Modulation of Gut Microbiota and Oxidative Stress to Counteract or Prevent Human Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 1824
Special Issue Editors
Interests: natural compounds; medicinal chemistry; food chemistry; antioxidants; antimicrobials; anti-inflammatory; anticancer; extraction; bioactive compounds; nutraceutical; well-being; food supplement; functional food
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Interests: food compounds; pharma-toxicological evaluation of herbal extracts and natural compounds
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Interests: medicinal chemistry; drug discovery; aromatase inhibitors; PPAR ligands; anticancer agents
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Interests: inflammation; hyaluronic acid; biomaterials; oxidative stress; tendons
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Special Issue Information
Dear Colleagues,
Several recent works have emphasized links between the gut and the brain, and the gut microbiota has been shown to play an essential role in neurodegenerative disorders. Moreover, in patients affected by neurodegenerative disorders, an imbalanced gut microbiota has been demonstrated to be a consequence of chronic neuroinflammation. Within the framework of the “THE - Tuscany Health Ecosystem” project, funded by the European Union—NextGenerationEU; MACMI CUP: D73C24000960003; Project code: ECS00000017—this research topic offers a comprehensive review of the state of the art in terms of research on processes such as increases in gut permeability, inflammation, oxidative stress, and microbiota composition and their impact on the gut–brain axis. Deepening understanding of how the gut–brain axis is influenced by the gut microbiota and its metabolites and which enzymes/pathways are involved could be beneficial for the design of new treatment protocols and to obtain better outcomes for certain related ailments. Several approaches involving probiotics, prebiotics, and dietary interventions are being researched in order to manipulate the gut microbiota and the evolution of related diseases. Natural and synthetic compounds can finely tune probiotic growth, metabolism, biofilm-producing capability, and colonization, unravelling the optimal growth conditions of different microbial species in counteracting dysbiosis, oxidative stress, inflammation, and host–probiotic interaction, positively modulating communication with the brain. In addition, on the one hand, some dietary compounds can exert anti-inflammatory and antioxidant activities, immunomodulating host response, and, on the other hand, they can exert a prebiotic effect, collectively preventing or halting dysbiosis-related symptoms.
Dr. Simone Carradori
Dr. Annalisa Chiavaroli
Dr. Alessandra Ammazzalorso
Dr. Marialucia Gallorini
Guest Editors
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Keywords
- medicinal chemistry
- enzyme modulators
- neurodegenerative disorders
- microbiota
- gut–brain axis
- inflammation
- probiotic metabolomics
- prebiotics
- postbiotics
- oxidative stress
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