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Journals
Antioxidants
Special Issues
Applications and Health Benefits of Novel Antioxidant Biomaterials—2nd Edition
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Applications and Health Benefits of Novel Antioxidant Biomaterials—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 1465

Special Issue Editors

Prof. Dr. Washington Luiz Esteves Magalhães

E-Mail Website
Guest Editor
1. Programa de Pós-Graduação em Engenharia e Ciência dos Materiais-PIPE, Universidade Federal do Paraná, Curitiba 81531-990, PR, Brazil
2. Embrapa Florestas, Colombo 83411-000, PR, Brazil
Interests: materials science; biomaterials; nanocellulose
Special Issues, Collections and Topics in MDPI journals
Dr. Tielidy Lima

E-Mail Website
Guest Editor Assistant
PRISM Research Institute, Technological University of the Shannon, N37 HD68 Athlone, Ireland
Interests: hydrogels; nanotechnology; controlled drug delivery; polymer materials; nanocellulose; biodegradable polymers; natural polymers; materials characterization; inflammation; antioxidants; natural compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials with different biological properties have gained prominence in the medical, dental, and tissue engineering fields due to their beneficial effects on health, and, as they are biocompatible materials, they can prevent cellular aging, protect against chronic diseases, and promote cell regeneration. Therefore, for this Special Issue on the “Applications and Health Benefits of Novel Antioxidant Biomaterials—2nd Edition”, we invite researchers to publish studies related to the use of new biomaterials for tissue regeneration and healing in a variety of areas; protection against chronic, inflammatory, and cancerous diseases; improving biocompatibility and reducing rejection of orthopedic and dental implants; creating replacement tissues, such as skin, cartilage, and bone; preventing premature aging; and the controlled release of therapeutic substances directed to target cells. In view of technological and scientific advances, other applications/studies are being explored and will be welcome these in our Special Issue. In this sense, antioxidant biomaterials, with their ability to neutralize reactive oxygen species, have become promising in terms of the prevention, treatment, and regeneration of tissues and organs.

Prof. Dr. Washington Luiz Esteves Magalhães
Guest Editor

Dr. Tielidy Lima
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant biomaterials
  • tissue regeneration
  • biocompatibility
  • controlled release
  • premature aging

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Published Papers (1 paper)

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Review

22 pages, 830 KB  
Review
Beyond Biocompatibility: Immune Dysregulation, Oxidative Stress, and Tissue Intolerance Associated with Ti-6Al-4V Dental Implants—A Critical Review and Perspective
by Żaneta Anna Mierzejewska, Łukasz Woźniak, Jérôme R. Lechien, Jan Borys, Kamila Łukaszuk and Bożena Antonowicz
Antioxidants 2026, 15(3), 365; https://doi.org/10.3390/antiox15030365 - 13 Mar 2026
Cited by 1 | Viewed by 949
Abstract
Titanium and its alloys are widely used in dental implantology due to their favorable mechanical properties and well-documented long-term clinical performance. Among them, Ti-6Al-4V is particularly common in load-bearing applications. Nevertheless, a growing body of experimental and clinical evidence suggests that Ti-6Al-4V implants [...] Read more.
Titanium and its alloys are widely used in dental implantology due to their favorable mechanical properties and well-documented long-term clinical performance. Among them, Ti-6Al-4V is particularly common in load-bearing applications. Nevertheless, a growing body of experimental and clinical evidence suggests that Ti-6Al-4V implants cannot be regarded as biologically inert in all patients. Adverse tissue responses, such as impaired healing, chronic peri-implant inflammation, and unexplained implant failure, have been reported even in the absence of classical risk factors, including infection, mechanical overload, or confirmed metal allergy. This critical review challenges the prevailing assumption that these complications are driven primarily by mechanical or immunoallergic mechanisms. Instead, oxidative stress is proposed as a central and unifying factor underlying adverse tissue reactions to Ti-6Al-4V dental implants. Corrosion, tribocorrosion, and mechanical wear lead to the release of titanium-, aluminum-, and vanadium-containing particles and ions, which promote excessive generation of reactive oxygen species at the implant–tissue interface. The resulting redox imbalance disrupts bone remodeling, impairs osteogenic differentiation, and maintains a pro-inflammatory microenvironment. Importantly, pathology arises not merely from increased reactive oxygen species production, but from the failure of local antioxidant defense systems to counteract this burden. Insufficient enzymatic and transcriptional antioxidant responses result in persistent redox imbalance, sustained innate immune activation, and progressive tissue intolerance. Oxidative stress is therefore conceptualized not as a secondary byproduct of inflammation, but as a primary driver of immune dysregulation through chronic macrophage activation and inflammasome signaling. This redox-driven feedback loop amplifies tissue damage and compromises long-term osseointegration independently of classical adaptive immune sensitization. Recognizing oxidative stress as a key determinant of implant–tissue interactions offers a more coherent framework for understanding implant-related complications and underscores the need for redox-aware biomaterial strategies and individualized patient risk assessment. Full article
(This article belongs to the Special Issue Applications and Health Benefits of Novel Antioxidant Biomaterials—2nd Edition)
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