Redox Regulation in COPD: Therapeutic Implications of Antioxidants

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 50

Special Issue Editor


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Guest Editor
Instituto de Ciências Biomedicas, Universidade Federal do Rio Janeiro, Rio de Janeiro 21941-590, RJ, Brazil
Interests: redox biology and inflammation related to acute and chronic lung diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Redox regulation is pivotal in the pathogenesis of chronic obstructive pulmonary disease (COPD) and related conditions, including asthma, emphysema, chronic bronchitis, bronchiectasis, and fibrosis. Oxidative stress, arising from an imbalance between oxidants and antioxidants, can induce chronic inflammation, tissue damage, and disease progression. Experimental studies in animal models and clinical trials in patients have investigated the therapeutic potential of natural and synthetic antioxidants in mitigating oxidative stress and modulating redox pathways. The findings suggest benefits in reducing exacerbations, improving lung function, and attenuating fibrotic processes; however, challenges pertaining to bioavailability and dosing persist. This Special Issue invites authors to submit original research or literature reviews addressing redox regulation in pulmonary diseases, focusing on molecular mechanisms, experimental models, or clinical interventions with antioxidants. Contributions exploring novel therapeutic strategies or elucidating current limitations are particularly encouraged, aiming to advance knowledge on and the treatment of these debilitating conditions.

Dr. Samuel Santos Valença
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • COPD
  • oxidative stress
  • antioxidants
  • pulmonary diseases
  • therapeutics

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Published Papers

This special issue is now open for submission.
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