Redox Regulation in Inflammation and Disease—3rd Edition
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 20 October 2025 | Viewed by 1589
Special Issue Editors
Interests: redox regulation; signal transduction; TRX family proteins; (neuro-) inflammation; cell communication; tumor–stroma crosstalk; neutrophil biology; translational immunology
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegenerative diseases; axonal transport; redox regulation; mitochondrial homeostasis; TRX family proteins
Special Issue Information
Dear Colleagues,
We differentiate between oxidative eu- and distress, recognizing the role of various factors such as i) the regulated enzymatic production and decay of specific reactive oxygen species (ROS), ii) their role as second messengers, and iii) the presence of regulatory thiol switches and their function in redox-mediated signaling.
Specific reactive species, including hydrogen peroxide, hydrogen sulfide, and nitric oxide, are essential for physiological processes including metabolism and signal transduction, as well as cell proliferation, differentiation, and death. Redox regulation of (membrane) proteins, enzymes, and transcription factors such as NFκB is crucial for the chemotaxis and activation of immune cells, the production and release of immune mediators, and cell communication within distinct physiological and pathological microenvironmental niches. Interestingly, extracellular redox proteins, low-molecular-weight thiols, and thiol switches can also affect signal transduction and cell communication.
Changes in the expression, protein levels, or distribution of specific redox proteins can be assessed using histological techniques. These changes have been associated with many disorders linked to ischemia and inflammation and more specifically to distinct subpopulations of immune cells. Redox changes can be analyzed in body fluids and isolated immune cell populations without using invasive and expensive techniques, maintaining their potential for developing new preventive and diagnostic tools and innovative treatments.
For this Special Issue, we invite researchers to provide original research articles that report results combining the topics of redox regulation, inflammatory signaling, and translational immunology. We encourage studies that highlight the role of specific reactive species, redox proteins, and/or thiol switches. Additionally, we welcome clinical studies demonstrating significant changes in the levels or activities of i) redox proteins, ii) low-molecular-weight thiols, and/or iii) altered redox states of proteins in diseases linked to inflammation or neuroinflammation. Review articles discussing the current state of the art are also welcome.
Yours faithfully,
Dr. Eva-Maria Hanschmann
Guest Editor
Dr. Mariana Ines Holubiec
Dr. Christoph Hudemann
Guest Editor Assistants
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- redox signaling
- reactive oxygen and nitrogen species
- inflammation
- signal transduction
- thiol switches
- regulation of immune cells
- translational immunology
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