Oxidative/Nitrosative Stress in Cardiovascular Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1972

Special Issue Editors


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Guest Editor
Laboratory of Cardiovascular Physiology, Dipartimento di Scienze Cliniche e Biologiche, Università Degli Studi di Torino, Regione Gonzole 10, 10043 Orbassano, Italy
Interests: cardiovascular system; physiological endothelial functions; coronary circulation; metabolism; contractility; myocardial protection; endothelial cells; vitamins
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Laboratory of Cardiovascular Physiology, Dipartimento di Scienze Cliniche e Biologiche, Università Degli Studi di Torino, Regione Gonzole 10, 10043 Orbassano, Italy
Interests: cardiovascular system; coronary circulation; myocardial protection; extracellular vesicles; ischemia/reperfusion injury

Special Issue Information

Dear Colleagues,

In recent years, greater knowledge has been achieved regarding the mechanisms underlying the oxidative stress leading to cardiovascular diseases. However, a more detailed understanding is required for the improvement and optimization of therapeutic approaches.

In this issue, we intend to focus on new advances in our knowledge of the pathogenesis of oxidative stress in cardiovascular disease pathogenesis, as well as new therapeutic strategies.

We therefore invite investigators to contribute original research articles, as well as review articles, in order to explore the pathological manifestations, molecular mechanisms, and innovative pharmacological approaches preventing and/or managing this condition. Articles involving different experimental models are welcome.

Potential topics include, but are not limited to, the following:

  • Novel molecules/signaling pathways/mechanisms implicated in oxidative stress associated with cardiovascular disease pathogenesis;
  • New therapeutic avenues/the development of specific treatments;
  • Novel animal experimental models, studying oxidative stress in I/R injury;
  • Omics as new approaches in cardiovascular diseases;
  • Extracellular vesicles as prognostic/diagnostic biomarkers;
  • Diets, exercise, and aging;
  • New clinical management strategies in cardiology and cardio-oncology fields.

Prof. Dr. Claudia Penna
Dr. Saveria Femminò
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • cardiovascular disease
  • therapeutic approaches
  • biomarkers
  • exercise
  • aging

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Published Papers (1 paper)

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Review

22 pages, 1436 KiB  
Review
Redox Homeostasis and Molecular Biomarkers in Precision Therapy for Cardiovascular Diseases
by Cristina Manuela Drăgoi, Camelia Cristina Diaconu, Alina Crenguța Nicolae and Ion-Bogdan Dumitrescu
Antioxidants 2024, 13(10), 1163; https://doi.org/10.3390/antiox13101163 - 25 Sep 2024
Cited by 6 | Viewed by 1396
Abstract
Precision medicine is envisioned as the future of cardiovascular healthcare, offering a more tailored and effective method for managing cardiovascular diseases compared to the traditional one-size-fits-all approaches. The complex role of oxidative stress in chronic diseases within the framework of precision medicine was [...] Read more.
Precision medicine is envisioned as the future of cardiovascular healthcare, offering a more tailored and effective method for managing cardiovascular diseases compared to the traditional one-size-fits-all approaches. The complex role of oxidative stress in chronic diseases within the framework of precision medicine was carefully explored, delving into the cellular redox status and its critical involvement in the pathophysiological complexity of cardiovascular diseases (CVDs). The review outlines the mechanisms of reactive oxygen species generation and the function of antioxidants in maintaining redox balance. It emphasizes the elevated reactive oxygen species concentrations observed in heart failure and their detrimental impact on cardiovascular health. Various sources of ROS within the cardiovascular system are examined, including mitochondrial dysfunction, which contributes to oxidative stress and mitochondrial DNA degradation. The article also addresses oxidative stress’s role in myocardial remodeling, a process pivotal to the progression of heart diseases. By integrating these aspects, the review underscores the importance of redox homeostasis and identifies molecular biomarkers that can enhance precision therapy for CVDs. The insights provided aim to pave the way for targeted therapeutic strategies that mitigate oxidative stress, thereby improving patient outcomes in cardiovascular medicine. Full article
(This article belongs to the Special Issue Oxidative/Nitrosative Stress in Cardiovascular Diseases)
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