Regulatory Effects of Curcumin, 2nd Edition

Dear Colleagues,

The first edition of the Special Issue "Regulatory Effects of Curcumin" has been assembled and has shown the ability of curcumin to affect multiple cellular pathways relevant for the prevention of disease in several organisms. At the molecular level, these effects can be explained by antioxidant, prooxidant, and non-antioxidant actions of curcumin and its metabolites, leading to changes in signaling and gene expression. At the cellular level, curcumin affects inflammation, lipid homeostasis, senescence, mitochondrial β-oxidation, the permeability of intestinal epithelial cell layers, and bacterial growth and biofilm formation, amongst other events. At the organism level, these regulatory effects are more difficult to achieve, and a myriad of nano-formulations are being developed with the increased solubility, stability, and bioavailability of curcumin. However, it turns out that nano-formulations do not equally facilitate the action of curcumin as they depend on the route of uptake, the chemical composition, and physical characteristics such as size and charge, and each application may require specific design and optimization.

In this second edition of the journal Antioxidants, we anticipate an expansion on these aforementioned topics and expect more studies assessing how diseases can be prevented by enhancing the bioavailability and bioactivity of curcumin and its metabolites.

Dr. Jean-Marc Zingg
Dr. Kiyotaka Nakagawa
Dr. Taiki Miyazawa
Guest Editors

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