Oxidative Stress and NRF2 in Diabetes
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 1268
Special Issue Editor
2. Metabolism Division, University of Minnesota Medical School, Minneapolis, MN, USA
Interests: pancreas islet; insulin dependent diabetes mellitus; cytokines; endocrinology; diabetes; oxidative stress; Nrf2
Special Issue Information
Dear Colleagues,
Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels, which can lead to severe complications if not managed properly. One of the critical pathological mechanisms in diabetes is oxidative stress, which arises from an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to detoxify these reactive intermediates through antioxidants.
Oxidative stress is implicated in the progression of both type 1 and type 2 diabetes, contributing to insulin resistance, impaired insulin secretion, and beta-cell dysfunction. It also plays a significant role in the development of diabetes-related complications such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. NRF2 is a transcription factor that regulates the expression of antioxidant proteins that protect against oxidative damage. In the context of diabetes, activating the NRF2 pathway could potentially restore redox balance, assist beta cell repair, improve insulin sensitivity, and reduce the incidence of complications.
The Special Issue on “Oxidative Stress and NRF2 in Diabetes” aims to bring together research and review articles that delve into the mechanisms by which NRF2 modulates oxidative stress in diabetes and explore therapeutic strategies targeting NRF2 to ameliorate diabetes-related oxidative damage. It will highlight advances in the understanding of how NRF2 can be leveraged to develop novel treatments that improve diabetic outcomes by enhancing the body’s antioxidant defenses.
Dr. R. Paul Robertson
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- NRF2
- ROS
- diabetes
- diabetes-related complications
- insulin
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