New Insight into Redox Homeostasis and Oxidative Stress in Health and Disease: Focus on Cardiac and Vascular Function

Dear Colleagues,

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a fundamental role in maintaining cardiovascular homeostasis through redox signaling mechanisms that regulate vascular tone, myocardial function, metabolic adaptation, and cell growth and survival, among other processes. Under physiological conditions, ROS/RNS signaling is subject to tight spatiotemporal regulation and is intimately integrated into metabolic networks. However, the dysregulation of these processes can shift cellular homeostasis towards oxidative or nitrosative stress, promoting endothelial dysfunction, inflammation, fibrosis, cellular senescence, and cell death, as observed in cardiovascular diseases such as atherosclerosis, hypertension, stroke, myocardial infarction, and heart failure. Clinical trials indiscriminately suppressing ROS/RNS pathways have yielded inconsistent results, highlighting the challenge of selectively modulating redox balance without disrupting essential physiological signaling. Furthermore, the paucity of research in areas such as sex-specific redox dynamics, genetically determined redox profiles, ROS/RNS interactions with metabolic pathways, and the absence of reliable, actionable biomarkers for patient stratification or therapy monitoring suggests additional avenues for investigation. The objective of this Special Issue is to promote this paradigm shift, which may entail the transformation of redox-based interventions into clinically effective strategies for the prevention and treatment of cardiovascular disease. We invite you to submit your latest research findings or a review article to this Special Issue.

Prof. Dr. István Szokodi
Prof. Dr. Endre Sulyok
Guest Editors

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