Oxidative Stress and Sperm: Technical, Biological and Clinical Aspects—2nd Edition
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 660
Special Issue Editor
Interests: male infertility; sperm biology; oxidative stress; sperm DNA fragmentation; semen analysis; flow cytometry; nutrition; environmental pollution
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress appears to be an underlying cause for many cases of male infertility, as it could be the converging step for several environmental, biological and lifestyle factors impacting sperm formation and function. Induction of reactive oxygen species production is detrimental during in vitro sperm manipulation, including selection for oocyte insemination and semen cryopreservation, posing a potential risk to couples treated with assisted reproductive techniques. Oxidative stress is one of the main mechanisms responsible for sperm DNA damage, including DNA fragmentation, a genome anomaly negatively affecting both natural and assisted reproduction. In addition, emerging data suggest that oxidative stress could alter the sperm epigenome. Both genetic and epigenetic damage has the potential to impact not only male reproductive function but also embryo development and the health of offspring.
In this context, further research in this field appears to be of the upmost importance. However, despite a huge number of published studies, there are many areas that remain little explored, including, but not limited to, the following: reliable techniques for revealing oxidative stress; the biological mechanisms of inducing genetic and epigenetic sperm damages; and the clinical meaning and use of the knowledge in this field. The poor clinical results obtained up to now for in vitro and/or in vitro treatment with antioxidant compounds further underline the need for deeper knowledge on this topic.
Dr. Monica Muratori
Guest Editor
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Keywords
- male infertility
- ROS
- oxidative sperm DNA damage
- sperm DNA fragmentation
- sperm epigenetic damage
- assisted reproductive techniques
- in vitro sperm manipulation
- antioxidants
- embryo development
- pregnancy
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