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Antioxidants
Special Issues
Unveiling the Essential Role of Coenzyme Q in Health
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Unveiling the Essential Role of Coenzyme Q in Health

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1568

Special Issue Editors

Dr. Guillermo López Lluch

E-Mail Website
Guest Editor
Department of Physiology, Anatomy and Cell Biology, Andalusian Centre of Developmental Biology, Universidad Pablo de Olavide, 41013 Seville, Spain
Interests: aging; metabolism; antioxidants; calorie restriction; physical activity; exercise; neurodegeneration; muscle; liver; immunology
Special Issues, Collections and Topics in MDPI journals
Dr. Steen Larsen

E-Mail Website
Guest Editor
1. Department of Biomedical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
2. Clinical Research Centre, Medical University of Bialystok, 15-089 Bialystok, Poland
Interests: exercise training; mitochondria; skeletal muscle; humans
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Welcome to the 11th Conference of the International Coenzyme Q10 Association, which will be held in a hybrid format at the University of Copenhagen, Denmark, from 16 to 19 June 2025. We look forward to your participation in this event. More details can be found at: https://icq10a.com/11th-conference-of-the-international-coenzyme-q-10-association/.

This Special Issue will publish selected papers presented during the meeting and will include insights and perspectives on the following topics:

  1. New advances in CoQ biosynthesis;
  2. Use of precursors to increase coenzyme Q biosynthesis;
  3. Primary and secondary deficiencies;
  4. Different clinical aspects of CoQ;
  5. CoQ in cognitive deficiency and persistent COVID;
  6. CoQ in cardiovascular disease and hearth failure;
  7. Bioavailability of coenzyme Q10;
  8. Sport, physical activity, and CoQ;
  9. CoQ in healthy aging;
  10. How to start CoQ10 supplementation in a patient?

We expect that this conference will present new and exciting developments on the role of coenzyme Q in health and disease, as well as new insights into its biosynthesis pathway. The Scientific Committee cordially welcomes you, and we look forward to your contribution.

Dr. Guillermo López Lluch
Dr. Steen Larsen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coenzyme Q10
  • CoQ biosynthesis
  • ROS
  • cognitive deficiency
  • cardiovascular disease

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Published Papers (1 paper)

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Research

13 pages, 4338 KB  
Article
A Nanoformulation of Ubiquinol and Selenium Promotes Proliferation of Human Induced Pluripotent Stem Cells
by Filomain Nguemo, Hai Zhang, Annette Koester, Susan Rohani, Sureshkumar Perumal Srinivasan and Jürgen Hescheler
Antioxidants 2025, 14(9), 1100; https://doi.org/10.3390/antiox14091100 - 10 Sep 2025
Viewed by 642
Abstract
Human induced pluripotent stem cells (hiPSCs) hold immense promise for regenerative medicine. However, a critical barrier to the clinical application of hiPSCs is the difficulty in promoting robust cell proliferation while preserving their pluripotent state. Efficient hiPSC expansion without loss of pluripotency is [...] Read more.
Human induced pluripotent stem cells (hiPSCs) hold immense promise for regenerative medicine. However, a critical barrier to the clinical application of hiPSCs is the difficulty in promoting robust cell proliferation while preserving their pluripotent state. Efficient hiPSC expansion without loss of pluripotency is crucial for generating high quality cells or therapeutic applications, disease modeling, and drug discovery. In our study, we investigated the effects of QuinoMit Q10® fluid (QMF-Se), a nanoformulated supplement containing Ubiquinol (the active form of Coenzyme Q10) and Selenium, on hiPSC growth and maintenance in vitro. Interesting, QMF-Se supplementation significantly enhances hiPSC proliferation compared to control cultures. This increase in cell number was accompanied by heightened mitochondrial activity, suggesting improved cellular energy metabolism. Importantly, the expression of core pluripotency markers OCT4, NANOG, and SOX2 remained unaltered, confirming that the stem cells retained their undifferentiated status. Moreover, we observed that QMF-Se treatment conferred protective effects during the freeze–thaw process, reducing cell death and supporting post-thaw recovery. These results indicate that QMF-Se may improve both cell culture efficiency and cryopreservation outcomes. Overall, our findings highlight the potential of QMF-Se as a valuable additive for hiPSC culture systems, contributing to more efficient and reliable expansion protocols in regenerative medicine research. Full article
(This article belongs to the Special Issue Unveiling the Essential Role of Coenzyme Q in Health)
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