity; synaptic transmission; cognitive function

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Dietary Polyphenols: Antioxidant Potential and Health Benefits

edited by

Małgorzata Olszowy-Tomczyk

submission deadline 25 Jul 2025 | Viewed by 301 | Submission Open

Keywords: dietary polyphenols; antioxidant properties; anticancer action; antimicrobial properties; anti-inflammatory actions; flavonoids; phenolic acids

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Protein Oxidative Modification in Brain Function, Brain Ageing and Neurological Diseases—2nd Edition

edited by

Sandra Anjo

Andreia N. Carvalho

and

Mattéa J. Finelli

submission deadline 25 Jul 2025 | Viewed by 292 | Submission Open

Keywords: protein oxidative modifications; post-translational modifications; S-glutathionylation; S-nitrosylation/S-nitrosation; persulfidation; redox signaling; oxidative and nitrosative stresses; cysteine oxidation; antioxidants; redox-based pharmacological/therapeutic approaches; mitochondrial dysfunction; mitochondria-targeted molecules; brain function and ageing; neurological/neurodegenerative diseases; proteomics

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Biology of Glyoxalases and Advanced Glycation End Products in Health and Diseases

edited by

Cinzia Antognelli

Marilena Pariano

and

Vincenzo Nicola Talesa

submission deadline 25 Jul 2025 | Viewed by 186 | Submission Open

Keywords: glyoxalases; methylglyoxal; advanced glycation end products; aging; diseases; antioxidants; apoptosis; cell proliferation; nutraceuticals; oxidative stress; inflammation; apoptosis; EMT; cell proliferation; signal transduction; biological mechanisms

(This special issue belongs to the Section Antioxidant Enzyme Systems)

The Role of Oxidative Stress in Male Infertility

edited by

Suresh C. Sikka

submission deadline 30 Jul 2025 | 2 articles | Viewed by 2199 | Submission Open

Keywords: male infertility; seminal reactive oxygen species; sperm; reactive nitrogen species; antioxidant

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Its Mitigation in Neurodegenerative Disorders

edited by

D. Allan Butterfield

submission deadline 30 Jul 2025 | Viewed by 363 | Submission Open

Keywords: oxidative stress; neurodegenerative disorders; brain; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Nrf2 and Cardiovascular Function, Diseases, and Therapeutic Targets

edited by

Gao Lie

and

Irving H. Zucker

submission deadline 30 Jul 2025 | Viewed by 334 | Submission Open

Keywords: nuclear factor erythroid 2-related factor 2 (Nrf2); Nrf2-targeted therapies; cardiovascular diseases; antioxidant; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Defenses Against Stress Caused by Physical or Chemical Environmental Changes

edited by

Paola Irato

submission deadline 30 Jul 2025 | Viewed by 157 | Submission Open

Keywords: antioxidant defenses; oxidative stress; redox state; physical stress; chemical stress; environmental changes; kingdoms living; heat stress; UV light; CO2 and O3; heavy metals

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Environmental Risk Factors and Oxidative Stress in the Retina

edited by

Adrian Gericke

submission deadline 30 Jul 2025 | Viewed by 125 | Submission Open

Keywords: environment; pollution; oxidative stress; retina

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Phytochemicals for Promoting Human Health and Well-Being

edited by

Teresa Mencherini

Francesca Sansone

and

Tiziana Esposito

submission deadline 30 Jul 2025 | Viewed by 124 | Submission Open

Keywords: antioxidant phytochemicals; oxidative stress; health promotion; chronic disease; functional foods; nutraceuticals

Antioxidant Response in Skeletal Muscle

edited by Jan Górski and

Elzbieta Supruniuk

submission deadline 31 Jul 2025 | 4 articles | Viewed by 9846 | Submission Open

Keywords: antioxidants; skeletal muscle; exercise; muscle injury; metabolic diseases; muscle dystrophy; cancer; immobilization

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant and Antimicrobial Activity of Honey Bee Products—2nd Edition

edited by

Josipa Vlainić

and

Ivana Tlak Gajger

submission deadline 31 Jul 2025 | 6 articles | Viewed by 7133 | Submission Open

Keywords: honey bee products; antioxidant capacity; antimicrobial efficacy; polyphenol content; functional food; health promotion

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Oxidative Stress and NRF2 in Health and Disease—2nd Edition

edited by

Lidija Milković

submission deadline 31 Jul 2025 | 3 articles | Viewed by 4385 | Submission Open

Keywords: oxidative stress; redox signaling; NRF2 and its regulation; redox-modifying therapeutic approach; omics approach; physiology; non-communicable diseases; metabolism; aging

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Harnessing Redox Status and Novel Molecular Signals and Targets Involved in Oxidative Stress to Afford Cardioprotection: From Experimental Insights to Clinical Applications

edited by

Tommaso Angelone

Carmine Rocca

and Anna De Bartolo

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3009 | Submission Open

Keywords: oxidative stress; redox signaling; cardioprotection; antioxidants; heart disease; vascular dysfunction; molecular targets; therapeutic approaches

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Influence of Gut Microbiota on Antioxidant Capacity of Foods—2nd Edition

edited by

Sergio Pérez Burillo

and

José Ángel Rufián-Henares

submission deadline 31 Jul 2025 | 1 articles | Viewed by 2368 | Submission Open

Keywords: antioxidant capacity; antioxidant molecules; polyphenols; gut microbiota; microbial metabolites

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

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