Oxidative Stress and Skin Disorders: Therapeutic Potential of Antioxidants
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 86
Special Issue Editor
Interests: melanin; melanocyte; melanosome; pigmentation; tyrosinase; ultraviolet light
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is known that the energy of ultraviolet radiation is absorbed by amino acids and vitamins in the skin and generates various kinds of reactive oxygen species (ROS). In addition, even without exposure to ultraviolet radiation, a substantial amount of superoxide, which is generated when mitochondria produce ATP, is converted into ROS by enzymes and metal ions in the skin. Although ROS are necessary for some physiological functions, they also accelerate aging and can cause various diseases. For example, many research studies have shown that hydrogen peroxide is deeply involved in triggering vitiligo, a cutaneous depigmentary disorder. Hydrogen peroxide has a longer half-life than other ROS and thus accumulates in the skin. If the hydrogen peroxide scavenging ability is reduced for some reason, the concentration of hydrogen peroxide in the skin increases, resulting in the death of melanocytes that produce melanin pigmentation and the detachment of melanocytes from the basement membrane, which reduces the production of cutaneous pigmentation. Therefore, the research and development of topical and/or oral agents or active ingredients that directly eliminate various kinds of ROS, or that activate the intracellular ROS scavenging system, are desirable. In this Special Issue, we invite submissions of research papers on skin diseases or related basic research using skin cells in which ROS have been suggested to be involved. Research on antioxidants and other agents that may prevent or ameliorate skin aging and diseases is also welcome.
Prof. Dr. Hideya Ando
Guest Editor
Manuscript Submission Information
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Keywords
- ultraviolet radiation
- reactive oxygen species
- oxidative stress
- skin disorders
- skin aging
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