Antioxidant Activity of Grape and Grape By-Products

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 926

Special Issue Editors


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Guest Editor
1. Faculty of Sciences and Arts, Valahia University of Targoviste, 13 Sinaia Alley, 130004 Targoviste, Romania
2. Doctoral School Chemical Engineering and Biotechnology, National University of Science and Technology Politehnica of Bucharest, 313 Splaiul Independenței, 060042 Bucharest, Romania
3. Academy of Romanian Scientists, 3 Ilfov, 050044 Bucharest, Romania
Interests: material science; nanomaterials; spectrometry; spectroscopy; heterocyclic compounds with biological potential
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Guest Editor Assistant
Faculty of Sciences and Arts, Valahia University of Targoviste, 13 Sinaia Alley, 130004 Targoviste, Romania
Interests: antioxidants; cosmetic formulation; vibrational spectroscopy; chromatography

Special Issue Information

Dear Colleagues,

Grapes are one the most consumed fruits worldwide, whether as fresh table fruits or as processed products such as wine, juice, and sauce, among others. It is well known that grapes are a major source of antioxidants, including phenolic compounds, flavonoids, and carotenoids, which can reduce the risk of oxidative damage by scavenging free radicals, oxygen, and chelating catalytic metals. Additionally, by-products of the winemaking industry are particularly rich in polyphenols with important biological activities. Grape pomace is currently only partially exploited for the extraction of seed oil, which is used as an additional source of oil in the pharmaceutical industry due to its pharmacodynamic properties, including antioxidant, antibacterial, hypocholesterolemic, and cytostatic effects, among others.  Additionally, grape extracts are a good natural source of antioxidants (i.e., anthocyanin, catechin, epicatechin, resveratrol, proanthocyanidin, etc.) and have anticarcinogenic, anti-inflammatory, and antiproliferative properties when they are included in different drug or cosmetic formulations. Most grape phenolic antioxidants are found in the skin and seeds. Resveratrol, anthocyanins, and catechins are present in grape skins, while procyanidins are concentrated in the seeds. In addition, grape seeds contain significant amounts of polyunsaturated fatty acids, especially linoleic acid.

Polyphenols’ health benefits are overwhelmingly affected by their instability. For this reason, encapsulation techniques and various agents, such as emulsion-based encapsulation techniques and encapsulation in collagen/the organic–inorganic matrix, represent valuable alternatives for the pharmaceutical/cosmetic industry. Microcapsules containing polyphenols as delivery systems for stable and bioavailable compounds represent an additional alternative for natural skin care and cosmetic formulations.

We invite researchers to submit original, innovative research articles and/or reviews that explore the potential of natural compounds from grapes and/or grape by-products to be applied in the medical, cosmetic, pharmaceutical, and/or food fields.

Prof. Dr. Cristiana Radulescu
Guest Editor

Dr. Radu Lucian Olteanu
Guest Editor Assistant

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Keywords

  • antioxidants
  • grapes and grape by-products
  • extracts
  • cosmetic formulations
  • chromatography
  • microencapsulation
  • phytochemical profile
  • microbiological assay

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Published Papers (1 paper)

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Research

29 pages, 2721 KB  
Article
Development and Characterization of Liposome-Based Dermocosmetic Formulations with Red Grape Pomace and Polygonum cuspidatum Extracts
by Cristiana Radulescu, Radu Lucian Olteanu, Claudia Lavinia Buruleanu, Raluca Maria Stirbescu, Andreea Laura Banica, Ramona-Daniela Pavaloiu, Fawzia Sha’at, Maria Monica Petrescu and Gabriela Stanciu
Antioxidants 2025, 14(10), 1182; https://doi.org/10.3390/antiox14101182 - 28 Sep 2025
Viewed by 544
Abstract
The use of antioxidants in the dermatocosmetic industry has become increasingly popular to help protect and stabilize other sensitive active ingredients, prolonging the effectiveness and durability of the cosmetic product. Grape pomace, as the main by-product generated through winemaking, and Polygonum cuspidatum, [...] Read more.
The use of antioxidants in the dermatocosmetic industry has become increasingly popular to help protect and stabilize other sensitive active ingredients, prolonging the effectiveness and durability of the cosmetic product. Grape pomace, as the main by-product generated through winemaking, and Polygonum cuspidatum, concentrate bioactive metabolites with high antioxidant activity. Hydroalcoholic extracts obtained from grape pomace (Merlot and Feteasca Neagra varieties) and the root and flower of Japanese knotweed, respectively, alone and in mixtures, were characterized, and preliminary assays were conducted for their incorporation in two gel-based cosmetic formulations. The characterization of the extracts revealed the presence of catechin, vanillic acid, caffeic acid, myricetin, resveratrol, and kaempferol. The hydroalcoholic extract of P. cuspidatum flower and root was found to have the highest content of total phenolic compounds (10.920 ± 0.268 mg GAE/mL, respectively, 4.751 ± 0.072 mg GAE/mL), and the highest antioxidant activity (expressed as DPPH Radical Scavenging Capacity, IC50) by 28.04 ± 1.12 µg GAE/mL and 83.91 ± 1.13 µg GAE/mL, respectively. Catechin was the most abundant polyphenol found in pomace extract (687.87 mg/kg). The type and the concentration of the plant extract used in dermatocosmetic gel formulations influenced their antioxidant activity. Encapsulation of P. cuspidatum flower extract in liposomes prior to their incorporation into the gel formulation demonstrated the role of liposomes in enhancing the stability and modulation of phenolic compound delivery. It is worth noting that this dermatocosmetic formulation, which contains the flower extract of P. cuspidatum, was the subject of a pending patent application. Full article
(This article belongs to the Special Issue Antioxidant Activity of Grape and Grape By-Products)
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