Modulation of Gut Microbiota and Oxidative Stress to Counteract or Prevent Human Disease

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 988

Special Issue Editors


E-Mail Website
Guest Editor
Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Interests: natural compounds; medicinal chemistry; food chemistry; antioxidants; antimicrobials; anti-inflammatory; anticancer; extraction; bioactive compounds; nutraceutical; well-being; food supplement; functional food
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy
Interests: food compounds; pharma-toxicological evaluation of herbal extracts and natural compounds
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy
Interests: medicinal chemistry; drug discovery; aromatase inhibitors; PPAR ligands; anticancer agents
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Department of Pharmacy, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Interests: inflammation; hyaluronic acid; biomaterials; oxidative stress; tendons
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Several recent works have emphasized links between the gut and the brain, and the gut microbiota has been shown to play an essential role in neurodegenerative disorders. Moreover, in patients affected by neurodegenerative disorders, an imbalanced gut microbiota has been demonstrated to be a consequence of chronic neuroinflammation. Within the framework of the “THE - Tuscany Health Ecosystem” project, funded by the European Union—NextGenerationEU; MACMI CUP: D73C24000960003; Project code: ECS00000017—this research topic offers a comprehensive review of the state of the art in terms of research on processes such as increases in gut permeability, inflammation, oxidative stress, and microbiota composition and their impact on the gut–brain axis. Deepening understanding of how the gut–brain axis is influenced by the gut microbiota and its metabolites and which enzymes/pathways are involved could be beneficial for the design of new treatment protocols and to obtain better outcomes for certain related ailments. Several approaches involving probiotics, prebiotics, and dietary interventions are being researched in order to manipulate the gut microbiota and the evolution of related diseases. Natural and synthetic compounds can finely tune probiotic growth, metabolism, biofilm-producing capability, and colonization, unravelling the optimal growth conditions of different microbial species in counteracting dysbiosis, oxidative stress, inflammation, and host–probiotic interaction, positively modulating communication with the brain. In addition, on the one hand, some dietary compounds can exert anti-inflammatory and antioxidant activities, immunomodulating host response, and, on the other hand, they can exert a prebiotic effect, collectively preventing or halting dysbiosis-related symptoms.

Dr. Simone Carradori
Dr. Annalisa Chiavaroli
Dr. Alessandra Ammazzalorso
Dr. Marialucia Gallorini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicinal chemistry
  • enzyme modulators
  • neurodegenerative disorders
  • microbiota
  • gut–brain axis
  • inflammation
  • probiotic metabolomics
  • prebiotics
  • postbiotics
  • oxidative stress

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

22 pages, 937 KiB  
Review
Early-Life Prevention of Cardiovascular–Kidney–Metabolic Syndrome: The DOHaD Perspective on Resveratrol and Short-Chain Fatty Acids
by Chien-Ning Hsu, Ying-Jui Lin, Chih-Yao Hou, Yu-Wei Chen and You-Lin Tain
Antioxidants 2025, 14(7), 851; https://doi.org/10.3390/antiox14070851 - 10 Jul 2025
Viewed by 769
Abstract
Cardiovascular–kidney–metabolic (CKM) syndrome underscores the interconnected biology of cardiovascular disease, kidney disease, and metabolic disorders such as obesity and type 2 diabetes. Although now recognized as a growing global health burden, accumulating preclinical evidence suggests that CKM syndrome may originate in early life—a [...] Read more.
Cardiovascular–kidney–metabolic (CKM) syndrome underscores the interconnected biology of cardiovascular disease, kidney disease, and metabolic disorders such as obesity and type 2 diabetes. Although now recognized as a growing global health burden, accumulating preclinical evidence suggests that CKM syndrome may originate in early life—a concept rooted in the developmental origins of health and disease (DOHaD) framework. Animal studies have greatly enhanced our comprehension of these mechanisms, emphasizing the promise of early interventions that focus on antioxidants and gut microbiota modulation to mitigate the development of CKM conditions. Resveratrol, a natural antioxidant and prebiotic, alongside short-chain fatty acids (SCFAs), a postbiotic, have demonstrated the ability to modulate gut microbiota and oxidative stress in experimental models. Various resveratrol derivatives have also been engineered to improve bioavailability, though their effects remain largely confined to animal studies. This review synthesizes preclinical findings on the impact of perinatal oxidative stress and gut dysbiosis on CKM outcomes, critically examining the roles of resveratrol, SCFAs, and their derivatives in animal models. Finally, we highlight the significant translational gap between experimental research and clinical application, underscoring the need for human studies to validate these early-life intervention strategies. Full article
Show Figures

Figure 1

Back to TopTop