Therapeutic Potential of Natural Antioxidants in Respiratory Diseases and Airway Inflammation

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 739

Special Issue Editor


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Guest Editor
Department of Microbiology, Wonkwang University School of Medicine, Iksan 54538, Republic of Korea.
Interests: antioxidants; oxidative stress; respiratory diseases; airway inflammation

Special Issue Information

Dear Colleagues,

Oxidative stress significantly contributes to respiratory diseases, causing acute and chronic lung injuries through inflammation and cellular damage. These reactive molecules disrupt cellular balance, weaken protective mechanisms, and trigger inflammatory responses, ultimately worsening lung conditions. The pulmonary epithelium, which is continually exposed to environmental and metabolic oxidants, relies on complex antioxidant defense systems to maintain redox balance and protect against oxidative damage. Although therapies based on antioxidants have been researched to combat these effects, their clinical effectiveness remains limited, making the development of new treatments essential.

Natural antioxidants, derived from various natural products and their bioactive compounds, have shown promise in reducing oxidative stress and lung inflammation. These antioxidants can help to restore cellular balance, decrease oxidative damage, and modulate inflammatory pathways, potentially providing therapeutic benefits. However, additional research is necessary to fully understand their mechanisms and optimize their clinical applications. This Special Issue of Antioxidants aims to present cutting-edge research on the therapeutic potential of natural antioxidants in respiratory diseases and airway inflammation. We welcome original studies and reviews that investigate the role of antioxidants in lung conditions related to oxidative stress, novel therapeutic approaches, and translational insights for clinical use.

Dr. Yo-Han Han
Guest Editor

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Keywords

  • natural product
  • acute/chronic lung injury
  • inflammation
  • oxidative stress

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Published Papers (1 paper)

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Review

19 pages, 305 KB  
Review
Recent Advances in Exosome-Based Therapeutic Strategies for Acute Lung Injury: Mechanisms and Translational Advances
by Joon-Ha Song, Hye-Ryun Kim, Dong-Ha Song, Su-Min Jin, Won-Jae Ko, Jinbong Park, Ki-Eun Hwang and Yohan Han
Antioxidants 2026, 15(5), 617; https://doi.org/10.3390/antiox15050617 - 13 May 2026
Viewed by 343
Abstract
Inflammatory lung diseases are characterized by complex immune dysregulation and structural tissue damage, demanding the development of novel therapeutic and diagnostic strategies. Exosomes (Exos) have emerged as promising alternatives to address these challenges by serving as key mediators and effective therapeutic nanocarriers. This [...] Read more.
Inflammatory lung diseases are characterized by complex immune dysregulation and structural tissue damage, demanding the development of novel therapeutic and diagnostic strategies. Exosomes (Exos) have emerged as promising alternatives to address these challenges by serving as key mediators and effective therapeutic nanocarriers. This review systematically analyzes the multifunctional roles of Exos derived from various sources, including immune cells, mesenchymal stem cells (MSCs), lung structural cells, and non-mammalian sources such as plants and milk, in the context of inflammatory lung diseases. These vesicles modulate critical pathological processes, such as macrophage polarization, oxidative stress, and programmed cell death, by delivering functional cargos, including miRNAs and proteins. Studies demonstrating the antioxidant properties of Exos are classified, and their roles in attenuating oxidative stress-mediated lung injury are discussed. Furthermore, engineering and priming strategies, as well as airway-directed delivery methods such as nebulization, are reported to enhance therapeutic efficacy and targeting. Evidence also indicates that plant-derived Exos could be scalable and safer alternatives to mammalian cell-derived Exos. Collectively, Exos represent a next-generation platform for precision medicine, functioning as potent therapeutic agents and efficient drug-delivery systems for the treatment of complex inflammatory lung diseases. Full article
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