Implication of Oxidative Stress in Promoting Cellular Senescence and Associated Pathologies—2nd Edition
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 2561
Special Issue Editor
Interests: redox signaling; oxidative stress; antioxidants; iron homeostasis; labile iron; apoptotic cell death; cellular senescence
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cellular responses to reactive oxygen species (ROS) depend on the nature, the level, the duration, and the cells’ ability to cope with the oxidant stimulus to which they are exposed. Basic steady-state levels of ROS oxidize specific targets and regulate the signaling pathways implicated in various physiological processes (redox signaling). However, deviation from this steady state leads to unspecific oxidation, thus disrupting redox signaling and/or causing macromolecular damage. Depending on the severity of the damage, cell responses can range from permanent growth arrest (cellular senescence) to programmed cell death (apoptosis or ferroptosis), or, in more extreme conditions, necrotic cell death.
Cellular senescence, as a stable growth arrest program, has evolved as a mechanism to prevent the propagation of unwanted cells. Yet, senescent cells are not inert; despite the accelerated accumulation of macromolecular damage, they remain alive for prolonged periods and release factors that can harm neighboring healthy cells, as well as the very cells that produce these factors. Accordingly, their accumulation within tissues and organs contributes to tissue dysfunction and gives rise to pathological manifestations, organ ageing, and age-related diseases.
In this regard, unraveling the underlying mechanisms of oxidative stress-induced cellular senescence will contribute significantly to the development of new strategies combatting ageing and age-related pathologies. This Special Issue aims to elucidate the interrelationships of oxidative stress and cellular senescence and their contribution to ageing and age-related pathologies.
We look forward to receiving your contributions.
Dr. Alexandra Barbouti
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- free radicals
- reactive oxygen species (ROS)
- cellular senescence
- ageing
- age-related pathologies
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